Abstract:
:Monitoring of disease/therapeutic conditions is an important application of circulating tumor DNA (ctDNA). We devised numerical indices, based on ctDNA dynamics, for therapeutic response and disease progression. 52 lung cancer patients subjected to the EGFR-TKI treatment were prospectively collected, and ctDNA levels represented by the activating and T790M mutations were measured using deep sequencing. Typically, ctDNA levels decreased sharply upon initiation of EGFR-TKI, however this did not occur in progressive disease (PD) cases. All 3 PD cases at initiation of EGFR-TKI were separated from other 27 cases in a two-dimensional space generated by the ratio of the ctDNA levels before and after therapy initiation (mutation allele ratio in therapy, MART) and the average ctDNA level. For responses to various agents after disease progression, PD/stable disease cases were separated from partial response cases using MART (accuracy, 94.7%; 95% CI, 73.5-100). For disease progression, the initiation of ctDNA elevation (initial positive point) was compared with the onset of objective disease progression. In 11 out of 28 eligible patients, both occurred within ±100 day range, suggesting a detection of the same change in disease condition. Our numerical indices have potential applicability in clinical practice, pending confirmation with designed prospective studies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kato K,Uchida J,Kukita Y,Kumagai T,Nishino K,Inoue T,Kimura M,Oba S,Imamura Fdoi
10.1038/srep29093subject
Has Abstractpub_date
2016-07-06 00:00:00pages
29093issn
2045-2322pii
srep29093journal_volume
6pub_type
杂志文章abstract::There are many types of autoregressive patterns in financial time series, and they form a transmission process. Here, we define autoregressive patterns quantitatively through an econometrical regression model. We present a computational algorithm that sets the autoregressive patterns as nodes and transmissions between...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06290
更新日期:2014-09-05 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-22369-8
更新日期:2018-03-06 00:00:00
abstract::The Irish Travellers are a population with a history of nomadism; consanguineous unions are common and they are socially isolated from the surrounding, 'settled' Irish people. Low-resolution genetic analysis suggests a common Irish origin between the settled and the Traveller populations. What is not known, however, i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42187
更新日期:2017-02-09 00:00:00
abstract::MicroRNAs (miRNAs) are small, non-coding RNAs that regulate a variety of biological processes. Recently, human liver-specific miRNA miR-122 has been reported to facilitate hepatitis C virus (HCV) replication in liver cells. HCV is one of the leading causes of liver diseases worldwide. In Pakistan, the estimated preval...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21510
更新日期:2016-02-22 00:00:00
abstract::Previous studies have shown that rabbit IgG antibodies against Schistosoma mansoni egg antigens (SmSEA) cross-react with allergens in natural rubber latex, peanuts and grass and tree pollens. Here we describe antigenic molecules that cross-react with rabbit anti-S. mansoni IgG antibodies in extracts of the house dust ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59892-6
更新日期:2020-02-25 00:00:00
abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-017-14857-0
更新日期:2017-11-16 00:00:00
abstract::Dyslipidemia and statin use have been associated with colorectal cancer (CRC), but prospective studies have shown mixed results. We aimed to determine whether dyslipidemia is causally linked to CRC risk using a Mendelian randomization approach and to explore the association of statins with CRC. A case-control study wa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49880-w
更新日期:2019-09-16 00:00:00
abstract::From mid-May to August 2011, extreme runoff in the Columbia River ranged from 14,000 to over 17,000 m(3)/s, more than two standard deviations above the mean for this period. The extreme runoff was the direct result of both melting of anomalously high snowpack and rainfall associated with the 2010-2011 La Niña. The eff...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17145
更新日期:2015-11-26 00:00:00
abstract::Voltage-gated sodium (NaV) channels have been related with cell migration and invasiveness in human cancers. We previously reported the contribution of NaV1.6 channels activity with the invasion capacity of cervical cancer (CeCa) positive to Human Papilloma Virus type 16 (HPV16), which accounts for 50% of all CeCa cas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31364-y
更新日期:2018-08-29 00:00:00
abstract::The biochemical abnormalities and oxidative stress during pathogenesis of hepatic fibrosis could lead to alteration of trace elements. We studied the alteration of major trace elements during the pathogenesis of N-nitrosodimethylamine (NDMA)-induced hepatic fibrosis in rats. The biochemical and pathological indices of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37516-4
更新日期:2019-01-24 00:00:00
abstract::Climate change significantly affects geographic distribution of plants pests and diseases worldwide. Understanding the influence of future climate change on the suitable areas of Diaphorina citri (Kuwayama) in our country and taking timely countermeasures are crucial for improving the effectiveness of control of pest....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66274-5
更新日期:2020-06-08 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-60917-3
更新日期:2020-03-06 00:00:00
abstract::TRAF-interacting protein with a forkhead-associated (FHA) domain (TIFA), originally identified as an adaptor protein of TRAF6, has recently been shown to be involved in innate immunity, induced by a pathogen-associated molecular pattern (PAMP). ADP-β-D-manno-heptose, a newly identified PAMP, binds to alpha-kinase 1 (A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61972-6
更新日期:2020-03-20 00:00:00
abstract::Saccharomyces cerevisiae strains vary in their ability to develop and enhance sensory attributes of alcoholic beverages and are often found growing in mixed strain fermentations; however, quantifying individual strains is challenging due to quantification inaccuracies, low marker longevity, and compromised kinetics. W...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06971
更新日期:2014-11-10 00:00:00
abstract::Land cover change analyses are common and, especially in the absence of explanatory variables, they are mainly carried out by employing qualitative methods such as transition matrices or raster operations. These methods do not provide any estimation of the statistical significance of the changes, or the uncertainty of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35319-1
更新日期:2018-11-16 00:00:00
abstract::Entamoeba possesses a highly divergent mitochondrion-related organelle known as the mitosome. Here, we report the discovery of a novel protein in Entamoeba, which we name Mitosomal β-barrel Outer Membrane Protein of 30 kDa (MBOMP30). Initially identified through in silico analysis, we experimentally confirmed that MBO...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08545
更新日期:2015-02-25 00:00:00
abstract::The ionizing radiation in aqueous solutions of gold nanoparticles, stabilized by electrostatic non-covalent intermolecular forces and steric interactions, with antimicrobial compounds, are investigated with picosecond pulse radiolysis techniques. Upon pulse radiolysis of an aqueous solution containing very low concent...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25711-2
更新日期:2018-05-08 00:00:00
abstract::Rodent species like Myodes glareolus and Microtus spp. are natural reservoirs for many zoonotic pathogens causing human diseases and are gaining increasing interest in the field of eco-immunology as candidate animal models. Despite their importance the lack of immunological reagents has hampered research in these anim...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21143-0
更新日期:2018-02-12 00:00:00
abstract::Type I interferons, particularly interferon-alpha (IFN-α), play a vital role in the host's anti-viral defenses by interfering with viral replication. However, the virus rapidly evolves to exploit the IFN-α response for its replication, spread, and pathogenic function. In this study, we attempted to determine IFN-α sus...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59596-x
更新日期:2020-02-17 00:00:00
abstract::Hollow microporous organic nanorods (HMORs) with hypercrosslinked polymer (HCPs) shells were synthesized through emulsion polymerization followed by hypercrosslinking. The HMORs have tunable aspect ratios, high BET surface areas and monodispersed morphologies, showing good performance in gas adsorpion. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31359
更新日期:2016-08-10 00:00:00
abstract::Monolayer germanene, a novel graphene-like germanium allotrope akin to silicene has been recently grown on metallic substrates. Lying directly on the metal surfaces the reconstructed atom-thin sheets are prone to lose the massless Dirac fermion character and unique associated physical properties of free standing germa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20714
更新日期:2016-02-10 00:00:00
abstract::Wolfram syndrome (WS) is a rare neurodegenerative disorder that is mainly characterized by diabetes mellitus, optic nerve atrophy, deafness, and progressive brainstem degeneration. Treatment with GLP-1 receptor agonists has shown a promising anti-diabetic effect in WS treatment in both animal models and in human patie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52295-2
更新日期:2019-10-31 00:00:00
abstract::In this study, a simple technique was developed for the electrochemical detection of anionic analytes in weakly supported media. This was conducted by the use of electrochemical paper-based analytical devices (ePADs). A sensing platform was modified with nereistoxin and used to determine nitrite as a case study. The e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71365-4
更新日期:2020-09-03 00:00:00
abstract::Arthroplasty is a surgical procedure to restore the function of the joint of patient suffering from knee osteoarthritis. However, postoperative functional deficits are reported even after a rehabilitation program. In order to determine the origin of functional deficits of patient suffering from knee osteoarthritis and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62146-0
更新日期:2020-03-24 00:00:00
abstract::In this report, we propose and demonstrate an air-mode photonic crystal ring resonator (PhCRR) on silicon-on-insulator platform. Air mode is utilized to confine the optical field into photonic crystal (PhC) air holes, which is confirmed by the three-dimensional finite-difference time-domain simulation. PhCRR structure...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19999
更新日期:2016-01-28 00:00:00
abstract::Many studies have revealed the cognitive decline induced by microwave radiation. However, the systematic study on dose-dependent, frequency-dependent and accumulative effects of microwave exposure at different frequencies was lacking. Here, we studied the relationship between the effects and the power and frequency of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11420-9
更新日期:2017-09-07 00:00:00
abstract::Kidney dysfunction, a deleterious effect of obesity, is now recognized as a relevant health risk. Chemokine (C-C Motif) Ligand 2 (CCL2) is one of the critical chemokines that play a vital role in the development of obesity-related metabolic disease. We aim to measure the changes in urinary CCL2 in our patients before ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57763-8
更新日期:2020-01-21 00:00:00
abstract::Neuromuscular impairment requires adherence to a rehabilitation regimen for maximum recovery of motor function. Consumer-grade game controllers have emerged as a viable means to relay supervised physical therapy to patients' homes, thereby increasing their accessibility to healthcare. These controllers allow patients ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59927-y
更新日期:2020-02-28 00:00:00
abstract::Copper ions play a vital role in a variety of fundamental physiological processes not only in human beings and plants, but also for extensive insects and microorganisms. In this paper, a novel water-soluble ruthenium(II) complex as a turn-on copper(II) ions luminescent sensor based on o-(phenylazo)aniline was designed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08172
更新日期:2015-02-02 00:00:00
abstract::Models on how perceptual and cognitive information on others' mental states are treated by the cognitive architecture are often framed as duplex models considering two independent systems. In the context of the neuroscience of empathy analogous systems have been described. Using event-related potentials (i.e., ERPs) t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07424
更新日期:2014-12-11 00:00:00