Observation of mesenteric microcirculatory disturbance in rat by laser oblique scanning optical microscopy.

Abstract:

:Ischemia-reperfusion (I/R) injury model has been widely applied to the study of microcirculation disturbance. In this work, we used laser oblique scanning optical microscopy (LOSOM) to observe the microcirculation system in the mesentery of rat model. Utilizing a localized point-scanning detection scheme, high-contrast images of leukocytes were obtained. The extended detection capability facilitated both the automatic in vivo cell counting and the accurate measurement of the rolling velocity of leukocytes. Statistical analysis of the different treatment groups suggested that the distinction between I/R and sham groups with time lapse is significant.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Ding Y,Zhang Y,Peng T,Lu Y,Jin D,Ren Q,Liu Y,Han J,Xi P

doi

10.1038/srep01762

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

1762

issn

2045-2322

pii

srep01762

journal_volume

3

pub_type

杂志文章
  • Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.

    abstract::Maternal overnutrition increases the risk of long-term metabolic dysfunction in offspring. Exercise improves metabolism partly by upregulating mitochondrial biogenesis or function, via increased levels of nicotinamide adenine dinucleotide (NAD+). We have shown that the NAD+ precursor, nicotinamide mononucleotide (NMN)...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14866-z

    authors: Uddin GM,Youngson NA,Doyle BM,Sinclair DA,Morris MJ

    更新日期:2017-11-08 00:00:00

  • Neutrophil Extracellular Traps protein composition is specific for patients with Lupus nephritis and includes methyl-oxidized αenolase (methionine sulfoxide 93).

    abstract::NETs constitute a network of DNA and proteins released by neutrophils in response to infectious and immunologic triggers. NET proteins are recognized as autoantigens in ANCA vasculitis; limited knowledge is available in other autoimmune pathologies. The composition of NETs produced ex vivo by resting and Phorbol-myris...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-019-44379-w

    authors: Bruschi M,Petretto A,Santucci L,Vaglio A,Pratesi F,Migliorini P,Bertelli R,Lavarello C,Bartolucci M,Candiano G,Prunotto M,Ghiggeri GM

    更新日期:2019-05-28 00:00:00

  • In situ response of Antarctic under-ice primary producers to experimentally altered pH.

    abstract::Elevated atmospheric CO2 concentrations are contributing to ocean acidification (reduced seawater pH and carbonate concentrations), with potentially major ramifications for marine ecosystems and their functioning. Using a novel in situ experiment we examined impacts of reduced seawater pH on Antarctic sea ice-associat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42329-0

    authors: Cummings VJ,Barr NG,Budd RG,Marriott PM,Safi KA,Lohrer AM

    更新日期:2019-04-15 00:00:00

  • Yap/Taz transcriptional activity in endothelial cells promotes intramembranous ossification via the BMP pathway.

    abstract::Osteogenesis is categorized into two groups based on developmental histology, intramembranous and endochondral ossification. The role of blood vessels during endochondral ossification is well known, while their role in intramembranous ossification, especially the intertissue pathway, is poorly understood. Here, we dem...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27473

    authors: Uemura M,Nagasawa A,Terai K

    更新日期:2016-06-07 00:00:00

  • Distinguishing extant elephants ivory from mammoth ivory using a short sequence of cytochrome b gene.

    abstract::Trade in ivory from extant elephant species namely Asian elephant (Elephas maximus), African savanna elephant (Loxodonta africana) and African forest elephant (Loxodonta cyclotis) is regulated internationally, while the trade in ivory from extinct species of Elephantidae, including woolly mammoth, is unregulated. This...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55094-x

    authors: Ngatia JN,Lan TM,Ma Y,Dinh TD,Wang Z,Dahmer TD,Chun Xu Y

    更新日期:2019-12-11 00:00:00

  • Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy.

    abstract::The aims of the study were to clarify the impact of storage time and centrifugation strategy on brain-derived neurotrophic factor (BDNF) levels in human serum and plasma samples. In addition, we analyzed associations between BDNF levels, cardiorespiratory fitness and waist circumference. Seventeen healthy males (25.2 ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45976-5

    authors: Gejl AK,Enevold C,Bugge A,Andersen MS,Nielsen CH,Andersen LB

    更新日期:2019-07-04 00:00:00

  • Microsatellite Borders and Micro-sequence Conservation in Juglans.

    abstract::Walnuts (Juglans spp.) are economically important nut and timber species with a worldwide distribution. Using the published Persian walnut genome as a reference for the assembly of short reads from six Juglans species and several interspecific hybrids, we identified simple sequence repeats in 12 Juglans nuclear and or...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39793-z

    authors: Ebrahimi A,Mathur S,Lawson SS,LaBonte NR,Lorch A,Coggeshall MV,Woeste KE

    更新日期:2019-03-06 00:00:00

  • Evidence of s-wave superconductivity in the noncentrosymmetric La7Ir3.

    abstract::Superconductivity in noncentrosymmetric compounds has attracted sustained interest in the last decades. Here we present a detailed study on the transport, thermodynamic properties and the band structure of the noncentrosymmetric superconductor La 7 Ir 3 (T c  ~ 2.3 K) that was recently proposed to break the time-rever...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-19042-x

    authors: Li B,Xu CQ,Zhou W,Jiao WH,Sankar R,Zhang FM,Hou HH,Jiang XF,Qian B,Chen B,Bangura AF,Xu X

    更新日期:2018-01-12 00:00:00

  • Identification of key influence factors and an empirical formula for spring snowmelt-runoff: A case study in mid-temperate zone of northeast China.

    abstract::Because of the unique climate characteristics, the runoff law in mid-temperate zone is very different from other regions in spring. Accurate runoff simulation and forecasting is of great importance to spring flood control and efficient use of water resources. Baishan reservoir is located in the upper Second Songhua Ri...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35282-x

    authors: Tian L,Li H,Li F,Li X,Du X,Ye X

    更新日期:2018-11-16 00:00:00

  • Acoustic frequency combs using gas bubble cluster oscillations in liquids: a proof of concept.

    abstract::We propose a new approach to the generation of acoustic frequency combs (AFC)-signals with spectra containing equidistant coherent peaks. AFCs are essential for a number of sensing and measurement applications, where the established technology of optical frequency combs suffers from fundamental physical limitations. O...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79567-6

    authors: Nguyen BQH,Maksymov IS,Suslov SA

    更新日期:2021-01-08 00:00:00

  • Micelle-stabilized Olfactory Receptors for a Bioelectronic Nose Detecting Butter Flavors in Real Fermented Alcoholic Beverages.

    abstract::A bioelectronic nose device based on micelle-stabilized olfactory receptors is developed for the selective discrimination of a butter flavor substance in commercial fermented alcoholic beverages. In this work, we have successfully overexpressed ODR-10, a type of olfactory receptor, from Caenorhabditis elegans using a ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65900-6

    authors: Shin N,Lee SH,Pham Ba VA,Park TH,Hong S

    更新日期:2020-06-03 00:00:00

  • Quantification of hepatic steatosis in chronic liver disease using novel automated method of second harmonic generation and two-photon excited fluorescence.

    abstract::The presence of hepatic steatosis (HS) is an important histological feature in a variety of liver disease. It is critical to assess HS accurately, particularly where it plays an integral part in defining the disease. Conventional methods of quantifying HS remain semi-quantitative, with potential limitations in precisi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39783-1

    authors: Goh GB,Leow WQ,Liang S,Wan WK,Lim TKH,Tan CK,Chang PE

    更新日期:2019-02-27 00:00:00

  • Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model.

    abstract::In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. However, there are cases in which patients develop progressive visual field loss even though their intraocular pressures ar...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78731-2

    authors: Hasegawa T,Ikeda HO,Iwai S,Sasaoka N,Kakizuka A,Tsujikawa A

    更新日期:2020-12-10 00:00:00

  • The Use of Whole Exome Sequencing in a Cohort of Transgender Individuals to Identify Rare Genetic Variants.

    abstract::Approximately 0.5-1.4% of natal males and 0.2-0.3% of natal females meet DSM-5 criteria for gender dysphoria, with many of these individuals self-describing as transgender men or women. Despite recent improvements both in social acceptance of transgender individuals as well as access to gender affirming therapy, progr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53500-y

    authors: Theisen JG,Sundaram V,Filchak MS,Chorich LP,Sullivan ME,Knight J,Kim HG,Layman LC

    更新日期:2019-12-27 00:00:00

  • Switching of spins and entanglement in surface-supported antiferromagnetic chains.

    abstract::Previous experimental studies discovered universal growth of chains and nanowires of various chemical elements on a corrugated molecular network of Cu3N on the Cu(110). Herein, performing combined ab initio and quantum Hamiltonian studies we demonstrate that such chains can be used for a fast spin switching and entang...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02972-x

    authors: Sivkov IN,Bazhanov DI,Stepanyuk VS

    更新日期:2017-06-05 00:00:00

  • The effectiveness of virtual reality based interventions for symptoms of anxiety and depression: A meta-analysis.

    abstract::We report a meta-analysis of virtual reality (VR) interventions for anxiety and depression outcomes, as well as treatment attrition. We included randomized controlled trials comparing VR interventions, alone or in combination, to control conditions or other active psychological interventions. Effects sizes (Hedges' g)...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/s41598-018-28113-6

    authors: Fodor LA,Coteț CD,Cuijpers P,Szamoskozi Ș,David D,Cristea IA

    更新日期:2018-07-09 00:00:00

  • Prognostic relevance of UCH-L1 and α-internexin in pancreatic neuroendocrine tumors.

    abstract::Prognostic biomarkers for the pancreatic neuroendocrine tumors are needed. Proteomic study on insulinoma has been rarely reported. We identified the differential expression of proteins between insulinoma and their paired tissues by proteomic analysis, and evaluated the prognostic significance of specific proteins in p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02051-1

    authors: Song YL,Yu R,Qiao XW,Bai CM,Lu CM,Xiao Y,Zhong DR,Chen J,Zhao YP,Zhang TP,Song TT,Gao HL,Wan YH,Shen L,Chen J,Lv B,Hao JJ,Zhang Y,Tang L,Chen YJ

    更新日期:2017-05-19 00:00:00

  • Prognostic significance of Rab27 expression in solid cancer: a systematic review and meta-analysis.

    abstract::Rab27 is an essential molecule of vesicle fusion and trafficking in exosome secretion process, which plays important roles in cancer progression and metastasis. Recent studies reported that Rab27 expression is also associated with cancer prognosis. Therefore, we performed a meta-analysis to reveal the prognostic signi...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/s41598-020-71104-9

    authors: Koh HM,Jang BG,Kim DC

    更新日期:2020-08-24 00:00:00

  • An atypical phosphodiesterase capable of degrading haloalkyl phosphate diesters from Sphingobium sp. strain TCM1.

    abstract::Sphingobium sp. strain TCM1 can degrade tris(2-chloroethyl) phosphate (TCEP) to inorganic phosphate and 2-chloroethanol. A phosphotriesterase (PTE), phosphodiesterase (PDE) and phosphomonoesterase (PME) are believed to be involved in the degradation of TCEP. The PTE and PME that respectively catalyze the first and thi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03142-9

    authors: Abe K,Mukai N,Morooka Y,Makino T,Oshima K,Takahashi S,Kera Y

    更新日期:2017-06-06 00:00:00

  • Identification of HLA-A*02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing.

    abstract::Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening acute inflammatory vesiculobullous reactions of the skin and mucous membranes. These severe cutaneous drug reactions are known to be caused by inciting drugs and infectious agents. Previously, we have reported the association of H...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52619-2

    authors: Nakatani K,Ueta M,Khor SS,Hitomi Y,Okudaira Y,Masuya A,Wada Y,Sotozono C,Kinoshita S,Inoko H,Tokunaga K

    更新日期:2019-11-07 00:00:00

  • CRISPR-PCS: a powerful new approach to inducing multiple chromosome splitting in Saccharomyces cerevisiae.

    abstract::PCR-mediated chromosome splitting (PCS) was developed in the yeast Saccharomyces cerevisiae. It is based on homologous recombination and enables division of a chromosome at any point to form two derived and functional chromosomes. However, because of low homologous recombination activity, PCS is limited to a single si...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30278

    authors: Sasano Y,Nagasawa K,Kaboli S,Sugiyama M,Harashima S

    更新日期:2016-08-17 00:00:00

  • Selenite reduction by Shewanella oneidensis MR-1 is mediated by fumarate reductase in periplasm.

    abstract::In situ reduction of selenite to elemental selenium (Se(0)), by microorganisms in sediments and soils is an important process and greatly affects the environmental distribution and the biological effects of selenium. However, the mechanism behind such a biological process remains unrevealed yet. Here we use Shewanella...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03735

    authors: Li DB,Cheng YY,Wu C,Li WW,Li N,Yang ZC,Tong ZH,Yu HQ

    更新日期:2014-01-17 00:00:00

  • Inhibition of Proteasome Activity by Low-dose Bortezomib Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm in Apo E(-/-) Mice.

    abstract::Abdominal aortic aneurysm (AAA) is a leading cause of sudden death in aged people. Activation of ubiquitin proteasome system (UPS) plays a critical role in the protein quality control and various diseases. However, the functional role of UPS in AAA formation remains unclear. In this study, we found that the proteasome...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15730

    authors: Ren H,Li F,Tian C,Nie H,Wang L,Li HH,Zheng Y

    更新日期:2015-10-28 00:00:00

  • Regulation of ribonucleotide synthesis by the Pseudomonas aeruginosa two-component system AlgR in response to oxidative stress.

    abstract::Ribonucleotide reductases (RNR) catalyze the last step of deoxyribonucleotide synthesis, and are therefore essential to DNA-based life. Three forms of RNR exist: classes I, II, and III. While eukaryotic cells use only class Ia RNR, bacteria can harbor any combination of classes, granting them adaptability. The opportu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17917-7

    authors: Crespo A,Pedraz L,Van Der Hofstadt M,Gomila G,Torrents E

    更新日期:2017-12-20 00:00:00

  • Cyclophilin A is associated with peripheral artery disease and chronic kidney disease in geriatrics: The Tianliao Old People (TOP) study.

    abstract::Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09937

    authors: Liu MC,Lee YW,Lee PT,Chang CS,Tai YL,Yu JR,Su XT,Hsu LW,Lin SH,Wu CH,Liu PY

    更新日期:2015-04-24 00:00:00

  • Stereopsis and retinal microstructures following macular hole surgery.

    abstract::The aim of this prospective study was to evaluate the changes in stereopsis in patients who underwent vitrectomy for macular hole (MH) and assess the relationship between stereopsis and retinal microstructures. Fifty-two patients who underwent successful vitrectomy for unilateral MH and 20 control participants were re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76648-4

    authors: Okamoto F,Moriya Y,Sugiura Y,Murakami T,Morikawa S,Hoshi S,Hiraoka T,Oshika T

    更新日期:2020-11-11 00:00:00

  • The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons.

    abstract::SLC7A10 (Asc-1) is a sodium-independent amino acid transporter known to facilitate transport of a number of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-enantiomers. It has been described as a neuronal transporter with a primary role related to modulation of excitatory glutama...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35592

    authors: Ehmsen JT,Liu Y,Wang Y,Paladugu N,Johnson AE,Rothstein JD,du Lac S,Mattson MP,Höke A

    更新日期:2016-10-19 00:00:00

  • The First Two Clostridium difficile Ribotype 027/ST1 Isolates Identified in Beijing, China-an Emerging Problem or a Neglected Threat?

    abstract::Clostridium difficile hyper-virulent ribotype 027 strain has become a significant concern globally, but has rarely been reported in Asian countries including China. Recently, a retrospective single-center study in Beijing, China, detected two ribotype 027 C. difficile isolates from two patients coming for outpatient v...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18834

    authors: Cheng JW,Xiao M,Kudinha T,Xu ZP,Hou X,Sun LY,Zhang L,Fan X,Kong F,Xu YC

    更新日期:2016-01-07 00:00:00

  • Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition.

    abstract::Although optimal therapy for myocardial infarction includes reperfusion to restore blood flow to the ischemic region, ischemia/reperfusion (IR) also initiates an inflammatory response likely contributing to adverse left ventricular (LV) extracellular matrix (ECM) remodeling. Galectin-3 (Gal-3), a β-galactoside-binding...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46119-6

    authors: Ibarrola J,Matilla L,Martínez-Martínez E,Gueret A,Fernández-Celis A,Henry JP,Nicol L,Jaisser F,Mulder P,Ouvrard-Pascaud A,López-Andrés N

    更新日期:2019-07-03 00:00:00

  • Mathematical modeling of the cardiovascular autonomic control in healthy subjects during a passive head-up tilt test.

    abstract::A mathematical model is proposed for the autonomic control of cardiovascular system, which takes into account two separated self-exciting sympathetic control loops of heart rate and peripheral vascular tone. The control loops are represented by self-exciting time-delay systems and their tone depends on activity of the...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71532-7

    authors: Ishbulatov YM,Karavaev AS,Kiselev AR,Simonyan MA,Prokhorov MD,Ponomarenko VI,Mironov SA,Gridnev VI,Bezruchko BP,Shvartz VA

    更新日期:2020-10-05 00:00:00