Inhibition of Proteasome Activity by Low-dose Bortezomib Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm in Apo E(-/-) Mice.

abstract：:Interleukin-36 (IL-36) represents three cytokines, IL-36α, IL-36β and IL-36γ, which bind to the same receptor, IL-1RL2; however, their physiological function(s) remain poorly understood. Here, the role of IL-36 in immunity against HSV-1 was examined using the flank skin infection mouse model. Expression analyses revea...

journal_title：Scientific reports

authors： Milora KA,Uppalapati SR,Sanmiguel JC,Zou W,Jensen LE

更新日期：2017-07-19 00:00:00

abstract：:Sub-gap density of states (DOS) is a key parameter to impact the electrical characteristics of semiconductor materials-based transistors in integrated circuits. Previously, spectroscopy methodologies for DOS extractions include the static methods, temperature dependent spectroscopy and photonic spectroscopy. However, ...

journal_title：Scientific reports

authors： Dai M,Khan K,Zhang S,Jiang K,Zhang X,Wang W,Liang L,Cao H,Wang P,Wang P,Miao L,Qin H,Jiang J,Xue L,Chu J

更新日期：2016-06-14 00:00:00

abstract：:Haloarchaea are unique microorganism's resistant to environmental and osmotic stresses and thrive in their habitats despite extreme fluctuating salinities. In the present study, haloarchaea were isolated from hypersaline thalossohaline salterns of Bhandup, Mumbai, India and were identified as Haloferax prahovense, Hal...

journal_title：Scientific reports

authors： Thombre RS,Shinde VD,Oke RS,Dhar SK,Shouche YS

更新日期：2016-05-27 00:00:00

abstract：:Tin selenide has attracted much research interest due to its unprecedentedly high thermoelectric figure of merit (ZT). For real applications, it is desirable to increase the ZT value in the lower-temperature range, as the peak ZT value currently exists near the melting point. It is shown in this paper that the structu...

journal_title：Scientific reports

authors： Yu H,Dai S,Chen Y

更新日期：2016-05-19 00:00:00

abstract：:Agrosilvopastoral and silvopastoral systems can increase carbon sequestration, offset greenhouse gas (GHG) emissions and reduce the carbon footprint generated by animal production. The objective of this study was to estimate GHG emissions, the tree and grass aboveground biomass production and carbon storage in differe...

journal_title：Scientific reports

authors： Torres CMME,Jacovine LAG,Nolasco de Olivera Neto S,Fraisse CW,Soares CPB,de Castro Neto F,Ferreira LR,Zanuncio JC,Lemes PG

更新日期：2017-12-01 00:00:00

abstract：:Plastic pollution is a rapidly worsening environmental problem, especially in oceanic habitats. Environmental pollution with microplastic particles is also causing food consumed by humans to be increasingly polluted, including table salts. Therefore, we present the first study which focuses only on table salt products...

journal_title：Scientific reports

authors： Lee H,Kunz A,Shim WJ,Walther BA

更新日期：2019-07-12 00:00:00

abstract：:In recent years, numerous methods have emerged for the synthesis of trifluoromethylated arenes based on the late-stage introduction of a trifluoromethyl group onto an aryl ring. In sharp comparison, the synthesis of trifluoromethylated arenes based on the pre-introduction of a trifluoromethyl group onto an "aromatic t...

journal_title：Scientific reports

authors： Dong J,Shi L,Pan L,Xu X,Liu Q

更新日期：2016-06-01 00:00:00

abstract：:To increase the generation efficiency of the terahertz wave in the Y band, the idea of dual-reflector is introduced in the relativistic surface wave oscillator (SWO) with large oversized structures. The dual-reflector and the slow-wave structure (SWS) construct a resonator where the field strength of TM01 mode inside ...

journal_title：Scientific reports

authors： Li S,Wang J,Wang D

更新日期：2020-01-15 00:00:00

abstract：:Quaternized polyacrylic polymer has many applications in water treatment because of its ion exchange effects, but its further industrial applications are largely restricted because of its poor mechanical strength. In this work, a magnetic anion exchange resin with a polyacrylic matrix (MAP) was prepared by incorporati...

journal_title：Scientific reports

authors： Zhang G,Li S,Shuang C,Mu Y,Li A,Tan L

更新日期：2020-03-23 00:00:00

abstract：:Some ant species have multiple worker castes that differ in body size; workers in one caste remain in the colony and those in the other forage outside the colony (caste polyethism). In other species, all workers engage in both tasks, but the younger workers remain in the colony and the older workers forage (age polyet...

journal_title：Scientific reports

authors： Iwasa Y,Yamaguchi S

更新日期：2020-02-24 00:00:00

abstract：:Mamiellophyceae (unicellular green algae) are a key phytoplankton group in coastal waters. Although extensively studied over the last 20 years, the overall oceanic distribution of the major species/clades is still poorly known. To address this problem, we analyzed the 2014 Ocean Sampling Day (OSD) metabarcoding datase...

journal_title：Scientific reports

authors： Tragin M,Vaulot D

更新日期：2019-03-26 00:00:00

abstract：:Particulate matter (PM) induces oxidative stress in vivo, leading to adverse health effects. Oxidative potential (OP) of PM is increasingly studied as a relevant metric for health impact (instead of PM mass concentration) as much of the ambient particle mass do not contribute to PM toxicity. Several assays have been d...

journal_title：Scientific reports

authors： Calas A,Uzu G,Martins JMF,Voisin D,Spadini L,Lacroix T,Jaffrezo JL

更新日期：2017-09-14 00:00:00

abstract：:Mutations affecting the transcription factor FOXP2 cause a rare form of severe speech and language disorder. Although it is clear that sufficient FOXP2 expression is crucial for normal brain development, little is known about how this transcription factor is regulated. To investigate post-translational mechanisms for ...

journal_title：Scientific reports

authors： Estruch SB,Graham SA,Deriziotis P,Fisher SE

更新日期：2016-02-12 00:00:00

abstract：:The introduction of antiretroviral drugs (ARVd) changed the prognosis of HIV infection from a deadly disease to a chronic disease. However, even with undetectable viral loads, patients still develop a wide range of pathologies, including cerebrovascular complications and stroke. It is hypothesized that toxic side effe...

journal_title：Scientific reports

authors： Bertrand L,Dygert L,Toborek M

更新日期：2016-12-23 00:00:00

abstract：:A growing body of research suggests that impaired bladder Cajal-like interstitial cells (ICCs) are a important component in the pathogenesis of diabetes-induced bladder dysfunction, although the molecular mechanisms have not been illustrated completely. The purpose of this study was to examine whether the hyperpolariz...

journal_title：Scientific reports

authors： Dong X,Song Q,Zhu J,Zhao J,Liu Q,Zhang T,Long Z,Li J,Wu C,Wang Q,Hu X,Damaser M,Li L

更新日期：2016-04-28 00:00:00

abstract：:Dysregulation of specific microRNAs or Wnt/β-catenin signaling pathway is critically implicated in the pathogenesis of various renal diseases. However, the relationship between microRNAs and Wnt/β-catenin signaling in diabetes-induced glomerular sclerosis remains unknown. Here, we found that decreased miR-29a expressi...

journal_title：Scientific reports

authors： Hsu YC,Chang PJ,Ho C,Huang YT,Shih YH,Wang CJ,Lin CL

更新日期：2016-07-27 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Wang J,Sun P,Chen Y,Yao H,Wang S

更新日期：2019-12-19 00:00:00

abstract：:Hedgehog (Hh) signaling plays a broad role in the development of many organs including bone and teeth. It is noted that sustained Hh activity in osteoblasts negatively regulates postnatal development in mice. However, it remains unknown whether Hh signaling contributes to cementum formation. In this study, to define t...

journal_title：Scientific reports

authors： Choi H,Liu Y,Yang L,Cho ES

更新日期：2020-04-29 00:00:00

abstract：:Efficient hematopoietic reconstitution of wild type mice requires preconditioning. Established experimental protocols exist to transplant hematopoietic stem cells into lethally irradiated or chemically myeloablated adult mice or unirradiated immunodeficient mice. We sought to develop a protocol to reconstitute immuno-...

journal_title：Scientific reports

authors： Laky K,Dugan P,Frischmeyer-Guerrerio PA

更新日期：2018-08-16 00:00:00

abstract：:Maculinea (=Phengaris) are endangered butterflies that are characterized by a very complex biological cycle. Maculinea larvae behave as obligate parasites whose survival is strictly dependent on both particular food plants and species-specific Myrmica ants. In this interaction, Maculinea caterpillars induce Myrmica wo...

journal_title：Scientific reports

authors： Di Salvo M,Calcagnile M,Talà A,Tredici SM,Maffei ME,Schönrogge K,Barbero F,Alifano P

更新日期：2019-05-29 00:00:00

abstract：:Lepus yarkandensis is a desert hare of the Tarim Basin in western China, and it has strong adaptability to arid environments. Aquaporins (AQPs) are a family of water channel proteins that facilitate transmembrane water transport. Gastrointestinal tract AQPs are involved in fluid absorption in the small intestine and c...

journal_title：Scientific reports

authors： Zhang J,Li S,Deng F,Baikeli B,Yu W,Liu G

更新日期：2019-11-12 00:00:00

abstract：:The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). Here we explored the effects of the...

journal_title：Scientific reports

authors： Eberhardt MJ,Schillers F,Eberhardt EM,Risser L,de la Roche J,Herzog C,Echtermeyer F,Leffler A

更新日期：2017-10-06 00:00:00

abstract：:Discriminating between inherited and non-inherited sporadic hearing loss is challenging. Here, we attempted to delineate genetic inheritance in simplex cases of severe-to-profound congenital hearing loss in Korean children. Variations in SLC26A4 and GJB2 in 28 children with bilateral severe-to-profound non-syndromic h...

journal_title：Scientific reports

authors： Jung J,Lee JS,Cho KJ,Yu S,Yoon JH,Yung Gee H,Choi JY

更新日期：2017-04-06 00:00:00

abstract：:The cholinergic system plays a major anti-inflammatory role in many diseases through acetylcholine (Ach) release after vagus nerve stimulation. Osteoarthritis (OA) is associated with local low-grade inflammation, but the regulatory mechanisms are unclear. Local Ach release could have anti-inflammatory activity since a...

journal_title：Scientific reports

authors： Courties A,Belle M,Senay S,Cambon-Binder A,Sautet A,Chédotal A,Berenbaum F,Sellam J

更新日期：2020-06-01 00:00:00

abstract：:Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants linked to PD in SNCA. However, the consequences of this genetic variabi...

journal_title：Scientific reports

authors： Sharma A,Osato N,Liu H,Asthana S,Dakal TC,Ambrosini G,Bucher P,Schmitt I,Wüllner U

更新日期：2019-12-05 00:00:00

abstract：:The inconsistent findings on the association between COMT (catecholamine-O-methyl-transferase) and suicidal behaviour gave reason to choose a clear phenotype description of suicidal behaviour and take childhood maltreatment as environmental factor into account. The aim of this candidate-gene-association study was to e...

journal_title：Scientific reports

authors： Bernegger A,Kienesberger K,Carlberg L,Swoboda P,Ludwig B,Koller R,Inaner M,Zotter M,Kapusta N,Aigner M,Haslacher H,Kasper S,Schosser A

更新日期：2018-01-12 00:00:00

abstract：:Little information is available on chemical forms of heavy metals on integrate plant roots. KNO3 (1 M), 0.05M EDTA at pH6 and 0.01 M HCl were used sequentially to extract the exchangeable, complexed and precipitated forms of Cu(II) and Cd(II) from soybean roots and then to investigate chemical form distribution of Cu(...

journal_title：Scientific reports

authors： Zhou Q,Liu ZD,Liu Y,Jiang J,Xu RK

更新日期：2016-11-02 00:00:00

abstract：:Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results showed that chroni...

journal_title：Scientific reports

authors： Zhang W,Zhong W,Sun Q,Sun X,Zhou Z

更新日期：2017-08-21 00:00:00

abstract：:A delicate balance between proliferating and differentiating signals is necessary to ensure proper growth and neuronal specification. By studying the developing zebrafish brain, we observed a specific and dynamic expression of a microtubule destabilizer gene, stathmin-like 4 (stmn4), in the dorsal midbrain region. The...

journal_title：Scientific reports

authors： Lin MJ,Lee SJ

更新日期：2016-11-07 00:00:00

abstract：:Sacroiliac (SI) screw loosening may indicate persistent instability, non-union and contribute to pain. Yet, there is no reliable objective measurement technique to detect and monitor SI screw loosening. In 9 cadaveric pelvises one of two SI screw was turned back approximately 20 mm and subsequently assessed by optical...

journal_title：Scientific reports

authors： Pieroh P,Lenk M,Hohmann T,Grunert R,Wagner D,Josten C,Höch A,Böhme J

更新日期：2019-02-28 00:00:00