Inhibition of Proteasome Activity by Low-dose Bortezomib Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm in Apo E(-/-) Mice.

Abstract:

:Abdominal aortic aneurysm (AAA) is a leading cause of sudden death in aged people. Activation of ubiquitin proteasome system (UPS) plays a critical role in the protein quality control and various diseases. However, the functional role of UPS in AAA formation remains unclear. In this study, we found that the proteasome activities and subunit expressions in AAA tissues from human and angiotensin II (Ang II)-infused apolipoprotein E knockout (Apo E(-/-)) mice were significantly increased. To investigate the effect of proteasome activation on the AAA formation, Apo E(-/-) mice were cotreated with bortezomib (BTZ) (a proteasome inhibitor, 50 μg/kg, 2 times per week) and Ang II (1000 ng/kg/min) up to 28 days. Ang II infusion significantly increased the incidence and severity of AAA in Apo E(-/-) mice, whereas BTZ treatment markedly inhibited proteasome activities and prevented AAA formation. Furthermore, BTZ treatment significantly reduced the inflammation, inhibited the metal matrix metalloprotease activity, and reversed the phenotypic SMC modulation in AAA tissue. In conclusion, these results provide a new evidence that proteasome activation plays a critical role in AAA formation through multiple mechanisms, and suggest that BTZ might be a novel therapeutic target for treatment of AAA formation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Ren H,Li F,Tian C,Nie H,Wang L,Li HH,Zheng Y

doi

10.1038/srep15730

subject

Has Abstract

pub_date

2015-10-28 00:00:00

pages

15730

issn

2045-2322

pii

srep15730

journal_volume

5

pub_type

杂志文章
  • Integrated mRNA and microRNA transcriptome analysis reveals miRNA regulation in response to PVA in potato.

    abstract::Potato (Solanum tuberosum L.) is the fourth most important crop worldwide. Potato virus A (PVA) is one of the most harmful viruses infecting potatoes. However, the molecular mechanisms governing the responses to PVA infection in potato at the transcriptional and post-transcriptional levels are not well understood. In ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17059-w

    authors: Li Y,Hu X,Chen J,Wang W,Xiong X,He C

    更新日期:2017-12-05 00:00:00

  • Integrative quantitative-phase and airy light-sheet imaging.

    abstract::Light-sheet microscopy enables considerable speed and phototoxicity gains, while quantitative-phase imaging confers label-free recognition of cells and organelles, and quantifies their number-density that, thermodynamically, is more representative of metabolism than size. Here, we report the fusion of these two imagin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76730-x

    authors: Subedi NR,Jung PS,Bredeweg EL,Nemati S,Baker SE,Christodoulides DN,Vasdekis AE

    更新日期:2020-11-19 00:00:00

  • The m6A-methylase complex recruits TREX and regulates mRNA export.

    abstract::N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic mRNA. This modification has previously been shown to alter the export kinetics for mRNAs though the molecular details surrounding this phenomenon remain poorly understood. Recruitment of the TREX mRNA export complex to mRNA is driven by ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32310-8

    authors: Lesbirel S,Viphakone N,Parker M,Parker J,Heath C,Sudbery I,Wilson SA

    更新日期:2018-09-14 00:00:00

  • Ectopic expression of Snord115 in choroid plexus interferes with editing but not splicing of 5-Ht2c receptor pre-mRNA in mice.

    abstract::Serotonin 5-HT2C receptor is a G-protein coupled excitatory receptor that regulates several biochemical pathways and has been implicated in obesity, mental state, sleep cycles, autism, neuropsychiatric disorders and neurodegenerative diseases. The activity of 5-HT2CR is regulated via alternative splicing and A to I ed...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39940-6

    authors: Raabe CA,Voss R,Kummerfeld DM,Brosius J,Galiveti CR,Wolters A,Seggewiss J,Huge A,Skryabin BV,Rozhdestvensky TS

    更新日期:2019-03-12 00:00:00

  • Mechanisms on the morphology variation of hematite crystals by Al substitution: The modification of Fe and O reticular densities.

    abstract::Al substitution in hematite is ubiquitous in soils. With the increase of Al amount, the hematite morphology changes from rhombohedral crystals to disk-shaped ones, but the underlying mechanism is poorly understood. Herein, a series of Al-substituted hematite were synthesized and characterized by synchrotron X-ray diff...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35960

    authors: Li W,Liang X,An P,Feng X,Tan W,Qiu G,Yin H,Liu F

    更新日期:2016-10-27 00:00:00

  • Author Correction: Magneto-Hybrid Nanofluids Flow via Mixed Convection past a Radiative Circular Cylinder.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-72921-8

    authors: El-Zahar ER,Rashad AM,Saad W,Seddek LF

    更新日期:2020-09-24 00:00:00

  • Sex-biased patterns shaped the genetic history of Roma.

    abstract::The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged into ethnolinguistically distinct migrant groups that spread across the continent. Previous geneti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71066-y

    authors: García-Fernández C,Font-Porterias N,Kučinskas V,Sukarova-Stefanovska E,Pamjav H,Makukh H,Dobon B,Bertranpetit J,Netea MG,Calafell F,Comas D

    更新日期:2020-09-02 00:00:00

  • Simulating thoughts to measure and study internal attention in mental health.

    abstract::Our mind's eye and the role of internal attention in mental life and suffering has intrigued scholars for centuries. Yet, experimental study of internal attention has been elusive due to our limited capacity to control the timing and content of internal stimuli. We thus developed the Simulated Thoughts Paradigm (STP) ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81756-w

    authors: Amir I,Ruimi L,Bernstein A

    更新日期:2021-01-26 00:00:00

  • The ubiquitin ligase Cullin5SOCS2 regulates NDR1/STK38 stability and NF-κB transactivation.

    abstract::SOCS2 is a pleiotropic E3 ligase. Its deficiency is associated with gigantism and organismal lethality upon inflammatory challenge. However, mechanistic understanding of SOCS2 function is dismal due to our unawareness of its protein substrates. We performed a mass spectrometry based proteomic profiling upon SOCS2 depl...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42800

    authors: Paul I,Batth TS,Iglesias-Gato D,Al-Araimi A,Al-Haddabi I,Alkharusi A,Norstedt G,Olsen JV,Zadjali F,Flores-Morales A

    更新日期:2017-02-20 00:00:00

  • Habitual use of GPS negatively impacts spatial memory during self-guided navigation.

    abstract::Global Positioning System (GPS) navigation devices and applications have become ubiquitous over the last decade. However, it is unclear whether using GPS affects our own internal navigation system, or spatial memory, which critically relies on the hippocampus. We assessed the lifetime GPS experience of 50 regular driv...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62877-0

    authors: Dahmani L,Bohbot VD

    更新日期:2020-04-14 00:00:00

  • Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes.

    abstract::To discover epigenetic changes that may underly neuroblastoma pathogenesis, we identified differentially methylated genes in neuroblastoma cells compared to neural crest cells, the presumptive precursors cells for neuroblastoma, by using genome-wide DNA methylation analysis. We previously described genes that were hyp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55382-6

    authors: Almutairi B,Charlet J,Dallosso AR,Szemes M,Etchevers HC,Malik KTA,Brown KW

    更新日期:2019-12-12 00:00:00

  • Author Correction: Impediometric Electrochemical Sensor Based on The Inspiration of Carnation Italian Ringspot Virus Structure to Detect an Attommolar of miR.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-70343-0

    authors: Ghazizadeh E,Moosavifard SE,Daneshmand N,Kaverlavani SK

    更新日期:2020-08-11 00:00:00

  • Structure and piezo-ferroelectricity relationship study of (K0.5Na0.5)0.985La0.005NbO3 epitaxial films deposited on SrTiO3 by sputtering.

    abstract::This work demonstrates that the rf-sputtering technique, combined with appropriate heat treatments, is potentially effective to develop new materials and devices based on oxide-interface and strain engineering. We report a study of the structural-physical properties relationship of high crystalline quality, highly ori...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17767-3

    authors: H Mŏk HL,Martínez-Aguilar E,Gervacio-Arciniega JJ,Vendrell X,Siqueiros-Beltrones JM,Raymond-Herrera O

    更新日期:2017-12-18 00:00:00

  • Gradient confinement induced uniform tensile ductility in metallic glass.

    abstract::Metallic glass (MG) generally fails in a brittle manner under uniaxial tension loading at room temperature. The lack of plastic strain of MG is due to the severe plastic instability via the easily formed one dominate shear band. There have been several approaches to improve the ductility in MG, but achieving uniform t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03319

    authors: Lu XL,Lu QH,Li Y,Lu L

    更新日期:2013-11-25 00:00:00

  • Triangular Black Phosphorus Atomic Layers by Liquid Exfoliation.

    abstract::Few-layer black phosphorus (BP) is the most promising material among the two-dimensional materials due to its layered structure and the excellent semiconductor properties. Currently, thin BP atomic layers are obtained mostly by mechanical exfoliation of bulk BP, which limits applications in thin-film based electronics...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23736

    authors: Seo S,Lee HU,Lee SC,Kim Y,Kim H,Bang J,Won J,Kim Y,Park B,Lee J

    更新日期:2016-03-30 00:00:00

  • Chimeric yellow fever 17D-Zika virus (ChimeriVax-Zika) as a live-attenuated Zika virus vaccine.

    abstract::Zika virus (ZIKV) is an emerging mosquito-borne pathogen representing a global health concern. It has been linked to fetal microcephaly and other birth defects and neurological disorders in adults. Sanofi Pasteur has engaged in the development of an inactivated ZIKV vaccine, as well as a live chimeric vaccine candidat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31375-9

    authors: Giel-Moloney M,Goncalvez AP,Catalan J,Lecouturier V,Girerd-Chambaz Y,Diaz F,Maldonado-Arocho F,Gomila RC,Bernard MC,Oomen R,Delagrave S,Burdin N,Kleanthous H,Jackson N,Heinrichs J,Pugachev KV

    更新日期:2018-09-04 00:00:00

  • Arabidopsis AtERF014 acts as a dual regulator that differentially modulates immunity against Pseudomonas syringae pv. tomato and Botrytis cinerea.

    abstract::ERF transcription factors play critical roles in plant immune responses. Here, we report the function of AtERF014, a nucleus-localized transcriptional activator, in Arabidopsis immunity. Expression of AtERF014 was induced by Pseudomonas syringae pv. tomato (Pst) and Botrytis cinerea (Bc). AtERF014-overexpressing (OE) ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30251

    authors: Zhang H,Hong Y,Huang L,Li D,Song F

    更新日期:2016-07-22 00:00:00

  • Grain boundary oxidation of proton-irradiated nuclear grade stainless steel in simulated primary water of pressurized water reactor.

    abstract::Grain boundary (GB) oxidation of proton-irradiated 304 nuclear grade stainless steel in primary water of pressurized water reactor was investigated. The investigation was conducted by studying microstructure of the oxide and oxide precursor formed at GB on an "atom-by-atom" basis by a combination of atom-probe tomogra...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80600-x

    authors: Deng P,Peng Q,Han EH

    更新日期:2021-01-14 00:00:00

  • Impact of dietary resistant starch type 4 on human gut microbiota and immunometabolic functions.

    abstract::Dietary modulation of the gut microbiota impacts human health. Here we investigated the hitherto unknown effects of resistant starch type 4 (RS4) enriched diet on gut microbiota composition and short-chain fatty acid (SCFA) concentrations in parallel with host immunometabolic functions in twenty individuals with signs...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28797

    authors: Upadhyaya B,McCormack L,Fardin-Kia AR,Juenemann R,Nichenametla S,Clapper J,Specker B,Dey M

    更新日期:2016-06-30 00:00:00

  • N-doped catalytic graphitized hard carbon for high-performance lithium/sodium-ion batteries.

    abstract::Hard carbon attracts wide attentions as the anode for high-energy rechargeable batteries due to its low cost and high theoretical capacities. However, the intrinsically disordered microstructure gives it poor electrical conductivity and unsatisfactory rate performance. Here we report a facile synthesis of N-doped grap...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28310-3

    authors: Wang N,Liu Q,Sun B,Gu J,Yu B,Zhang W,Zhang D

    更新日期:2018-07-02 00:00:00

  • Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2) virus cap-snatching process.

    abstract::The influenza A virus RNA polymerase cleaves the 5' end of host pre-mRNAs and uses the capped RNA fragments as primers for viral mRNA synthesis. We performed deep sequencing of the 5' ends of viral mRNAs from all genome segments transcribed in both human (A549) and mouse (M-1) cells infected with the influenza A/HongK...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06181

    authors: Sikora D,Rocheleau L,Brown EG,Pelchat M

    更新日期:2014-08-26 00:00:00

  • Etiology matters - Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy.

    abstract::This study tested the hypothesis that acquired epileptogenesis is accompanied by DNA methylation changes independent of etiology. We investigated DNA methylation and gene expression in the hippocampal CA3/dentate gyrus fields at 3 months following epileptogenic injury in three experimental models of epilepsy: focal am...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25668

    authors: Dębski KJ,Pitkanen A,Puhakka N,Bot AM,Khurana I,Harikrishnan KN,Ziemann M,Kaspi A,El-Osta A,Lukasiuk K,Kobow K

    更新日期:2016-05-09 00:00:00

  • Palladium/palladium oxide coated electrospun fibers for wearable sweat pH-sensors.

    abstract::The work describes the development of a flexible, hydrogel embedded pH-sensor that can be integrated in inexpensive wearable and non-invasive devices at epidermal level for electrochemical quantification of H+ ions in sweat. Such a device can be useful for swift, real time diagnosis and for monitoring specific conditi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45399-2

    authors: Diculescu VC,Beregoi M,Evanghelidis A,Negrea RF,Apostol NG,Enculescu I

    更新日期:2019-06-20 00:00:00

  • Deep Learning Fundus Image Analysis for Diabetic Retinopathy and Macular Edema Grading.

    abstract::Diabetes is a globally prevalent disease that can cause visible microvascular complications such as diabetic retinopathy and macular edema in the human eye retina, the images of which are today used for manual disease screening and diagnosis. This labor-intensive task could greatly benefit from automatic detection usi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47181-w

    authors: Sahlsten J,Jaskari J,Kivinen J,Turunen L,Jaanio E,Hietala K,Kaski K

    更新日期:2019-07-24 00:00:00

  • Targeting BMK1 Impairs the Drug Resistance to Combined Inhibition of BRAF and MEK1/2 in Melanoma.

    abstract::Combined inhibition of BRAF and MEK1/2 (CIBM) improves therapeutic efficacy of BRAF-mutant melanoma. However, drug resistance to CIBM is inevitable and the drug resistance mechanisms still remain to be elucidated. Here, we show that BMK1 pathway contributes to the drug resistance to CIBM. Considering that ERK1/2 pathw...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46244

    authors: Song C,Wang L,Xu Q,Wang K,Xie D,Yu Z,Jiang K,Liao L,Yates JR,Lee JD,Yang Q

    更新日期:2017-04-07 00:00:00

  • Retention Mechanisms of Citric Acid in Ternary Kaolinite-Fe(III)-Citrate Acid Systems Using Fe K-edge EXAFS and L3,2-edge XANES Spectroscopy.

    abstract::Organic carbon (OC) stability in tropical soils is strongly interlinked with multivalent cation interaction and mineral association. Low molecular weight organic acids (LMWOAs) represent the readily biodegradable OC. Therefore, investigating retention mechanisms of LMWOAs in mineral-cation-LMWOAs systems is critical t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26127

    authors: Yang J,Wang J,Pan W,Regier T,Hu Y,Rumpel C,Bolan N,Sparks D

    更新日期:2016-05-23 00:00:00

  • Taming of Modulation Instability by Spatio-Temporal Modulation of the Potential.

    abstract::Spontaneous pattern formation in a variety of spatially extended nonlinear systems always occurs through a modulation instability, sometimes called Turing instability: the homogeneous state of the system becomes unstable with respect to growing modulation modes. Therefore, the manipulation of the modulation instabilit...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13268

    authors: Kumar S,Herrero R,Botey M,Staliunas K

    更新日期:2015-08-19 00:00:00

  • Identification of the amino acid position controlling the different enzymatic activities in walnut tyrosinase isoenzymes (jrPPO1 and jrPPO2).

    abstract::Polyphenol oxidases (PPOs) are ubiquitously distributed among plants, bacteria, fungi and animals. They catalyze the hydroxylation of monophenols (monophenolase activity) and the oxidation of o-diphenols (diphenolase activity) to o-quinones. PPOs are commonly present as an isoenzyme family. In walnut (Juglans regia), ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-67415-6

    authors: Panis F,Rompel A

    更新日期:2020-07-02 00:00:00

  • Broadband and Broad-angle Polarization-independent Metasurface for Radar Cross Section Reduction.

    abstract::In this work, a broadband and broad-angle polarization-independent random coding metasurface structure is proposed for radar cross section (RCS) reduction. An efficient genetic algorithm is utilized to obtain the optimal layout of the unit cells of the metasurface to get a uniform backscattering under normal incidence...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40782

    authors: Sun H,Gu C,Chen X,Li Z,Liu L,Xu B,Zhou Z

    更新日期:2017-01-20 00:00:00

  • Light sintering of ultra-smooth and robust silver nanowire networks embedded in poly(vinyl-butyral) for flexible OLED.

    abstract::A conductive, uniform, and ultra-smooth flexible transparent composite film is produced by embedding silver nanowires (AgNWs) into poly(vinyl-butyral) (PVB) without pressure or high-temperature annealing. The adhesion of AgNWs was greatly improved by embedding them in PVB, and surface roughness and sheet resistance (R...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32590-0

    authors: Lee DJ,Oh Y,Hong JM,Park YW,Ju BK

    更新日期:2018-09-21 00:00:00