Abstract：
:Abdominal aortic aneurysm (AAA) is a leading cause of sudden death in aged people. Activation of ubiquitin proteasome system (UPS) plays a critical role in the protein quality control and various diseases. However, the functional role of UPS in AAA formation remains unclear. In this study, we found that the proteasome activities and subunit expressions in AAA tissues from human and angiotensin II (Ang II)-infused apolipoprotein E knockout (Apo E(-/-)) mice were significantly increased. To investigate the effect of proteasome activation on the AAA formation, Apo E(-/-) mice were cotreated with bortezomib (BTZ) (a proteasome inhibitor, 50 μg/kg, 2 times per week) and Ang II (1000 ng/kg/min) up to 28 days. Ang II infusion significantly increased the incidence and severity of AAA in Apo E(-/-) mice, whereas BTZ treatment markedly inhibited proteasome activities and prevented AAA formation. Furthermore, BTZ treatment significantly reduced the inflammation, inhibited the metal matrix metalloprotease activity, and reversed the phenotypic SMC modulation in AAA tissue. In conclusion, these results provide a new evidence that proteasome activation plays a critical role in AAA formation through multiple mechanisms, and suggest that BTZ might be a novel therapeutic target for treatment of AAA formation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ren H,Li F,Tian C,Nie H,Wang L,Li HH,Zheng Ydoi
10.1038/srep15730subject
Has Abstractpub_date
2015-10-28 00:00:00pages
15730issn
2045-2322pii
srep15730journal_volume
5pub_type
杂志文章abstract：:Measuring the Parathyroid hormone (PTH) levels assists in the investigation and management of patients with parathyroid disorders. Rapid PTH monitoring is a valid tool for accurate assessment intraoperatively. Rapid Electro-Analytical Device (READ) is a point-of-care device that uses impedance change between target an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75856-2
更新日期：2020-11-02 00:00:00
abstract：:Leaf senescence provides a unique window to explore the age-dependent programmed degradation at organ label in plants. Here, spectral domain optical coherence tomography (SD-OCT) has been used to study in vivo senescing leaf microstructural changes in the deciduous plant Acer serrulatum Hayata. Hayata leaves show autu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38165-3
更新日期：2019-02-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41919
更新日期：2017-02-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34120-4
更新日期：2018-10-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60379-7
更新日期：2020-03-04 00:00:00
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journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2018-05-10 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-07-29 00:00:00
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journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2020-07-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-04-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-01-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19045-8
更新日期：2018-01-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18697-w
更新日期：2018-01-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44426
更新日期：2017-03-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20466-2
更新日期：2018-02-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/srep31724
更新日期：2016-08-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-10-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26412-6
更新日期：2018-05-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-05-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39611-6
更新日期：2019-03-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-05-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37852
更新日期：2016-11-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-03-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-08-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13542
更新日期：2015-09-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60535-z
更新日期：2020-03-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33261-w
更新日期：2018-10-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21205
更新日期：2016-02-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
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更新日期：2019-11-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14638-9
更新日期：2017-10-30 00:00:00
