Genome-wide analysis of horizontally acquired genes in the genus Mycobacterium.


:Horizontal gene transfer (HGT) was attributed as a major driving force for the innovation and evolution of prokaryotic genomes. Previously, multiple research endeavors were undertaken to decipher HGT in different bacterial lineages. The genus Mycobacterium houses some of the most deadly human pathogens; however, the impact of HGT in Mycobacterium has never been addressed in a systematic way. Previous initiatives to explore the genomic imprints of HGTs in Mycobacterium were focused on few selected species, specifically among the members of Mycobacterium tuberculosis complex. Considering the recent availability of a large number of genomes, the current study was initiated to decipher the probable events of HGTs among 109 completely sequenced Mycobacterium species. Our comprehensive phylogenetic analysis with more than 9,000 families of Mycobacterium proteins allowed us to list several instances of gene transfers spread across the Mycobacterium phylogeny. Moreover, by examining the topology of gene phylogenies here, we identified the species most likely to donate and receive these genes and provided a detailed overview of the putative functions these genes may be involved in. Our study suggested that horizontally acquired foreign genes had played an enduring role in the evolution of Mycobacterium genomes and have contributed to their metabolic versatility and pathogenicity.


Sci Rep


Scientific reports


Panda A,Drancourt M,Tuller T,Pontarotti P




Has Abstract


2018-10-04 00:00:00












  • Associations of oxygenated hemoglobin with disease burden and prognosis in stable COPD: Results from COSYCONET.

    abstract::We studied whether in patients with stable COPD blood gases (BG), especially oxygenated hemoglobin (OxyHem) as a novel biomarker confer information on disease burden and prognosis and how this adds to the information provided by the comorbidity pattern and systemic inflammation. Data from 2137 patients (GOLD grades 1-...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Trudzinski FC,Jörres RA,Alter P,Kahnert K,Waschki B,Herr C,Kellerer C,Omlor A,Vogelmeier CF,Fähndrich S,Watz H,Welte T,Jany B,Söhler S,Biertz F,Herth F,Kauczor HU,Bals R,COSYCONET consortium.

    更新日期:2020-06-29 00:00:00

  • Neuromusculoskeletal model that walks and runs across a speed range with a few motor control parameter changes based on the muscle synergy hypothesis.

    abstract::Humans walk and run, as well as change their gait speed, through the control of their complicated and redundant musculoskeletal system. These gaits exhibit different locomotor behaviors, such as a double-stance phase in walking and flight phase in running. The complex and redundant nature of the musculoskeletal system...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Aoi S,Ohashi T,Bamba R,Fujiki S,Tamura D,Funato T,Senda K,Ivanenko Y,Tsuchiya K

    更新日期:2019-01-23 00:00:00

  • Modeling reservoir management for malaria control in Ethiopia.

    abstract::This study investigated how changes in reservoir water level affect mosquito abundance and malaria transmission in Ethiopia. Digital elevation models of three Ethiopian dams at lowland, midland and highland elevations were used to quantify water surface area and wetted shoreline at different reservoir water levels (70...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kibret S,Ryder D,Wilson GG,Kumar L

    更新日期:2019-12-02 00:00:00

  • Isophorone derivatives as a new structural motif of aggregation pheromones in Curculionidae.

    abstract::The beetle Homalinotus depressus (Coleoptera: Curculionidae) is a major pest of coconuts in the Northern region of Brazil, for which environmentally friendly methods of control are desired. Behavioral responses of H. depressus to airborne volatile extracts from conspecifics suggested the presence of a male-produced ag...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Vidal DM,Moreira MAB,Coracini MDA,Zarbin PHG

    更新日期:2019-01-28 00:00:00

  • Molecular evidence of Chlamydia pecorum and arthropod-associated Chlamydiae in an expanded range of marsupials.

    abstract::The order Chlamydiales are biphasic intracellular bacterial pathogens infecting humans and domesticated animals. Wildlife infections have also been reported, with the most studied example being Chlamydia pecorum infections in the koala, an iconic Australian marsupial. In koalas, molecular evidence suggests that spill-...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Burnard D,Huston WM,Webb JK,Jelocnik M,Reiss A,Gillett A,Fitzgibbon S,Carver S,Carrucan J,Flanagan C,Timms P,Polkinghorne A

    更新日期:2017-10-09 00:00:00

  • A dual drug regimen synergistically blocks human parainfluenza virus infection.

    abstract::Human parainfluenza type-3 virus (hPIV-3) is one of the principal aetiological agents of acute respiratory illness in infants worldwide and also shows high disease severity in the elderly and immunocompromised, but neither therapies nor vaccines are available to treat or prevent infection, respectively. Using a multid...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Bailly B,Dirr L,El-Deeb IM,Altmeyer R,Guillon P,von Itzstein M

    更新日期:2016-04-07 00:00:00

  • Comparing feedforward and recurrent neural network architectures with human behavior in artificial grammar learning.

    abstract::In recent years artificial neural networks achieved performance close to or better than humans in several domains: tasks that were previously human prerogatives, such as language processing, have witnessed remarkable improvements in state of the art models. One advantage of this technological boost is to facilitate co...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Alamia A,Gauducheau V,Paisios D,VanRullen R

    更新日期:2020-12-17 00:00:00

  • In-situ localization and biochemical analysis of bio-molecules reveals Pb-stress amelioration in Brassica juncea L. by co-application of 24-Epibrassinolide and Salicylic Acid.

    abstract::Lead (Pb) toxicity is a major environmental concern affirming the need of proper mitigation strategies. In the present work, potential of combined treatment of 24-Epibrassinolide (24-EBL) and Salicylic acid (SA) against Pb toxicity to Brassica juncea L. seedlings were evaluated. Seedlings pre-imbibed in EBL (0.1 mM) a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kohli SK,Bali S,Tejpal R,Bhalla V,Verma V,Bhardwaj R,Alqarawi AA,Abd Allah EF,Ahmad P

    更新日期:2019-03-05 00:00:00

  • Identification of RNA-binding proteins that partner with Lin28a to regulate Dnmt3a expression.

    abstract::Lin28 is an evolutionary conserved RNA-binding protein that plays important roles during embryonic development and tumorigenesis. It regulates gene expression through two different post-transcriptional mechanisms. The first one is based on the regulation of miRNA biogenesis, in particular that of the let-7 family, who...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Parisi S,Castaldo D,Piscitelli S,D'Ambrosio C,Divisato G,Passaro F,Avolio R,Castellucci A,Gianfico P,Masullo M,Scaloni A,Russo T

    更新日期:2021-01-27 00:00:00

  • Vacancy-induced brittle to ductile transition of W-M co-doped Al3Ti (M=Si, Ge, Sn and Pb).

    abstract::We investigated the effect of vacancy formation on brittle (D022) to ductile (L12-like) transition in Al3Ti using DFT calculations. The well-known pseudogap on the density of states of Al3Ti migrates towards its Fermi level from far above, via a W - M co-doping strategy, where M is Si, Ge, Sn or Pb respectively. In pa...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhu M,Wu P,Li Q,Xu B

    更新日期:2017-10-25 00:00:00

  • Characterizing the type 2 diabetes mellitus epidemic in Jordan up to 2050.

    abstract::We aimed to characterize the type 2 diabetes mellitus (T2DM) epidemic and the role of key risk factors in Jordan between 1990-2050, and to forecast the T2DM-related costs. A recently-developed population-level T2DM mathematical model was adapted and applied to Jordan. The model was fitted to six population-based surve...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Awad SF,Huangfu P,Dargham SR,Ajlouni K,Batieha A,Khader YS,Critchley JA,Abu-Raddad LJ

    更新日期:2020-12-03 00:00:00

  • Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs.

    abstract::Current preclinical screening methods do not adequately detect cardiotoxicity. Using human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs), more physiologically relevant preclinical or patient-specific screening to detect potential cardiotoxic effects of drug candidates may be possible. However, one of ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lee EK,Kurokawa YK,Tu R,George SC,Khine M

    更新日期:2015-07-03 00:00:00

  • The remarkable activity and stability of a highly dispersive beta-brass Cu-Zn catalyst for the production of ethylene glycol.

    abstract::Incorporation of Zn atoms into a nanosize Cu lattice is known to alter the electronic properties of Cu, improving catalytic performance in a number of industrially important reactions. However the structural influence of Zn on the Cu phase is not well studied. Here, we show that Cu nano-clusters modified with increasi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Li MM,Zheng J,Qu J,Liao F,Raine E,Kuo WC,Su SS,Po P,Yuan Y,Tsang SC

    更新日期:2016-02-09 00:00:00

  • A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein.

    abstract::The intermediate filament protein nestin is expressed during embryonic development, but considered largely restricted to areas of regeneration in the adult. Here, we perform a body-wide transcriptome and protein-profiling analysis to reveal that nestin is constitutively, and highly-selectively, expressed in adult huma...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dusart P,Fagerberg L,Perisic L,Civelek M,Struck E,Hedin U,Uhlén M,Trégouët DA,Renné T,Odeberg J,Butler LM

    更新日期:2018-10-02 00:00:00

  • Nosema ceranae, Fipronil and their combination compromise honey bee reproduction via changes in male physiology.

    abstract::The honey bee is threatened by biological agents and pesticides that can act in combination to induce synergistic effects on its physiology and lifespan. The synergistic effects of a parasite/pesticide combination have been demonstrated on workers and queens, but no studies have been performed on drones despite their ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kairo G,Biron DG,Ben Abdelkader F,Bonnet M,Tchamitchian S,Cousin M,Dussaubat C,Benoit B,Kretzschmar A,Belzunces LP,Brunet JL

    更新日期:2017-08-17 00:00:00

  • Cessation of Bezafibrate in patients with chronic kidney disease improves renal function.

    abstract::Bezafibrate (BzF) is eliminated by renal excretion and dosage must be reduced in patients with chronic kidney disease (CKD). There is a concern that BzF causes a further deterioration in renal function in patients with CKD. This study assessed whether BzF discontinuation or dose reduction in CKD patients improves rena...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zingerman B,Ziv D,Feder Krengel N,Korzets A,Matok I

    更新日期:2020-11-13 00:00:00

  • Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection.

    abstract::Peptides derived from the N-terminal heptad repeat (NHR) of HIV-1 gp41 can be potent inhibitors against viral entry when presented in a nonaggregating trimeric coiled-coil conformation via the introduction of exogenous trimerization motifs and intermolecular disulfide bonds. We recently discovered that crosslinking is...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang C,Li X,Yu F,Lu L,Jiang X,Xu X,Wang H,Lai W,Zhang T,Zhang Z,Ye L,Jiang S,Liu K

    更新日期:2016-08-26 00:00:00

  • Large diameter scleral lens benefits for Asians with intractable ocular surface diseases: a prospective, single-arm clinical trial.

    abstract::To report the efficacy and safety of large diameter scleral lenses and determine their suitability in Asian subjects with intractable ocular surface diseases. This prospective study enrolled intractable ocular surface diseases subjects with uncorrected visual acuity > counting finger but ≥ 0.3 logMAR and best-correcte...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Moon J,Lee SM,Hyon JY,Kim MK,Oh JY,Choi HJ

    更新日期:2021-01-27 00:00:00

  • Author Correction: A Recombinant Newcastle Disease Virus (NDV) Expressing S Protein of Infectious Bronchitis Virus (IBV) Protects Chickens against IBV and NDV.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Shirvani E,Paldurai A,Manoharan VK,Varghese BP,Samal SK

    更新日期:2020-01-15 00:00:00

  • Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model.

    abstract::The estrogen receptor (ER) regulates the survival and growth of breast cancer cells, but it is less clear how components of the tissue microenvironment affect ER-mediated responses. We set out to test how human mammary fibroblasts (HMFs) modulate ER signaling and downstream cellular responses. We exposed an organotypi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Morgan MM,Livingston MK,Warrick JW,Stanek EM,Alarid ET,Beebe DJ,Johnson BP

    更新日期:2018-05-08 00:00:00

  • Rapid, CRISPR-Based, Field-Deployable Detection Of White Spot Syndrome Virus In Shrimp.

    abstract::Rapid, sensitive, point-of-care diagnostics are critical for managing infectious diseases. Here we adapt the CRISPR-based SHERLOCK method to develop a rapid, accurate, single copy detection assay for White Spot Syndrome Virus, the most devastating virus impacting global shrimp aquaculture. Further, we combine paper ma...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Sullivan TJ,Dhar AK,Cruz-Flores R,Bodnar AG

    更新日期:2019-12-23 00:00:00

  • Endothelial dysfunction in nonalcoholic steatohepatitis with low cardiac disease risk.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. We prospectively evaluated endothelial function by assessing flow-mediated dilatation (FMD) of the brachial artery in patients with biopsy-proven NAFLD. This prospective study included 139 patients (50 healthy controls, 47 patients wi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Al-Hamoudi W,Alsadoon A,Hassanian M,Alkhalidi H,Abdo A,Nour M,Halwani R,Sanai F,Alsharaabi A,Alswat K,Hersi A,Albenmousa A,Alsaif F

    更新日期:2020-06-01 00:00:00

  • Optimization of Performance and Emission Characteristics of Catalytic Coated IC Engine with Biodiesel Using Grey-Taguchi Method.

    abstract::The performance and emission affected by piston catalytic coating have been analyzed in this study. The main contributing factors for improving performance such as load, fuel and speed have been preferred to reduce the emission and improve the performance of an IC engine. These specific standard parameters have been m...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yessian S,Varthanan PA

    更新日期:2020-02-07 00:00:00

  • Author Correction: Simulation of visual acuity by personalizable neuro-physiological model of the human eye.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Fülep C,Kovács I,Kránitz K,Erdei G

    更新日期:2019-11-22 00:00:00

  • A Novel Lubricant Based on Covalent Functionalized Graphene Oxide Quantum Dots.

    abstract::Dodecyl amine edge functionalized few-layer graphene oxide quantum dots were synthesized in good yields. The covalent functionalization was demonstrated with NMR and AFM-IR. The resulting structure and particle size was measured with AFM and HRTEM. The thermal stability of the compound was investigated and showed a st...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wolk A,Rosenthal M,Neuhaus S,Huber K,Brassat K,Lindner JKN,Grothe R,Grundmeier G,Bremser W,Wilhelm R

    更新日期:2018-04-11 00:00:00

  • Increased frequency of activated CD8+ T cell effectors in patients with psoriatic arthritis.

    abstract::The aim of this study is to identify subsets of T cells differentially represented in the circulation of patients with psoriatic arthritis and to evaluate the possibility that they can recirculate between peripheral blood and the inflamed joints. We analyzed the phenotype and cytokine expression in circulating CD8+ an...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Diani M,Casciano F,Marongiu L,Longhi M,Altomare A,Pigatto PD,Secchiero P,Gambari R,Banfi G,Manfredi AA,Altomare G,Granucci F,Reali E

    更新日期:2019-07-26 00:00:00

  • FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition.

    abstract::FTY720 is a sphingoid base analog that acts as an anticancer agent in animal models. Its effect on tumor cells stems largely from its ability to trigger endocytosis of several nutrient transporters. The observation that FTY720 similarly stimulates downregulation of amino acid permeases in yeast suggests that the cellu...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Barthelemy C,Barry AO,Twyffels L,André B

    更新日期:2017-10-23 00:00:00

  • Perinatal depression and anxiety of primipara is higher than that of multipara in Japanese women.

    abstract::The proportion of women who experience a depressive state after delivery differs between primiparas and multiparas, so it is important to clarify the different factors related to depression between the two groups. In this study, we confirmed the differences in depressive states, the perinatal period, and social suppor...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Nakamura Y,Okada T,Morikawa M,Yamauchi A,Sato M,Ando M,Ozaki N

    更新日期:2020-10-13 00:00:00

  • Multimodal Fluorescent Polymer Sensor for Highly Sensitive Detection of Nitroaromatics.

    abstract::Detection of nitroaromatic explosives with high sensitivity and selectivity is extremely important for civilian and military safety. Here, we report the synthesis and multimodal sensing applications of an emissive alanine based dansyl tagged copolymer P(MMA-co-Dansyl-Ala-HEMA) (DCP), synthesized by RAFT copolymerizati...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kumar V,Maiti B,Chini MK,De P,Satapathi S

    更新日期:2019-05-13 00:00:00

  • Author Correction: Interleukin-6/STAT3 signalling regulates adipocyte induced epithelial-mesenchymal transition in breast cancer cells.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Gyamfi J,Lee YH,Eom M,Choi J

    更新日期:2020-07-29 00:00:00