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Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model.

Abstract：

:In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. However, there are cases in which patients develop progressive visual field loss even though their intraocular pressures are within normal ranges. Therefore, the development of novel therapeutic strategies is an urgent endeavor. Besides high intraocular pressure, several other factors have been proposed to be associated with glaucoma progression, e.g., myopia, blood flow impairment, and amyloid β accumulation. We have previously reported that hop flower extracts possess γ-secretase inhibitory activities and reduce amyloid β deposition in the brains of Alzheimer's disease model mice. In the current study, we showed that administration of hop flower extracts to glutamate-aspartate transporter (GLAST) knockout mice, the glaucoma model mice, attenuated glaucomatous retinal ganglion cell degeneration. Preservation of retinal ganglion cells in hop flower extract-administered mice was confirmed using optical coherence tomography, confocal scanning laser ophthalmoscopy, and retinal flatmount and histological evaluations. Hop flower extracts are, therefore, deemed a possible candidate as a novel therapeutic agent to treat glaucoma.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Hasegawa T,Ikeda HO,Iwai S,Sasaoka N,Kakizuka A,Tsujikawa A

doi

10.1038/s41598-020-78731-2

subject

Has Abstract

pub_date

2020-12-10 00:00:00

pages

21653

issue

1

issn

2045-2322

pii

10.1038/s41598-020-78731-2

journal_volume

10

pub_type

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