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Age-related changes in the response of retinal structure, function and blood flow to pressure modification in rats.

Abstract：

:Age-related changes to the balance between the pressure inside the eye (intraocular pressure, IOP) and the pressure inside the brain (intracranial pressure, ICP) can modify the risk of glaucoma. In this study, we consider whether the optic nerve in older rat eyes is more susceptible to acute IOP and ICP modification. We systematically manipulate both ICP and IOP and quantify their effects on ganglion cell function (electroretinography, ERG), optic nerve structure (optical coherence tomography, OCT) and retinal blood flow (Doppler OCT). We show that ganglion cell function in older eyes was more susceptible to a higher optic nerve pressure difference (ONPD = IOP - ICP). This age-related susceptibility could not be explained by poorer blood flow with elevated ONPD. Rather, as ONPD increased the retinal nerve fibre layer showed greater compression, and the retinal surface showed less deformation in older eyes. Our data suggest that age-related changes to connective tissues in and around the rat optic nerve make it less flexible, which may result in greater strain on ganglion cell axons. This may account for greater functional susceptibility to higher optic nerve pressure differences in older rat eyes. Further studies in a species with a well-developed lamina cribrosa are needed to determine the clinical importance of these observations.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhao D,Nguyen CTO,He Z,Wong VHY,van Koeverden AK,Vingrys AJ,Bui BV

doi

10.1038/s41598-018-21203-5

subject

Has Abstract

pub_date

2018-02-13 00:00:00

pages

2947

issue

1

issn

2045-2322

pii

10.1038/s41598-018-21203-5

journal_volume

8

pub_type

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