当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Neutrophil Extracellular Traps protein composition is specific for patients with Lupus nephritis and includes methyl-oxidized αenolase (methionine sulfoxide 93).

Neutrophil Extracellular Traps protein composition is specific for patients with Lupus nephritis and includes methyl-oxidized αenolase (methionine sulfoxide 93).

Abstract：

:NETs constitute a network of DNA and proteins released by neutrophils in response to infectious and immunologic triggers. NET proteins are recognized as autoantigens in ANCA vasculitis; limited knowledge is available in other autoimmune pathologies. The composition of NETs produced ex vivo by resting and Phorbol-myristate acetate (PMA) stimulated neutrophils was analyzed by high-throughput Fusion Orbitrap technology in 16 patients with Systemic Lupus Erythematosus/Lupus nephritis (9 SLE/7 LN) and in 11 controls. Seven-hundred proteins were characterized and specific fingerprints discriminated LN from SLE. We focused on methyl-oxidized αenolase (methionine sulfoxide 93) that was markedly increased in NETs from LN and was localized in NET filaments in tight connection and outlying DNA. The isotype of anti-αenolase antibodies was IgG2 in LN and IgG4 in other autoimmune glomerulonephritis (Membranous Nephropathy, MN); serum anti-αenolase IgG2 were higher in LN than in SLE and absent in MN. The same IgG2 antibodies recognized 5 epitopes of the protein one containing methionine sulphoxide 93. In conclusion, specific NET protein fingerprints characterize different subsets of SLE; methyl-oxidized αenolase is over-expressed in LN. Circulating anti-αenolase IgG2 recognize the oxidized epitope and are high in serum of LN patients. Post-translational modified NET proteins contribute to autoimmunity in patients with LN.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Bruschi M,Petretto A,Santucci L,Vaglio A,Pratesi F,Migliorini P,Bertelli R,Lavarello C,Bartolucci M,Candiano G,Prunotto M,Ghiggeri GM

doi

10.1038/s41598-019-44379-w

subject

Has Abstract

pub_date

2019-05-28 00:00:00

pages

7934

issue

1

issn

2045-2322

pii

10.1038/s41598-019-44379-w

journal_volume

9

pub_type

临床试验,杂志文章

相关文献

Scientific Reports文献大全
  • Harvesting more grain zinc of wheat for human health.

    abstract：:Increasing grain zinc (Zn) concentration of cereals for minimizing Zn malnutrition in two billion people represents an important global humanitarian challenge. Grain Zn in field-grown wheat at the global scale ranges from 20.4 to 30.5 mg kg-1, showing a solid gap to the biofortification target for human health (40 mg ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07484-2

    authors： Chen XP,Zhang YQ,Tong YP,Xue YF,Liu DY,Zhang W,Deng Y,Meng QF,Yue SC,Yan P,Cui ZL,Shi XJ,Guo SW,Sun YX,Ye YL,Wang ZH,Jia LL,Ma WQ,He MR,Zhang XY,Kou CL,Li YT,Tan DS,Cakmak I,Zhang FS,Zou CQ

    更新日期：2017-08-01 00:00:00

  • The Andaman day gecko paradox: an ancient endemic without pronounced phylogeographic structure.

    abstract：:The Andaman day gecko (Phelsuma andamanensis) is endemic to the Andaman Archipelago, located ~ 6000 km away from Madagascar where the genus Phelsuma likely evolved. We complemented existing phylogenetic data with additional markers to show that this species consistently branches off early in the evolution of the genus...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68402-7

    authors： Mohan AV,Orozco-terWengel P,Shanker K,Vences M

    更新日期：2020-07-16 00:00:00

  • Hyponatremia upon presentation to the emergency department - the need for urgent neuroimaging studies.

    abstract：:This study aims to evaluate the necessity of urgent neuroimaging for emergency admissions exhibiting symptomatology of profound hyponatremia. We retrospectively analyzed the medical records of all patients admitted to the emergency room of the University Hospital Münster from 2010 to 2014 with a serum sodium value < 1...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02030-6

    authors： Bokemeyer A,Dziewas R,Wiendl H,Schwindt W,Bicsán P,Kümpers P,Pavenstädt H

    更新日期：2017-05-16 00:00:00

  • Density of coral larvae can influence settlement, post-settlement colony abundance and coral cover in larval restoration.

    abstract：:Successful recruitment of new individuals is essential for recovery of degraded coral reefs. Enhancing supply of coral larvae increases initial settlement, however post-settlement survival can be influenced by density-dependent processes. We investigated the influence of larval density on settlement, colony abundance ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62366-4

    authors： Cameron KA,Harrison PL

    更新日期：2020-03-26 00:00:00

  • SNP co-association and network analyses identify E2F3, KDM5A and BACH2 as key regulators of the bovine milk fatty acid profile.

    abstract：:The fatty acid (FA) profile has a considerable impact on the nutritional and technological quality of milk and dairy products. The molecular mechanism underlying the regulation of fat metabolism in bovine mammary gland have been not completely elucidated. We conducted genome-wide association studies (GWAS) across 65 m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17434-7

    authors： Pegolo S,Dadousis C,Mach N,Ramayo-Caldas Y,Mele M,Conte G,Schiavon S,Bittante G,Cecchinato A

    更新日期：2017-12-11 00:00:00

  • ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development.

    abstract：:Mechanistic studies of deregulated ERG in prostate cancer and other cancers continue to enhance its role in cancer biology and its utility as a biomarker and therapeutic target. Here, we show that ERG, through its physical interaction with androgen receptor, induces AR aggregation and endoplasmic reticulum stress in t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01187-4

    authors： Sreenath TL,Macalindong SS,Mikhalkevich N,Sharad S,Mohamed A,Young D,Borbiev T,Xavier C,Gupta R,Jamal M,Babcock K,Tan SH,Nevalainen MT,Dobi A,Petrovics G,Sesterhenn IA,Rosner IL,Bieberich CJ,Nelson P,Vasioukhin V,

    更新日期：2017-04-24 00:00:00

  • Effect of physical stimuli on hair follicle deposition of clobetasol-loaded Lipid Nanocarriers.

    abstract：:Clobetasol propionate (CLO) is a potent glucocorticoid used to treat inflammation-based skin, scalp, and hair disorders. In such conditions, hair follicles (HF) are not only the target site but can also act as drug reservoirs when certain formulations are topically applied. Recently, we have demonstrated nanostructure...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56760-w

    authors： Angelo T,El-Sayed N,Jurisic M,Koenneke A,Gelfuso GM,Cunha-Filho M,Taveira SF,Lemor R,Schneider M,Gratieri T

    更新日期：2020-01-13 00:00:00

  • Evolution of Sex Determination Loci in Atlantic Salmon.

    abstract：:Teleost fish exhibit a remarkable diversity in the control of sex determination, offering the opportunity to identify novel differentiation mechanisms and their ecological consequences. Here, we perform GWAS using 4715 fish and 46,501 SNP to map sex determination to three separate genomic locations in Atlantic salmon ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23984-1

    authors： Kijas J,McWilliam S,Naval Sanchez M,Kube P,King H,Evans B,Nome T,Lien S,Verbyla K

    更新日期：2018-04-04 00:00:00

  • Isolation and characterization of a multifunctional flavonoid glycosyltransferase from Ornithogalum caudatum with glycosidase activity.

    abstract：:Glycosyltransferases (GTs) are bidirectional biocatalysts catalyzing the glycosylation of diverse molecules. However, the extensive applications of GTs in glycosides formation are limited due to their requirements of expensive nucleotide diphosphate (NDP)-sugars or NDP as the substrates. Here, in an effort to characte...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24277-3

    authors： Yuan S,Yin S,Liu M,Kong JQ

    更新日期：2018-04-12 00:00:00

  • Rediscovering the genus Lyticum, multiflagellated symbionts of the order Rickettsiales.

    abstract：:Among the bacterial symbionts harbored by the model organism Paramecium, many still lack a recent investigation that includes a molecular characterization. The genus Lyticum consists of two species of large-sized bacteria displaying numerous flagella, despite their inability to move inside their hosts' cytoplasm. We p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep03305

    authors： Boscaro V,Schrallhammer M,Benken KA,Krenek S,Szokoli F,Berendonk TU,Schweikert M,Verni F,Sabaneyeva EV,Petroni G

    更新日期：2013-11-22 00:00:00

  • Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133.

    abstract：:Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be a key to developing therapeutic strategy, but metabolic characteristics have not yet been studied. Here, we systematically analyzed and comp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45557

    authors： Hur W,Ryu JY,Kim HU,Hong SW,Lee EB,Lee SY,Yoon SK

    更新日期：2017-04-03 00:00:00

  • Mechanized transplanting with side deep fertilization increases yield and nitrogen use efficiency of rice in Eastern China.

    abstract：:The application of nitrogen (N) fertilizer deep in soil at the same time as mechanical transplanting of rice seedlings is an effective alternative to conventional broadcasting of fertilizer, but its effects on yields and profitability have not been analysed in detail. Here, we analysed the effects of a side deep appli...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42039-7

    authors： Zhu C,Xiang J,Zhang Y,Zhang Y,Zhu D,Chen H

    更新日期：2019-04-04 00:00:00

  • Evolution and functional divergence of MADS-box genes in Pyrus.

    abstract：:MADS-box transcription factors widely regulate all aspects of plant growth including development and reproduction. Although the MADS-box gene family genes have been extensively characterized in many plants, they have not been studied in closely related species. In this study, 73 and 74 MADS-box genes were identified i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37897-6

    authors： Meng D,Cao Y,Chen T,Abdullah M,Jin Q,Fan H,Lin Y,Cai Y

    更新日期：2019-02-04 00:00:00

  • Effect of Electron Energy Distribution on the Hysteresis of Plasma Discharge: Theory, Experiment, and Modeling.

    abstract：:Hysteresis, which is the history dependence of physical systems, is one of the most important topics in physics. Interestingly, bi-stability of plasma with a huge hysteresis loop has been observed in inductive plasma discharges. Despite long plasma research, how this plasma hysteresis occurs remains an unresolved ques...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15254

    authors： Lee HC,Chung CW

    更新日期：2015-10-20 00:00:00

  • Comparative mode of action of the antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa.

    abstract：:Melimine and Mel4 are chimeric cationic peptides with broad-spectrum antimicrobial activity. They have been shown to be highly biocompatible in animal models and human clinical trials. The current study examined the mechanism of action of these two antimicrobial peptides against P. aeruginosa. The effect of the peptid...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42440-2

    authors： Yasir M,Dutta D,Willcox MDP

    更新日期：2019-05-08 00:00:00

  • Room temperature electrical spin injection into GaAs by an oxide spin injector.

    abstract：:Spin injection, manipulation and detection are the integral parts of spintronics devices and have attracted tremendous attention in the last decade. It is necessary to judiciously choose the right combination of materials to have compatibility with the existing semiconductor technology. Conventional metallic magnets w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05588

    authors： Bhat SG,Kumar PS

    更新日期：2014-07-07 00:00:00

  • Three-dimensional Fe2O3 nanocubes/nitrogen-doped graphene aerogels: nucleation mechanism and lithium storage properties.

    abstract：:We developed a solvothermal-induced self-assembly approach to construct three dimensional (3D) macroscopic Fe2O3 nanocubes/nitrogen-doped graphene (Fe2O3-NC/GN) aerogel as anode materials for lithium-ion batteries (LIBs). The Fe2O3 nanocubes with length of ~50 nm are homogeneously anchored on 3D GN frameworks and as s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07171

    authors： Wang R,Xu C,Sun J,Gao L

    更新日期：2014-11-25 00:00:00

  • Flood-conditioned place aversion as a novel non-pharmacological aversive learning procedure in mice.

    abstract：:The place conditioning paradigm is an efficient, widely-used method to study mechanisms that underlie appetitive or aversive learning and memory processes. However, pharmacological agents used to induce conditioned place preference (CPP) or aversion (CPA) can per se interfere with learning and memory processing, hence...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25568-5

    authors： Goltseker K,Barak S

    更新日期：2018-05-08 00:00:00

  • Reconfigurable chaos in electro-optomechanical system with negative Duffing resonators.

    abstract：:Generating various laser sources is important in the communication systems. We propose an approach that uses a mechanical resonator coupled with the optical fibre system to produce periodic and chaotic optical signals. The resonator is structured in such a way that the nonlinear oscillation occurs conveniently. The me...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05020-w

    authors： Jin L,Guo Y,Ji X,Li L

    更新日期：2017-07-06 00:00:00

  • Extracting h-Backbone as a Core Structure in Weighted Networks.

    abstract：:Determining the core structure of complex network systems allows us to simplify them. Using h-bridge and h-strength measurements in a weighted network, we extract the h-backbone core structure. We find that focusing on the h-backbone in a network allows greater simplification because it has fewer edges and thus fewer ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32430-1

    authors： Zhang RJ,Stanley HE,Ye FY

    更新日期：2018-09-25 00:00:00

  • Dysbiosis patterns during re-induction/salvage versus induction chemotherapy for acute leukemia.

    abstract：:Acute leukemia (AL) patients undergoing intensive induction chemotherapy develop severe gut dysbiosis, placing them at heightened risk for infectious complications. Some AL patients will undergo "repeat therapy" (re-induction or salvage) due to persistent or relapsed disease. We hypothesized that prior injury to the m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42652-6

    authors： Rashidi A,Kaiser T,Shields-Cutler R,Graiziger C,Holtan SG,Rehman TU,Wasko J,Weisdorf DJ,Dunny G,Khoruts A,Staley C

    更新日期：2019-04-15 00:00:00

  • Responses of the marine diatom Thalassiosira pseudonana to changes in CO2 concentration: a proteomic approach.

    abstract：:The concentration of CO2 in many aquatic systems is variable, often lower than the KM of the primary carboxylating enzyme Rubisco, and in order to photosynthesize efficiently, many algae operate a facultative CO2 concentrating mechanism (CCM). Here we measured the responses of a marine diatom, Thalassiosira pseudonana...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42333

    authors： Clement R,Lignon S,Mansuelle P,Jensen E,Pophillat M,Lebrun R,Denis Y,Puppo C,Maberly SC,Gontero B

    更新日期：2017-02-09 00:00:00

  • Structural characterization of site-modified nanocapsid with monodispersed gold clusters.

    abstract：:Hepatitis E Virus-like particles self-assemble in to noninfectious nanocapsids that are resistant to proteolytic/acidic mucosal delivery conditions. Previously, the nanocapsid was engineered to specifically bind and enter breast cancer cells, where successful tumor targeting was demonstrated in animal models. In the p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17171-x

    authors： Stark MC,Baikoghli MA,Lahtinen T,Malola S,Xing L,Nguyen M,Nguyen M,Sikaroudi A,Marjomäki V,Häkkinen H,Cheng RH

    更新日期：2017-12-06 00:00:00

  • Remediation of diesel-contaminated soil enhanced with firefighting foam application.

    abstract：:During rescue operations related to the elimination of the effects of industrial accidents or natural disasters, extinguishing agents are used that affect the migration and transformation of contamination in the environment. Firefighting foam sprayed onto an oil spill slowly drains to an aqueous solution and penetrate...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65660-3

    authors： Rakowska J

    更新日期：2020-06-01 00:00:00

  • A novel dry-bonding approach to reduce collagen degradation and optimize resin-dentin interfaces.

    abstract：:In dentistry, the wet-bonding approach relies on water to maintain demineralized collagen expanded for proper resin infiltration; nevertheless, hydrolytic instability of the resin-dentin interface is inevitable with current bonding techniques. Considering dimethyl sulfoxide's (DMSO) ability to "biomodify" collagen and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34726-8

    authors： Stape THS,Seseogullari-Dirihan R,Tjäderhane L,Abuna G,Martins LRM,Tezvergil-Mutluay A

    更新日期：2018-11-15 00:00:00

  • Light guiding and switching using eccentric core-shell geometries.

    abstract：:High Refractive Index (HRI) dielectric nanoparticles have been proposed as an alternative to metallic ones due to their low absorption and magnetodielectric response in the VIS and NIR ranges. For the latter, important scattering directionality effects can be obtained. Also, systems constituted by dimers of HRI dielec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11401-y

    authors： Barreda ÁI,Gutiérrez Y,Sanz JM,González F,Moreno F

    更新日期：2017-09-11 00:00:00

  • Advanced-Retarded Differential Equations in Quantum Photonic Systems.

    abstract：:We propose the realization of photonic circuits whose dynamics is governed by advanced-retarded differential equations. Beyond their mathematical interest, these photonic configurations enable the implementation of quantum feedback and feedforward without requiring any intermediate measurement. We show how this protoc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42933

    authors： Alvarez-Rodriguez U,Perez-Leija A,Egusquiza IL,Gräfe M,Sanz M,Lamata L,Szameit A,Solano E

    更新日期：2017-02-23 00:00:00

  • Elastography of the bone-implant interface.

    abstract：:The stress distribution around endosseous implants is an important determinant of the surgical success. However, no method developed so far to determine the implant stability is sensitive to the loading conditions of the bone-implant interface (BII). The objective of this study is to investigate whether a quantitative...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50665-4

    authors： Hériveaux Y,Nguyen VH,Geiger D,Haïat G

    更新日期：2019-10-02 00:00:00

  • Leakage of astrocyte-derived extracellular vesicles in stress-induced exhaustion disorder: a cross-sectional study.

    abstract：:Patients with stress-induced exhaustion disorder (SED) demonstrate cognitive dysfunction similar to patients with minor traumatic brain injury (TBI). We have previously detected elevated concentrations of astrocyte-derived extracellular vesicles (EVs) in patients with TBI. As such, we hypothesized that astrocyte-deriv...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81453-8

    authors： Wallensten J,Nager A,Åsberg M,Borg K,Beser A,Wilczek A,Mobarrez F

    更新日期：2021-01-21 00:00:00

  • Characteristics of Atrial Fibrillation Patients Suffering Esophageal Injury Caused by Ablation for Atrial Fibrillation.

    abstract：:The close proximity of esophagus to the left atrial posterior wall predisposes esophagus to thermal injury during catheter ablation for atrial fibrillation (AF). In this retrospective study, we aimed to investigate risk factors of esophageal injury (EI) caused by catheter ablation for AF. Patients who underwent first-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59539-6

    authors： Zhang P,Zhang YY,Ye Q,Jiang RH,Liu Q,Ye Y,Wu JG,Sheng X,Fu GS,Cha YM,Jiang CY

    更新日期：2020-02-17 00:00:00