Extracting h-Backbone as a Core Structure in Weighted Networks.

abstract：:The airway epithelium forms the interface between the inhaled environment and the lung. The airway epithelium is dysfunctional in asthma and epigenetic mechanisms are considered a contributory factor. We hypothesised that the DNA methylation profiles of cultured primary airway epithelial cells (AECs) would differ betw...

journal_title：Scientific reports

authors： Clifford RL,Patel J,MacIsaac JL,McEwen LM,Johnson SR,Shaw D,Knox AJ,Hackett TL,Kobor MS

更新日期：2019-10-08 00:00:00

abstract：:Alp14 is a TOG-family microtubule polymerase from S. pombe that tracks plus ends and accelerates their growth. To interrogate its mechanism, we reconstituted dynamically unstable single isoform S. pombe microtubules with full length Alp14/TOG and Alp7, the TACC-family binding partner of Alp14. We find that Alp14 can d...

journal_title：Scientific reports

authors： Hussmann F,Drummond DR,Peet DR,Martin DS,Cross RA

更新日期：2016-02-11 00:00:00

abstract：:In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. However, there are cases in which patients develop progressive visual field loss even though their intraocular pressures ar...

journal_title：Scientific reports

authors： Hasegawa T,Ikeda HO,Iwai S,Sasaoka N,Kakizuka A,Tsujikawa A

更新日期：2020-12-10 00:00:00

abstract：:Our understanding of a variety of phenomena in physics, biology and economics crucially depends on the analysis of multivariate time series. While a wide range tools and techniques for time series analysis already exist, the increasing availability of massive data structures calls for new approaches for multidimension...

journal_title：Scientific reports

authors： Lacasa L,Nicosia V,Latora V

更新日期：2015-10-21 00:00:00

abstract：:DNA is organized and compacted into higher-order structures in order to fit within nuclei and to facilitate gene regulation. Mechanisms by which higher order chromatin structures are established and maintained are poorly understood. In C. elegans, nuclear-localized small RNAs engage the nuclear RNAi machinery to regul...

journal_title：Scientific reports

authors： Fields BD,Kennedy S

更新日期：2019-06-21 00:00:00

abstract：:Plastic pollution is a rapidly worsening environmental problem, especially in oceanic habitats. Environmental pollution with microplastic particles is also causing food consumed by humans to be increasingly polluted, including table salts. Therefore, we present the first study which focuses only on table salt products...

journal_title：Scientific reports

authors： Lee H,Kunz A,Shim WJ,Walther BA

更新日期：2019-07-12 00:00:00

abstract：:Graphene oxide is being used in energy, optical, electronic and sensor devices due to its unique properties. However, unlike its counterpart - graphene - the thermal transport properties of graphene oxide remain unknown. In this work, we use large-scale molecular dynamics simulations with reactive potentials to system...

journal_title：Scientific reports

authors： Mu X,Wu X,Zhang T,Go DB,Luo T

更新日期：2014-01-28 00:00:00

abstract：:Previous observational studies supported a positive association of glycated hemoglobin A1c (HbA1c) level with serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). However, the causal relationship between HbA1c and either one of ...

journal_title：Scientific reports

authors： Jia X,Hou Y,Xu M,Zhao Z,Xuan L,Wang T,Li M,Xu Y,Lu J,Bi Y,Wang W,Chen Y

更新日期：2019-04-02 00:00:00

abstract：:The lack of vaccines and antiviral treatment, along with the increasing number of cases of Zika virus (ZIKV) and Chikungunya virus (CHIKV) infections, emphasize the need for searching for new therapeutic strategies. In this context, the marine brown seaweed Canistrocarpus cervicornis has been proved to hold great anti...

journal_title：Scientific reports

authors： Cirne-Santos CC,de Souza Barros C,de Oliveira MC,Rabelo VW,Azevedo RC,Teixeira VL,Ferreira DF,de Palmer Paixão ICN

更新日期：2020-05-19 00:00:00

abstract：:Mobility of people and goods during the Upper Paleolithic has proven difficult to reconstruct given the relative rareness of remains. Nevertheless, archaeological contexts like the Late Pleistocene horizon of Borsuka Cave (Southern Poland) represent a unique opportunity to explore patterns of objects' transportation a...

journal_title：Scientific reports

authors： Kowalik N,Anczkiewicz R,Wilczyński J,Wojtal P,Müller W,Bondioli L,Nava A,Gasparik M

更新日期：2020-06-25 00:00:00

abstract：:Genetic characterization of local breeds is essential to preserve their genomic variability, to advance conservation policies and to contribute to their promotion and sustainability. Genomic diversity of twenty European local pig breeds and a small sample of Spanish wild pigs was assessed using high density SNP chips....

journal_title：Scientific reports

authors： Muñoz M,Bozzi R,García-Casco J,Núñez Y,Ribani A,Franci O,García F,Škrlep M,Schiavo G,Bovo S,Utzeri VJ,Charneca R,Martins JM,Quintanilla R,Tibau J,Margeta V,Djurkin-Kušec I,Mercat MJ,Riquet J,Estellé J,Zimmer C,R

更新日期：2019-09-19 00:00:00

abstract：:Vitamin D deficiency, a major public-health worldwide, is associated with hyperuricemia but casual association is questioned. The study was conducted to determine potential causal associations between 25-hydroxy vitamin D (25(OH)D) and uric acid (UA). A cross-sectional study of the Electricity Generating Authority of ...

journal_title：Scientific reports

authors： Thakkinstian A,Anothaisintawee T,Chailurkit L,Ratanachaiwong W,Yamwong S,Sritara P,Ongphiphadhanakul B

更新日期：2015-09-29 00:00:00

abstract：:Based on the electric rotating magnetoresistance method, the shape anisotropy of a Co microstrip has been systematically investigated. We find that the shape anisotropy is dependent not only on the shape itself, but also on the magnetization distribution controlled by an applied magnetic field. Together with micro-mag...

journal_title：Scientific reports

authors： Fan X,Zhou H,Rao J,Zhao X,Zhao J,Zhang F,Xue D

更新日期：2015-11-13 00:00:00

abstract：:Cellular locomotion is a central hallmark of eukaryotic life. It is governed by cell-extrinsic molecular factors, which can either emerge in the soluble phase or as immobilized, often adhesive ligands. To encode for direction, every cue must be present as a spatial or temporal gradient. Here, we developed a microfluid...

journal_title：Scientific reports

authors： Schwarz J,Bierbaum V,Merrin J,Frank T,Hauschild R,Bollenbach T,Tay S,Sixt M,Mehling M

更新日期：2016-11-07 00:00:00

abstract：:Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in patients. Our data showed a sharp decrease in platelet counts at day...

journal_title：Scientific reports

authors： Ojha A,Nandi D,Batra H,Singhal R,Annarapu GK,Bhattacharyya S,Seth T,Dar L,Medigeshi GR,Vrati S,Vikram NK,Guchhait P

更新日期：2017-01-31 00:00:00

abstract：:Liver resection remains the popular treatment for hepatocellular carcinoma (HCC). The aim of this study was to explore the alteration of immune cells in HCC patients with liver resections. Nineteen patients were included and their peripheral blood samples were taken before and after liver resections for immune-cell an...

journal_title：Scientific reports

authors： Lee WC,Wang YC,Cheng CH,Wu TH,Lee CF,Wu TJ,Chou HS,Chan KM

更新日期：2019-02-19 00:00:00

abstract：:With the development and application of nanotechnology, large amounts of nanoparticles will be potentially released to the environment and possibly cause many severe health problems. Although the toxicity of nanoparticles has been investigated, prevention and treatment of damages caused by nanoparticles have been rare...

journal_title：Scientific reports

authors： Qi W,Tian L,An W,Wu Q,Liu J,Jiang C,Yang J,Tang B,Zhang Y,Xie K,Wang X,Li Z,Wu W

更新日期：2017-06-06 00:00:00

abstract：:Rats are effective model animals and have contributed to the development of human medicine and basic research. However, the application of reproductive engineering techniques to rats is not as advanced compared with mice, and genome editing in rats has not been achieved using embryos obtained by in vitro fertilization...

journal_title：Scientific reports

authors： Honda A,Tachibana R,Hamada K,Morita K,Mizuno N,Morita K,Asano M

更新日期：2019-08-09 00:00:00

abstract：:L-Asparaginase (L-asparagine aminohydrolase, E.C. 3.5.1.1) has been proven to be competent in treating Acute Lymphoblastic Leukaemia (ALL), which is widely observed in paediatric and adult groups. Currently, clinical L-Asparaginase formulations are derived from bacterial sources such as Escherichia coli and Erwinia ch...

journal_title：Scientific reports

authors： Ashok A,Doriya K,Rao JV,Qureshi A,Tiwari AK,Kumar DS

更新日期：2019-02-05 00:00:00

abstract：:The accumulation of mannosyl-glycerate (MG), the salinity stress response osmolyte of Thermococcales, was investigated as a function of hydrostatic pressure in Thermococcus barophilus strain MP, a hyperthermophilic, piezophilic archaeon isolated from the Snake Pit site (MAR), which grows optimally at 40 MPa. Strain MP...

journal_title：Scientific reports

authors： Cario A,Jebbar M,Thiel A,Kervarec N,Oger PM

更新日期：2016-07-05 00:00:00

abstract：:Human lactoferrin (hLF) is a valuable protein for pharmaceutical products and functional foods, and worldwide demand for this protein has steadily increased. However, large-scale recombinant human lactoferrin (rhLF) production using current animal bioreactor techniques is limited by the low expression of foreign prote...

journal_title：Scientific reports

authors： Wang M,Sun Z,Yu T,Ding F,Li L,Wang X,Fu M,Wang H,Huang J,Li N,Dai Y

更新日期：2017-09-06 00:00:00

abstract：:When acoustic signals from different sound sources are mixed upon arrival at the ears, the auditory system organizes these acoustic elements by their features. This study shows that individuals with autism spectrum disorder (ASD) performed better in terms of hearing a target sequence among distractors that had similar...

journal_title：Scientific reports

authors： Lin IF,Yamada T,Komine Y,Kato N,Kashino M

更新日期：2015-05-22 00:00:00

abstract：:Sesame is prized for its oil. Genetic improvement of sesame can be enhanced through marker-assisted breeding. However, few simple sequence repeat (SSR) markers and SSR-based genetic maps were available in sesame. In this study, 7,357 SSR markers were developed from the sesame genome and transcriptomes, and a genetic m...

journal_title：Scientific reports

authors： Wang L,Zhang Y,Zhu X,Zhu X,Li D,Zhang X,Gao Y,Xiao G,Wei X,Zhang X

更新日期：2017-08-21 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Amano SI,Ogawa KI,Miyake Y

更新日期：2018-08-20 00:00:00

abstract：:Hepatocyte-specific HMGB1 deletion has been found to worsen the injury and inflammation in liver ischemia-reperfusion injury (IRI), highlighting a role for intracellular HMGB1 in cellular protection. Down-regulation of nuclear HMGB1 by small interfering RNA (siRNA) might not only decrease its injurious extracellular r...

journal_title：Scientific reports

authors： Zhao G,Fu C,Wang L,Zhu L,Yan Y,Xiang Y,Zheng F,Gong F,Chen S,Chen G

更新日期：2017-04-06 00:00:00

abstract：:Anti-cytokine therapeutic antibodies have been demonstrated to be effective in the treatment of several auto-immune disorders. However, The problems in antibody manufacture and the immunogenicity caused by multiple doses of antibodies inspire people to use auto-cytokine as immunogen to induce anti-cytokine antibodies....

journal_title：Scientific reports

authors： Liu C,Zhao Y,He W,Wang W,Chen Y,Zhang S,Ma Y,Gohda J,Ishida T,Walter TS,Owens RJ,Stuart DI,Ren J,Gao B

更新日期：2015-09-28 00:00:00

abstract：:Due to the potentially detrimental consequences of low performance in basic functional tasks, individuals are expected to improve performance with age and show the most marked changes during early stages of life. Soaring-gliding birds use rising-air columns (thermals) to reduce energy expenditure allocated to flight. ...

journal_title：Scientific reports

authors： Harel R,Horvitz N,Nathan R

更新日期：2016-06-13 00:00:00

abstract：:At present, it remains poorly understood how the olfactory neuron migrates through the thick neuroepithelium during its maturation from a stem cell and how it develops a specific sensitivity to environmental odorants after maturation. We investigated the cytochemical features associated with the development of olfacto...

journal_title：Scientific reports

authors： Klimenkov IV,Sudakov NP,Pastukhov MV,Svinov MM,Kositsyn NS

更新日期：2018-02-27 00:00:00

abstract：:We aimed to explore the effects of type-2 diabetes mellitus (T2DM) and hypoglycemic therapy on the salivary microbiome in periodontitis patients and identify the potential salivary micro-biomarker for the early warning of T2DM. Saliva samples were collected from healthy individuals (Health), periodontitis patients (P)...

journal_title：Scientific reports

authors： Sun X,Li M,Xia L,Fang Z,Yu S,Gao J,Feng Q,Yang P

更新日期：2020-09-21 00:00:00

abstract：:Despite the unique nature of endemic species, their origin and population history remain poorly studied. We investigated the population history of 28 coral reef fish species, close related, from the Gambier and Marquesas Islands, from five families, with range size varying from widespread to small-range endemic. We an...

journal_title：Scientific reports

authors： Delrieu-Trottin E,Mona S,Maynard J,Neglia V,Veuille M,Planes S

更新日期：2017-01-16 00:00:00