Abstract：
:DNA is organized and compacted into higher-order structures in order to fit within nuclei and to facilitate gene regulation. Mechanisms by which higher order chromatin structures are established and maintained are poorly understood. In C. elegans, nuclear-localized small RNAs engage the nuclear RNAi machinery to regulate gene expression and direct the post-translational modification of histone proteins. Here we confirm a recent report suggesting that nuclear small RNAs initiate or maintain chromatin compaction states in C. elegans germ cells. Additionally, we show that experimentally provided small RNAs are sufficient to direct chromatin compaction and that this compaction requires the small RNA-binding Argonaute NRDE-3, the pre-mRNA associated factor NRDE-2, and the HP1-like protein HPL-2. Our results show that small RNAs, acting via the nuclear RNAi machinery and an HP1-like protein, are capable of driving chromatin compaction in C. elegans.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fields BD,Kennedy Sdoi
10.1038/s41598-019-45052-ysubject
Has Abstractpub_date
2019-06-21 00:00:00pages
9030issue
1issn
2045-2322pii
10.1038/s41598-019-45052-yjournal_volume
9pub_type
杂志文章abstract：:Prophages are known to encode important virulence factors in the human pathogen Vibrio cholerae. However, little is known about the occurrence and composition of prophage-encoded traits in environmental vibrios. A database of 5,674 prophage-like elements constructed from 1,874 Vibrio genome sequences, covering sixty-f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28326-9
更新日期：2018-07-02 00:00:00
abstract：:Our understanding of innate immune responses in human rectal mucosal tissues (RM) and their contributions to promoting or restricting HIV transmission is limited. We defined the RM composition of innate and innate-like cell subsets, including plasmacytoid dendritic cells; CD1c + myeloid DCs; neutrophils; macrophages; ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76976-5
更新日期：2020-11-19 00:00:00
abstract：:Randomizing the layer thickness of superlattices (SL) can lead to localization of coherent phonons and thereby reduces the lattice thermal conductivity κ l . In this work, we propose strategies that can suppress incoherent phonon transport in the above random multilayer (RML) structure to further reduce κ l . Molecula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08359-2
更新日期：2017-08-15 00:00:00
abstract：:The rapid urbanization in China has been associated with a growing hunger for energy consumption and steadily-increasing CO2 emissions. In this paper, an integrated system dynamics model composed of four sub-models is developed to simulate the urbanization and energy consumption in China from 1998 to 2050. Three scena...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66125-3
更新日期：2020-06-19 00:00:00
abstract：:The objective of this study was to determine if Ihh is required for fracture healing. Fibular fracture was created in adult Col2a1-CreERT2; Ihhfl/fl mice. Ihhfl/fl mice received Tamoxifen (TM) to delete Ihh. WT mice received Cyclopamine to inhibit Hh pathway. Callus tissue properties and Ihh pathway were analyzed at 1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28657-7
更新日期：2018-07-09 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep18803. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46987
更新日期：2018-05-22 00:00:00
abstract：:Previously, we cloned a new gene termed 'tongue cancer resistance-associated protein 1' (TCRP1), which modulates tumorigenesis, enhances cisplatin (cDDP) resistance in cancers, and may be a potential target for reversing drug resistance. However, the mechanisms for regulating TCRP1 expression remain unclear. Herein, w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03763-0
更新日期：2017-06-16 00:00:00
abstract：:Autoantibodies against ion channels are the cause of numerous neurologic autoimmune disorders. Frequently, such pathogenic autoantibodies have a restricted epitope-specificity. In such cases, competing antibody formats devoid of pathogenic effector functions (blocker antibodies) have the potential to treat disease by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01019-5
更新日期：2017-04-20 00:00:00
abstract：:Air-core magnetometers are amongst the most commonly used magnetic field detectors in biomedical instruments. They offer excellent sensitivity, low fabrication complexity and a robust, cost-effective solution. However, air-core magnetometers must be tailored to the specific application to achieve high sensitivity, whi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02099-z
更新日期：2017-05-23 00:00:00
abstract：:The cause and source of the heat released from Earth's interior have not yet been determined. Some research groups have proposed that the heat is supplied by radioactive decay or by a nuclear georeactor. Here we postulate that the generation of heat is the result of three-body nuclear fusion of deuterons confined in h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37740
更新日期：2016-11-23 00:00:00
abstract：:The ideal strategy for hair cell regeneration is promoting residual supporting cell proliferation followed by induction of hair cell differentiation. In this study, cultured neonatal mouse organs of Corti were treated with neomycin to eliminate hair cells followed by incubation with recombined adenovirus expressing Pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02996
更新日期：2013-10-21 00:00:00
abstract：:Iridescent color appearances are widespread in nature. They arise from the interaction of light with micron- and submicron-sized physical structures spatially arranged with periodic geometry and are usually associated with bright angle-dependent hues. Iridescence has been reported for many animals and marine organisms...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19906
更新日期：2016-01-28 00:00:00
abstract：:Coriander foliage is a distinctive spice employed on a daily basis in curry and other Indian traditional food preparations mainly for the unique flavour attributes and health benefits. Radical scavenging activity has been demonstrated previously for coriander foliage. However, specific molecules responsible were not i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35836-z
更新日期：2018-11-27 00:00:00
abstract：:Here we report the study of two bioengineered variants of human trace amine-associated receptor 5 (hTAAR5) that were expressed in stable tetracycline-inducible HEK293S cell lines. A systematic detergent screen showed that fos-choline-14 was the optimal detergent to solubilize and subsequently purify the receptors. Mil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00102
更新日期：2011-01-01 00:00:00
abstract：:The analysis of cell type-specific activity patterns during behaviors is important for better understanding of how neural circuits generate cognition, but has not been well explored from in vivo neurophysiological datasets. Here, we describe a computational approach to uncover distinct cell subpopulations from in vivo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12474
更新日期：2015-07-27 00:00:00
abstract：:In this paper, the periodic double-layer graphene ribbon arrays placed near a metallic ground plate coated by a dielectric layer are proposed and analyzed by the coupled-mode theory (CMT) to predict the perfect absorption response in the mid-infrared region. Numerical simulations of the finite-difference time-domain (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36651
更新日期：2016-11-15 00:00:00
abstract：:A structurally simple dielectric barrier discharge based mercury-free plasma UV-light source has been developed for efficient water disinfection. The source comprises of a dielectric barrier discharge arrangement between two co-axial quartz tubes with an optimized gas gap. The outer electrode is an aluminium baked foi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17455-2
更新日期：2017-12-12 00:00:00
abstract：:Fully elucidating the molecular mechanisms of non-coding RNAs (ncRNAs), including micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs), underlying hepatocarcinogenesis is challenging. We characterized the expression profiles of ncRNAs and constructed a regulatory mRNA-lncRNA-miRNA (MLMI) network based on transcripto...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52559-x
更新日期：2019-11-06 00:00:00
abstract：:SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane activator Smoothened (Smo), have shown the rapid development of dru...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44079
更新日期：2017-03-09 00:00:00
abstract：:Species and populations are disappearing at an alarming rate as a direct result of human activities. Loss of genetic diversity associated with population decline directly impacts species' long-term survival. Therefore, preserving genetic diversity is of considerable conservation importance. However, to assist in conse...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24497-7
更新日期：2018-04-25 00:00:00
abstract：:The morphology of hexagonal phase NaYF4:Er(3+) nanorods synthesized by hydrothermal method changed greatly after a continuing calcination, along with a phase transformation to cubic phase. Photoluminescence (PL) spectra indicated that mid-infrared (MIR) emission was obtained in both hexagonal and cubic phase NaYF4:Er(...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29871
更新日期：2016-07-25 00:00:00
abstract：:Many animals use sounds produced by conspecifics for mate identification. Female insects and anuran amphibians, for instance, use acoustic cues to localize, orient toward and approach conspecific males prior to mating. Here we present a novel technique that utilizes multiple, distributed sound-indication devices and a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11150-y
更新日期：2017-09-05 00:00:00
abstract：:SERS spectra excited at 785 nm of the bacteria Chlamydia trahomatis (elementary bodies, EB) and Neisseria gonorrheoae, the causative pathogens for the two most common sexually transmitted diseases (STD), chlamydia and gonorrhea, respectively, are reported. Although both are Gram-negative bacteria, the SERS signatures ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23562-5
更新日期：2018-03-26 00:00:00
abstract：:Management of curable sexually-transmitted infections (STI) such as Chlamydia can be revolutionized by highly sensitive nucleic acid testing that is deployable at the point-of-care (POC). Here we report the development of a mobile nucleic acid amplification testing (mobiNAAT) platform utilizing a mobile phone and drop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04781-8
更新日期：2017-07-03 00:00:00
abstract：:Raman microspectroscopy provides the means to obtain local orientations on polycrystalline materials at the submicrometer level. The present work demonstrates how orientation-distribution maps composed of Raman intensity distributions can be acquired on large areas of several hundreds of square micrometers. A polycrys...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18410
更新日期：2015-12-17 00:00:00
abstract：:Single nucleotide polymorphisms (SNPs) and genes associated with susceptibility to hepatitis B virus (HBV) infection that have been identified by genome-wide association studies explain only a limited portion of the known heritability, indicating more genetic variants remain to be discovered. In this study, we adopted...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49777-8
更新日期：2019-09-17 00:00:00
abstract：:The increasing demand for healthy baked goods boosted studies on sourdough microbiota with beneficial metabolic traits, to be used as potential functional starters. Here, 139 yeasts isolated from cereal-based fermented foods were in vitro characterized for their phytase and antioxidant activities. The molecular charac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69774-6
更新日期：2020-07-30 00:00:00
abstract：:Stability and integration are the goals for developing photonic devices. Spirooxazines have the property of photoinduced merocyanine-aggregation in polymer matrix, which can be applied to fluorescence emission and stable information storage. Although visible light coherent radiation with UV-assist has been used to ach...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22202-2
更新日期：2018-02-28 00:00:00
abstract：:Control of genetic regulatory networks is challenging to define and quantify. Previous control centrality metrics, which aim to capture the ability of individual nodes to control the system, have been found to suffer from plausibility and applicability problems. Here we present a new approach to control centrality bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09746
更新日期：2015-06-11 00:00:00
abstract：:Hepatitis C virus (HCV) has long been observed to take advantage of the host mitochondria to support viral replication and assembly. The HCV core protein has been implicated to fragment host mitochondria. In this report, we have discovered that the non-structural protein 5A (NS5A) plays an instructive role in attachin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23464
更新日期：2016-03-24 00:00:00
