Abstract：
:The accumulation of mannosyl-glycerate (MG), the salinity stress response osmolyte of Thermococcales, was investigated as a function of hydrostatic pressure in Thermococcus barophilus strain MP, a hyperthermophilic, piezophilic archaeon isolated from the Snake Pit site (MAR), which grows optimally at 40 MPa. Strain MP accumulated MG primarily in response to salinity stress, but in contrast to other Thermococcales, MG was also accumulated in response to thermal stress. MG accumulation peaked for combined stresses. The accumulation of MG was drastically increased under sub-optimal hydrostatic pressure conditions, demonstrating that low pressure is perceived as a stress in this piezophile, and that the proteome of T. barophilus is low-pressure sensitive. MG accumulation was strongly reduced under supra-optimal pressure conditions clearly demonstrating the structural adaptation of this proteome to high hydrostatic pressure. The lack of MG synthesis only slightly altered the growth characteristics of two different MG synthesis deletion mutants. No shift to other osmolytes was observed. Altogether our observations suggest that the salinity stress response in T. barophilus is not essential and may be under negative selective pressure, similarly to what has been observed for its thermal stress response.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cario A,Jebbar M,Thiel A,Kervarec N,Oger PMdoi
10.1038/srep29483subject
Has Abstractpub_date
2016-07-05 00:00:00pages
29483issn
2045-2322pii
srep29483journal_volume
6pub_type
杂志文章abstract：:The most important goals of brain network analyses are to (a) detect pivotal regions and connections that contribute to disproportionate communication flow, (b) integrate global information, and (c) increase the brain network efficiency. Most centrality measures assume that information propagates in networks with the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42322-7
更新日期：2019-04-11 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-22369-8
更新日期：2018-03-06 00:00:00
abstract：:Porphyra 334 (P334), a mycosporine-like amino acid (MAA), is a secondary metabolite found in diverse marine and terrestrial organisms and has several beneficial effects on fibroblast proliferation, wound healing, and antioxidant activity. Here, we report that P334 accelerates the cell reprogramming process of mouse ta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60680-5
更新日期：2020-02-28 00:00:00
abstract：:Acclimation and adaptation, which are key to species survival in a changing climate, can be observed in terms of membrane lipid composition. Remodelling membrane lipids, via homeoviscous adaptation (HVA), counteracts membrane dysfunction due to temperature in poikilotherms. In order to assess the potential for acclima...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35669
更新日期：2016-10-20 00:00:00
abstract：:The development of metal-based agents has had a tremendous role in the present progress in cancer chemotherapy. One well-known example of metal-based agents is Schiff based metal complexes, which hold great promise for cancer therapy. Based on the potential of Schiff based complexes for the induction of apoptosis, thi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09097
更新日期：2015-03-13 00:00:00
abstract：:Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. But the combined inhibition of both pathways was rarely investigated. This study investigated how inhibiting both glutamine metabolism with 6-diazo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42932-1
更新日期：2019-04-23 00:00:00
abstract：:Despite the detailed characterization of the inflammatory and endothelial changes observed in Sickle Cell Disease (SCD), the hierarchical relationship between elements involved in the pathogenesis of this complex disease is yet to be described. Meta-analyses of gene expression studies from public repositories represen...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep17822
更新日期：2015-12-09 00:00:00
abstract：:Herbicide resistance has been observed in Chloris truncata, an Australian native C4 grass and a summer-fallow weed, which is common in no-till agriculture situations where herbicides are involved in crop management. To investigate the role of drought and increased atmospheric carbon dioxide (CO2) in determining weed g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47237-x
更新日期：2019-07-24 00:00:00
abstract：:This study was to investigate the association between dietary patterns and rhinitis in primary school children. 1,599 students without rhinitis at baseline survey were selected from a primary school children cohort. Information on food consumption, respiratory symptoms, and confounders was collected using questionnair...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44610
更新日期：2017-03-15 00:00:00
abstract：:Natural competence for genetic transformation refers to the natural ability of various bacteria to take up exogenous DNA from their surroundings and to incorporate internalized genetic information into their genomes. By promoting bacterial diversification and adaptability, this process represents a major driving force...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47423-x
更新日期：2019-07-30 00:00:00
abstract：:Neurogenesis of hippocampal granule cells (GCs) persists throughout mammalian life and is important for learning and memory. How newborn GCs differentiate and mature into an existing circuit during this time period is not yet fully understood. We established a method to visualize postnatally generated GCs in organotyp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43724
更新日期：2017-03-03 00:00:00
abstract：:Graphene has shown enormous potential for innovation in various research fields. The current chemical approaches based on exfoliation of graphite via graphite oxide (GO) are potential for large-scale synthesis of graphene but suffer from high cost, great operation difficulties, and serious waste discharge. We report a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03439
更新日期：2013-12-06 00:00:00
abstract：:X-linked severe combined immunodeficiency (SCID-X1) caused by mutations in interleukin 2 receptor gamma (IL2RG) gene threatens the survival of affected boys during the first year of life unless hematopoietic stem cell transplantation is provided. Although viral vector-mediated gene therapy has been successfully perfor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05043
更新日期：2014-05-23 00:00:00
abstract：:Tinnitus (phantom auditory perception associated with hearing loss) can seriously affect wellbeing. Its neural substrate is unknown however it has been linked with abnormal activity in auditory pathways. Though no cure currently exists, repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce tinni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38234
更新日期：2016-12-01 00:00:00
abstract：:Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical impr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13931
更新日期：2015-09-10 00:00:00
abstract：:Human papillomavirus (HPV) infection, a primary cause of genital cancer, is also related to the increasing incidence of oropharyngeal cancer among young men. Relatively little is known about the concurrence of oral and genital infection among healthy individuals. Oral and genital swab exfoliated cells were collected s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15637
更新日期：2015-10-27 00:00:00
abstract：:Induction of autophagy can have beneficial effects in several human diseases, e.g. cancer and neurodegenerative diseases (ND). Here, we therefore evaluated the potential of two novel autophagy-inducing compounds, i.e. STF-62247 and pimozide, to stimulate autophagy as well as autophagic cell death (ACD) using mouse emb...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56990-y
更新日期：2020-01-20 00:00:00
abstract：:Zeolites/molecular sieves with uniform, molecular-sized pores are important for many adsorption-based separation processes. Pore size gaps, however, exist in the current zeolite family. This leads to a great challenge of separating molecules with size differences at ~0.01 nm level. Here, we report a novel concept, por...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13981
更新日期：2015-09-11 00:00:00
abstract：:Meishan boars are known for their early sexual maturity. However, they exhibit a significantly smaller testicular size and a reduced proportion of Sertoli cells and daily sperm production compared with Duroc boars. The testes of Duroc and Meishan boars at 20, 75 and 270 days of age were used for histological and trans...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20758
更新日期：2016-02-11 00:00:00
abstract：:Calibration of quantum computers is essential to the effective utilisation of their quantum resources. Specifically, the performance of quantum annealers is likely to be significantly impaired by noise in their programmable parameters, effectively misspecification of the computational problem to be solved, often resul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18628
更新日期：2016-01-19 00:00:00
abstract：:Gastric diseases are common in China, and gastroduodenoscopy could provide accurate diagnoses. Our previous study verified that linked colour imaging (LCI) can improve endoscopic diagnostic accuracy. This study aimed for the first time to establish an LCI-based endoscopic model called colour-microstructure-vessel (CMV...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05847-3
更新日期：2017-07-17 00:00:00
abstract：:Being one of the most common trees in forests, Pinus sylvestris L. is a frequently used raw material for wood products. Its specific odour is, however, mostly unresolved to date. Accordingly, we investigated Scots pine wood samples grown in Germany for their main odorant composition. We employed dedicated odorant anal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26626-8
更新日期：2018-05-29 00:00:00
abstract：:Gelatin-coupled cellulose (GCC) microgel with whisker-like structure is prepared and used to incorporate into casein (CA) matrix to construct reinforced CA-based composite films by solution casting. The GCC microgel has excellent dispersibility and stability in water, which contributes to the hydrophobicity and signif...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37848-1
更新日期：2019-02-04 00:00:00
abstract：:Hominin dietary specialization is crucial to understanding the evolutionary changes of craniofacial biomechanics and the interaction of food processing methods' effects on teeth. However, the diet-related dental wear processes of the earliest European hominins remain unknown because most of the academic attention has ...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/srep43319
更新日期：2017-02-27 00:00:00
abstract：:Environmental pollutants as non-heritable factors are now recognized as triggers for multiple human inflammatory diseases involving T cells. We postulated that lipid antigen presentation mediated by cluster of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophilic environmental pollutants....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02229-7
更新日期：2017-05-18 00:00:00
abstract：:CLN3 mutations cause the fatal neurodegenerative disorder, CLN3 Batten disease. The Cln3-/- mouse model displays characteristic features of the human disease including motor deficits. When mice received acidified drinking water (pH 2.5-2.9) instead of normal tap water (pH 8.4) for several generations, the motor skills...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51488-z
更新日期：2019-10-18 00:00:00
abstract：:Enrichment of colloidal particles in continuous flow has not only numerous applications but also poses a great challenge in controlling physical forces that are required for achieving particle enrichment. Here, we for the first time experimentally demonstrate the electrokinetically-driven continuous-flow enrichment of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11473-w
更新日期：2017-09-07 00:00:00
abstract：:Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment. We investigated whether alterations of intranetwork and internetwork functional connectivity with T2DM progression exist, by using resting-state functional MRI. MRI data were analysed from 19 T2DM patients with normal cognition (DMCN) and 19 T2DM...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32980
更新日期：2016-09-13 00:00:00
abstract：:Networks are widely used as a tool for describing diverse real complex systems and have been successfully applied to many fields. The distance between networks is one of the most fundamental concepts for properly classifying real networks, detecting temporal changes in network structures, and effectively predicting th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34944
更新日期：2016-10-11 00:00:00
abstract：:Rapid vertebrate diversity evaluation is invaluable for monitoring changing ecosystems worldwide. Wild blow flies naturally recover DNA and chemical signatures from animal carcasses and feces. We demonstrate the power of blow flies as biodiversity monitors through sampling of flies in three environments with varying h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46758-9
更新日期：2019-07-22 00:00:00
