Abstract：
:Porphyra 334 (P334), a mycosporine-like amino acid (MAA), is a secondary metabolite found in diverse marine and terrestrial organisms and has several beneficial effects on fibroblast proliferation, wound healing, and antioxidant activity. Here, we report that P334 accelerates the cell reprogramming process of mouse tail-tip fibroblasts (TTFs) and human dermal papilla (HDP) cells into induced pluripotent stem cells (iPSCs). We found that P334 significantly improved the cell reprogramming efficiency by activating the tri-methylation of histone 3 lysine 4 (H3K4me3), which controls mesenchymal to epithelial transition (MET) during the reprogramming process. Thus, we found that P334 directly regulates epigenetic changes, providing an efficient approach for natural compound-based cell reprogramming.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yoo J,Kim J,Lee JH,Kim H,Jang SJ,Seo HH,Oh ST,Hyeon SJ,Ryu H,Kim J,Moh SHdoi
10.1038/s41598-020-60680-5subject
Has Abstractpub_date
2020-02-28 00:00:00pages
3684issue
1issn
2045-2322pii
10.1038/s41598-020-60680-5journal_volume
10pub_type
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