Abstract:
:Animals living at high altitudes have evolved distinct phenotypic and genotypic adaptations against stressful environments. We studied the adaptive patterns of altitudinal stresses on transcriptome turnover in subterranean plateau zokors (Myospalax baileyi) in the high-altitude Qinghai-Tibetan Plateau. Transcriptomes of zokors from three populations with distinct altitudes and ecologies (Low: 2846 m, Middle: 3282 m, High: 3,714 m) were sequenced and compared. Phylogenetic and principal component analyses classified them into three divergent altitudinal population clusters. Genetic polymorphisms showed that the population at H, approaching the uppermost species boundary, harbors the highest genetic polymorphism. Moreover, 1056 highly up-regulated UniGenes were identified from M to H. Gene ontologies reveal genes like EPAS1 and COX1 were overexpressed under hypoxia conditions. EPAS1, EGLN1, and COX1 were convergent in high-altitude adaptation against stresses in other species. The fixation indices (F ST and G ST )-based outlier analysis identified 191 and 211 genes, highly differentiated among L, M, and H. We observed adaptive transcriptome changes in Myospalax baileyi, across a few hundred meters, near the uppermost species boundary, regardless of their relatively stable underground burrows' microclimate. The highly variant genes identified in Myospalax were involved in hypoxia tolerance, hypercapnia tolerance, ATP-pathway energetics, and temperature changes.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cai Z,Wang L,Song X,Tagore S,Li X,Wang H,Chen J,Li K,Frenkel Z,Gao D,Frenkel-Morgenstern M,Zhang T,Nevo Edoi
10.1038/s41598-018-22483-7subject
Has Abstractpub_date
2018-03-16 00:00:00pages
4671issue
1issn
2045-2322pii
10.1038/s41598-018-22483-7journal_volume
8pub_type
杂志文章abstract::Segmentation of the vertebrate hindbrain is an evolutionarily conserved process. Here, we identify the transcription factor early growth response 4 (egr4) as a novel regulator of posterior hindbrain development in Xenopus. egr4 is specifically and transiently expressed in rhombomeres 5 and 6 (r5/r6), and Egr4 knockdow...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07750
更新日期:2015-01-13 00:00:00
abstract::Neutron grating interferometry (nGI) is a unique technique allowing to probe magnetic and nuclear properties of materials not accessible in standard neutron imaging. The signal-to-noise ratio of an nGI setup is strongly dependent on the achievable visibility. Hence, for analysis of weak signals or short measurement ti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58504-7
更新日期:2020-02-04 00:00:00
abstract::Mayaro virus (MAYV) is endemic in South American countries where it is responsible for sporadic outbreaks of acute febrile illness. The hallmark of MAYV infection is a highly debilitating and chronic arthralgia. Although MAYV emergence is a potential threat, there are no specific therapies or licensed vaccine. In this...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62084-x
更新日期:2020-03-24 00:00:00
abstract::There has been a significant increase in autism spectrum disorder (ASD) in the last decades that cannot be exclusively attributed to better diagnosis and an increase in the communication of new cases. Patients with ASD often show dysregulation of proteins associated with synaptic plasticity, notably brain-derived neur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74239-x
更新日期:2020-10-15 00:00:00
abstract::A better understanding of the mechanisms of action of human adjuvants could inform a rational development of next generation vaccines for human use. Here, we exploited a genome wide transcriptomics analysis combined with a systems biology approach to determine the molecular signatures induced by four clinically tested...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39097
更新日期:2016-12-13 00:00:00
abstract::Bleeding risk with antiplatelet therapy is an increasing clinical challenge. However, the inter-individual variation in this risk is poorly understood. We assessed whether the level of plasma creatine kinase, the enzyme that utilizes ADP and phosphocreatine to rapidly regenerate ATP, may modulate bleeding risk through...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06551
更新日期:2014-10-09 00:00:00
abstract::Wooden shipwrecks are a significant part of the underwater cultural heritage. In 2007, the Nanhai No. 1 shipwreck was salvaged from the seabed and moved into the Marine Silk Road Museum, where it is still stored in a water tank. We analysed the microbial communities colonizing the hull surface of the Nanhai No. 1 ship...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25484-8
更新日期:2018-05-08 00:00:00
abstract::Lactobacillus species are the predominant vaginal microbiota found in healthy women of reproductive age and help to prevent pathogen infection by producing lactic acid, H2O2 and anti-microbial compounds. Identification of novel vaginal Lactobacillus isolates that exhibit efficient colonisation and secrete anti-Candida...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44579-4
更新日期:2019-05-31 00:00:00
abstract::The queens of eusocial bees, ants and wasps mate only during a very short period early in life and males therefore produce ejaculates consisting of large numbers of high quality sperm. Such extreme selection for high fecundity resulted in males investing minimally into their somatic survival, including their immune sy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10565
更新日期:2015-06-30 00:00:00
abstract::Optical projection tomography (OPT) is a tool used for three-dimensional imaging of millimeter-scale biological samples, with the advantage of exhibiting isotropic resolution typically in the micron range. OPT can be divided into two types: transmission OPT (tOPT) and emission OPT (eOPT). Compared with eOPT, tOPT disc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19241
更新日期:2016-01-11 00:00:00
abstract::Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen ((1)O2) generation via a laser excited photosensitiser (PS) to kill cancer cells. However, prolonged sensitivity to intensive light (6-8 weeks for lung cancer), relatively...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03484
更新日期:2013-12-12 00:00:00
abstract::Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06937-y
更新日期:2017-08-01 00:00:00
abstract::We have designed a new type of composite materials which not only has a Young's modulus much larger than the Voigt limit, but also is always nearly isotropic. Moreover, its Poisson's ratio can be designed at a desired value, e.g. positive, or negative, or zero. We have also demonstrated that structural hierarchy can h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14103
更新日期:2015-09-11 00:00:00
abstract::In this work, disordered-IrMn3/insulating-Y3Fe5O12 exchange-biased bilayers are studied. The behavior of the net magnetic moment ΔmAFM in the antiferromagnet is directly probed by anomalous and planar Hall effects, and anisotropic magnetoresistance. The ΔmAFM is proved to come from the interfacial uncompensated magnet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09183
更新日期:2015-03-17 00:00:00
abstract::Hearing loss becomes increasingly common with age and affects quality of life. Recently, scientists have published articles about the relationship between metabolic disease and hearing loss. Metabolic disease was previously found to be highly related to an increase in alkaline phosphatase. Thus, there may be an indire...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/s41598-020-60979-3
更新日期:2020-03-04 00:00:00
abstract::Porous three-dimensional (3D) polyurethane-based biocomposites were produced utilizing diatomite and hydroxyapatite as fillers. Diatomite and Hydroxyapatite (HA) were utilized to reinforce the morphological, chemical, mechanical, and thermal properties of polyurethane foam (PUF). Diatomite and Hydroxyapatite were adde...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70421-3
更新日期:2020-08-06 00:00:00
abstract::In many real-world networks, the ability to withstand targeted or global attacks; extinctions; or shocks is vital to the survival of the network itself, and of dependent structures such as economies (for financial networks) or even the planet (for ecosystems). Previous attempts to characterise robustness include neste...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59959-4
更新日期:2020-02-25 00:00:00
abstract::BiFeO3 is one of the most promising multiferroic materials but undergoes two major drawbacks: low dielectric susceptibility and high dielectric loss. Here we report high in-plane dielectric permittivity (ε' ∼2500) and low dielectric loss (tan δ < 0.01) obtained on Bi0.95Y0.05FeO3 films epitaxially grown on SrTiO3 (001...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25535
更新日期:2016-05-09 00:00:00
abstract::The nervous system controls most rhythmic behaviors, with a remarkable exception. In Caenorhabditis elegans periodic defecation rhythm does not appear to involve the nervous system. Such oscillations are studied in detail with genetic and molecular biology tools. The small size of C. elegans cells impairs the use of s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18118-y
更新日期:2017-12-19 00:00:00
abstract::To improve the understanding of the complex biological processes underlying the development of non-alcoholic steatohepatitis (NASH), a multi-omics approach combining bulk RNA-sequencing based transcriptomics, quantitative proteomics and single-cell RNA-sequencing was used to characterize tissue biopsies from histologi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58059-7
更新日期:2020-01-24 00:00:00
abstract::In this study we present an image analysis methodology capable of quantifying morphological changes in tissue collagen fibril organization caused by pathological conditions. Texture analysis based on first-order statistics (FOS) and second-order statistics such as gray level co-occurrence matrix (GLCM) was explored to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02190
更新日期:2013-01-01 00:00:00
abstract::Saccharomyces cerevisiae is used as a host strain in bioproduction, because of its rapid growth, ease of genetic manipulation, and high reducing capacity. However, the heat produced during the fermentation processes inhibits the biological activities and growth of the yeast cells. We performed whole-genome sequencing ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23157
更新日期:2016-03-17 00:00:00
abstract::The increasing use of new and emerging tobacco products has raised public health concern worldwide. This study aimed to assess the association between tobacco product use and the risk of allergic diseases. We used cross-sectional data of 58,336 students aged 12-18 years from the 2018 Korea Youth Risk Behavior Survey. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54102-4
更新日期:2019-11-27 00:00:00
abstract::The properties of the human mind affect the quality of scientific knowledge through the insertion of unconscious biases during the research process. These biases frequently cause overestimation of the effects under study, thereby violating the reproducibility of the research and potentially leading to incorrect conclu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80677-4
更新日期:2021-01-08 00:00:00
abstract::Mass spectrometry (MS) for the detection of proteins is an indispensable tool for evaluating the biological processes of the proteome. Proteomics frequently requires proteolysis of proteins into peptide fragments. Proteins can be refractory to ideal proteolysis at the sequence level rendering them difficult to analyze...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33265
更新日期:2016-09-14 00:00:00
abstract::Cyclamen persicum (cyclamen) is a commercially valuable, winter-blooming perennial plant. We cloned two cyclamen orthologues of AGAMOUS (AG), CpAG1 and CpAG2, which are mainly expressed in the stamen and carpel, respectively. Cyclamen flowers have 5 petals, but expression of a chimeric repressor of CpAG1 (CpAG1-SRDX) ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02641
更新日期:2013-01-01 00:00:00
abstract::MicroRNAs hold great promise as biomarkers of disease. However, there are few efficient and robust methods for measuring microRNAs from low input samples. Here, we develop a high-throughput sequencing protocol that efficiently captures small RNAs while minimizing inherent biases associated with library production. The...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38458-7
更新日期:2019-02-19 00:00:00
abstract::Antitumor drug development based on the concept of intervening in the antioxidant system of cancer cells has been gaining increased interest. In this study, we propose a promising strategy for cancer treatment using modulation of oxidative stress by suppression of glutathione S-transferases (GSTs), a typical antioxida...
journal_title:Scientific reports
pub_type: 杂志文章,收录出版
doi:10.1038/s41598-019-51462-9
更新日期:2019-10-14 00:00:00
abstract::Earthquakes are important natural events, yet their impacts on animal communities are poorly known. Understanding earthquake impacts on groundwater communities is essential to assess their resilience and hence to perform conservation actions. We investigated how a 6.3 Mw earthquake that occurred in 2009 altered the co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20011-1
更新日期:2018-01-24 00:00:00
abstract::Glycyrrhetinic acid monoglucuronide (GAMG) is a great value-added and has considerable commercial interest due to its strong pharmacological activities and functional low-calorie sweetener. However GAMG is quite rare in natural plants, and it must be prepared from glycyrrhizin (GL) by hydrolysing one terminal glucuron...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10154-y
更新日期:2017-10-02 00:00:00