Abstract：
:Neurogenesis of hippocampal granule cells (GCs) persists throughout mammalian life and is important for learning and memory. How newborn GCs differentiate and mature into an existing circuit during this time period is not yet fully understood. We established a method to visualize postnatally generated GCs in organotypic entorhino-hippocampal slice cultures (OTCs) using retroviral (RV) GFP-labeling and performed time-lapse imaging to study their morphological development in vitro. Using anterograde tracing we could, furthermore, demonstrate that the postnatally generated GCs in OTCs, similar to adult born GCs, grow into an existing entorhino-dentate circuitry. RV-labeled GCs were identified and individual cells were followed for up to four weeks post injection. Postnatally born GCs exhibited highly dynamic structural changes, including dendritic growth spurts but also retraction of dendrites and phases of dendritic stabilization. In contrast, older, presumably prenatally born GCs labeled with an adeno-associated virus (AAV), were far less dynamic. We propose that the high degree of structural flexibility seen in our preparations is necessary for the integration of newborn granule cells into an already existing neuronal circuit of the dentate gyrus in which they have to compete for entorhinal input with cells generated and integrated earlier.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Radic T,Jungenitz T,Singer M,Beining M,Cuntz H,Vlachos A,Deller T,Schwarzacher SWdoi
10.1038/srep43724subject
Has Abstractpub_date
2017-03-03 00:00:00pages
43724issn
2045-2322pii
srep43724journal_volume
7pub_type
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pub_type： 杂志文章
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更新日期：2016-03-03 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 已发布勘误
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pub_type： 已发布勘误
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