Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus.

abstract：:It has been thought that incretin signaling prevents arteriosclerosis, and very recently anti-arteriosclerotic effects through GLP-1 receptor were finally demonstrated in clinical human study. The purpose of this study was to investigate how vascular GLP-1 receptor expression is influenced in human subjects. First, we...

journal_title：Scientific reports

authors： Kimura T,Obata A,Shimoda M,Shimizu I,da Silva Xavier G,Okauchi S,Hirukawa H,Kohara K,Mune T,Moriuchi S,Hiraoka A,Tamura K,Chikazawa G,Ishida A,Yoshitaka H,Rutter GA,Kaku K,Kaneto H

更新日期：2018-07-13 00:00:00

abstract：:Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of circulating tumour cells (CTCs)...

journal_title：Scientific reports

authors： Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA

更新日期：2018-02-13 00:00:00

abstract：:Magnetic carboxyl functional nanoporous polymer (MCFNP) was chemically fabricated by incorporation of magnetic Fe3O4 precursor into the carboxyl functional nanoporous polymer (CFNP). The as-synthesized MCFNP was characterized and used as an adsorbent for rapid adsorption removal of methylene blue (MB) from wastewater....

journal_title：Scientific reports

authors： Su H,Li W,Han Y,Liu N

更新日期：2018-04-25 00:00:00

abstract：:Ceramide (Cer) release from glucosylceramides (GlcCer) is critical for the formation of the skin permeability barrier. Changes in β-glucocerebrosidase (GlcCer'ase) activity lead to diminished Cer, GlcCer accumulation and structural defects in SC lipid lamellae; however, the molecular basis for this impairment is not c...

journal_title：Scientific reports

authors： Sochorová M,Staňková K,Pullmannová P,Kováčik A,Zbytovská J,Vávrová K

更新日期：2017-07-25 00:00:00

abstract：:Engineering of efflux pumps is a promising way to improve host's tolerance to biofuels such as medium-chain alcohols (CmOHs); however, this strategy is restricted by poor understanding of the efflux pumps engaged in extrusion of solvents. In this study, several Escherichia coli mutants of multidrug transporters were e...

journal_title：Scientific reports

authors： Wang C,Yang L,Shah AA,Choi ES,Kim SW

更新日期：2015-11-13 00:00:00

abstract：:High-carrier mobility semiconductors on insulators are essential for fabricating advanced thin-film transistors, allowing for three-dimensional integrated circuits or high-performance mobile terminals. We investigate the low-temperature (375-450 °C) solid-phase crystallization (SPC) of Ge on a glass substrate, focusin...

journal_title：Scientific reports

authors： Toko K,Yoshimine R,Moto K,Suemasu T

更新日期：2017-12-05 00:00:00

abstract：:The patient-derived tumor xenograft (PDTX) model has become the most realistic model for preclinical studies. PDTX models of gastric cancer using surgical tissues are reported occasionally; however, the PDTX models using gastroscopic biopsies, which are best for evaluating new drugs, are unreported. In our study, a to...

journal_title：Scientific reports

authors： Zhu Y,Tian T,Li Z,Tang Z,Wang L,Wu J,Li Y,Dong B,Li Y,Li N,Zou J,Gao J,Shen L

更新日期：2015-02-25 00:00:00

abstract：:Fibroblast growth factor-21 (FGF21) is closely related to various metabolic and cardiovascular disorders. However, the direct targets and mechanisms linking FGF21 to blood pressure control and hypertension are still elusive. Here we demonstrated a novel regulatory function of FGF21 in the baroreflex afferent pathway (...

journal_title：Scientific reports

authors： He JL,Zhao M,Xia JJ,Guan J,Liu Y,Wang LQ,Song DX,Qu MY,Zuo M,Wen X,Yu X,Huo R,Pan ZW,Ban T,Zhang Y,Zhu JX,Shou W,Qiao GF,Li BY

更新日期：2016-07-08 00:00:00

abstract：:The nuclear pore complex (NPC) is one of the largest supramolecular structures in eukaryotic cells. Its octagonal ring-scaffold perforates the nuclear envelope and features a unique molecular machinery that regulates nucleocytoplasmic transport. NPCs are composed of ~30 different nucleoporins (Nups), averaged at 8, 16...

journal_title：Scientific reports

authors： Mi L,Goryaynov A,Lindquist A,Rexach M,Yang W

更新日期：2015-03-23 00:00:00

abstract：:The overall goal of this work was to measure the efficacy of fMRI for predicting whether a dog would be a successful service dog. The training and imaging were performed in 49 dogs entering service training at 17-21 months of age. 33 dogs completed service training and were matched with a person, while 10 were release...

journal_title：Scientific reports

authors： Berns GS,Brooks AM,Spivak M,Levy K

更新日期：2017-03-07 00:00:00

abstract：:In clinical pathology, stent interposition is used to treat vascular disease but can lead to restenosis. Drug-eluting stents (DES) are most commonly used to suppress restenosis but can also have side effects. Therefore, we investigated the anti-proliferative effect and its possible target in vitro and in vivo. We foun...

journal_title：Scientific reports

authors： Lee JJ,Lee JH,Yim NH,Han JH,Ma JY

更新日期：2017-08-15 00:00:00

abstract：:To understand the mechanisms of male sterility in cotton (Gossypium spp.), combined histological, biochemical and transcription analysis using RNA-Seq was carried out in the anther of the single-gene recessive genic male sterility system of male sterile line 1355A and male fertile line 1355B, which are near-isogenic l...

journal_title：Scientific reports

authors： Wu Y,Min L,Wu Z,Yang L,Zhu L,Yang X,Yuan D,Guo X,Zhang X

更新日期：2015-06-05 00:00:00

abstract：:We conduct textual analysis of a sample of more than 200,000 papers written on HIV/AIDS during the past three decades. Using the Latent Dirichlet Allocation method, we disentangle studies that address behavioral and social aspects from other studies and measure the trends of different topics as related to HIV/AIDS. We...

journal_title：Scientific reports

authors： Baghaei Lakeh A,Ghaffarzadegan N

更新日期：2017-06-23 00:00:00

abstract：:Our previous study suggested that microtubule network alteration affects the process of glycolysis in cardiomyocytes (CMs) via the regulation of hypoxia-inducible factor (HIF)-1α during the early stages of hypoxia. However, little is known regarding the underlying mechanisms of microtubule network alteration-induced c...

journal_title：Scientific reports

authors： Jiang X,Zhang D,Zhang H,Huang Y,Teng M

更新日期：2015-03-17 00:00:00

abstract：:Traffic-related air pollution is known to be associated with skin aging manifestations. We previously found that the use of fossil fuels was associated with skin aging, but no direct link between indoor air pollutants and skin aging manifestations has ever been shown. Here we directly measured the indoor PM2.5 exposur...

journal_title：Scientific reports

authors： Ding A,Yang Y,Zhao Z,Hüls A,Vierkötter A,Yuan Z,Cai J,Zhang J,Gao W,Li J,Zhang M,Matsui M,Krutmann J,Kan H,Schikowski T,Jin L,Wang S

更新日期：2017-11-10 00:00:00

abstract：:We present a comparative study of plasmonic antennas fabricated by electron beam lithography and direct focused ion beam milling. We have investigated optical and structural properties and chemical composition of gold disc-shaped plasmonic antennas on a silicon nitride membrane fabricated by both methods to identify t...

journal_title：Scientific reports

authors： Horák M,Bukvišová K,Švarc V,Jaskowiec J,Křápek V,Šikola T

更新日期：2018-06-25 00:00:00

abstract：:Patients with end stage renal disease (ESRD) suffer high mortality from arrhythmias linked to fibrosis, but are contraindicated to late gadolinium enhancement magnetic resonance imaging (MRI). We present a quantitative method for gadolinium-free cardiac fibrosis imaging using magnetization transfer (MT) weighted MRI, ...

journal_title：Scientific reports

authors： Stromp TA,Spear TJ,Holtkamp RM,Andres KN,Kaine JC,Alghuraibawi WH,Leung SW,Fornwalt BK,Vandsburger MH

更新日期：2018-11-19 00:00:00

abstract：:Geographical origin determination of white rice has become the major issue of food industry. However, there is still lack of a high-throughput method for rapidly and reproducibly differentiating the geographical origins of commercial white rice. In this study, we developed a method that employed lipidomics and deep le...

journal_title：Scientific reports

authors： Long NP,Lim DK,Mo C,Kim G,Kwon SW

更新日期：2017-08-17 00:00:00

abstract：:Circular RNAs (circRNAs) are abundantly expressed in the haematopoietic compartment, but knowledge on their diversity among blood cell types is still limited. Nevertheless, emerging data indicate an array of circRNA functions exerted through interactions with other RNAs and proteins, by translation into peptides, and ...

journal_title：Scientific reports

authors： Gaffo E,Boldrin E,Dal Molin A,Bresolin S,Bonizzato A,Trentin L,Frasson C,Debatin KM,Meyer LH,Te Kronnie G,Bortoluzzi S

更新日期：2019-10-11 00:00:00

abstract：:Mounting evidence indicated that human mesenchymal stem cells (hMSCs) are responsive not only to biochemical but also to physical cues, such as substrate topography and stiffness. To simulate the dynamic structures of extracellular environments of the marrow in vivo, we designed a novel surrogate substrate for marrow ...

journal_title：Scientific reports

authors： Frank V,Kaufmann S,Wright R,Horn P,Yoshikawa HY,Wuchter P,Madsen J,Lewis AL,Armes SP,Ho AD,Tanaka M

更新日期：2016-04-15 00:00:00

abstract：:In this paper, we developed a new method to produce large-area single crystal arrays by using the organic semiconductor 9, 10-bis (phenylethynyl) anthracene (BPEA). This method involves an easy operation, is efficient, meets the demands of being low-cost and is independent of the substrate for large-area arrays fabric...

journal_title：Scientific reports

authors： Li Y,Ji D,Liu J,Yao Y,Fu X,Zhu W,Xu C,Dong H,Li J,Hu W

更新日期：2015-08-18 00:00:00

abstract：:Sterility mosaic disease (SMD) is one of the serious production constraints that may lead to complete yield loss in pigeonpea. Three mapping populations including two recombinant inbred lines and one F2, were used for phenotyping for SMD resistance at two locations in three different years. Genotyping-by-sequencing ap...

journal_title：Scientific reports

authors： Saxena RK,Kale SM,Kumar V,Parupali S,Joshi S,Singh V,Garg V,Das RR,Sharma M,Yamini KN,Ghanta A,Rathore A,Sameerkumar CV,Saxena KB,Varshney RK

更新日期：2017-05-12 00:00:00

abstract：:Ecological adaptations to seasonal changes are often observed in the phenotypic traits of plants and animals, and these adaptations are usually expressed through the production of different biochemical end products. In this study, ecological adaptations are observed in a biochemical pathway without alteration of the e...

journal_title：Scientific reports

authors： Hirata H,Ohnishi T,Tomida K,Ishida H,Kanda M,Sakai M,Yoshimura J,Suzuki H,Ishikawa T,Dohra H,Watanabe N

更新日期：2016-02-01 00:00:00

abstract：:Site-specific genome modification (SSM) is an important tool for mosquito functional genomics and comparative gene expression studies, which contribute to a better understanding of mosquito biology and are thus a key to finding new strategies to eliminate vector-borne diseases. Moreover, it allows for the creation of ...

journal_title：Scientific reports

authors： Häcker I,Harrell Ii RA,Eichner G,Pilitt KL,O'Brochta DA,Handler AM,Schetelig MF

更新日期：2017-03-07 00:00:00

abstract：:Individuals infected with hepatitis C virus (HCV) are at high risk of developing progressive liver disease, including cirrhosis and hepatocellular carcinoma (HCC). How HCV infection causes liver destruction has been of significant interest for many years, and apoptosis has been proposed as one operative mechanism. In ...

journal_title：Scientific reports

authors： Kofahi HM,Taylor NG,Hirasawa K,Grant MD,Russell RS

更新日期：2016-12-15 00:00:00

abstract：:Due to the obesity epidemic, non-alcoholic steatohepatitis (NASH) is a prevalent liver disease, characterized by fat accumulation and inflammation of the liver. However, due to a lack of mechanistic insight, diagnostic and therapeutic options for NASH are poor. Recent evidence has indicated cathepsin D (CTSD), a lysos...

journal_title：Scientific reports

authors： Houben T,Oligschlaeger Y,Hendrikx T,Bitorina AV,Walenbergh SMA,van Gorp PJ,Gijbels MJJ,Friedrichs S,Plat J,Schaap FG,Lütjohann D,Hofker MH,Shiri-Sverdlov R

更新日期：2017-06-14 00:00:00

abstract：:Understanding and control of heat dissipation is an important challenge in nanoelectronics wherein field-accelerated hot carriers in current-carrying ballistic systems release a large part of the kinetic energy into external bulk phonon baths. Here we report on a physical mechanism of this remote heat dissipation and ...

journal_title：Scientific reports

authors： Tsutsui M,Morikawa T,Yokota K,Taniguchi M

更新日期：2018-05-18 00:00:00

abstract：:Gram-positive bacteria homeostasis and antibiotic resistance mechanisms are dependent on the intricate architecture of the cell wall, where amidated peptidoglycan plays an important role. The amidation reaction is carried out by the bi-enzymatic complex MurT-GatD, for which biochemical and structural information is ve...

journal_title：Scientific reports

authors： Leisico F,V Vieira D,Figueiredo TA,Silva M,Cabrita EJ,Sobral RG,Ludovice AM,Trincão J,Romão MJ,de Lencastre H,Santos-Silva T

更新日期：2018-03-28 00:00:00

abstract：:Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms. To determine its effects on female reproductive physiology and investigate whether changes in the expression levels of genes related...

journal_title：Scientific reports

authors： Santangeli S,Maradonna F,Gioacchini G,Cobellis G,Piccinetti CC,Dalla Valle L,Carnevali O

更新日期：2016-02-25 00:00:00

abstract：:Omono River virus (OmRV) is a double-stranded RNA virus isolated from Culex mosquitos, and it belongs to a group of unassigned insect viruses that appear to be related to Totiviridae. This paper describes electron cryo-microscopy (cryoEM) structures for the intact OmRV virion to 8.9 Å resolution and the structure of t...

journal_title：Scientific reports

authors： Okamoto K,Miyazaki N,Larsson DS,Kobayashi D,Svenda M,Mühlig K,Maia FR,Gunn LH,Isawa H,Kobayashi M,Sawabe K,Murata K,Hajdu J

更新日期：2016-09-12 00:00:00