Abstract:
:Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms. To determine its effects on female reproductive physiology and investigate whether changes in the expression levels of genes related to reproduction are caused by histone modifications, BPA concentrations consistent with environmental exposure were administered to zebrafish for three weeks. Effects on oocyte growth and maturation, autophagy and apoptosis processes, histone modifications, and DNA methylation were assessed by Real-Time PCR (qPCR), histology, and chromatin immunoprecipitation combined with qPCR analysis (ChIP-qPCR). The results showed that 5 μg/L BPA down-regulated oocyte maturation-promoting signals, likely through changes in the chromatin structure mediated by histone modifications, and promoted apoptosis in mature follicles. These data indicate that the negative effects of BPA on the female reproductive system may be due to its upstream ability to deregulate epigenetic mechanism.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Santangeli S,Maradonna F,Gioacchini G,Cobellis G,Piccinetti CC,Dalla Valle L,Carnevali Odoi
10.1038/srep21982subject
Has Abstractpub_date
2016-02-25 00:00:00pages
21982issn
2045-2322pii
srep21982journal_volume
6pub_type
杂志文章abstract::The study of the preparation phase of large earthquakes is essential to understand the physical processes involved, and potentially useful also to develop a future reliable short-term warning system. Here we analyse electron density and magnetic field data measured by Swarm three-satellite constellation for 4.7 years,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56599-1
更新日期:2019-12-30 00:00:00
abstract::A positive Indian Ocean Dipole (IOD) and a warm phase of the El Niño-Southern Oscillation (ENSO) reduce rainfall over the Indian subcontinent and southern Australia. However, since the 1980s, El Niño's influence has been decreasing, accompanied by a strengthening in the IOD's influence on southern Australia but a reve...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31767
更新日期:2016-08-22 00:00:00
abstract::The spinal cord is an integration center for descending, ascending, and segmental neural signals. Noninvasive transspinal stimulation may thus constitute an effective method for concomitant modulation of local and distal neural circuits. In this study, we established changes in cortical excitability and input/output f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18872-z
更新日期:2018-01-15 00:00:00
abstract::The plasmodial CTP:phosphocholine cytidylyltransferase (PfCCT) is a promising antimalarial target, which can be inhibited to exploit the need for increased lipid biosynthesis during the erythrocytic life stage of Plasmodium falciparum. Notable structural and regulatory differences of plasmodial and mammalian CCTs offe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27183-w
更新日期:2018-06-12 00:00:00
abstract::Vertical hot electron transistors incorporating atomically-thin 2D materials, such as graphene or MoS2, in the base region have been proposed and demonstrated in the development of electronic and optoelectronic applications. To the best of our knowledge, all previous 2D material-base hot electron transistors only cons...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32503
更新日期:2016-09-01 00:00:00
abstract::Microalgae have great potential for the production of biofuels due to the ability of the organism to accumulate large quantities of storage lipids under stress conditions. Mitogen activated protein kinase (MAPK) signaling cascades are widely recognized for their role in stress response signal transduction in eukaryote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32216-5
更新日期:2018-09-14 00:00:00
abstract::Symbiodinium is best-known as the photosynthetic symbiont of corals, but some clades are symbiotic in other organisms or include free-living forms. Identifying similarities and differences among these clades can help us understand their relationship with corals, and thereby inform on measures to manage coral reefs in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15029-w
更新日期:2017-11-03 00:00:00
abstract::We engineered a transdermal neuromodulation approach that targets peripheral (cranial and spinal) nerves and utilizes their afferent pathways as signaling conduits to influence brain function. We investigated the effects of this transdermal electrical neurosignaling (TEN) method on sympathetic physiology under differe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13865
更新日期:2015-09-10 00:00:00
abstract::We developed an optimal noninvasive index comprising routine laboratory parameters for predicting cirrhosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) patients. This study included 992 CHB patients and 1,284 CHC patients who received liver biopsy. We developed the new index, named modified Fibrosis-4 (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03589-w
更新日期:2017-06-12 00:00:00
abstract::Rhizomorphic lycopsids are the land plant group that includes the first giant trees to grow on Earth and extant species in the genus Isoetes. Two mutually exclusive hypotheses account for the evolution of terminal rooting axes called rootlets among the rhizomorphic lycopsids. One hypothesis states that rootlets are tr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78171-y
更新日期:2020-12-09 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-23047-5
更新日期:2018-03-12 00:00:00
abstract::Increased glucose uptake and aerobic glycolysis are striking features of many cancers. These features have led to many techniques for screening and diagnosis, but many are expensive, less feasible or have harmful side-effects. Here, we report a sensitive 1H/2H NMR method to measure the kinetics of lactate isotopomer a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65839-8
更新日期:2020-06-01 00:00:00
abstract::Although the demand for high-speed telecommunications has increased in recent years, the performance of transistors fabricated with traditional semiconductors such as silicon, gallium arsenide, and gallium nitride have reached their physical performance limits. Therefore, new materials with high carrier velocities sho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03951
更新日期:2014-02-04 00:00:00
abstract::Demand for clinical decision support systems in medicine and self-diagnostic symptom checkers has substantially increased in recent years. Existing platforms rely on knowledge bases manually compiled through a labor-intensive process or automatically derived using simple pairwise statistics. This study explored an aut...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05778-z
更新日期:2017-07-20 00:00:00
abstract::Neuromuscular impairment requires adherence to a rehabilitation regimen for maximum recovery of motor function. Consumer-grade game controllers have emerged as a viable means to relay supervised physical therapy to patients' homes, thereby increasing their accessibility to healthcare. These controllers allow patients ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59927-y
更新日期:2020-02-28 00:00:00
abstract::The ends of eukaryotic chromosomes are capped by telomeres which consist of tandem G-rich DNA repeats stabilized by the shelterin protein complex. Telomeres shorten progressively in most normal cells due to the end replication problem. In more than 85% of cancers however, the telomere length is maintained by telomeras...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06391
更新日期:2014-09-29 00:00:00
abstract::Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer's disease. In situ identification of early-stage amyloid aggregates in Alzheimer's disease is relevant for their importance as potential targets for effective drugs. Synchrotron-based infrared imaging i...
journal_title:Scientific reports
pub_type: 杂志文章,收录出版
doi:10.1038/s41598-020-62708-2
更新日期:2020-04-03 00:00:00
abstract::The secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin signaling is frequently inactivated by promoter methylation and oncogenic activation of the Wnt signaling pathway is common in many cancers. The curcumin-rich Curcuma longa has been reported to potent anti-cancer property involved i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53509-3
更新日期:2019-11-21 00:00:00
abstract::To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide associatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20844-w
更新日期:2018-02-05 00:00:00
abstract::Fuel substrate supply and oxidative phosphorylation are key determinants of muscle performance. Numerous studies of mammalian mitochondria are carried out (i) with substrate supply that limits electron flow, and (ii) far below physiological temperature. To analyze potentially implicated biases, we studied mitochondria...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02789-8
更新日期:2017-06-06 00:00:00
abstract::Topical anesthetics are widely applied in order to relieve the discomfort and anxiety caused by needle insertion and other painful superficial interventions at the oral cavity. So far, there are no commercially available effective topical anesthetic formulations for that purpose, and the most of developments are relat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68247-0
更新日期:2020-07-09 00:00:00
abstract::Many community detection algorithms have been developed to uncover the mesoscopic properties of complex networks. However how good an algorithm is, in terms of accuracy and computing time, remains still open. Testing algorithms on real-world network has certain restrictions which made their insights potentially biased...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30750
更新日期:2016-08-01 00:00:00
abstract::The use of anti-cancer adjuvant therapy is rationalized by potentiating the efficacy, and/or protecting from major side effects of chemotherapeutics. Thymoquinone (TQ) is a naturally occurring compound with cumulative evidence of anti-cancer properties. In this study, we assessed the chemomodulatory potential of TQ to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30046-z
更新日期:2018-08-03 00:00:00
abstract::When compared to surface ecosystems, groundwater sampling has unique constraints, including limited access to ecosystems through wells. In order to monitor groundwater, a detailed understanding of groundwater biota and what biological sampling of wells truly reflects, is paramount. This study aims to address this unce...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40702
更新日期:2017-01-19 00:00:00
abstract::N-myc downstream regulated gene 1 (NDRG1) is a responsible gene for a hereditary motor and sensory neuropathy-Lom (Charcot-Marie-Tooth disease type 4D). This is the first study aiming to assess the contribution of NDRG1 to differentiation of macrophage lineage cells, which has important implications for bone remodelin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19470
更新日期:2016-01-18 00:00:00
abstract::Liquid biopsy can provide a strong basis for precision medicine. We aimed to identify novel single-nucleotide variants (SNVs) in circulating tumor DNA (ctDNA) in patients with hepatocellular carcinoma (HCC). Deep sequencing of plasma-derived ctDNA from 59 patients with HCC was performed using a panel of 2924 SNVs in 6...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74494-y
更新日期:2020-10-20 00:00:00
abstract::The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) with anti-inflammatory properties. In UC patients, sST2 is further increased by corticosteroid t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10465-0
更新日期:2017-08-31 00:00:00
abstract::Effects of elevated seawater temperatures on deep-water benthos has been poorly studied, despite reports of increased seawater temperature (up to 4 °C over 24 hrs) coinciding with mass mortality events of the sponge Geodia barretti at Tisler Reef, Norway. While the mechanisms driving these mortality events are unclear...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01091-x
更新日期:2017-05-22 00:00:00
abstract::Core-shell Nb2O5/TiO2 composite with hierarchical heterostructure is successfully synthesized In-situ by a facile template-free and acid-free solvothermal method based on the mechanism of liquid phase epitaxy. The chemical circumstance change induced by the alcoholysis of NbCl5 is utilized tactically to trigger core-s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25260
更新日期:2016-04-28 00:00:00
abstract::Inflammation is considered as a major contributor to brain injury following cerebral ischemia. The therapeutic potential of both MLC601/MLC901, which are herbal extract preparations derived from Chinese Medicine, has been reported both in advanced stroke clinical trials and also in animal and cellular models. The aim ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36138-0
更新日期:2018-12-24 00:00:00