MLH1 single-nucleotide variant in circulating tumor DNA predicts overall survival of patients with hepatocellular carcinoma.

abstract：:The GntR family transcription regulator HpaR1 identified from Xanthomonas campestris pv. campestris has been previously shown to positively regulate the genes responsible for hypersensitive reaction and pathogenicity and to autorepress its own expression. Here, we demonstrated that HpaR1 is a global regulator that pos...

journal_title：Scientific reports

authors： Su HZ,Wu L,Qi YH,Liu GF,Lu GT,Tang JL

更新日期：2016-01-28 00:00:00

abstract：:Humans are good at selectively listening to specific target conversations, even in the presence of multiple concurrent speakers. In our research, we study how auditory-visual cues modulate this selective listening. We do so by using immersive Virtual Reality technologies with spatialized audio. Exposing 32 participant...

journal_title：Scientific reports

authors： Gonzalez-Franco M,Maselli A,Florencio D,Smolyanskiy N,Zhang Z

更新日期：2017-06-19 00:00:00

abstract：:Decline in episodic memory performance usually causes the first clinical symptoms of Alzheimer's disease. At present, Alzheimer's disease can only be diagnosed at a very late stage when neurodegeneration and cognitive impairment is already irreversible. New early disease markers are needed for earlier and more efficie...

journal_title：Scientific reports

authors： Konki M,Lindgren N,Kyläniemi M,Venho R,Laajala E,Ghimire B,Lahesmaa R,Kaprio J,Rinne JO,Lund RJ

更新日期：2020-08-25 00:00:00

abstract：:Identifying the unintended effects of drugs (side effects) is a very important issue in pharmacological studies. The laboratory verification of associations between drugs and side effects requires costly, time-intensive research. Thus, an approach to predicting drug side effects based on known side effects, using a co...

journal_title：Scientific reports

authors： Timilsina M,Tandan M,d'Aquin M,Yang H

更新日期：2019-07-18 00:00:00

abstract：:Sample pooling enabled by dedicated indexes is a common strategy for cost-effective and robust high-throughput sequencing. Index misassignment leading to mutual contamination between pooled samples has however been described as a general problem of the latest Illumina sequencing instruments utilizing exclusion amplifi...

journal_title：Scientific reports

authors： Vodák D,Lorenz S,Nakken S,Aasheim LB,Holte H,Bai B,Myklebost O,Meza-Zepeda LA,Hovig E

更新日期：2018-03-28 00:00:00

abstract：:The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer of vascular leakage and angiogenesis both of which are fundamental pathophysiology of diabe...

journal_title：Scientific reports

authors： Lee CS,Kim YG,Cho HJ,Park J,Jeong H,Lee SE,Lee SP,Kang HJ,Kim HS

更新日期：2016-07-06 00:00:00

abstract：:Tumor microenvironment favors tumor cells to promote their growth and metastasis such as migration, invasion, and angiogenesis. IL-1β, one of the inflammatory cytokines released from myeloid cells in tumor microenvironment, plays an important role in development and progress of tumor. The activation of inflammasome is...

journal_title：Scientific reports

authors： Lee HE,Lee JY,Yang G,Kang HC,Cho YY,Lee HS,Lee JY

更新日期：2019-08-22 00:00:00

abstract：:Periocular skin warming reportedly improves the objective and subjective sleep quality in adults with mild difficulty in falling asleep. To clarify the effects of periocular warming, we examined the distal skin temperatures (hands and feet), proximal skin temperature (infraclavicular region) and core body temperature ...

journal_title：Scientific reports

authors： Ichiba T,Suzuki M,Aritake-Okada S,Uchiyama M

更新日期：2019-04-05 00:00:00

abstract：:The application of metabolic phenotyping in clinical and epidemiological studies is limited by a poor understanding of inter-individual, intra-individual and temporal variability in metabolic phenotypes. Using 1H NMR spectroscopy we characterised short-term variability in urinary metabolites measured from 20 children ...

journal_title：Scientific reports

authors： Maitre L,Lau CE,Vizcaino E,Robinson O,Casas M,Siskos AP,Want EJ,Athersuch T,Slama R,Vrijheid M,Keun HC,Coen M

更新日期：2017-04-19 00:00:00

abstract：:Probing the oligomeric state of abundant molecules, such as membrane proteins in intact cells, is essential, but has not been straightforward. We address this challenge with a simple counting strategy that is capable of reporting the oligomeric state of dense, membrane-bound protein complexes. It is based on single-mo...

journal_title：Scientific reports

authors： Fricke F,Beaudouin J,Eils R,Heilemann M

更新日期：2015-09-11 00:00:00

abstract：:Telomere length (TL) is linked to various age-related diseases, but little is known about telomeres in gestational diabetes mellitus (GDM). We surveyed 509 subjects (113 GDM patients and 396 frequency matched controls) in Nanjing Drum Tower Hospital, Jiangsu province of eastern China. Relative telomere length (RTL) of...

journal_title：Scientific reports

authors： Weng Q,Deng K,Wu F,Gan M,Li J,Dai Y,Jiang Y,Chen J,Dai J,Ma H,Hu Z,Shen H,Du J,Hu Y,Jin G

更新日期：2019-06-11 00:00:00

abstract：:The implementation of HTS (high-throughput sequencing) approaches is rapidly changing our understanding of the lichen symbiosis, by uncovering high bacterial and fungal diversity, which is often host-specific. Recently, HTS methods revealed the presence of multiple photobionts inside a single thallus in several lichen...

journal_title：Scientific reports

authors： Paul F,Otte J,Schmitt I,Dal Grande F

更新日期：2018-06-05 00:00:00

abstract：:High-performance locally resonant metamaterials represent the next frontier in materials technology due to their extraordinary properties obtained through materials design, enabling a variety of potential applications. The most exceptional feature of locally resonant metamaterials is the subwavelength size of their un...

journal_title：Scientific reports

authors： Zega V,Silva PB,Geers MGD,Kouznetsova VG

更新日期：2020-07-21 00:00:00

abstract：:Motivational, cognitive and action goals are processed by distinct, topographically organized, corticostriatal circuits. We aimed to test whether processing in the striatum is under causal control by cortical regions in the human brain by investigating the effects of offline transcranial magnetic stimulation (TMS) ove...

journal_title：Scientific reports

authors： van Holstein M,Froböse MI,O'Shea J,Aarts E,Cools R

更新日期：2018-02-19 00:00:00

abstract：:Bimetallic catalysts due to the synergistic effects often outperform their single-component counterparts while exhibiting structure and composition-dependent enhancement in active sites, thereby having the potential to improve the current density and over-potential parameters in the water oxidation reaction. Herein, w...

journal_title：Scientific reports

authors： Ehsan MA,Hakeem AS,Rehman A

更新日期：2020-09-02 00:00:00

abstract：:Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a...

journal_title：Scientific reports

authors： Petursdottir Maack H,Skalkidou A,Sjöholm A,Eurenius-Orre K,Mulic-Lutvica A,Wikström AK,Sundström Poromaa I

更新日期：2019-04-17 00:00:00

abstract：:Amorphous thin films from Ge-As-Te system were prepared by pulsed laser deposition to study their intrinsic photostability, morphology, chemical composition, structure and optical properties. Photostability of fabricated layers was studied by spectroscopic ellipsometry within as-deposited as well as relaxed (annealed)...

journal_title：Scientific reports

authors： Hawlová P,Verger F,Nazabal V,Boidin R,Němec P

更新日期：2015-03-23 00:00:00

abstract：:Due to the two dimensional confinement of electrons in a monolayer of 2D materials, the properties of monolayer can be controlled by electrical field formed on the monolayer surface. F4TCNQ was evaporated on MoS2 and WS2 monolayer forming dipoles between strong acceptor, F4TCNQ, and monolayers of MoS2 or WS2. The stro...

journal_title：Scientific reports

authors： Hu P,Ye J,He X,Du K,Zhang KK,Wang X,Xiong Q,Liu Z,Jiang H,Kloc C

更新日期：2016-04-07 00:00:00

abstract：:The type II bacterial CRISPR/Cas9 system is rapidly becoming popular for genome-engineering due to its simplicity, flexibility, and high efficiency. Recently, targeted knock-in of a long DNA fragment via homology-independent DNA repair has been achieved in zebrafish using CRISPR/Cas9 system. This raised the possibilit...

journal_title：Scientific reports

authors： Kimura Y,Hisano Y,Kawahara A,Higashijima S

更新日期：2014-10-08 00:00:00

abstract：:Results from live cell imaging of fluorescently tagged Cellulose Synthase (CESA) proteins in Cellulose Synthesis Complexes (CSCs) have enhanced our understanding of cellulose biosynthesis, including the mechanisms of action of cellulose synthesis inhibitors. However, this method has been applied only in Arabidopsis th...

journal_title：Scientific reports

authors： Tran ML,McCarthy TW,Sun H,Wu SZ,Norris JH,Bezanilla M,Vidali L,Anderson CT,Roberts AW

更新日期：2018-01-15 00:00:00

abstract：:During our research, we explored a novel way to represent subwavelength imaging and derived a transmission equation to explicate the FP (Fabry-Pérot) resonance phenomena. Subsequently, using analysis and observation, we performed deep-subwavelength imaging. Both numerically and experimentally, imaging with super-resol...

journal_title：Scientific reports

authors： Anzan-Uz-Zaman M,Song K,Lee DG,Hur S

更新日期：2020-07-01 00:00:00

abstract：:Spotted seal (Phoca largha) is a critically endangered pinniped in China and South Korea. The conventional method to protect and maintain the P. largha population is to keep them captive in artificially controlled environments. However, little is known about the physiological differences between wild and captive P. la...

journal_title：Scientific reports

authors： Tian J,Du J,Han J,Bao X,Song X,Lu Z

更新日期：2020-10-30 00:00:00

abstract：:The remineralization mechanism in dental caries lesions is not completely understood. This study reports on ultrastructural and chemical changes observed within arrested caries lesions. Carious human teeth were observed using scanning electron microscopy (SEM) and focused-ion-beam (FIB)-SEM. The crystals detected in t...

journal_title：Scientific reports

authors： Yoshihara K,Nagaoka N,Nakamura A,Hara T,Hayakawa S,Yoshida Y,Van Meerbeek B

更新日期：2020-03-09 00:00:00

abstract：:We report on the first realization of an ultrafast Airy beam optical parametric oscillator (OPO). By introducing intracavity cubic phase modulation to the resonant Gaussian signal in a synchronously-pumped singly-resonant OPO cavity and its subsequent Fourier transformation, we have generated 2-dimensional Airy beam i...

journal_title：Scientific reports

authors： Apurv Chaitanya N,Kumar SC,Aadhi A,Samanta GK,Ebrahim-Zadeh M

更新日期：2016-08-01 00:00:00

abstract：:Porous materials display enhanced scattering mechanisms that greatly influence their transport properties. Metal-assisted chemical etching (MACE) enables fabrication of porous silicon nanowires starting from a doped Si wafer by using a metal template that catalyzes the etching process. Here, we report on the low therm...

journal_title：Scientific reports

authors： Ferrando-Villalba P,D'Ortenzi L,Dalkiranis GG,Cara E,Lopeandia AF,Abad L,Rurali R,Cartoixà X,De Leo N,Saghi Z,Jacob M,Gambacorti N,Boarino L,Rodríguez-Viejo J

更新日期：2018-08-24 00:00:00

abstract：:The biodosimetric information is critical for evaluating the human health hazards caused by radon and its progeny. Here, we demonstrated that the formation of phosphorylated histone variant H2AX (γ-H2AX), p53-binding protein 1 (53BP1) and phosphorylated KRAB-associated protein 1 (pKAP-1) foci and their linear tracks i...

journal_title：Scientific reports

authors： Ding D,Zhang Y,Wang J,Wang X,Fan D,He L,Zhang X,Gao Y,Li Q,Chen H

更新日期：2016-12-06 00:00:00

abstract：:Formic acid (FA) has been used for decades to control Varroa destructor, one of the most important parasites of the western honey bee, Apis mellifera. The rather unselective molecular mode of action of FA and its possible effects on honeybees have long been a concern of beekeepers, as it has undesirable side effects t...

journal_title：Scientific reports

authors： Genath A,Sharbati S,Buer B,Nauen R,Einspanier R

更新日期：2020-12-14 00:00:00

abstract：:In this work we derive an effective Hamiltonian for the surface states of a hollow topological insulator (TI) nanotube with finite width walls. Unlike a solid TI cylinder, a TI nanotube possesses both an inner as well as outer surface on which the states localized at each surface are coupled together. The curvature al...

journal_title：Scientific reports

authors： Siu ZB,Tan SG,Jalil MB

更新日期：2017-04-03 00:00:00

abstract：:Dravet syndrome is the prototype of SCN1A-mutation associated epilepsies. It is characterised by prolonged seizures, typically provoked by fever. We describe the evaluation of an SCN1A mutation in a child with early-onset temperature-sensitive seizures. The patient carries a heterozygous missense variant (c3818C > T; ...

journal_title：Scientific reports

authors： Peters C,Rosch RE,Hughes E,Ruben PC

更新日期：2016-09-01 00:00:00

abstract：:We report the results of a game-theoretic experiment with human players who solve problems of increasing complexity by cooperating in groups of increasing size. Our experimental environment is set up to make it complicated for players to use rational calculation for making the cooperative decisions. This environment i...

journal_title：Scientific reports

authors： Guazzini A,Stefanelli F,Imbimbo E,Vilone D,Bagnoli F,Levnajić Z

更新日期：2019-04-02 00:00:00