Abstract:
:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lin RT,Lin CK,Christiani DC,Kawachi I,Cheng Y,Verguet S,Jong Sdoi
10.1038/s41598-018-23047-5subject
Has Abstractpub_date
2018-03-12 00:00:00pages
4654issue
1issn
2045-2322pii
10.1038/s41598-018-23047-5journal_volume
8pub_type
已发布勘误abstract::The CRISPR system holds much promise for successful genome engineering, but therapeutic, industrial, and research applications will place high demand on improving the specificity and efficiency of this tool. CT-Finder (http://bioinfolab.miamioh.edu/ct-finder) is a web service to help users design guide RNAs (gRNAs) op...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25516
更新日期:2016-05-23 00:00:00
abstract::Extracellular vesicles (EVs) are membrane-enclosed nanoparticles containing specific repertoires of genetic material. In mammals, EVs can mediate the horizontal transfer of various cargos and signaling molecules, notably miRNA and mRNA species. Whether this form of intercellular communication prevails in other metazoa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27680
更新日期:2016-06-10 00:00:00
abstract::Cervical oesophageal cancer (CEC) is a relatively uncommon malignancy. The biological behaviour and treatment have not been well studied. This retrospective study reviewed the clinicopathological features of 28 patients with CEC who underwent surgical resection to investigate the biological behaviour, treatment and pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03593-0
更新日期:2017-06-12 00:00:00
abstract::The interaction between cellulase enzymes and their substrates is of central importance to several technological and scientific challenges. Here we report that the binding of cellulose binding modules (CBM) from Trichoderma reesei cellulases Cel6A and Cel7A show a major difference in how they interact with substrates ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35358
更新日期:2016-10-17 00:00:00
abstract::The ability of wild animals to respond flexibly to anthropogenic environmental changes, including agriculture, is critical to survival in human-impacted habitats. Understanding use of human foods by wildlife can shed light on the acquisition of novel feeding habits and how animals respond to human-driven land-use chan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05956
更新日期:2014-08-05 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is usually preceded by the oral premalignant lesions, mainly oral leukoplakia (OLK) after repeated insults of carcinogens, tobacco. B(a)P and DMBA are key carcinogens in tobacco smoke. In the present study, for the first time we established the cancerous cell line OSCC-BD induced by...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12668
更新日期:2015-08-03 00:00:00
abstract::In recent years, the monolithic material has been developed increasingly in the high performance liquid phase field, and it could also be applied in the field of catalyst, as a monolithic catalyst carrier, since it has a large specific surface area, and could be customized based on the mould. The monolithic catalyst i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35021-2
更新日期:2018-11-09 00:00:00
abstract::Curcumin is an important bioactive component of turmeric and also one of the important natural products, which has been investigated extensively. The precise mode of action of curcumin and its impact on system level protein networks are still not well studied. To identify the curcumin governed regulatory action on pro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69011-0
更新日期:2020-07-21 00:00:00
abstract::There is still much to understand about the brain's colour processing mechanisms and the transformation from cone-opponent representations to perceptual hues. Moreover, it is unclear which area(s) in the brain represent unique hues. We propose a hierarchical model inspired by the neuronal mechanisms in the brain for l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64969-3
更新日期:2020-05-22 00:00:00
abstract::Previous reports suggest that offspring of mothers who smoke during pregnancy have greater risk of developing depression. However, it is unclear whether this is due to intrauterine effects. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) from the UK (N = 2,869), the Nord-Trøndelag health s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11836-3
更新日期:2017-10-03 00:00:00
abstract::Towards exploring advanced applications of terahertz (THz) electromagnetic waves, great efforts are being applied to develop a compact and sensitive THz receiver. Here, we propose a simple coherent detection system using a single resonant tunnelling diode (RTD) oscillator through self-oscillating mixing with an RTD os...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54627-8
更新日期:2019-12-02 00:00:00
abstract::Although graphene is a typical two dimensional materials, it has converted to multi-dimensional materials with many unique properties. As an example, the one dimensional graphene fiber is fabricated by utilizing ionic liquid as coagulation and functional diamines as cross-linkers to connect graphene oxide layers. The ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29534
更新日期:2016-07-08 00:00:00
abstract::Salinity is one of the major abiotic factors that affect productivity in oat. Here, we report a comparison of the transcriptomes of two hexaploid oat cultivars, 'Hanyou-5' and 'Huazao-2', which differ with respect to salt tolerance, in seedlings exposed to salt stress. Analysis of the assembled unigenes from the osmot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34505-5
更新日期:2018-11-02 00:00:00
abstract::Hepatocellular carcinoma is the third leading cause of cancer-related deaths worldwide. Many patients are not eligible for curative therapies, such as surgical resection of the tumor or a liver transplant. Transarterial embolization is one therapy clinically used in these cases; however, this requires a long procedure...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47309-y
更新日期:2019-07-30 00:00:00
abstract::Quantum cryptography is set to become a key technology for future secure communications. However, to get maximum benefit in communication networks, transmission links will need to be shared among several quantum keys for several independent users. Such links will enable switching in quantum network nodes of the quantu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12309-3
更新日期:2017-09-29 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-28651-z
更新日期:2018-07-05 00:00:00
abstract::Many studies have revealed the cognitive decline induced by microwave radiation. However, the systematic study on dose-dependent, frequency-dependent and accumulative effects of microwave exposure at different frequencies was lacking. Here, we studied the relationship between the effects and the power and frequency of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11420-9
更新日期:2017-09-07 00:00:00
abstract::Aquaculture has become imperative to cover the demands for dietary animal protein. Simultaneously, it has to overcome prejudices from excessive use of antibiotics and environmental impacts. Natural supplements are traditionally applied orally. In this study, we demonstrated another pathway: the gills. Humic substances...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80449-0
更新日期:2021-01-08 00:00:00
abstract::In this paper, we investigate the relationship between the quantum speedup, non-Markovianity and formation of a system-environment bound state. Previous results show a monotonic relation between these three such that providing bound states with more negative energy can lead to a higher degree of non-Markovianity, and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51290-x
更新日期:2019-10-18 00:00:00
abstract::Endoscopic submucosal dissection (ESD) permits en bloc removal of superficial oesophageal squamous cell carcinoma (ESCC). However, post-procedure stricture is common after ESD for widespread tumours, and multiple endoscopic balloon dilation (EBD) procedures are required. We aimed to evaluate the safety and effectivene...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-17663-w
更新日期:2017-12-12 00:00:00
abstract::The development of metal-based agents has had a tremendous role in the present progress in cancer chemotherapy. One well-known example of metal-based agents is Schiff based metal complexes, which hold great promise for cancer therapy. Based on the potential of Schiff based complexes for the induction of apoptosis, thi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09097
更新日期:2015-03-13 00:00:00
abstract::Available CFTR modulators provide no therapeutic benefit for cystic fibrosis (CF) caused by many loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, including N1303K. We previously introduced the concept of 'co-potentiators' (combination-potentiators) to rescu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54158-2
更新日期:2019-11-27 00:00:00
abstract::This retrospective study was undertaken to provide more modern data of real-life management of non-metastatic rectal cancer, to compare therapeutic strategies, and to identify prognostic factors of overall survival (OS) in a large cohort of patients. Data on efficacy and on acute/late toxicity were retrospectively col...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29040-2
更新日期:2018-07-16 00:00:00
abstract::Online gambling sites offer many different gambling games. In this work we analyse the gambling logs of numerous solely probability-based gambling games and extract the wager and odds distributions. We find that the log-normal distribution describes the wager distribution at the aggregate level. Viewing the gamblers' ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50168-2
更新日期:2019-10-11 00:00:00
abstract::Optical antennas can be used to manipulate the direction and polarization of radiation from an emitter. Usually, these metallic nanostructures utilize localized plasmon resonances to generate highly directional and strongly polarized emission, which is determined predominantly by the antenna geometry alone, and is thu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06456
更新日期:2014-09-24 00:00:00
abstract::Balance is a very important function that allows maintaining a stable stance needed for many daily life activities and for preventing falls. We investigated whether balance control could be improved by a placebo procedure consisting of verbal suggestion. Thirty healthy volunteers were randomized in two groups (placebo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42888-2
更新日期:2019-04-23 00:00:00
abstract::The innate and adaptive immune systems fail to control HCV infection in the majority of infected individuals. HCV is an ssRNA virus, which suggests a role for Toll-like receptors (TLRs) 7 and 8 in initiating the anti-viral response. Here we demonstrate that HCV genomic RNA harbours specific sequences that initiate an ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29447
更新日期:2016-07-07 00:00:00
abstract::During the Final Eneolithic the Corded Ware Complex (CWC) emerges, chiefly identified by its specific burial rites. This complex spanned most of central Europe and exhibits demographic and cultural associations to the Yamnaya culture. To study the genetic structure and kin relations in CWC communities, we sequenced th...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-020-63138-w
更新日期:2020-04-14 00:00:00
abstract::This is the first study to investigate the impact of a second fibula flap or a soft tissue flap combined with bridging plate for a repeated segmental mandibulectomy reconstruction on flap outcomes in head and neck cancer patients. A retrospective comparative analysis (2007-2016) of 61 patients who underwent a second s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44467-x
更新日期:2019-05-28 00:00:00
abstract::Metabolic syndrome (MS) could be associated with liver function. Our study aimed to investigate the association between liver function and MS in a large cohort of Chinese men and women. We enrolled 32,768 ostensibly healthy participants. The associations between liver function and MS of both genders were analyzed sepa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44844
更新日期:2017-03-20 00:00:00