A 3D printing approach toward targeted intervention in telerehabilitation.

Abstract:

:Neuromuscular impairment requires adherence to a rehabilitation regimen for maximum recovery of motor function. Consumer-grade game controllers have emerged as a viable means to relay supervised physical therapy to patients' homes, thereby increasing their accessibility to healthcare. These controllers allow patients to perform exercise frequently and improve their rehabilitation outcomes. However, the non-universal design of game controllers targets healthy people and does not always accommodate people with disability. Consequently, many patients experience considerable difficulty assuming certain hand postures and performing the prescribed exercise correctly. Here, we explore the feasibility of improving rehabilitation outcomes through a 3D printing approach that enhances off-the-shelf game controllers in home therapy. Specifically, a custom attachment was 3D printed for a commercial haptic device that mediates fine motor rehabilitation. In an experimental study, 25 healthy subjects performed a navigation task, with the retrofit attachment and without it, while simulating disability of the upper limb. When using the attachment, subjects extended their wrist range of motion, yet maintained their level of compensation. The subjects also showed higher motivation to repeat the exercise with the enhanced device. The results bring forward evidence for the potential of this approach in transforming game controllers toward targeted interventions in home therapy.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Barak Ventura R,Rizzo A,Nov O,Porfiri M

doi

10.1038/s41598-020-59927-y

subject

Has Abstract

pub_date

2020-02-28 00:00:00

pages

3694

issue

1

issn

2045-2322

pii

10.1038/s41598-020-59927-y

journal_volume

10

pub_type

杂志文章
  • CO oxidation and organic dyes degradation over graphene-Cu and graphene-CuNi catalysts obtained by solution combustion synthesis.

    abstract::Graphene and its analogs in combination with metal nanopowders are among the most promising catalysts for various industry valuable processes. The newly obtained solution combustion synthesized graphene-Cu and graphene-CuNi nanocomposites were examined in heterogeneous catalysis of thermal activated CO oxidation and p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72872-0

    authors: Khort A,Romanovski V,Leybo D,Moskovskikh D

    更新日期:2020-09-30 00:00:00

  • Disorder and defects are not intrinsic to boron carbide.

    abstract::A unique combination of useful properties in boron-carbide, such as extreme hardness, excellent fracture toughness, a low density, a high melting point, thermoelectricity, semi-conducting behavior, catalytic activity and a remarkably good chemical stability, makes it an ideal material for a wide range of technological...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19330

    authors: Mondal S,Bykova E,Dey S,Ali SI,Dubrovinskaia N,Dubrovinsky L,Parakhonskiy G,van Smaalen S

    更新日期:2016-01-18 00:00:00

  • Analysis of IS6110 insertion sites provide a glimpse into genome evolution of Mycobacterium tuberculosis.

    abstract::Insertion sequence (IS) 6110 is found at multiple sites in the Mycobacterium tuberculosis genome and displays a high degree of polymorphism with respect to copy number and insertion sites. Therefore, IS6110 is considered to be a useful molecular marker for diagnosis and strain typing of M. tuberculosis. Generally IS61...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12567

    authors: Roychowdhury T,Mandal S,Bhattacharya A

    更新日期:2015-07-28 00:00:00

  • Interferon γ-induced GTPase promotes invasion of Listeria monocytogenes into trophoblast giant cells.

    abstract::Listeria monocytogenes is well known for having the ability to cross the placental barrier, leading to fetal infections and abortion. However, the mechanisms leading to infectious abortion are poorly understood. In this study, we demonstrate that interferon γ-induced GTPase (IGTP) contributes to the invasion of L. mon...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08195

    authors: Tachibana M,Hashino M,Watanabe K,Shimizu T,Watarai M

    更新日期:2015-02-03 00:00:00

  • Runaway multi-allelic copy number variation at the α-defensin locus in African and Asian populations.

    abstract::Alpha defensins are anti-microbial peptides of the innate immune system. The defensin A1 and A3 genes are located in a repeat array of variable copy number (the DEFA1A3 locus) and encode the human neutrophil peptides 1, 2 and 3. The possibility that copy number variation (CNV) may be associated with infection suscepti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65675-w

    authors: Hughes T,Hansson L,Akkouh I,Hajdarevic R,Bringsli JS,Torsvik A,Inderhaug E,Steen VM,Djurovic S

    更新日期:2020-06-04 00:00:00

  • Entangled-photon decision maker.

    abstract::The competitive multi-armed bandit (CMAB) problem is related to social issues such as maximizing total social benefits while preserving equality among individuals by overcoming conflicts between individual decisions, which could seriously decrease social benefits. The study described herein provides experimental evide...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48647-7

    authors: Chauvet N,Jegouso D,Boulanger B,Saigo H,Okamura K,Hori H,Drezet A,Huant S,Bachelier G,Naruse M

    更新日期:2019-08-22 00:00:00

  • Fast cooling in dispersively and dissipatively coupled optomechanics.

    abstract::The cooling performance of an optomechanical system comprising both dispersive and dissipative coupling is studied. Here, we present a scheme to cool a mechanical resonator to its ground state in finite time using a chirped pulse. We show that there is distinct advantage in using the chirp-pulse scheme to cool a reson...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07745

    authors: Chen T,Wang XB

    更新日期:2015-01-13 00:00:00

  • Density of bulk trap states of hybrid lead halide perovskite single crystals: temperature modulated space-charge-limited-currents.

    abstract::Temperature-modulated space-charge-limited-current spectroscopy (TMSCLC) is applied to quantitatively evaluate the density of trap states in the band-gap with high energy resolution of semiconducting hybrid lead halide perovskite single crystals. Interestingly multicomponent deep trap states were observed in the pure ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40139-y

    authors: Pospisil J,Zmeskal O,Nespurek S,Krajcovic J,Weiter M,Kovalenko A

    更新日期:2019-03-04 00:00:00

  • Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A.

    abstract::Plasmodium falciparum merozoite invasion into erythrocytes is an essential step of the blood-stage cycle, survival of parasites, and malaria pathogenesis. P. falciparum merozoite Rh5 interacting protein (PfRipr) forms a complex with Rh5 and CyRPA in sequential molecular events leading to erythrocyte invasion. Recently...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63611-6

    authors: Nagaoka H,Kanoi BN,Ntege EH,Aoki M,Fukushima A,Tsuboi T,Takashima E

    更新日期:2020-04-20 00:00:00

  • Effects of bio-Au nanoparticles on electrochemical activity of Shewanella oneidensis wild type and ΔomcA/mtrC mutant.

    abstract::Both Shewanella oneidensis MR-1 wild type and its mutant ΔomcA/mtrC are capable of transforming Au(III) into Au nanoparticles (AuNPs). Cyclic voltammetry reveals a decrease in redox current after the wild type is exposed to Au(III) but an increase in oxidation current for the mutant. The peak current of the wild type ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03307

    authors: Wu R,Cui L,Chen L,Wang C,Cao C,Sheng G,Yu H,Zhao F

    更新日期:2013-11-22 00:00:00

  • Fluoxetine and thioridazine inhibit efflux and attenuate crystalline biofilm formation by Proteus mirabilis.

    abstract::Proteus mirabilis forms extensive crystalline biofilms on indwelling urethral catheters that block urine flow and lead to serious clinical complications. The Bcr/CflA efflux system has previously been identified as important for development of P. mirabilis crystalline biofilms, highlighting the potential for efflux pu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12445-w

    authors: Nzakizwanayo J,Scavone P,Jamshidi S,Hawthorne JA,Pelling H,Dedi C,Salvage JP,Hind CK,Guppy FM,Barnes LM,Patel BA,Rahman KM,Sutton MJ,Jones BV

    更新日期:2017-09-22 00:00:00

  • Efficient single-pixel multispectral imaging via non-mechanical spatio-spectral modulation.

    abstract::Combining spectral imaging with compressive sensing (CS) enables efficient data acquisition by fully utilizing the intrinsic redundancies in natural images. Current compressive multispectral imagers, which are mostly based on array sensors (e.g, CCD or CMOS), suffer from limited spectral range and relatively low photo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41435

    authors: Li Z,Suo J,Hu X,Deng C,Fan J,Dai Q

    更新日期:2017-01-27 00:00:00

  • Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.

    abstract::The emergence of resistance to imatinib mediated by mutations in the BCR-ABL has become a major challenge in the treatment of chronic myeloid leukemia (CML). Alternative therapeutic strategies to override imatinib-resistant CML are urgently needed. In this study, we investigated the effect of AKI603, a novel small mol...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35533

    authors: Wang LX,Wang JD,Chen JJ,Long B,Liu LL,Tu XX,Luo Y,Hu Y,Lin DJ,Lu G,Long ZJ,Liu Q

    更新日期:2016-11-08 00:00:00

  • Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP.

    abstract::Cleavage of the amyloid precursor protein's (APP) transmembrane domain (TMD) by γ-secretase is a crucial step in the aetiology of Alzheimer's Disease (AD). Mutations in the APP TMD alter cleavage and lead to familial forms of AD (FAD). The majority of FAD mutations shift the preference of initial cleavage from ε49 to ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41766-1

    authors: Götz A,Högel P,Silber M,Chaitoglou I,Luy B,Muhle-Goll C,Scharnagl C,Langosch D

    更新日期:2019-03-29 00:00:00

  • Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats.

    abstract::We have previously demonstrated that the Thymus algeriensis and Thymus fontanesii extracts have powerful anti-inflammatory, antipyretic, and analgesic effects against acute pain models. We profiled their chemical composition and found many phenolic acids, flavonoids, and phenolic diterpenes. In this work, we investiga...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77424-0

    authors: Rezq S,Alsemeh AE,D'Elia L,El-Shazly AM,Monti DM,Sobeh M,Mahmoud MF

    更新日期:2020-11-25 00:00:00

  • Lower serum calcium is independently associated with CKD progression.

    abstract::Disturbances in calcium metabolism are common in individuals with chronic kidney disease (CKD), but whether they are associated with subsequent kidney function decline is less clear. In a CKD 3-5 cohort of 15,755 adult citizens of Stockholm with creatinine tests taken during 2006-2011 and concurrent calcium testing at...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23500-5

    authors: Janmaat CJ,van Diepen M,Gasparini A,Evans M,Qureshi AR,Ärnlöv J,Barany P,Elinder CG,Rotmans JI,Vervloet M,Dekker FW,Carrero JJ

    更新日期:2018-03-26 00:00:00

  • Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus.

    abstract::The capture and activation of individual T cells on functionalised surfaces enables real-time analyses of the magnitude and rhythm of intracellular calcium release. Application of Haarlet transformations generate a calcium flux 'threshold', with the frequency of the 'threshold crossings' correlating with the strength ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07760

    authors: Christo SN,Diener KR,Nordon RE,Brown MP,Griesser HJ,Vasilev K,Christo FC,Hayball JD

    更新日期:2015-01-14 00:00:00

  • A deep learning model for detecting mental illness from user content on social media.

    abstract::Users of social media often share their feelings or emotional states through their posts. In this study, we developed a deep learning model to identify a user's mental state based on his/her posting information. To this end, we collected posts from mental health communities in Reddit. By analyzing and learning posting...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68764-y

    authors: Kim J,Lee J,Park E,Han J

    更新日期:2020-07-16 00:00:00

  • Antimicrobial peptides from Rana [Lithobates] catesbeiana: Gene structure and bioinformatic identification of novel forms from tadpoles.

    abstract::Antimicrobial peptides (AMPs) exhibit broad-spectrum antimicrobial activity, and have promise as new therapeutic agents. While the adult North American bullfrog (Rana [Lithobates] catesbeiana) is a prolific source of high-potency AMPs, the aquatic tadpole represents a relatively untapped source for new AMP discovery. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-38442-1

    authors: Helbing CC,Hammond SA,Jackman SH,Houston S,Warren RL,Cameron CE,Birol I

    更新日期:2019-02-06 00:00:00

  • Effect of chain flexibility on cell adhesion: Semi-flexible model-based analysis of cell adhesion to hydrogels.

    abstract::Hydrogels have been developed and applied to various biomedical applications due to their biocompatibility. However, understanding of modulation between cells to hydrogel interface is still unclear, and parameters to explain the interaction are not sophisticated enough. In this report, we studied the effect of polymer...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-38951-7

    authors: Lee J,Song B,Subbiah R,Chung JJ,Choi UH,Park K,Kim SH,Oh SJ

    更新日期:2019-02-21 00:00:00

  • Invisibility Cloaking Scheme by Evanescent Fields Distortion on Composite Plasmonic Waveguides with Si Nano-Spacer.

    abstract::A new, composite plasmonic waveguide based electromagnetic cloaking scheme is proposed with Si nano-spacer. Here we show, that the scattering fields of an object located on the cloak do not interact with the evanescent field, resulting in object's invisibility. Finite difference time domain (FDTD) numerical calculatio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10578-6

    authors: Galutin Y,Falek E,Karabchevsky A

    更新日期:2017-09-21 00:00:00

  • Birth weight and prematurity with lung function at ~17.5 years: "Children of 1997" birth cohort.

    abstract::We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong's "Children of 1997" birth cohort, adjusted associations of prematurity and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56086-7

    authors: He B,Kwok MK,Au Yeung SL,Lin SL,Leung JYY,Hui LL,Li AM,Leung GM,Schooling CM

    更新日期:2020-01-15 00:00:00

  • An Efficient LCM-Based Method for Tissue Specific Expression Analysis of Genes and miRNAs.

    abstract::Laser Capture Microdissection (LCM) is a powerful tool to isolate and study gene expression pattern of desired and less accessible cells or tissues from a heterogeneous population. Existing LCM-based methods fail to obtain high quality RNA including small RNAs from small microdissected plant tissue and therefore, are ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21577

    authors: Gautam V,Singh A,Singh S,Sarkar AK

    更新日期:2016-02-10 00:00:00

  • Proteomic Analysis Reveals That Metabolic Flows Affect the Susceptibility of Aeromonas hydrophila to Antibiotics.

    abstract::The overuse of antibiotics results in the development of antibiotic resistance and limits the useful life of these drugs in fighting bacteria, including Aeromonas hydrophila, a well-known opportunistic pathogen that causes serious infections in fish and other animals. In this study, we investigated the adaptive resist...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39413

    authors: Yao Z,Li W,Lin Y,Wu Q,Yu F,Lin W,Lin X

    更新日期:2016-12-19 00:00:00

  • The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia.

    abstract::Inflammation is considered as a major contributor to brain injury following cerebral ischemia. The therapeutic potential of both MLC601/MLC901, which are herbal extract preparations derived from Chinese Medicine, has been reported both in advanced stroke clinical trials and also in animal and cellular models. The aim ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36138-0

    authors: Widmann C,Gandin C,Petit-Paitel A,Lazdunski M,Heurteaux C

    更新日期:2018-12-24 00:00:00

  • The neural correlates of integrated aesthetics between moral and facial beauty.

    abstract::Facial beauty and moral beauty have been suggested to be two significant forms of social aesthetics. However, it remains unknown the extent to which there are neural underpinnings of the integration of these two forms of beauty. In the present study, participants were asked to make general aesthetic judgments of facia...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-38553-3

    authors: Luo Q,Yu M,Li Y,Mo L

    更新日期:2019-02-13 00:00:00

  • Male mice, caged in the International Space Station for 35 days, sire healthy offspring.

    abstract::The effect on the reproductive system and fertility of living in a space environment remains unclear. Here, we caged 12 male mice under artificial gravity (≈1 gravity) (AG) or microgravity (MG) in the International Space Station (ISS) for 35 days, and characterized the male reproductive organs (testes, epididymides, a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50128-w

    authors: Matsumura T,Noda T,Muratani M,Okada R,Yamane M,Isotani A,Kudo T,Takahashi S,Ikawa M

    更新日期:2019-09-24 00:00:00

  • Traumatic Brain Injury Leads to Accelerated Atherosclerosis in Apolipoprotein E Deficient Mice.

    abstract::Traumatic brain injury (TBI) has been associated with atherosclerosis and cardiovascular mortality in humans. However the causal relationship between TBI and vascular disease is unclear. This study investigated the direct role of TBI on vascular disease using a murine model of atherosclerosis. Apolipoprotein E deficie...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23959-2

    authors: Wang J,Su E,Wang H,Guo C,Lawrence DA,Eitzman DT

    更新日期:2018-04-04 00:00:00

  • Environmental Fate of Chiral Herbicide Fenoxaprop-ethyl in Water-Sediment Microcosms.

    abstract::The environmental fate of the herbicide fenoxaprop-ethyl (FE) in water, sediment and water-sediment microcosm was studied and degradation products fenoxaprop (FA), ethyl-2-(4-hydroxyphenoxy)propanoate (EHPP), 2-(4-hydroxyphenoxy)propanoic acid (HPPA) and 6-chloro-2,3-dihydrobenzoxazol-2-one (CDHB) were monitored. FE, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26797

    authors: Jing X,Yao G,Liu D,Liu M,Wang P,Zhou Z

    更新日期:2016-05-26 00:00:00

  • Camphor-Engine-Driven Micro-Boat Guides Evolution of Chemical Gardens.

    abstract::A micro-boat self-propelled by a camphor engine, carrying seed crystals of FeCl3, promoted the evolution of chemical gardens when placed on the surface of aqueous solutions of potassium hexacyanoferrate. Inverse chemical gardens (growing from the top downward) were observed. The growth of the "inverse" chemical garden...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04337-w

    authors: Frenkel M,Multanen V,Grynyov R,Musin A,Bormashenko Y,Bormashenko E

    更新日期:2017-06-21 00:00:00