The infectious particle of insect-borne totivirus-like Omono River virus has raised ridges and lacks fibre complexes.

Abstract:

:Omono River virus (OmRV) is a double-stranded RNA virus isolated from Culex mosquitos, and it belongs to a group of unassigned insect viruses that appear to be related to Totiviridae. This paper describes electron cryo-microscopy (cryoEM) structures for the intact OmRV virion to 8.9 Å resolution and the structure of the empty virus-like-particle, that lacks RNA, to 8.3 Å resolution. The icosahedral capsid contains 120-subunits and resembles another closely related arthropod-borne totivirus-like virus, the infectious myonecrosis virus (IMNV) from shrimps. Both viruses have an elevated plateau around their icosahedral 5-fold axes, surrounded by a deep canyon. Sequence and structural analysis suggests that this plateau region is mainly composed of the extended C-terminal region of the capsid proteins. In contrast to IMNV, the infectious form of OmRV lacks extensive fibre complexes at its 5-fold axes as directly confirmed by a contrast-enhancement technique, using Zernike phase-contrast cryo-EM. Instead, these fibre complexes are replaced by a short "plug" structure at the five-fold axes of OmRV. OmRV and IMNV have acquired an extracellular phase, and the structures at the five-fold axes may be significant in adaptation to cell-to-cell transmission in metazoan hosts.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Okamoto K,Miyazaki N,Larsson DS,Kobayashi D,Svenda M,Mühlig K,Maia FR,Gunn LH,Isawa H,Kobayashi M,Sawabe K,Murata K,Hajdu J

doi

10.1038/srep33170

subject

Has Abstract

pub_date

2016-09-12 00:00:00

pages

33170

issn

2045-2322

pii

srep33170

journal_volume

6

pub_type

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