Abstract：
:Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in patients. Our data showed a sharp decrease in platelet counts at day 4 of fever in patients. The high DENV genome copies in platelets correlated directly with the elevated platelet activation along with increased binding of complement factor C3 and IgG on their surface at day 4. Recovery in platelet count was observed on day 10 through day 6 and 8 with simultaneous decrease in platelet activation markers. Further, our in vitro data supported the above observations describing a concentration-dependent increase in platelet activation by DENV serotype-2. The high copy number of DENV2 genome in the platelet pellet correlated directly with platelet activation, microparticle generation and clot formation. Furthermore the DENV2-activated platelets were phagocytosed in large numbers by the monocytes. The DENV2-mediated lysis and clearance of platelets were abrogated in presence of platelet activation inhibitor, prostacyclin. These observations collectively suggest that platelet activation status is an important determinant of thrombocytopenia in dengue infections. A careful strategy of inactivation of platelets may rescue them from rapid destruction during DENV infections.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ojha A,Nandi D,Batra H,Singhal R,Annarapu GK,Bhattacharyya S,Seth T,Dar L,Medigeshi GR,Vrati S,Vikram NK,Guchhait Pdoi
10.1038/srep41697subject
Has Abstractpub_date
2017-01-31 00:00:00pages
41697issn
2045-2322pii
srep41697journal_volume
7pub_type
杂志文章abstract：:In this article a new spent catalyst sample preparation method was implemented for the purpose of molybdenum leaching in a single step. Further molybdenum and vanadium in the leach liquor were separated and their concentrations were enriched using the solvent extraction and stripping techniques. The impervious sulfur ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58972-x
更新日期：2020-02-06 00:00:00
abstract：:This retrospective study was undertaken to identify predictors for the development of hypocalcaemia even with prophylactic administration of calcium and vitamin D, and to help guide future strategies to improve the safety, efficacy, and QOL of patients receiving denosumab. Between January 2016 and February 2020, a tot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80243-y
更新日期：2021-01-13 00:00:00
abstract：:Drug addiction remains a prevalent and fatal disease worldwide that carries significant social and economic impacts. Recent reports suggest illicit pregabalin (Lyrica) use may be increasing among youth, however the addictive potential of pregabalin has not been well established. Drug seeking behavior and chronic drug ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51556-4
更新日期：2019-10-22 00:00:00
abstract：:Musical performance requires extremely fast and dexterous limb movements. The underlying biological mechanisms have been an object of interest among scientists and non-scientists for centuries. Numerous studies of musicians and non-musicians have demonstrated that neuroplastic adaptations through early and deliberate ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15750
更新日期：2015-10-27 00:00:00
abstract：:Emergence of DS-1-like-G1P[8] rotavirus in Asia have been recently reported. We report for the first time the detection and the whole genome phylogenetic analysis of DS-1-like-G1P[8] strains in America. From 2013 to 2017, a total of 4226 fecal samples were screened for rotavirus by ELISA, PAGE, RT-PCR and sequencing. ...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-019-38703-7
更新日期：2019-02-18 00:00:00
abstract：:CD134 (OX40) is a member of the tumour necrosis factor receptor superfamily (TNFRSF). It acts as a costimulatory receptor on T cells, but its role on NK cells is poorly understood. CD137, another TNFRSF member has been shown to enhance the anti-tumour activity of NK cells in various malignancies. Here, we examine the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20656-y
更新日期：2018-02-02 00:00:00
abstract：:For one-dimensional (1d) nonlinear atomic lattices, the models with on-site nonlinearities such as the Frenkel-Kontorova (FK) and ϕ4 lattices have normal energy transport while the models with inter-site nonlinearities such as the Fermi-Pasta-Ulam-β (FPU-β) lattice exhibit anomalous energy transport. The 1d Discrete N...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23719-2
更新日期：2018-03-28 00:00:00
abstract：:Hypothermic oxygenated machine perfusion (HOPE) was introduced in liver transplantation (LT) to mitigate ischemia-reperfusion injury. Available clinical data mainly concern LT with donors after circulatory-determined death, whereas data on brain-dead donors (DBD) are scarce. To assess the impact of end-ischemic HOPE i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45843-3
更新日期：2019-06-27 00:00:00
abstract：:Clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology is a powerful tool to manipulate the genome with extraordinary simplicity and speed. To generate genetically modified animals, CRISPR/Cas9-mediated genome editing is typically accomplished by microinjectio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42244
更新日期：2017-02-08 00:00:00
abstract：:PAP80-2a, purified from Pholiota adiposa mycelia, is a polysaccharide exhibiting prominent antitumor effects. However, the yield of PAP80-2a was low and its structure has not been characterized, impeding the exploration of its structure-function relationship, thus influencing the development of oral drugs for antitumo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38251-6
更新日期：2019-02-11 00:00:00
abstract：:Equine athletes have a pattern of exercise which is analogous to human athletes and the cardiovascular risks in both species are similar. Both species have a propensity for atrial fibrillation (AF), which is challenging to detect by ECG analysis when in paroxysmal form. We hypothesised that the proarrhythmic backgroun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63343-7
更新日期：2020-04-22 00:00:00
abstract：:Spin-wave dynamics in full-Heusler Co2FeAl0.5Si0.5 films are studied using all-optical pump-probe magneto-optical polar Kerr spectroscopy. Backward volume magnetostatic spin-wave (BVMSW) mode is observed in films with thickness ranging from 20 to 100 nm besides perpendicular standing spin-wave (PSSW) mode, and found t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42513
更新日期：2017-02-14 00:00:00
abstract：:Bilirubin neurotoxicity has been studied for decades and has been shown to affect various mechanisms via significant modulation of gene expression. This suggests that vital regulatory mechanisms of gene expression, such as epigenetic mechanisms, could play a role in bilirubin neurotoxicity. Histone acetylation has rec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32106-w
更新日期：2018-09-12 00:00:00
abstract：:The essential cochaperone Sgt1 recruits Hsp90 chaperone activity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryotes. In these pathways Sgt1 interacts with Skp1, a small protein that heterodimerizes with proteins containing the F-box motif. We have determined the crystal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41626
更新日期：2017-01-31 00:00:00
abstract：:Clinical data from 172 cases of uterine fibroids with different appearances on MRI-T2WI and accepted ultrasound guided high intensity focused ultrasound (USgHIFU) treatment were retrospectively analyzed. This study aimed to evaluate the clinical safety and efficacy of ablating different types of fibroids, classified b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11486-5
更新日期：2017-09-07 00:00:00
abstract：:Mercury pollution in soil poses serious risks to human health through consumption of contaminated vegetables. We used a meta-analysis to examine the mercury enrichment ability of different vegetables and the main factors affecting mercury uptake. We drew the following conclusions. (1) Plants with a lower bioconcentrat...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-19519-3
更新日期：2018-01-19 00:00:00
abstract：:The ability to measure biomolecular dynamics within cells and tissues is very important to understand fundamental physiological processes including cell adhesion, signalling, movement, division or metabolism. Usually, such information is obtained using particle tracking methods or single point fluctuation spectroscopy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07048
更新日期：2014-11-14 00:00:00
abstract：:In higher plants, L-galactono-1,4-lactone dehydrogenase (GLDH) plays important roles in ascorbic acid (AsA) biosynthesis and assembly of respiration complex I. Here we report three homoeologous genes (TaGLDH-A1, -B1 and -D1) encoding common wheat GLDH isozymes and a unique allelic variant (TaGLDH-A1b) associated with ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30177
更新日期：2016-07-22 00:00:00
abstract：:To enhance the carbon dioxide (CO2) uptake of metal-organic frameworks (MOFs), amine functionalization of their pore surfaces has been studied extensively. In general, amine-functionalized MOFs have been synthesized via post-synthetic modifications. Herein, we introduce a one-step construction of a MOF ([(NiLethylamin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19337
更新日期：2016-01-13 00:00:00
abstract：:Cylindrical shell fused silica resonators coated with 8 axisymmetric Pb(Zr0.53Ti0.47)O3 (PZT) thin film electrodes (thickness ~2 μm) were reported. The resonators were firstly designed and fabricated, then annealed and processed by chemical etching to increase mechanical quality factor (Q factor) of resonators, which ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45180-5
更新日期：2019-07-01 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-22377-8
更新日期：2018-03-06 00:00:00
abstract：:A comprehensive identification of sphingoid bases and ceramides in wild Cordyceps was performed by integrating a sequential chromatographic enrichment procedure and an UHPLC-ultrahigh definition-Q-TOF-MS based sphingolipidomic approach. A total of 43 sphingoid bases and 303 ceramides were identified from wild Cordycep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38641
更新日期：2016-12-14 00:00:00
abstract：:NLRP3 inflammasomes recognize non-microbial danger signals and induce release of proinflammatory cytokine interleukin (IL)-1β, leading to sterile inflammation in cardiovascular disease. Because sterile inflammation is involved in doxorubicin (Dox)-induced cardiotoxicity, we investigated the role of NLRP3 inflammasomes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26489
更新日期：2016-05-26 00:00:00
abstract：:Successful synthetic biology efforts rely on conceptual and experimental designs in combination with testing of multi-gene constructs. Despite recent progresses, several limitations still hinder the ability to flexibly assemble and collectively share different types of DNA segments. Here, we describe an advanced syste...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19278
更新日期：2016-01-13 00:00:00
abstract：:When making choices between smaller, sooner rewards and larger, later ones, people tend to discount future outcomes. Individual differences in temporal discounting in older adults have been associated with episodic memory abilities and entorhinal cortical thickness. The cause of this association between better memory ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63373-1
更新日期：2020-04-14 00:00:00
abstract：:A 3D cell culture is preferred to 2D cell culture since it allows cells to grow in all directions in vitro, similar to how they would in vivo. 3D cell culture plates currently used in tissue engineering research have limited access to control the geometry. Furthermore, 3D cell culture plate manufacturing methods are r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50186-0
更新日期：2019-09-27 00:00:00
abstract：:Lymph node (LN) metastasis through the lymphatic network is a major route for cancer dissemination. Tumor cells reach the marginal sinuses of LNs via afferent lymphatic vessels (LVs) and form metastatic lesions that lead to distant metastasis. Thus, targeting of metastatic cells in the marginal sinuses could improve c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49386-5
更新日期：2019-09-13 00:00:00
abstract：:Chromatin folding shows spatio-temporal fluctuations in living undifferentiated cells, but fixed spatial heterogeneity in differentiated cells. However, little is known about variation in folding stability along the chromatin fibres during differentiation. In addition, effective methods to investigate folding stabilit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31975-5
更新日期：2018-09-12 00:00:00
abstract：:Medical folk wisdom (MFW) refers to widely held, but factually inaccurate, beliefs about disease, immunity, pregnancy, and other medically-relevant topics. Examples include the idea that fasting when feverish ("starving a fever") can increase the pace of recovery, or that showering after sex can prevent pregnancy. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67744-6
更新日期：2020-07-01 00:00:00
abstract：:To investigate the role of the circadian clock in the development of alcohol-induced fatty liver disease we examined livers of mice chronically alcohol-fed over 4-weeks that resulted in steatosis. Here we show time-of-day specific changes in expression of clock genes and clock-controlled genes, including those associa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03725
更新日期：2014-01-16 00:00:00
