Abstract：
:Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be a key to developing therapeutic strategy, but metabolic characteristics have not yet been studied. Here, we systematically analyzed and compared the global metabolic phenotype between LCSCs and non-LCSCs using transcriptome and metabolome data. We also reconstructed genome-scale metabolic models (GEMs) for LCSC and non-LCSC to comparatively examine differences in their metabolism at genome-scale. We demonstrated that LCSCs exhibited an increased proliferation rate through enhancing glycolysis compared with non-LCSCs. We also confirmed that MYC, a central point of regulation in cancer metabolism, was significantly up-regulated in LCSCs compared with non-LCSCs. Moreover, LCSCs tend to have less active fatty acid oxidation. In this study, the metabolic characteristics of LCSCs were identified using integrative systems analysis, and these characteristics could be potential cures for the resistance of liver cancer cells to anticancer treatments.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hur W,Ryu JY,Kim HU,Hong SW,Lee EB,Lee SY,Yoon SKdoi
10.1038/srep45557subject
Has Abstractpub_date
2017-04-03 00:00:00pages
45557issn
2045-2322pii
srep45557journal_volume
7pub_type
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pub_type： 历史文章,杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-05-31 00:00:00
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更新日期：2014-09-11 00:00:00
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更新日期：2017-11-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-11-16 00:00:00
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pub_type： 杂志文章
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更新日期：2017-03-06 00:00:00
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