Abstract:
:Xenobiotic resistance is commonly found in species with short generation times such as bacteria, annual plants, and insects. Nevertheless, the fundamental evolutionary principles that govern the spread of resistance alleles hold true for species with longer generation times. One such example could occur with sea lamprey (Petromyzon marinus), a parasitic invasive species in the Laurentian Great Lakes that decimated native fish populations prior to its control with the pesticide 3-trifluoromethyl-4-nitrophenol (TFM). Since the 1950s, tributaries have been treated annually with TFM, where treatments effectively remove most, but not all, larval sea lamprey. We developed an eco-genetic model of sea lamprey to examine factors affecting the evolution of resistance and found that resistance alleles rapidly rise to fixation after 40-80 years of treatment, despite the species' relatively long generation time (4-7 years). The absence of natal homing allows resistant individuals to spread quickly throughout the entire system, but also makes the early detection of resistance challenging. High costs of resistance and density independent reproduction can delay, but not prevent, the onset of resistance. These results illustrate that sea lamprey have the potential to evolve resistance to their primary control agent in the near future, highlighting the urgent need for alternative controls.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Christie MR,Sepúlveda MS,Dunlop ESdoi
10.1038/s41598-019-54260-5subject
Has Abstractpub_date
2019-12-03 00:00:00pages
18157issue
1issn
2045-2322pii
10.1038/s41598-019-54260-5journal_volume
9pub_type
杂志文章abstract::One of the factors that has increased the incidence and worse prognosis of breast cancer is obesity. In this condition, high amounts of leptin are secreted, which have proliferative, mitogenic, antiapoptotic, and proinflammatory activity that may be antagonistic to treatment with tamoxifen, considered the first choice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55674-x
更新日期:2019-12-16 00:00:00
abstract::The human brain has evolved specialised mechanisms to enable the rapid detection of threat cues, including emotional face expressions (e.g., fear and anger). However, contextual cues - such as gaze direction - influence the ability to recognise emotional expressions. For instance, anger paired with direct gaze, and fe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52728-y
更新日期:2019-11-07 00:00:00
abstract::Paeonia ostii, a member of tree peony, is an emerging oil crop with important medical and oil uses and widely cultivated in China. Dissolving the genetic diversity and domestication history of this species is important for further genetic improvements and deployments. We firstly selected 29 simple sequence repeats (SS...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04744-z
更新日期:2017-07-13 00:00:00
abstract::Predation has driven the evolution of diverse adaptations for defence among prey, and one striking example is the deimatic display. While such displays can resemble, or indeed co-occur with, aposematic 'warning' signals, theory suggests deimatic displays may function independently of predator learning. The survival va...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36995-9
更新日期:2019-01-24 00:00:00
abstract::The gist of natural scenes can be extracted very rapidly and even without focal attention. However, it is unclear whether and to what extent the gist of natural scenes can break through the bottleneck of crowding, a phenomenon in which object recognition will be immensely impaired. In the first two experiments, a targ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32455-6
更新日期:2018-09-19 00:00:00
abstract::Currently little is known about structure-function mappings in the human subcortex. Here we present a large-scale automated meta-analysis on the literature to understand the structure-function mapping in the human subcortex. The results provide converging evidence into unique large scale structure-function mappings of...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-018-33796-y
更新日期:2018-10-26 00:00:00
abstract::Inhibition of return (IOR), typically explored in cueing paradigms, is a performance cost associated with previously attended locations and has been suggested as a crucial attentional mechanism that biases orientation towards novelty. In their seminal IOR paper, Posner and Cohen (1984) showed that IOR is coded in spat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16586
更新日期:2015-11-13 00:00:00
abstract::Reprogramming of somatic cells has become a versatile tool for biomedical research and for regenerative medicine. In the current study, we show that manipulating alternative splicing (AS) is a highly potent strategy to produce cells for therapeutic applications. We demonstrate that silencing of hTAF4-TAFH activity of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30852
更新日期:2016-08-08 00:00:00
abstract::Magnetic refrigeration is of great interest due to its high energy efficiency, environmental friendliness and low cost. However, undesired hysteresis losses, concentrated working temperature interval (WTI) and poor mechanical stability are vital drawbacks that hinder its practical application. Off-stoichiometric Ni-Mn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35028-9
更新日期:2018-11-08 00:00:00
abstract::Childhood and adolescent overweight and obesity are increasing in China, but limited information is available on its secular trends in Guangzhou. In this cross-sectional study, ten-wave successive data were obtained from the physical fitness surveillance for students in Guangzhou from 2003 to 2012. A total of 2,619,15...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-12094-z
更新日期:2017-09-21 00:00:00
abstract::This paper presented a conformal smoothing theory, and smoothing capability evaluation was established on the proposed theory. According to pressure distribution model, processing parameters have been optimized and the CPP sample with a size of 340 × 340 mm was applied in conformal smoothing. The middle spatial freque...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59484-4
更新日期:2020-02-13 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-56284-3
更新日期:2019-12-16 00:00:00
abstract::The physiological roles of the protease inhibitor SERPINB3 (SB3) are still largely unknown. The study was addressed to assess the biological effects of this serpin in vivo using a SB3 transgenic mouse model. Two colonies of mice (123 transgenic for SB3 and 148 C57BL/6J controls) have been studied. Transgenic (TG) mice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03056
更新日期:2013-10-28 00:00:00
abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41598-018-20356-7
更新日期:2018-02-02 00:00:00
abstract::Applications from finance to epidemiology and cyber-security require accurate forecasts of dynamic phenomena, which are often only partially observed. We demonstrate that a system's predictability degrades as a function of temporal sampling, regardless of the adopted forecasting model. We quantify the loss of predicta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77091-1
更新日期:2020-11-24 00:00:00
abstract::Great Indian Bustard (GIB) is listed as Critically Endangered, with less than 250 individuals surviving in three fragmented populations. The species is under tremendous threat due to various anthropogenic pressures. Effective management and conservation of GIB requires a proper monitoring protocol, which we propose us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48193-2
更新日期:2019-08-12 00:00:00
abstract::The pathogenesis of severe dengue remains unclear, particularly the mechanisms underlying the plasma leakage that results in hypovolaemic shock in a small proportion of individuals. Maximal leakage occurs several days after peak viraemia implicating immunological pathways. Skin is a highly vascular organ and also an i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14640-1
更新日期:2017-10-27 00:00:00
abstract::Atropa acuminata Royle Ex Lindl (Atropa acuminata) under tremendous threat of extinction in its natural habitat. However, the antimicrobial, antileishmanial and anticancer effects of the plant's extracts have not been reported yet. In the current study, an attempt has been made to evaluate the pharmacological potentia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29231-x
更新日期:2018-07-23 00:00:00
abstract::Web search tools are widely used by the general public to obtain health-related information, and analysis of search data is often suggested for public health monitoring. We analyzed popularity of searches related to smell loss and taste loss, recently listed as symptoms of COVID-19. Searches on sight loss and hearing ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77316-3
更新日期:2020-11-25 00:00:00
abstract::Willow (Salix spp.) seeds are able to tolerate desiccation, but differ from typical orthodox seeds in that they lose viability in a few days at room temperature, and in that the chloroplasts in embryo tissues do not dedifferentiate during maturation drying, thus retaining chlorophyll and maintaining intact their thyla...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35476-3
更新日期:2018-11-21 00:00:00
abstract::Tissue fibrosis underlies the majority of human mortality to date with close to half of all reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and reputed irreversible once established. Although some preventive options are being reported, therapeutic options are still scarce and in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67514-4
更新日期:2020-06-30 00:00:00
abstract::CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications. Typically, sgRNA is constitutively expressed relying on RNA polymerase III promoters. Polymerase II promoters initiate transcription in a flexible manner, but sgRNAs generated by RNA polymerase II promoter lost their nuclease ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06216-w
更新日期:2017-07-19 00:00:00
abstract::Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pregnenolone 16α-carbonitrile (PCN...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53101-9
更新日期:2019-11-13 00:00:00
abstract::Global exponential increase in levels of Photovoltaic (PV) module waste is an increasing concern. The purpose of this study is to investigate if there is energy value in the polymers contained within first-generation crystalline silicon (c-Si) PV modules to help contribute positively to recycling rates and the circula...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41762-5
更新日期:2019-03-27 00:00:00
abstract::Microorganisms associated with plants are highly diverse and can produce a large number of secondary metabolites, with antimicrobial, anti-parasitic and cytotoxic activities. We are particularly interested in exploring endophytes from medicinal plants found in the Pantanal, a unique and widely unexplored wetland in Br...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21400-2
更新日期:2018-02-15 00:00:00
abstract::Although the effects of osteoporosis on the skeleton are well studied, site-specific and long-term studies on the mandible are still lacking. This study investigated the time-course changes of the bone microarchitecture in the mandibular condyle in comparison to the corresponding changes in the alveolar bone, body of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50554-w
更新日期:2019-10-02 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-65968-0
更新日期:2020-06-04 00:00:00
abstract::Survivin is an independent prognostic factor for joint destruction in rheumatoid arthritis (RA). However, the expression and function of survivin in RA synoviocytes remain unclear. We certified the expression of survivin in RA synovial tissues and performed the experiment using RA fibroblast-like synoviocytes (RA-FLS)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09795
更新日期:2015-05-22 00:00:00
abstract::This work provides new insights into the dynamics of silica nanoparticle-based removal of organic fluids (here oil) from naturally occurring porous media. We have used 4D (time-resolved 3D) imaging at pore-scale using X-ray computed micro-tomography (μCT) technique. The captured 3D tomographic time-series data reveal ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29569-2
更新日期:2018-07-24 00:00:00
abstract::In vivo, bone morphogenetic protein 2 (BMP-2) exists both in solution and bound to the extracellular matrix (ECM). While these two modes of presentation are known to influence cell behavior distinctly, their role in the niche microenvironment and their functional relevance in the genesis of a biological response has s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41479
更新日期:2017-01-30 00:00:00