Abstract：
:The treatment of testicular cancer includes unilateral orchiectomy and chemotherapy and is curative for most patients. However, observational studies revealed an association with depression, anxiety and cognitive impairment. It is unclear whether these side effects are caused by chemotherapy, hemicastration or the disease itself. The aim of our study was to analyse the behavioural effects of hemicastration and chemotherapy in adult male mice. The animals were randomly divided into four groups - control, chemotherapy, hemicastration and hemicastration with chemotherapy. After chemotherapy that included three cycles of bleomycin, etoposide, cisplatin mice underwent a battery of behavioural tests. To assess the long-term effects animals were tested also 3 months after the end of treatment. Chemotherapy led to lower locomotor- and exploratory activity, higher anxiety-like behaviour and worse spatial memory immediately after treatment. These behavioural effects were not present three months later. Hemicastration had no effect on most of the observed outcomes. In conclusion, adverse behavioural effects induced by chemotherapy in mice are transient and disappear later in life. Further studies are needed to elucidate the mechanisms responsible for the observed effects.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Borbélyová V,Renczés E,Chovanec M,Mego M,Celec Pdoi
10.1038/s41598-020-67081-8subject
Has Abstractpub_date
2020-06-23 00:00:00pages
10224issue
1issn
2045-2322pii
10.1038/s41598-020-67081-8journal_volume
10pub_type
杂志文章abstract：:Though carbon (C): nitrogen (N) stoichiometry has been widely studied in terrestrial ecosystems, little is known about its variation following afforestation. By synthesizing the results of 53 studies, we examined temporal and spatial variation in C: N ratios and in N-C scaling relationships of both the organic and the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19117
更新日期：2016-01-08 00:00:00
abstract：:Understanding adipose tissue cellular heterogeneity and homeostasis is essential to comprehend the cell type dynamics in metabolic diseases. Cellular subpopulations in the adipose tissue have been related to disease development, but efforts towards characterizing the adipose tissue cell type composition are limited. H...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67177-1
更新日期：2020-06-26 00:00:00
abstract：:Beaver have been referred to as ecosystem engineers because of the large impacts their dam building activities have on the landscape; however, the benefits they may provide to fluvial fish species has been debated. We conducted a watershed-scale experiment to test how increasing beaver dam and colony persistence in a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28581
更新日期：2016-07-04 00:00:00
abstract：:Networks in nature are often formed within a spatial domain in a dynamical manner, gaining links and nodes as they develop over time. Motivated by the growth and development of neuronal networks, we propose a class of spatially-based growing network models and investigate the resulting statistical network properties a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07047
更新日期：2014-11-14 00:00:00
abstract：:A wide-band and tunable Q-switched erbium-doped fiber (EDF) laser operating at 1560.5 nm with a tungsten ditelluride (WTe2) saturable absorber (SA) is demonstrated. The semi-metallic nature of WTe2 as well as its small band gap and excellent nonlinear optical properties make it an excellent SA material. The laser cavi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66664-9
更新日期：2020-06-17 00:00:00
abstract：:This study demonstrates that 24 h following viral vector-based vaccination IL-13Rα2 functions as a master sensor on conventional dendritic cells (cDCs), abetted by high protein stability coupled with minimal mRNA expression, to rapidly regulate DC mediated IL-13 responses at the lung mucosae, unlike IL-13Rα1. Under lo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57815-z
更新日期：2020-01-23 00:00:00
abstract：:Porous three-dimensional (3D) polyurethane-based biocomposites were produced utilizing diatomite and hydroxyapatite as fillers. Diatomite and Hydroxyapatite (HA) were utilized to reinforce the morphological, chemical, mechanical, and thermal properties of polyurethane foam (PUF). Diatomite and Hydroxyapatite were adde...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70421-3
更新日期：2020-08-06 00:00:00
abstract：:Injection of pure spin current using a nonlocal geometry is a promising method for controlling magnetization in spintronic devices from the viewpoints of increasing freedom in device structure and avoiding problems related to charge current. Here, we report an experimental demonstration of magnetization switching of a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56082-x
更新日期：2019-12-20 00:00:00
abstract：:The mitochondrial genome almost exclusively encodes a handful of transmembrane constituents of the oxidative phosphorylation (OXPHOS) system. Coordinated expression of these genes ensures the correct stoichiometry of the system's components. Translation initiation in mitochondria is assisted by two general initiation ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18749
更新日期：2016-01-05 00:00:00
abstract：:Bioactive nanosilicates are emerging prominent next generation biomaterials due to their intrinsic functional properties such as advanced biochemical and biophysical cues. Recent studies show interesting dose-dependent effect of fluoride ions on the stem cells. Despite of interesting properties of fluoride ions as wel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37327-7
更新日期：2019-01-29 00:00:00
abstract：:Soil pH is commonly considered a dominant factor affecting the function of microbiota. Few studies, however, have focused on communities of bacteria able to solubilize inorganic phosphate (iPSB), which are important for the mobilization of soil phosphorus (P), because finding an effective method to assess the abundanc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37003-w
更新日期：2019-01-10 00:00:00
abstract：:In clinical populations, olfactory abilities parallel executive function, implicating shared neuroanatomical substrates within the ventral prefrontal cortex. In healthy individuals, the relationship between olfaction and personality traits or certain cognitive and behavioural characteristics remains unexplored. We the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34056-9
更新日期：2018-10-22 00:00:00
abstract：:We demonstrated modulation of charge carrier densities in all-solution-processed organic field-effect transistors (OFETs) by modifying the injection properties with self-assembled monolayers (SAMs). The all-solution-processed OFETs based on an n-type polymer with inkjet-printed Ag electrodes were fabricated as a test ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46365
更新日期：2017-04-12 00:00:00
abstract：:Using time-gated fluorescence lifetime imaging microscopy, significantly more signals from 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide (o-BMVC) foci, characterized by the longer fluorescent decay time of o-BMVC, were detected in six types of cancer cells than in three types of normal cells. Accumulating ev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34378-8
更新日期：2018-10-31 00:00:00
abstract：:The place conditioning paradigm is an efficient, widely-used method to study mechanisms that underlie appetitive or aversive learning and memory processes. However, pharmacological agents used to induce conditioned place preference (CPP) or aversion (CPA) can per se interfere with learning and memory processing, hence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25568-5
更新日期：2018-05-08 00:00:00
abstract：:EndMT has an important effect on metastasis and progression of tumor. This work will elucidate the effect of miR-494 on EndMT and development of HCC. Therefore, the differential miRNA expression among non-tumorous, para-tumorous and tumorous tissues was analyzed. Moreover, luciferase activities of SIRT3 3'UTR treated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43731-4
更新日期：2019-05-10 00:00:00
abstract：:The TCP transcription factors usually act as integrators of multiple growth regulatory and environmental stimuli. However, little is known about this gene family in the important tropical crop cassava (Manihot esculenta). In this study, 36 TCP genes were identified and renamed based on cassava whole-genome sequence an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09398-5
更新日期：2017-08-30 00:00:00
abstract：:Cohesins are vital for chromosome organisation during meiosis and mitosis. In addition to the important function in sister chromatid cohesion, these complexes play key roles in meiotic recombination, DSB repair, homologous chromosome pairing and segregation. Egg-laying mammals (monotremes) feature an unusually complex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04560-5
更新日期：2017-06-26 00:00:00
abstract：:There are no clinical guidelines for the timing of cholecystectomy (CCY) after performing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis. We tried to analyze the clinical practice patterns, medical expenses, and subsequent outcomes between the early CCY, delayed CCY, and no C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38428-z
更新日期：2019-02-18 00:00:00
abstract：:We report the synthesis of single-crystal iron germanium nanowires via chemical vapor deposition without the assistance of any catalysts. The assembly of single-crystal FeGe2 nanowires with tetragonal C16 crystal structure shows anisotropic magnetic behavior along the radial direction or the growth axial direction, wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05771-6
更新日期：2017-08-02 00:00:00
abstract：:Crystalline materials exhibit long-range ordered lattice unit, within which resides nonperiodic structural features called defects. These crystallographic defects play a vital role in determining the physical and mechanical properties of a wide range of material systems. While computer vision has demonstrated success ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49105-0
更新日期：2019-09-04 00:00:00
abstract：:The repeated measurements of heart rate variability (HRV) is more relevant than a single HRV measurement in predicting patient prognosis but is less addressed previously. This prospective study aimed to investigate the association between repeated measurements of HRV and long-term mortality in chronic hemodialysis pat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57792-3
更新日期：2020-01-21 00:00:00
abstract：:Given the prevalence of poor adherence to therapy and the biases of self-reporting across healthcare, we hypothesized that an engaging, personalized therapy may improve adherence and treatment outcomes in the home. We tested this hypothesis in the initial indication of amblyopia, a neurodevelopmental disorder for whic...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-65234-3
更新日期：2020-05-20 00:00:00
abstract：:Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system. However, the mechanisms underlying its tumor initiation, progression, and metastasis are not yet fully understood. The annexin A4 (ANXA4) gene is highly expressed in GBC tissues and may play an important role in the initiation and progr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31056
更新日期：2016-08-05 00:00:00
abstract：:The number of magnetoelectric multiferroic materials reported to date is scarce, as magnetic structures that break inversion symmetry and induce an improper ferroelectric polarization typically arise through subtle competition between different magnetic interactions. The (NH4)2[FeCl5(H2O)] compound is a rare case wher...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14475
更新日期：2015-09-29 00:00:00
abstract：:Mast cells act as sensors in innate immunity and as effector cells in adaptive immune reactions. Here we demonstrate that SLC10A4, also referred to as the vesicular aminergic-associated transporter, VAAT, modifies mast cell degranulation. Strikingly, Slc10a4 -/- bone marrow-derived mast cells (BMMCs) had a significant...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01121-8
更新日期：2017-04-24 00:00:00
abstract：:Previous studies showed that better adherence to the Mediterranean diet (MD) is associated with lower risk of chronic diseases, but limited data are available on bone health. We investigated the association of the MD with bone mineral density (BMD) in Chinese adults. We included 2371 participants aged 40-75 years in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25662
更新日期：2016-05-09 00:00:00
abstract：:Early cow-calf separation prevents much of cows' natural maternal behaviour. Early separation is thought to prevent the development of a cow-calf bond. To assess this bond, we measured motivation of dairy cows to reunite with their calf. To vary the degree of bonding, some cows were allowed continued contact with thei...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70927-w
更新日期：2020-08-28 00:00:00
abstract：:We show that the width of an arbitrary function and the width of the distribution of its values cannot be made arbitrarily small simultaneously. In the case of ergodic stochastic processes, an ensuing uncertainty relationship is then demonstrated for the product of correlation length and variance. A closely related un...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64539-7
更新日期：2020-05-12 00:00:00
abstract：:Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05568-7
更新日期：2017-07-11 00:00:00
