The G-quadruplex fluorescent probe 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide as a biosensor for human cancers.

abstract：:Mechanotransduction is crucial for touch sensation, hearing, proprioception, and pain sensing. In C. elegans, male ray neurons have been implicated to be involved in the mechanosensation required for mating behavior. However, whether ray neurons directly sense mechanical stimulation is not yet known, and the underlyin...

journal_title：Scientific reports

authors： Zhang H,Yue X,Cheng H,Zhang X,Cai Y,Zou W,Huang G,Cheng L,Ye F,Kang L

更新日期：2018-05-08 00:00:00

abstract：:To compare the efficacy and safety of triple therapy combining intravitreal injection of anti-vascular endothelial growth factor, trabeculectomy, and pan-retinal photocoagulation via binocular indirect ophthalmoscopy, with that of transscleral cyclophotocoagulation (TCP) to treat neovascular glaucoma in the angle-clos...

journal_title：Scientific reports

authors： Hong Y,Hu Y,Dou H,Wang C,Zhang C,Ma Z

更新日期：2018-05-04 00:00:00

abstract：:Small amphipods (Halice sp. MT-2017) with body length <1 cm were collected from the Challenger Deep (~10,920 m below sea level). The divergence time of their lineage was approximately 109 Mya, making this group ancient compared to others under study. The mitochondrial genome of Halice sp. shared the usual gene compone...

journal_title：Scientific reports

authors： Li JY,Zeng C,Yan GY,He LS

更新日期：2019-02-22 00:00:00

abstract：:The structure, mechanism of action and copper stoichiometry of the transmembrane sensor domain of the plant ethylene receptor ETR1 and homologs have remained elusive, hampering the understanding on how the perception of the plant hormone ethylene is transformed into a downstream signal. We generated the first structur...

journal_title：Scientific reports

authors： Schott-Verdugo S,Müller L,Classen E,Gohlke H,Groth G

更新日期：2019-06-20 00:00:00

abstract：:Histological molecular classification of hepatocellular carcinoma (HCC) is clinically important for predicting the prognosis. However, a reliable serum marker has not been established. The aim of this study was to evaluate the diagnostic value of serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 (WFA-si...

journal_title：Scientific reports

authors： Tamaki N,Kuno A,Matsuda A,Tsujikawa H,Yamazaki K,Yasui Y,Tsuchiya K,Nakanishi H,Itakura J,Korenaga M,Mizokami M,Kurosaki M,Sakamoto M,Narimatsu H,Izumi N

更新日期：2017-03-21 00:00:00

abstract：:This paper explores the empirical links between achieving the Sustainable Development Goals (SDGs) and subjective well-being. Globally, we find that in terms of well-being, there are increasing marginal returns to sustainable development. Unpacking the SDGs by looking at how each SDG relates to well-being shows, in mo...

journal_title：Scientific reports

authors： De Neve JE,Sachs JD

更新日期：2020-09-15 00:00:00

abstract：:Bradysia odoriphaga and Bradysia difformis are devastating pests of vegetable, ornamental crops and edible mushrooms causing significant losses. Temperature may be an important factor restricting their population abundance in the summer. To determine the effects of short-term heat shock on adults, their survival, long...

journal_title：Scientific reports

authors： Zhu G,Xue M,Luo Y,Ji G,Liu F,Zhao H,Sun X

更新日期：2017-10-17 00:00:00

abstract：:Exploiting new, low-cost and efficient electrocatalysts for hydrogen evolution reaction (HER) is important to resolve the energy crisis and environment pollution. In this work, graphene decorated with Ni nanoparticles (NPs) were synthesized via one-pot reduction using graphene oxide (GO, the obtained composite was den...

journal_title：Scientific reports

authors： Zhang W,Li Y,Zeng X,Peng S

更新日期：2015-06-12 00:00:00

abstract：:Protein kinase B (PKB) also known as Akt is involved in many signal transduction pathways. As alterations of the PKB pathway are found in a number of human malignancies, PKB is considered an important drug target for cancer therapy. However, production of sufficient amounts of active PKB for biochemical and structural...

journal_title：Scientific reports

authors： Maesaki R,Satoh R,Taoka M,Kanaba T,Asano T,Fujita C,Fujiwara T,Ito Y,Isobe T,Hakoshima T,Maenaka K,Mishima M

更新日期：2014-08-15 00:00:00

abstract：:Screening and in silico modeling are critical activities for the reduction of experimental costs. They also speed up research notably and strengthen the theoretical framework, thus allowing researchers to numerically quantify the importance of a particular subset of information. For example, in fields such as cancer a...

journal_title：Scientific reports

authors： Blanco JL,Porto-Pazos AB,Pazos A,Fernandez-Lozano C

更新日期：2018-10-24 00:00:00

abstract：:The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its progression from the preoperative MR radiomics. 57 newly diagnosed cerebral glioblastoma patients were ...

journal_title：Scientific reports

authors： Yan JL,Li C,van der Hoorn A,Boonzaier NR,Matys T,Price SJ

更新日期：2020-06-16 00:00:00

abstract：:Although Heme Oxygenase-1 (HO-1) induction in various forms of kidney injury is protective, its role in age-related renal pathology is unknown. In the ageing kidney there is nephron loss and lesions of focal glomerulosclerosis, interstitial fibrosis, tubular atrophy and arteriolosclerosis. Underlying mechanisms includ...

journal_title：Scientific reports

authors： Poulaki E,Detsika MG,Fourtziala E,Lianos EA,Gakiopoulou H

更新日期：2020-03-31 00:00:00

abstract：:The two most common techniques for absolute protein quantification are based on either mass spectrometry (MS) or on immunochemical techniques, such as western blotting (WB). Western blotting is most often used for protein identification or relative quantification, but can also be deployed for absolute quantification i...

journal_title：Scientific reports

authors： Bennett RJ,Simpson DM,Holman SW,Ryan S,Brownridge P,Eyers CE,Colyer J,Beynon RJ

更新日期：2017-04-03 00:00:00

abstract：:Invasive motor Cortex Stimulation (iMCS) was introduced in the 1990's for the treatment of chronic neuropathic orofacial pain (CNOP), although its effectiveness remains doubtful. However, CNOP is known to be a heterogeneous group of orofacial pain disorders, which can lead to different responses to iMCS. Therefore, th...

journal_title：Scientific reports

authors： Henssen D,Kurt E,van Walsum AVC,Kozicz T,van Dongen R,Bartels R

更新日期：2020-04-28 00:00:00

abstract：:One of the major challenges in olfaction research is to relate the structural features of the odorants to different features of olfactory system. However, no relationship has been yet discovered between the structure of the olfactory stimulus, and the structure of respiratory signal. This study reveals the plasticity ...

journal_title：Scientific reports

authors： Namazi H,Akrami A,Kulish VV

更新日期：2016-05-31 00:00:00

abstract：:Adaptation to new environmental stress is often associated with an alteration of one or more life history parameters. Insecticide resistant populations of insects often have reduced fitness relative to susceptible populations in insecticide free environments. Our previous work showed that three populations of bed bugs...

journal_title：Scientific reports

authors： Gordon JR,Potter MF,Haynes KF

更新日期：2015-06-03 00:00:00

abstract：:Age of complementary foods introduction is associated with childhood anemia, but the ideal age for the introduction of complementary foods to infants is a continuing topic of debate. We examined the longitudinal association between complementary foods introduction age and risk of anemia in 18,446 children from the Jia...

journal_title：Scientific reports

authors： Wang F,Liu H,Wan Y,Li J,Chen Y,Zheng J,Huang T,Li D

更新日期：2017-03-23 00:00:00

abstract：:RT-qPCR offers high sensitivity, for accurate interpretations of qPCR results however, normalisation using suitable reference genes is fundamental. Androgens can regulate transcriptional expression including reference gene expression in prostate cancer. In this study, we evaluated ten mRNA and six non-protein coding R...

journal_title：Scientific reports

authors： Zhao H,Ma TF,Lin J,Liu LL,Sun WJ,Guo LX,Wang SQ,Otecko NO,Zhang YP

更新日期：2018-01-31 00:00:00

abstract：:Wrist worn raw-data accelerometers are used increasingly in large-scale population research. We examined whether sleep parameters can be estimated from these data in the absence of sleep diaries. Our heuristic algorithm uses the variance in estimated z-axis angle and makes basic assumptions about sleep interruptions. ...

journal_title：Scientific reports

authors： van Hees VT,Sabia S,Jones SE,Wood AR,Anderson KN,Kivimäki M,Frayling TM,Pack AI,Bucan M,Trenell MI,Mazzotti DR,Gehrman PR,Singh-Manoux BA,Weedon MN

更新日期：2018-08-28 00:00:00

abstract：:Atomistic chemical inhomogeneities are anticipated to induce dissimilarities in surface potentials, which control corrosion initiation of alloys at the atomic scale. Precise understanding of corrosion is therefore hampered by lack of definite information describing how atomistic heterogeneities regulate the process. H...

journal_title：Scientific reports

authors： Zhang B,Wang J,Wu B,Oguzie EE,Luo K,Ma XL

更新日期：2016-12-21 00:00:00

abstract：:The vascular smooth muscle cells (VSMCs) are exposed to interstitial flow induced shear stress that may be sensed by the surface glycocalyx, a surface layer composed primarily of proteoglycans and glycoproteins, to mediate cell contraction during the myogenic response. We, therefore, attempted to elucidate the signal ...

journal_title：Scientific reports

authors： Kang H,Liu J,Sun A,Liu X,Fan Y,Deng X

更新日期：2017-02-13 00:00:00

abstract：:Recently, a large number of long noncoding RNAs (lncRNAs) have emerged as important regulators of many biological processes in animals and plants. However, how lncRNAs function during plant DNA virus infection is largely unknown. We performed strand-specific paired-end RNA sequencing of tomato samples infected with To...

journal_title：Scientific reports

authors： Wang J,Yu W,Yang Y,Li X,Chen T,Liu T,Ma N,Yang X,Liu R,Zhang B

更新日期：2015-12-18 00:00:00

abstract：:The commensal microbiome is known to influence a variety of host phenotypes. Microbiome profiling followed by differential abundance analysis has been established as an effective approach to study the mechanisms of host-microbiome interactions. However, it is challenging to interpret the collective functions of the re...

journal_title：Scientific reports

authors： Kou Y,Xu X,Zhu Z,Dai L,Tan Y

更新日期：2020-12-08 00:00:00

abstract：:In eusocial Hymenoptera (ants, bees and wasps), queen and worker adult castes typically arise via environmental influences. A fundamental challenge is to understand how a single genome can thereby produce alternative phenotypes. A powerful approach is to compare the molecular basis of caste determination and different...

journal_title：Scientific reports

authors： Collins DH,Mohorianu I,Beckers M,Moulton V,Dalmay T,Bourke AF

更新日期：2017-03-31 00:00:00

abstract：:Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid protein of Alzheimer's disease. However, little is known about the association between fibrinogen a...

journal_title：Scientific reports

authors： Page MJ,Thomson GJA,Nunes JM,Engelbrecht AM,Nell TA,de Villiers WJS,de Beer MC,Engelbrecht L,Kell DB,Pretorius E

更新日期：2019-02-28 00:00:00

abstract：:Water Droplet Erosion (WDE) as a material degradation phenomenon has been a concern in power generation industries for decades. Steam turbine blades and the compressor blades of gas turbines that use water injection usually suffer from WDE. The present work focuses on studying erosion resistance of TiAl as a potential...

journal_title：Scientific reports

authors： Mahdipoor MS,Kirols HS,Kevorkov D,Jedrzejowski P,Medraj M

更新日期：2015-09-22 00:00:00

abstract：:NETs constitute a network of DNA and proteins released by neutrophils in response to infectious and immunologic triggers. NET proteins are recognized as autoantigens in ANCA vasculitis; limited knowledge is available in other autoimmune pathologies. The composition of NETs produced ex vivo by resting and Phorbol-myris...

journal_title：Scientific reports

authors： Bruschi M,Petretto A,Santucci L,Vaglio A,Pratesi F,Migliorini P,Bertelli R,Lavarello C,Bartolucci M,Candiano G,Prunotto M,Ghiggeri GM

更新日期：2019-05-28 00:00:00

abstract：:This study contrasted the impact of Tai Chi Chuan and general aerobic exercise on brain plasticity in terms of an increased grey matter volume and functional connectivity during structural magnetic resonance imaging (sMRI) and resting-state functional magnetic resonance imaging (rs-fMRI), explored the advantages of Ta...

journal_title：Scientific reports

authors： Cui L,Yin H,Lyu S,Shen Q,Wang Y,Li X,Li J,Li Y,Zhu L

更新日期：2019-11-21 00:00:00

abstract：:The Sigma-1 receptor (S1R) is known to play a protective role in the central nervous system including the retina. A major barrier for understanding the underlying mechanism is an ambiguity of S1R subcellular localizations. We thus conducted the first electron microscopy (EM) study of S1R subcellular distribution in th...

journal_title：Scientific reports

authors： Mavlyutov TA,Epstein M,Guo LW

更新日期：2015-06-02 00:00:00

abstract：:Aerosols impact clear-sky surface irradiance () through the effects of scattering and absorption. Linear or nonlinear relationships between aerosol optical depth (τa) and have been established to describe the aerosol direct radiative effect on (ADRE). However, considerable uncertainties remain associated with ADRE due...

journal_title：Scientific reports

authors： Xia X

更新日期：2015-09-23 00:00:00