Abstract:
:A mathematical model is proposed for the autonomic control of cardiovascular system, which takes into account two separated self-exciting sympathetic control loops of heart rate and peripheral vascular tone. The control loops are represented by self-exciting time-delay systems and their tone depends on activity of the aortic, carotid, and lower-body baroreceptors. The model is used to study the dynamics of the adaptive processes that manifest in a healthy cardiovascular system during the passive head-up tilt test. Computer simulation provides continuous observation of the dynamics of the indexes and variables that cannot be measured in the direct experiment, including the noradrenaline concentration in vessel wall and heart muscle, tone of the sympathetic and parasympathetic control, peripheral vascular resistance, and blood pressure. In the supine and upright positions, we estimated the spectral characteristics of the model variables, especially in the low-frequency band, and the original index of total percent of phase synchronization between the low-frequency oscillations in heart rate and blood pressure signals. The model demonstrates good quantitative agreement with the dynamics of the experimentally observed indexes of cardiovascular system that were averaged for 50 healthy subjects.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ishbulatov YM,Karavaev AS,Kiselev AR,Simonyan MA,Prokhorov MD,Ponomarenko VI,Mironov SA,Gridnev VI,Bezruchko BP,Shvartz VAdoi
10.1038/s41598-020-71532-7subject
Has Abstractpub_date
2020-10-05 00:00:00pages
16525issue
1issn
2045-2322pii
10.1038/s41598-020-71532-7journal_volume
10pub_type
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