Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models.

Abstract:

:A bioresorbable metallic helical stent was explored as a new device opportunity (magnesium scaffold), which can be absorbed by the body without leaving a trace and simultaneously allowing restoration of vasoreactivity with the potential for vessel remodeling. In this study, developed Mg-based helical stent was inserted and expanded in vessels with subsequent degradation in various environments including static, dynamic, and porcine ex vivo models. By assessing stent degradation in three different environments, we observed: (1) stress- and flow-induced degradation; (2) a high degradation rate in the dynamic reactor; (3) production of intermediate products (MgO/Mg(OH)2 and Ca/P) during degradation; and (4) intermediate micro-gas pocket formation in the neighboring tissue ex vivo model. Overall, the expandable Mg-based helical stent employed as a scaffold performed well, with expansion rate (>100%) in porcine ex vivo model.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Koo Y,Tiasha T,Shanov VN,Yun Y

doi

10.1038/s41598-017-01214-4

subject

Has Abstract

pub_date

2017-04-26 00:00:00

pages

1173

issue

1

issn

2045-2322

pii

10.1038/s41598-017-01214-4

journal_volume

7

pub_type

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