Abstract：
:A bioresorbable metallic helical stent was explored as a new device opportunity (magnesium scaffold), which can be absorbed by the body without leaving a trace and simultaneously allowing restoration of vasoreactivity with the potential for vessel remodeling. In this study, developed Mg-based helical stent was inserted and expanded in vessels with subsequent degradation in various environments including static, dynamic, and porcine ex vivo models. By assessing stent degradation in three different environments, we observed: (1) stress- and flow-induced degradation; (2) a high degradation rate in the dynamic reactor; (3) production of intermediate products (MgO/Mg(OH)2 and Ca/P) during degradation; and (4) intermediate micro-gas pocket formation in the neighboring tissue ex vivo model. Overall, the expandable Mg-based helical stent employed as a scaffold performed well, with expansion rate (>100%) in porcine ex vivo model.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Koo Y,Tiasha T,Shanov VN,Yun Ydoi
10.1038/s41598-017-01214-4subject
Has Abstractpub_date
2017-04-26 00:00:00pages
1173issue
1issn
2045-2322pii
10.1038/s41598-017-01214-4journal_volume
7pub_type
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