Abstract:
:We evaluated changes in incidence, relative survival (RS), and conditional survival (CS) of head and neck squamous cell carcinoma (HNSCC), focusing on oral tongue squamous cell carcinoma (OTSCC). Data of 74 680 HNSCC patients from 1976 to 2015 were obtained from the Surveillance, Epidemiology, and End Results database. Five anatomical sites and their subsites were analyzed. Annual percent change (APC) of incidence was calculated. RS and CS were compared across the four decades. Adjusted hazard ratios (aHRs) of RS were evaluated using multivariate regression. OTSCC incidence decreased from 1976 (APC = -0.76, P < 0.05) but has increased since 1999 (APC = 2.36, P < 0.05). During 2006-2015, the 5-year CS exceeded 90% only for OTSCC and oropharyngeal squamous cell carcinoma (OPSCC). RS improved in OTSCC (aHR = 0.697, 95% confidence interval [CI] 0.642-0.757, P < 0.001) and OPSCC (aHR = 0.669, 95% CI 0.633-0.706, P < 0.001) during the last two decades. For both OTSCC and OPSCC, improved survival was observed regardless of treatment. Incidence and survival remained unchanged for nasopharyngeal, hypopharyngeal, and laryngeal cancers during this period. In conclusion, OTSCC incidence has been increasing since the 2000s, with improving prognosis irrespective of treatment. Given its similarity to OPSCC, OTSCC may represent an emerging HNSCC, warranting further research and clinical recognition.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kim YJ,Kim JHdoi
10.1038/s41598-020-64748-0subject
Has Abstractpub_date
2020-05-12 00:00:00pages
7877issue
1issn
2045-2322pii
10.1038/s41598-020-64748-0journal_volume
10pub_type
杂志文章abstract::The abundance and diversity of bacteria in two types of ponds were investigated by quantitative PCR and Illumina MiSeq sequencing. The results revealed that the abundance of bacterial 16S rRNA genes in D ponds (with grass carp fed sudan grass) was significantly lower than that in E ponds (with grass carp fed commercia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35232
更新日期:2016-10-19 00:00:00
abstract::In arthropods, retinoid X receptor (RXR) is a highly conserved nuclear hormone receptor. By forming a heterodimeric complex with the ecdysone receptor (EcR), RXR is known to be vital importance for various physiological processes. However, in comparison to EcR, the RXR signaling pathway and its roles in crustacean rep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23654
更新日期:2016-03-24 00:00:00
abstract::To investigate the role of the altered activation of the immune system in the prognosis of patients affected by laryngeal squamous cell carcinoma (LSCC). We analyzed 56 patients with advanced LSCC divided into two groups according to their prognosis: the first group relapsed within 24 months after treatment, the secon...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73747-0
更新日期:2020-10-27 00:00:00
abstract::Genome-scale metabolic network models can be used for various analyses including the prediction of metabolic responses to changes in the environment. Legumes are well known for their rhizobial symbiosis that introduces nitrogen into the global nutrient cycle. Here, we describe a fully compartmentalised, mass and charg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30884-x
更新日期:2018-08-21 00:00:00
abstract::Hbs1, which is homologous to the GTPase eRF3, is a small G protein implicated in mRNA quality control. It interacts with a translation-release factor 1-like protein Dom34/Pelota to direct decay of mRNAs with ribosomal stalls. Although both proteins are evolutionarily conserved in eukaryotes, the biological function of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39530-6
更新日期:2019-03-01 00:00:00
abstract::Networks are a powerful abstraction with applicability to a variety of scientific fields. Models explaining their morphology and growth processes permit a wide range of phenomena to be more systematically analysed and understood. At the same time, creating such models is often challenging and requires insights that ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06284
更新日期:2014-09-05 00:00:00
abstract::Conventional transistor electronics are reaching their limits in terms of scalability, power dissipation, and the underlying Boolean system architecture. To overcome this obstacle neuromorphic analogue systems are recently highly investigated. Particularly, the use of memristive devices in VLSI analogue concepts provi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27033-9
更新日期:2018-06-11 00:00:00
abstract::RNA interference (RNAi) is being developed for the management of pests that destroy crops. The twospotted Spider Mite (TSSM), Tetranychus urticae is a worldwide pest due to its unique physiological and behavioral characteristics including extraordinary ability to detoxify a wide range of pesticides and feed on many ho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32742-2
更新日期:2018-10-02 00:00:00
abstract::Large spin splitting at Rashba interface, giving rise to strong spin-momentum locking, is essential for efficient spin-to-charge conversion. Recently, a Cu/Bismuth oxide (Bi2O3) interface has been found to exhibit an efficient spin-to-charge conversion similar to a Ag/Bi interface with large Rashba spin splitting. How...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23787-4
更新日期:2018-04-03 00:00:00
abstract::Application of PCR to multiplexing assays is not trivial; it requires multiple fluorescent labels for amplicon detection and sophisticated software for data interpretation. Alternative PCR-free methods exploiting new concepts in nanotechnology exhibit high sensitivities but require multiple labeling and/or amplificati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02033
更新日期:2013-01-01 00:00:00
abstract::The innate immune system helps animals to navigate the microbial world. The response to microbes relies on the specific recognition of microbial-associated molecular patterns (MAMPs) by immune receptors. Sponges (phylum Porifera), as early-diverging animals, provide insights into conserved mechanisms for animal-microb...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34330-w
更新日期:2018-10-31 00:00:00
abstract::Propionibacterium acnes (P. acnes) is a major skin-associated bacterium that was long considered commensal, until several studies revealed it to be an opportunistic pathogen. We investigated the ability of P. acnes surface proteins to recognize ECM proteins and showed that a 58 kDa P. acnes surface protein was specifi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06940-3
更新日期:2017-07-25 00:00:00
abstract::The Pregnane X Receptor (PXR) is a ligand-activated transcription factor belonging to the nuclear receptor family. PXR can bind diverse drugs and environmental toxicants with different binding modes, making it an intriguing target for drug discovery. Here we investigated the binding mechanism of the SR12813 ligand to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34373-z
更新日期:2018-11-01 00:00:00
abstract::The application of CLSI and EUCAST guidelines led to many discrepancies. Various doubts have already appeared in preliminary stages of microbiological diagnostics of Haemophilus spp. A total of 87 H. parainfluenzae isolates were obtained from throat or nasopharyngeal swabs from adults 18 to 70 years old, both healthy ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68161-5
更新日期:2020-07-13 00:00:00
abstract::Heterodonty is one of the hallmarks of mammals. It has been suggested that, homeobox genes, differentially expressed in the ectomesenchyme of the jaw primordium along the distal-proximal axis, would determine the tooth classes (homeobox code model) based on mouse studies. Because mouse has highly specialized tooth pat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49116-x
更新日期:2019-09-06 00:00:00
abstract::Little research on coronaviruses has been conducted on wild animals in Africa. Here, we screened a wide range of wild animals collected in six provinces and five caves of Gabon between 2009 and 2015. We collected a total of 1867 animal samples (cave-dwelling bats, rodents, non-human primates and other wild animals). W...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64159-1
更新日期:2020-04-30 00:00:00
abstract::Plant-based proteins are increasingly being used in aquafeeds, but one of the limitations is taurine deficiency that can be especially detrimental for carnivorous fish. In this study, taurine supplementation in high plant protein diets (low fish meal, 15%) was investigated on the growth performance and fillet organole...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69014-x
更新日期:2020-07-23 00:00:00
abstract::The aim of this study was to estimate substitution rate and imprints of natural selection on parvovirus B19 genotype 1. Studied datasets included 137 near complete coding B19 genomes (positions 665 to 4851) for phylogenetic and substitution rate analysis and 146 and 214 partial genomes for selection analyses in open r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35759
更新日期:2016-10-24 00:00:00
abstract::Hypothermic oxygenated machine perfusion (HOPE) was recently tested in preclinical trials in kidney transplantation (KT). Here we investigate the effects of HOPE on extended-criteria-donation (ECD) kidney allografts (KA). Fifteen ECD-KA were submitted to 152 ± 92 min of end-ischemic HOPE and were compared to a matched...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74839-7
更新日期:2020-10-20 00:00:00
abstract::Oviposition site-selection in insects is mediated through innate recognition templates (IRTs) tuned to specific chemical cues. These cues aid gravid insects in choosing suitable oviposition sites and may even enhance the fitness of their offspring by warding off predators and parasitoids. However, studies on the evolu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07472
更新日期:2014-12-15 00:00:00
abstract::High and low hematocrit (Hct) and hemoglobin (Hb) levels are associated with the risk of cardiovascular disease. The purpose of this study was to determine the relationships of Hct, Hb and red blood cells (RBCs) with vascular function and structure. We measured flow-mediated vasodilation (FMD), nitroglycerin-induced v...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68319-1
更新日期:2020-07-10 00:00:00
abstract::The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation in vivo remains to be u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10984
更新日期:2015-06-04 00:00:00
abstract::Ghrelin is the only orexigenic peptide currently known and a potent prokinetic by promoting gastric motility but novel insights suggest that its role extends beyond satiety regulation. Whereas ghrelin was shown to provide somatic and colonic antinociception, its impact on gastric sensitivity is unknown even though sto...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67053-y
更新日期:2020-06-19 00:00:00
abstract::Gallid alphaherpesvirus 2 (GaHV2) is an oncogenic avian herpesvirus inducing Marek's disease (MD) and rapid-onset T-cell lymphomas. To reveal molecular events in MD pathogenesis and tumorigenesis, the dynamic splenic transcriptome of GaHV2-infected chickens during early infection and pathogenic phases has been determi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11304-y
更新日期:2017-09-14 00:00:00
abstract::The advent of flexible optoelectronic devices has accelerated the development of semiconducting polymeric materials. We seek to replace conventional expensive semiconducting photodetector materials with our cost-effective composite system. We demonstrate in this work the successful fabrication of a photoconductive com...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16761
更新日期:2015-11-16 00:00:00
abstract::The hair bundle of cochlear hair cells is the site of auditory mechanoelectrical transduction. It is formed by three rows of stiff microvilli-like protrusions of graduated heights, the short, middle-sized, and tall stereocilia. In developing and mature sensory hair cells, stereocilia are connected to each other by var...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73158-1
更新日期:2020-10-02 00:00:00
abstract::We investigate the Lorentz-covariant deformed algebra for Dirac oscillator problem, which is a generalization of Kempf deformed algebra in 3 + 1 dimension of space-time, where Lorentz symmetry are preserved. The energy spectrum of the system is analyzed by taking advantage of the corresponding wave functions with expl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03221
更新日期:2013-11-14 00:00:00
abstract::Pyramidal neurons in the rodent hippocampus exhibit spatial tuning during spatial navigation, and they are reactivated in specific temporal order during sharp-wave ripples observed in quiet wakefulness or slow wave sleep. However, analyzing representations of sleep-associated hippocampal ensemble spike activity remain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32193
更新日期:2016-08-30 00:00:00
abstract::The p53 protein is a key mediator of the cellular response to various stress signals. In response to DNA damage, the concentration of p53 can temporally oscillate with fluctuations in both the amplitude and period. The underlying mechanism for p53 variability is not fully understood. Here, we construct a core regulato...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41904-9
更新日期:2019-04-10 00:00:00
abstract::Arctic amplification of global warming has led to increased summer sea ice retreat, which influences gas exchange between the Arctic Ocean and the atmosphere where sea ice previously acted as a physical barrier. Indeed, recently observed enhanced atmospheric methane concentrations in Arctic regions with fractional sea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16179
更新日期:2015-11-10 00:00:00