Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons.

abstract：:We report a multi-channel optical frequency synthesizer developed to generate extremely stable continuous-wave lasers directly out of the optical comb of an Er-doped fiber oscillator. Being stabilized to a high-finesse cavity with a fractional frequency stability of 3.8 × 10-15 at 0.1 s, the comb-rooted synthesizer pr...

journal_title：Scientific reports

authors： Jang H,Kim BS,Chun BJ,Kang HJ,Jang YS,Kim YW,Kim YJ,Kim SW

更新日期：2019-05-21 00:00:00

abstract：:Intestinal epithelial cells continuously migrate and mature along crypt-villus axis (CVA), while the changes in energy metabolism during maturation are unclear in neonates. The present study was conducted to test the hypothesis that the energy metabolism in intestinal epithelial cells would be changed during maturatio...

journal_title：Scientific reports

authors： Yang H,Wang X,Xiong X,Yin Y

更新日期：2016-08-25 00:00:00

abstract：:The considerable range of genetic variation in human populations may partly reflect distinctive processes of adaptation to variable environmental conditions. However, the adaptive genomic signatures remain to be completely elucidated. This research explores candidate loci under selection at the population level by cha...

journal_title：Scientific reports

authors： Fujikura K

更新日期：2016-03-02 00:00:00

abstract：:Silver (Ag) is one of the seven metals of antiquity and an important engineering material in the electronic, medical, and chemical industries because of its unique noble and catalytic properties. Ag thin films are extensively used in modern electronics primarily because of their oxidation-resistance. Here we report a ...

journal_title：Scientific reports

authors： Lin SK,Nagao S,Yokoi E,Oh C,Zhang H,Liu YC,Lin SG,Suganuma K

更新日期：2016-10-05 00:00:00

abstract：:Colorectal cancer (CRC) is the leading cause of cancer-related mortality worldwide. Although the role of tumor programmed cell death 1 ligand 1 (PD-L1) in suppressing antitumor immunity has been validated in various malignances, the impact of PD-L2 (PD-L2/PDCD1LG2) within tumors remains elusive. Here, we examined tumo...

journal_title：Scientific reports

authors： Huang KC,Chiang SF,Chen TW,Chen WT,Yang PC,Ke TW,Chao KSC

更新日期：2020-12-18 00:00:00

abstract：:Diffusion processes are widespread in biological and chemical systems, where they play a fundamental role in the exchange of substances at the cellular level and in determining the rate of chemical reactions. Recently, the classical picture that portrays diffusion as random uncorrelated motion of molecules has been re...

journal_title：Scientific reports

authors： Cerbino R,Sun Y,Donev A,Vailati A

更新日期：2015-09-30 00:00:00

abstract：:Checkpoint kinases are important in cellular surveillance pathways that help cells to cope with DNA damage and protect their genomes. In cycling cells, DNA replication is one of the most sensitive processes and therefore all organisms carefully regulate replication initiation and progression. The checkpoint kinase ATR...

journal_title：Scientific reports

authors： Bøe CA,Håland TW,Boye E,Syljuåsen RG,Grallert B

更新日期：2018-05-02 00:00:00

abstract：:Here we investigated whether endothelial colony forming cells (ECFC) and mesenchymal progenitor cells (MPC) form vascular networks and restore blood flow in ischemic skeletal muscle, and whether host myeloid cells play a role. ECFC + MPC, ECFC alone, MPC alone, or vehicle alone were injected into the hind limb ischemi...

journal_title：Scientific reports

authors： Kang KT,Lin RZ,Kuppermann D,Melero-Martin JM,Bischoff J

更新日期：2017-04-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： McGrath EC,Woods L,Jompa J,Haris A,Bell JJ

更新日期：2019-11-27 00:00:00

abstract：:Early admission to the neurosciences intensive care unit (NSICU) is associated with improved patient outcomes. Natural language processing offers new possibilities for mining free text in electronic health record data. We sought to develop a machine learning model using both tabular and free text data to identify pati...

journal_title：Scientific reports

authors： Klang E,Kummer BR,Dangayach NS,Zhong A,Kia MA,Timsina P,Cossentino I,Costa AB,Levin MA,Oermann EK

更新日期：2021-01-14 00:00:00

abstract：:The trade of bumble bees started in the early nineties for pollinator-dependent greenhouse plants. Nowadays, its rearing and transport have received public attention, since managed bees can transfer pathogens to wild bee populations. Therefore, guaranteeing pathogen-free bumble bees is fundamental. The major protein s...

journal_title：Scientific reports

authors： Pereira KS,Meeus I,Smagghe G

更新日期：2019-03-12 00:00:00

abstract：:Lysophospholipids (LPLs) are known to have potentially important roles in the initiation and maintenance of neuropathic pain in animal models. This study investigated the association between the clinical severity of lumbar spinal stenosis (LSS) and the cerebrospinal fluid (CSF) levels of LPLs, using human samples. We ...

journal_title：Scientific reports

authors： Hayakawa K,Kurano M,Ohya J,Oichi T,Kano K,Nishikawa M,Uranbileg B,Kuwajima K,Sumitani M,Tanaka S,Aoki J,Yatomi Y,Chikuda H

更新日期：2019-06-24 00:00:00

abstract：:Polypoidal choroidal vasculopathy (PCV) is a distinctive type of neovascular age-related macular degeneration prevalent in many Asian countries. However, there is still some controversy in how the subtypes of PCV are classified. This post-hoc study redefined the branching vascular network (BVN) and PCV subtypes throug...

journal_title：Scientific reports

authors： Yeung L,Lai CC,Chen SN,Cheng CK,Yang CM,Hsieh YT,Tsai A,Yang CH

更新日期：2021-01-11 00:00:00

abstract：:Ancient human remains of paleopathological interest typically contain highly degraded DNA in which pathogenic taxa are often minority components, making sequence-based metagenomic characterization costly. Microarrays may hold a potential solution to these challenges, offering a rapid, affordable, and highly informativ...

journal_title：Scientific reports

authors： Devault AM,McLoughlin K,Jaing C,Gardner S,Porter TM,Enk JM,Thissen J,Allen J,Borucki M,DeWitte SN,Dhody AN,Poinar HN

更新日期：2014-03-06 00:00:00

abstract：:Development of cost-effective counter electrode (CE) materials is a key issue for practical applications of photoelectrochemical solar energy conversion. Kesterite Cu2ZnSnS4 (CZTS) has been recognized as a potential CE material, but its electrocatalytic activity is still insufficient for the recovery of I-/I3- electro...

journal_title：Scientific reports

authors： Lu S,Yang H,Li F,Wang Y,Chen S,Yang G,Liu Y,Zhang X

更新日期：2018-06-07 00:00:00

abstract：:Spatially-resolved neutron powder diffraction with a gauge volume of 2 × 2 × 20 mm(3) has been applied as an in situ method to probe the lithium concentration in the graphite anode of different Li-ion cells of 18650-type in charged state. Structural studies performed in combination with electrochemical measurements an...

journal_title：Scientific reports

authors： Senyshyn A,Mühlbauer MJ,Dolotko O,Hofmann M,Ehrenberg H

更新日期：2015-12-18 00:00:00

abstract：:The Japanese macaque (Macaca fuscata) exhibits a species-specific communication sound called the "coo call" to locate group members and maintain within-group contact. Monkeys have been demonstrated to be capable of discriminating between individuals based only on their voices, but there is still debate regarding how t...

journal_title：Scientific reports

authors： Furuyama T,Kobayasi KI,Riquimaroux H

更新日期：2016-08-23 00:00:00

abstract：:In this paper, the effect of binder decay rather than a change in the pigments on the blurring of ancient wall paintings was researched. The simulated wall paintings were prepared by brushing an aqueous solution containing gelatine and ochre grains on the surface of cylindrical compressed soil samples. Then, the dried...

journal_title：Scientific reports

authors： Zheng L,Wang Z,Shen S,Xia Y,Li Y,Hu D

更新日期：2020-12-03 00:00:00

abstract：:Pain is a highly unpleasant sensory and emotional experience, and no objective diagnosis test exists to assess it. In clinical practice there are two main methods for the estimation of pain, a patient's self-report and clinical judgement. However, these methods are highly subjective and the need of biomarkers to measu...

journal_title：Scientific reports

authors： Fernandez Rojas R,Huang X,Ou KL

更新日期：2019-04-04 00:00:00

abstract：:Coriander foliage is a distinctive spice employed on a daily basis in curry and other Indian traditional food preparations mainly for the unique flavour attributes and health benefits. Radical scavenging activity has been demonstrated previously for coriander foliage. However, specific molecules responsible were not i...

journal_title：Scientific reports

authors： Priyadarshi S,Harohally NV,Roopavathi C,Naidu MM

更新日期：2018-11-27 00:00:00

abstract：:We report on a new colorimetric DNA detection method that takes advantage of the power of polymerase chain reaction (PCR) and the simplicity of the classic litmus test. The strategy makes use of a modified set of primers for PCR to facilitate ensuing manipulations of resultant DNA amplicons: their tagging with urease ...

journal_title：Scientific reports

authors： Chang D,Tram K,Li B,Feng Q,Shen Z,Lee CH,Salena BJ,Li Y

更新日期：2017-06-08 00:00:00

abstract：:An accurate method to predict the mortality in the intensive care unit (ICU) patients has been required, especially in children. The aim of this study is to evaluate the value of serum anion gap (AG) for predicting mortality in pediatric ICU (PICU). We reviewed a data of 461 pediatric patients were collected on PICU a...

journal_title：Scientific reports

authors： Kim MJ,Kim YH,Sol IS,Kim SY,Kim JD,Kim HY,Kim KW,Sohn MH,Kim KE

更新日期：2017-05-03 00:00:00

abstract：:GDP-mannose pyrophosphorylase (GMP) catalyzed the formation of GDP-mannose, which serves as a donor for the biosynthesis of mannose-containing polysaccharides. In this study, three GMP genes from Dendrobium officinale (i.e., DoGMPs) were cloned and analyzed. The putative 1000 bp upstream regulatory region of these DoG...

journal_title：Scientific reports

authors： He C,Yu Z,Teixeira da Silva JA,Zhang J,Liu X,Wang X,Zhang X,Zeng S,Wu K,Tan J,Ma G,Luo J,Duan J

更新日期：2017-02-08 00:00:00

abstract：:To report the efficacy and safety of large diameter scleral lenses and determine their suitability in Asian subjects with intractable ocular surface diseases. This prospective study enrolled intractable ocular surface diseases subjects with uncorrected visual acuity > counting finger but ≥ 0.3 logMAR and best-correcte...

journal_title：Scientific reports

authors： Moon J,Lee SM,Hyon JY,Kim MK,Oh JY,Choi HJ

更新日期：2021-01-27 00:00:00

abstract：:Chronic pulmonary inflammation (CPI) gives rise to serious lung injuries in rheumatoid arthritis (RA) patients. However, the molecular mechanism underlying the pathogenesis of RA-associated CPI remains little understood. Here we established a novel tree shrew-based collagen-induced arthritis (TsCIA) model to study RA-...

journal_title：Scientific reports

authors： Gao B,Lin J,Jiang Z,Yang Z,Yu H,Ding L,Yu M,Cui Q,Dunavin N,Zhang M,Li M

更新日期：2018-07-03 00:00:00

abstract：:There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that over-expression of EC4-Fc (truncated N-cadherin), or deletion of matr...

journal_title：Scientific reports

authors： Lyon CA,Williams H,Bianco R,Simmonds SJ,Brown BA,Wadey KS,Smith FCT,Johnson JL,George SJ

更新日期：2017-12-11 00:00:00

abstract：:Certain bacteria produce iron oxide material assembled with nanoparticles (NPs) that are doped with silicon (Fe:Si ~ 3:1) in ambient environment. Such biogenous iron oxides (BIOX) proved to be an excellent electrode material for lithium-ion batteries, but underlying atomistic mechanisms remain elusive. Here, quantum m...

journal_title：Scientific reports

authors： Misawa M,Hashimoto H,Kalia RK,Matsumoto S,Nakano A,Shimojo F,Takada J,Tiwari S,Tsuruta K,Vashishta P

更新日期：2019-02-12 00:00:00

abstract：:Magma transport through the Earth's crust occurs dominantly via sheet intrusions, such as dykes and cone-sheets, and is fundamental to crustal evolution, volcanic eruptions and geochemical element cycling. However, reliable methods to reconstruct flow direction in solidified sheet intrusions have proved elusive. Aniso...

journal_title：Scientific reports

authors： Andersson M,Almqvist BS,Burchardt S,Troll VR,Malehmir A,Snowball I,Kübler L

更新日期：2016-06-10 00:00:00

abstract：:Moonlighting proteins, including metabolic enzymes acting as transcription factors (TF), are present in a variety of organisms but have not been described in higher fungi so far. In a previous genome-wide analysis of the TF repertoire of the plant-symbiotic fungus Tuber melanosporum, we identified various enzymes, inc...

journal_title：Scientific reports

authors： Levati E,Sartini S,Bolchi A,Ottonello S,Montanini B

更新日期：2016-04-28 00:00:00

abstract：:Many freshwater and coastal marine ecosystems across the world may have undergone an ecosystem regime change due to a combination of rising anthropogenic disturbances and regional climate change. Such a change in aquatic ecosystems is commonly seen as shifts in algal species. But considerably less detail is known abou...

journal_title：Scientific reports

authors： Yuan F,Depew R,Soltis-Muth C

更新日期：2014-12-01 00:00:00