Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment.

abstract：:Seeing with two eyes usually helps one respond faster. Here we show that with ambiguous stimuli, binocular viewing can paradoxically slow down reaction time. This is explained by the observers basing their decision on a noisy neuronal representation within the visual system, with the added noise breaking the symmetry ...

journal_title：Scientific reports

authors： Yehezkel O,Sterkin A,Sagi D,Polat U

更新日期：2015-11-18 00:00:00

abstract：:Any processing delay between the two eyes can result in illusory 3D percepts for moving objects because of either changes in the pure disparities over time for disparity sensors or by changes to sensors that encode motion/disparity conjointly. This is demonstrated by viewing a fronto-parallel pendulum through a neutra...

journal_title：Scientific reports

authors： Reynaud A,Hess RF

更新日期：2017-07-17 00:00:00

abstract：:This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004-2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe (pH < 7.1). Two multiple logistic regression models ...

journal_title：Scientific reports

authors： Cherubini V,Skrami E,Ferrito L,Zucchini S,Scaramuzza A,Bonfanti R,Buono P,Cardella F,Cauvin V,Chiari G,D Annunzio G,Frongia AP,Iafusco D,Patera IP,Toni S,Tumini S,Rabbone I,Lombardo F,Carle F,Gesuita R,Diabetes St

更新日期：2016-12-19 00:00:00

abstract：:A sensitive and selective chemiluminescence (CL) sensor based on the peroxidase-like activity of copper nanoclusters was established for the detection of cholesterol. Copper nanoclusters catalyse the CL reaction between luminol and H2O2. Because H2O2 is the oxidative product of cholesterol in the presence of cholester...

journal_title：Scientific reports

authors： Xu S,Wang Y,Zhou D,Kuang M,Fang D,Yang W,Wei S,Ma L

更新日期：2016-12-14 00:00:00

abstract：:Primordial germ cells (PGCs), the embryonic precursors of the sperm and egg, are used for the introduction of genetic modifications into avian genome. Introduction of small defined sequences using genome editing has not been demonstrated in bird species. Here, we compared oligonucleotide-mediated HDR using wild type S...

journal_title：Scientific reports

authors： Idoko-Akoh A,Taylor L,Sang HM,McGrew MJ

更新日期：2018-10-11 00:00:00

abstract：:Amine quantification is an important strategy in patient stratification and personalised medicine. This is because amines, including amino acids and methylarginines impact on many homeostatic processes. One important pathway regulated by amine levels is nitric oxide synthase (NOS). NOS is regulated by levels of (i) th...

journal_title：Scientific reports

authors： Ahmetaj-Shala B,Olanipekun M,Tesfai A,MacCallum N,Kirkby NS,Quinlan GJ,Shih CC,Kawai R,Mumby S,Paul-Clark M,Want EJ,Mitchell JA

更新日期：2018-09-18 00:00:00

abstract：:Headache is a common reason to visit the emergency department (ED). Tension-type headache (TTH) is the commonest headache. The diagnosis of TTH implies a mild condition, with no need for special tests. We evaluated the use of the International Classification of Headache Disorders (ICHD) criteria for TTH in the ED. We ...

journal_title：Scientific reports

authors： García-Azorín D,Farid-Zahran M,Gutiérrez-Sánchez M,González-García MN,Guerrero AL,Porta-Etessam J

更新日期：2020-02-12 00:00:00

abstract：:Microalgae have great potential for the production of biofuels due to the ability of the organism to accumulate large quantities of storage lipids under stress conditions. Mitogen activated protein kinase (MAPK) signaling cascades are widely recognized for their role in stress response signal transduction in eukaryote...

journal_title：Scientific reports

authors： Yang A,Suh WI,Kang NK,Lee B,Chang YK

更新日期：2018-09-14 00:00:00

abstract：:The association between blood urea nitrogen to creatinine ratio (UCR) and survival is uncertain in hemodialysis patients. We examined the influence of UCR on mortality and morbidity in hemodialysis patients. A total of 3,401 hemodialysis patients were prospectively followed for 4 years. The association between UCR wit...

journal_title：Scientific reports

authors： Tanaka S,Ninomiya T,Taniguchi M,Tokumoto M,Masutani K,Ooboshi H,Kitazono T,Tsuruya K

更新日期：2017-11-02 00:00:00

abstract：:Although it is known that malaria parasites proliferate in the midgut of mosquito vector, their detailed behaviors, from gamete maturation to formation of next generation sporozoite, have not been fully understood at cellular or molecular level. This is mainly attributed to technical difficulties of dissection and who...

journal_title：Scientific reports

authors： Mori T,Hirai M,Mita T

更新日期：2019-02-11 00:00:00

abstract：:Protein phosphorylation enables a rapid adjustment of cellular activities to diverse intracellular and environmental stimuli. Many phosphoproteins are targeted on more than one site, which allows the integration of multiple signals and the implementation of complex responses. However, the hierarchy and interplay betwe...

journal_title：Scientific reports

authors： Dengler L,Örd M,Schwab LM,Loog M,Ewald JC

更新日期：2021-01-13 00:00:00

abstract：:Glaucoma is a leading cause of blindness worldwide. Purpose of this study was to identify molecular markers that were significantly correlated with presence of glaucoma and outcome of glaucoma surgery. To accomplish this, we determined the profiles of pro-inflammatory cytokines in the aqueous humor of 101 glaucoma pat...

journal_title：Scientific reports

authors： Chono I,Miyazaki D,Miyake H,Komatsu N,Ehara F,Nagase D,Kawamoto Y,Shimizu Y,Ideta R,Inoue Y

更新日期：2018-09-28 00:00:00

abstract：:Recent studies suggest that glypican-1 (GPC-1) is a biomarker for prostate cancer, but there are few studies elucidating the role of GPC-1 in prostate cancer progression. We observed high expression of GPC-1 in more aggressive prostate cancer cell lines such as PC-3 and DU-145. While inhibition of GPC-1 expression in ...

journal_title：Scientific reports

authors： Quach ND,Kaur SP,Eggert MW,Ingram L,Ghosh D,Sheth S,Nagy T,Dawson MR,Arnold RD,Cummings BS

更新日期：2019-08-07 00:00:00

abstract：:Freshwater mussels are ecosystem engineers and keystone species in aquatic environments. Unfortunately, due to dramatic declines this fauna is among the most threatened globally. Here, we clarify the taxonomy and biogeography of Russian Unionidae species based on the most comprehensive multi-locus dataset sampled to d...

journal_title：Scientific reports

authors： Bolotov IN,Kondakov AV,Konopleva ES,Vikhrev IV,Aksenova OV,Aksenov AS,Bespalaya YV,Borovskoy AV,Danilov PP,Dvoryankin GA,Gofarov MY,Kabakov MB,Klishko OK,Kolosova YS,Lyubas AA,Novoselov AP,Palatov DM,Savvinov GN,Solom

更新日期：2020-02-20 00:00:00

abstract：:We report a daily-updated sequenced/species Tree Of Life (sTOL) as a reference for the increasing number of cellular organisms with their genomes sequenced. The sTOL builds on a likelihood-based weight calibration algorithm to consolidate NCBI taxonomy information in concert with unbiased sampling of molecular charact...

journal_title：Scientific reports

authors： Fang H,Oates ME,Pethica RB,Greenwood JM,Sardar AJ,Rackham OJ,Donoghue PC,Stamatakis A,de Lima Morais DA,Gough J

更新日期：2013-01-01 00:00:00

abstract：:Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine production are closely associated with inflammatory bone disease. However, the expression and fun...

journal_title：Scientific reports

authors： Si Y,Chen YB,Chen SJ,Zheng YQ,Liu X,Liu Y,Jiang HL,Xu G,Li ZH,Huang QH,Xiong H,Zhang ZG

更新日期：2015-12-07 00:00:00

abstract：:Studies on dsDNA bacteriophages have revealed that a DNA packaging complex assembles at a special vertex called the 'portal vertex' and consists of a portal, a DNA packaging ATPase and other components. AdV protein IVa2 is presumed to function as a DNA packaging ATPase. However, a protein that functions as a portal is...

journal_title：Scientific reports

authors： Ahi YS,Hassan AO,Vemula SV,Li K,Jiang W,Zhang GJ,Mittal SK

更新日期：2017-08-08 00:00:00

abstract：:Traditional strengthening ways, such as strain, precipitation, and solid-solution, come into effect by pinning the motion of dislocation. Here, through first-principles calculations we report on an extra-electron induced covalent strengthening mechanism, which alters chemical bonding upon the introduction of extra-val...

journal_title：Scientific reports

authors： Niu H,Chen XQ,Liu P,Xing W,Cheng X,Li D,Li Y

更新日期：2012-01-01 00:00:00

abstract：:An individual's immune system is driven by both genetic and environmental factors that vary over time. To better understand the temporal and inter-individual variability of gene expression within distinct immune cell types, we developed a platform that leverages multiplexed single-cell sequencing and out-of-clinic cap...

journal_title：Scientific reports

authors： Dobreva T,Brown D,Park JH,Thomson M

更新日期：2020-11-25 00:00:00

abstract：:Rheumatoid arthritis (RA) patients have been observed to be at a lower risk of developing Alzheimer's Disease (AD). Clinical trials have showed no relationship between nonsteroidal anti-inflammatory drug (NSAID) use and AD. The aim of this study was to establish if there is a causal link between RA and AD. A systemati...

journal_title：Scientific reports

authors： Policicchio S,Ahmad AN,Powell JF,Proitsi P

更新日期：2017-10-09 00:00:00

abstract：:The biliary tree is an essential component of transplantable human liver tissue. Despite recent advances in liver tissue engineering, attempts at re-creating the intrahepatic biliary tree have not progressed significantly. The finer branches of the biliary tree are structurally and functionally complex and heterogeneo...

journal_title：Scientific reports

authors： Lewis PL,Su J,Yan M,Meng F,Glaser SS,Alpini GD,Green RM,Sosa-Pineda B,Shah RN

更新日期：2018-08-15 00:00:00

abstract：:We established in vivo and in vitro models to investigate the role of αB-Crystallin (CryAB) and assess the ability of aspirin (ASA) to protect the myocardium during prolonged heat stress. Thirty-day-old chickens were divided into three groups (n = 90): heat stress (HS, 40±1 °C); ASA(-)HS(+), 1 mg/kg ASA orally 2 h bef...

journal_title：Scientific reports

authors： Tang S,Yin B,Song E,Chen H,Cheng Y,Zhang X,Bao E,Hartung J

更新日期：2016-11-18 00:00:00

abstract：:Safe management of high level nuclear waste is a worldwide significant issue for which vitrification has been selected by many countries. There exists a crucial need for improving our understanding of the ageing of the glass under irradiation. While external irradiation by ions provides a rapid simulation of damage in...

journal_title：Scientific reports

authors： Charpentier T,Martel L,Mir AH,Somers J,Jégou C,Peuget S

更新日期：2016-05-05 00:00:00

abstract：:It has been reported that non-selective autophagy of infected hepatocytes could facilitate the development of malaria in the liver stage, but the fate of parasites following selective autophagy of infected hepatocytes is still not very clear. Here, we confirmed that sporozoite infection can induce a selective autophag...

journal_title：Scientific reports

authors： Zhao C,Liu T,Zhou T,Fu Y,Zheng H,Ding Y,Zhang K,Xu W

更新日期：2016-11-30 00:00:00

abstract：:After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. The Guarani-Kaiowá people are an indigenous population in Paraguay an...

journal_title：Scientific reports

authors： Hadi SA,Kolte IV,Brenner EP,Cunha EAT,Simonsen V,Ferrazoli L,Villela DAM,Santos RS,Ravi J,Sreevatsan S,Basta PC

更新日期：2021-01-13 00:00:00

abstract：:Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70...

journal_title：Scientific reports

authors： Lee HL,Jang JW,Lee SW,Yoo SH,Kwon JH,Nam SW,Bae SH,Choi JY,Han NI,Yoon SK

更新日期：2019-03-01 00:00:00

abstract：:The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue...

journal_title：Scientific reports

authors： Scaduto P,Sequeira A,Vawter MP,Bunney W,Limon A

更新日期：2020-05-25 00:00:00

abstract：:DNA double-strand breaks pose a direct threat to genomic stability. Studies of DNA damage and chromatin dynamics have yielded opposing results that support either increased or decreased chromatin motion after damage. In this study, we independently measure the dynamics of transcriptionally active or repressed chromati...

journal_title：Scientific reports

authors： Whitefield DB,Spagnol ST,Armiger TJ,Lan L,Dahl KN

更新日期：2018-12-27 00:00:00

abstract：:The physiological function of the pancreas is controlled by the circadian clock. The aim of this study was to determine whether aging-induced changes in glucose homeostasis affect properties of the circadian clock in the pancreas and/or its sensitivity to disturbances in environmental lighting conditions. mPer2Luc mic...

journal_title：Scientific reports

authors： Novosadová Z,Polidarová L,Sládek M,Sumová A

更新日期：2018-08-03 00:00:00

abstract：:The concept of milk as a healthy food has opened the way for studies on milk components, from nutrients to microRNAs, molecules with broad regulatory properties present in large quantities in milk. Characterization of these components has been performed in several species, such as humans and bovine, depending on the s...

journal_title：Scientific reports

authors： Le Guillou S,Leduc A,Laubier J,Barbey S,Rossignol MN,Lefebvre R,Marthey S,Laloë D,Le Provost F

更新日期：2019-12-30 00:00:00