Abstract：
:A sensitive and selective chemiluminescence (CL) sensor based on the peroxidase-like activity of copper nanoclusters was established for the detection of cholesterol. Copper nanoclusters catalyse the CL reaction between luminol and H2O2. Because H2O2 is the oxidative product of cholesterol in the presence of cholesterol oxidase, the oxidation of cholesterol can be quantitatively converted to a CL response by combining the two reactions. The proposed method is simple and can be completed in a few minutes with high sensitivity. Under the optimal conditions, the CL intensity was proportional to the concentration of cholesterol over a wide range of 0.05-10 mM, with a detection limit of 1.5 μM. Furthermore, the method was successfully applied to determine cholesterol in milk powder and human serum with satisfactory accuracy and precision. This method expands the applications of nano-mimic enzymes in the field of CL-based sensors.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xu S,Wang Y,Zhou D,Kuang M,Fang D,Yang W,Wei S,Ma Ldoi
10.1038/srep39157subject
Has Abstractpub_date
2016-12-14 00:00:00pages
39157issn
2045-2322pii
srep39157journal_volume
6pub_type
杂志文章abstract：:A relation exists between network proximity of molecular entities in interaction networks, functional similarity and association with diseases. The identification of network regions associated with biological functions and pathologies is a major goal in systems biology. We describe a network diffusion-based pipeline f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34841
更新日期：2016-10-12 00:00:00
abstract：:Archaeological evidence suggests that dogs were introduced to the islands of Oceania via Island Southeast Asia around 3,300 years ago, and reached the eastern islands of Polynesia by the fourteenth century AD. This dispersal is intimately tied to human expansion, but the involvement of dogs in Pacific migrations is no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27363-8
更新日期：2018-06-14 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58755-4
更新日期：2020-01-30 00:00:00
abstract：:Prognostic biomarkers serve a variety of purposes in cancer treatment and research, such as prediction of cancer progression, and treatment eligibility. Despite growing interest in multi-omic data integration for defining prognostic biomarkers, validated methods have been slow to emerge. Given that breast cancer has b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23494-0
更新日期：2018-03-26 00:00:00
abstract：:Understanding the excited-state dynamics in perovskite photovoltaics is necessary for progress in these materials, but changes in dynamics depending on the fabrication processes used for perovskite photoactive layers remain poorly characterised. Here we report a comparative study on femtosecond transient absorption (T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16654-1
更新日期：2017-11-28 00:00:00
abstract：:An encapsulated formulation of Bacillus thuringiensis (Bt) was produced by the Pickering emulsion technique to improve its activity and stability under UV-A radiation. In this technique latex particles, GO nanosheets, olive oil, ethanol, and water were used to encapsulate Bt in colloidosomes. The protective efficacy o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77721-8
更新日期：2020-11-26 00:00:00
abstract：:Diverse magnetic and electronic properties of halogen-adsorbed silicene are investigated by the first-principle theoretical framework, including the adatom-diversified geometric structures, atom-dominated energy bands, spatial spin density distributions, spatial charge density distributions and its variations, and orb...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50233-w
更新日期：2019-09-24 00:00:00
abstract：:In this paper, we propose an angle- and polarization-insensitive metamaterial absorber. We design a metamaterial unit cell that is based on a split ring cross resonator (SRCR). We observe that the absorption frequency and absorption ratio are insensitive to incident angles when a via array surrounds the SRR. We demons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39686
更新日期：2016-12-21 00:00:00
abstract：:Histological chorioamnionitis (HCA) is an infection of fetal membranes and complicates 5.2% to 28.5% of all live births. HCA is associated with increased mortality and morbidity in both premature and term neonates. Exposure to HCA may have long-term consequences, including an increased risk for allergic disorders and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42205-x
更新日期：2019-04-10 00:00:00
abstract：:Colorectal cancer, the third most commonly diagnosed cancer, is a lifestyle disease where diet and gut microbiome contribute intricately in its initiation and progression. Prophylactic bio-interventions mainly probiotics offer an alternate approach towards reducing or delaying its progression. Therefore, the present s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51361-z
更新日期：2019-10-14 00:00:00
abstract：:Systemic Lupus Erythematosus (SLE) is the prototype of autoimmune diseases, characterized by extensive gene expression perturbations in peripheral blood immune cells. Circumstantial evidence suggests that these perturbations may be due to altered epigenetic profiles and chromatin accessibility but the relationship bet...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73654-4
更新日期：2020-10-06 00:00:00
abstract：:Hypoxia is a recognized characteristic of tumors that influences efficacy of radiotherapy (RT). Photoacoustic imaging (PAI) is a relatively new imaging technique that exploits the optical characteristics of hemoglobin to provide information on tissue oxygenation. In the present study, PAI based measures of tumor oxyge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21237
更新日期：2016-02-17 00:00:00
abstract：:Fluorine-19 (19F) magnetic resonance imaging (MRI) of injected perfluorocarbons (PFCs) can be used for the quantification and monitoring of inflammation in diseases such as atherosclerosis. To advance the translation of this technique to the clinical setting, we aimed to 1) demonstrate the feasibility of quantitative ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53905-9
更新日期：2019-11-25 00:00:00
abstract：:Renal fibrosis, the characteristic feature of progressive chronic kidney disease, is associated with unremitting renal inflammation. Although it is reported that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, elicits an anti-renal fibrotic effect, its molecular mechanism is still unknown. In thi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35339-x
更新日期：2018-11-26 00:00:00
abstract：:The room-temperature magnetic properties of ball-milled strontium hexaferrite particles consolidated by spark-plasma sintering are strongly influenced by the milling time. Scanning electron microscopy revealed the ball-milled SrFe12O19 particles to have sizes varying over several hundred nanometers. X-Ray powder-diffr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14112
更新日期：2015-09-15 00:00:00
abstract：:This study aims to evaluate the diagnostic accuracy of digital breast tomosynthesis-guided vacuum assisted breast biopsy (DBT-VABB) of screening detected suspicious mammographic abnormalities comprising of calcifications, asymmetric densities, architectural distortions and spiculated masses. In this institutionally ap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80124-4
更新日期：2021-01-08 00:00:00
abstract：:Graphene has shown enormous potential for innovation in various research fields. The current chemical approaches based on exfoliation of graphite via graphite oxide (GO) are potential for large-scale synthesis of graphene but suffer from high cost, great operation difficulties, and serious waste discharge. We report a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03439
更新日期：2013-12-06 00:00:00
abstract：:Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neuro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32616-7
更新日期：2018-09-21 00:00:00
abstract：:Bast fibres are long extraxylary cells which mechanically support the phloem and they are divided into xylan- and gelatinous-type, depending on the composition of their secondary cell walls. The former, typical of jute/kenaf bast fibres, are characterized by the presence of xylan and a high degree of lignification, wh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05200-8
更新日期：2017-07-10 00:00:00
abstract：:The one-step nucleic acid amplification (OSNA) assay is a molecular procedure that can identify deposits of breast cancer (BC) cells in the sentinel lymph node (SLN). We examined the consistency of the OSNA assay with a classic hematoxylin-eosin (H&E)-based immunohistochemistry (IHC) study and evaluated how OSNA-based...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05743
更新日期：2014-07-18 00:00:00
abstract：:Staphylococcus epidermidis is the predominant cause of recalcitrant biofilm-associated infections, which are often highly resistant to antibiotics. Thus, the use of physico-chemical agents for disinfection offers a more effective approach to the control of S. epidermidis biofilm infections. However, the underlying tol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41797-8
更新日期：2019-03-29 00:00:00
abstract：:Members of the TGF-β superfamily are important regulators of chondrocyte function. Sox9, a key transcriptional regulator of chondrogenesis, is required for TGF-β-mediated regulation of specific cartilage genes. TGF-β can signal through a canonical, Smad-mediated pathway or non-conical pathways, including p38. Here we ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38616
更新日期：2016-12-08 00:00:00
abstract：:Histone methyltransferase EZH2 is upregulated during osteoarthritis (OA), which is the most widespread rheumatic disease worldwide, and a leading cause of disability. This study aimed to assess the impact of EZH2 inhibition on cartilage degradation, inflammation and functional disability. In vitro, gain and loss of EZ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76724-9
更新日期：2020-11-11 00:00:00
abstract：:Past evidence of an early Processing Negativity in auditory Go/NoGo event-related potential (ERP) data suggests that young adults proactively process sensory information in two-choice tasks. This study aimed to clarify the occurrence of Go/NoGo Processing Negativity and investigate the ERP component series related to ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-61060-9
更新日期：2020-03-04 00:00:00
abstract：:GABAergic and glutamatergic dysfunction in the dorsolateral prefrontal cortex (DLPFC) are thought to be the core pathophysiological mechanisms of schizophrenia. Recently, we have established a method to index these functions from the DLPFC using the paired transcranial magnetic stimulation (TMS) paradigms of short int...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17052-3
更新日期：2017-12-06 00:00:00
abstract：:Diatoms are among the most diverse eukaryotic microorganisms on Earth, they are responsible for a large fraction of primary production in the oceans and can be found in different habitats. Pseudo-nitzschia are marine planktonic diatoms responsible for blooms in coastal and oceanic waters. We analyzed the transcriptome...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12329
更新日期：2015-07-20 00:00:00
abstract：:The present study investigated the treatment and survival outcomes of patients with synchronous primary esophageal squamous cell carcinoma and gastric adenocarcinoma. The medical records of 10,783 patients with primary esophageal squamous cancer treated at our institution between 1995 and 2012 were retrospectively rev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13335
更新日期：2015-08-20 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-77348-9
更新日期：2020-11-18 00:00:00
abstract：:In humans, stress can be contagiously transmitted via chemosignals on a subconscious level. This study investigates how pregnancy affects neural responses to anxiety chemosignals. Using cotton pads, 28 men donated axillary sweat immediately before an academic examination (anxiety sweat) and during ergometer training (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07985-0
更新日期：2017-08-23 00:00:00
abstract：:The endoplasmic reticulum (ER) is a multi functional organelle and plays a crucial role in protein folding and lipid biosynthesis. The SEC59 gene encodes dolichol kinase, required for protein glycosylation in the ER. The mutation of sec59-1 caused a protein N-glycosylation defect mediated ER stress resulting in increa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51054-7
更新日期：2019-10-09 00:00:00
