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Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals.

Abstract：

:The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Scaduto P,Sequeira A,Vawter MP,Bunney W,Limon A

doi

10.1038/s41598-020-65377-3

subject

Has Abstract

pub_date

2020-05-25 00:00:00

pages

8626

issue

1

issn

2045-2322

pii

10.1038/s41598-020-65377-3

journal_volume

10

pub_type

杂志文章

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