Reactive oxygen species generated from skeletal muscles are required for gecko tail regeneration.

abstract：:The known angiotensin II (AngII) physiological effect of aldosterone synthesis and secretion is mediated by either Gq/11 proteins or βarrestin1 (βarr1), both of which can couple to its type 1 receptors (AT₁Rs), present in adrenocortical zona glomerulosa (AZG) cell membranes. In the present study, we examined the relat...

journal_title：Scientific reports

authors： Dabul S,Bathgate-Siryk A,Valero TR,Jafferjee M,Sturchler E,McDonald P,Koch WJ,Lymperopoulos A

更新日期：2015-01-29 00:00:00

abstract：:Due to limited availability of pharmacological therapies, triple-negative breast cancer (TNBC) is the subtype with worst outcome. We hypothesised that 2-Deoxy-D-Glucose (2-DG), a glucose analogue, may hold potential as a therapy for particularly aggressive TNBC. We investigated 2-DG's effects on TNBC cell line variant...

journal_title：Scientific reports

authors： O'Neill S,Porter RK,McNamee N,Martinez VG,O'Driscoll L

更新日期：2019-03-07 00:00:00

abstract：:High-carrier mobility semiconductors on insulators are essential for fabricating advanced thin-film transistors, allowing for three-dimensional integrated circuits or high-performance mobile terminals. We investigate the low-temperature (375-450 °C) solid-phase crystallization (SPC) of Ge on a glass substrate, focusin...

journal_title：Scientific reports

authors： Toko K,Yoshimine R,Moto K,Suemasu T

更新日期：2017-12-05 00:00:00

abstract：:Neuropeptide Y Y1 receptors (Y1R) have been found to be overexpressed in a number of different tumours, such as breast, ovarian or renal cell cancer. In mammary carcinoma the high Y1R density together with its high incidence of 85% in primary human breast cancers and 100% in breast cancer derived lymph node metastases...

journal_title：Scientific reports

authors： Maschauer S,Ott JJ,Bernhardt G,Kuwert T,Keller M,Prante O

更新日期：2019-09-10 00:00:00

abstract：:SiO2 is the most significantly used insulator layer in semiconductor devices. Its functionality was recently extended to resistance switching random access memory, where the defective SiO2 played an active role as the resistance switching (RS) layer. In this report, the bias-polarity-dependent RS behaviours in the top...

journal_title：Scientific reports

authors： Jiang H,Li XY,Chen R,Shao XL,Yoon JH,Hu X,Hwang CS,Zhao J

更新日期：2016-02-26 00:00:00

abstract：:An inexpensive and compact frequency multi-mode diode laser enables a compact two-photon polarization entanglement source via the continuous wave broadband pumped spontaneous parametric down-conversion (SPDC) process. Entanglement degradation caused by polarization mode dispersion (PMD) is one of the critical issues i...

journal_title：Scientific reports

authors： Lim HT,Hong KH,Kim YH

更新日期：2016-05-13 00:00:00

abstract：:Nearly half of the world's population obtains its daily calories from rice grains, which lack or have insufficient levels of essential micronutrients. The deficiency of micronutrients vital for normal growth is a global health problem, and iron, zinc and vitamin A deficiencies are the most prevalent ones. We developed...

journal_title：Scientific reports

authors： Singh SP,Gruissem W,Bhullar NK

更新日期：2017-07-31 00:00:00

abstract：:Osteogenesis is categorized into two groups based on developmental histology, intramembranous and endochondral ossification. The role of blood vessels during endochondral ossification is well known, while their role in intramembranous ossification, especially the intertissue pathway, is poorly understood. Here, we dem...

journal_title：Scientific reports

authors： Uemura M,Nagasawa A,Terai K

更新日期：2016-06-07 00:00:00

abstract：:From the viewpoint of thermodynamics, the formation of DNA loops and the interaction between them, which are all non-equilibrium processes, result in the change of free energy, affecting gene expression and further cell-to-cell variability as observed experimentally. However, how these processes dissipate free energy ...

journal_title：Scientific reports

authors： Huang L,Liu P,Yuan Z,Zhou T,Yu J

更新日期：2017-10-03 00:00:00

abstract：:Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expression is used to predict anti-PD-1 therapy responses in NSCLC, its accuracy is relatively less. Therefore, we ...

journal_title：Scientific reports

authors： Youn JI,Park SM,Park S,Kim G,Lee HJ,Son J,Hong MH,Ghaderpour A,Baik B,Islam J,Choi JW,Lee EY,Kim HR,Seo SU,Paik S,Yoon HI,Jung I,Xin CF,Jin HT,Cho BC,Seong SY,Ha SJ,Kim HR

更新日期：2020-06-03 00:00:00

abstract：:Attachment of nanoparticles (NPs) to the surface of carrier red blood cells (RBCs) profoundly alters their interactions with the host organism, decelerating NP clearance from the bloodstream while enabling NP transfer from the RBC surface to the vascular cells. These changes in pharmacokinetics of NPs imposed by carri...

journal_title：Scientific reports

authors： Pan DC,Myerson JW,Brenner JS,Patel PN,Anselmo AC,Mitragotri S,Muzykantov V

更新日期：2018-01-25 00:00:00

abstract：:To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their pe...

journal_title：Scientific reports

authors： Zhang Q,Ma J,Liu H,He D,Chen L,Wu H,Jiang H,Lu Q,Bai S

更新日期：2018-01-09 00:00:00

abstract：:Agrobacterium pathogens of octopine- and nopaline-types force host plants to produce either octopine or nopaline compounds, which they use as nutrients. Two Agrobacterium ABC-transporters and their cognate periplasmic binding proteins (PBPs) OccJ and NocT import octopine and nopaline/octopine, respectively. Here, we s...

journal_title：Scientific reports

authors： Vigouroux A,El Sahili A,Lang J,Aumont-Nicaise M,Dessaux Y,Faure D,Moréra S

更新日期：2017-12-21 00:00:00

abstract：:Childhood obesity and early rapid growth increase the risk for type 2 diabetes. Such early overnutrition can be modeled in mice by reducing litter size. We investigated the effects of early overnutrition and increased dietary fat intake on β cell function in Swiss Webster mice. On a moderate-fat diet, early overnutrit...

journal_title：Scientific reports

authors： Glavas MM,Hui Q,Tudurí E,Erener S,Kasteel NL,Johnson JD,Kieffer TJ

更新日期：2019-03-06 00:00:00

abstract：:The natural alkaloid berberine has several pharmacological properties and recently received attention as a potential anticancer agent. In this work, we investigated the molecular mechanisms underlying the anti-tumor effect of berberine on glioblastoma U343 and pancreatic carcinoma MIA PaCa-2 cells. Human dermal fibrob...

journal_title：Scientific reports

authors： Agnarelli A,Natali M,Garcia-Gil M,Pesi R,Tozzi MG,Ippolito C,Bernardini N,Vignali R,Batistoni R,Bianucci AM,Marracci S

更新日期：2018-07-13 00:00:00

abstract：:High quality factor (High-Q) and transmission optical devices are required for various applications in the fields of physics and engineering. Critical for these applications is the realization of a structure with high-Q, complete transmission and small volume. A robust high-Q filter with complete transmission by conju...

journal_title：Scientific reports

authors： Lin YC,Chou SH,Hsueh WJ

更新日期：2020-04-27 00:00:00

abstract：:Nano-flowers reported so far were mostly constituted of inorganic or hybrid materials. We have synthesized and crystallized a new organic compound, 1, 2-bis(tritylthio)ethane forming an organic nano-flower consisting of single crystalline petals. Crystal structure at nano and micro level indicates that π-π stacking in...

journal_title：Scientific reports

authors： Sasidharan S,P C S,Chaudhary N,Ramakrishnan V

更新日期：2017-12-11 00:00:00

abstract：:This study tested the hypothesis that acquired epileptogenesis is accompanied by DNA methylation changes independent of etiology. We investigated DNA methylation and gene expression in the hippocampal CA3/dentate gyrus fields at 3 months following epileptogenic injury in three experimental models of epilepsy: focal am...

journal_title：Scientific reports

authors： Dębski KJ,Pitkanen A,Puhakka N,Bot AM,Khurana I,Harikrishnan KN,Ziemann M,Kaspi A,El-Osta A,Lukasiuk K,Kobow K

更新日期：2016-05-09 00:00:00

abstract：:We report a strategy to achieve a discrete cage molecule featuring a high level of structural hierarchy through a multiple-assembly process. A cobalt (Co) supramolecular triple-stranded helicate (Co-TSH)-based discrete molecular cage (1) is successfully synthesized and fully characterized. The solid-state structure of...

journal_title：Scientific reports

authors： Mai HD,Kang P,Kim JK,Yoo H

更新日期：2017-03-06 00:00:00

abstract：:III-nitride materials have been linked with a vast number of exciting applications from power electronics to solar cells. Herein, polycrystalline InN, GaN and systematically controlled InxGa1-xN composite thin films are fabricated on FTO glass by a facile, low-cost and scalable aerosol assisted chemical vapor depositi...

journal_title：Scientific reports

authors： McInnes A,Sagu JS,Mehta D,Wijayantha KGU

更新日期：2019-02-19 00:00:00

abstract：:Materials' mechanical properties highly depend on their internal structures. Designing novel structure is an effective route to improve materials' performance. One-dimensional disordered (ODD) structure is a kind of particular structure in silicon carbide (SiC), which highly affects its mechanical properties. Herein, ...

journal_title：Scientific reports

authors： Zhang X,Wang J,Yang Z,Tang X,Yue Y

更新日期：2020-07-09 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. Therefore, we assessed the possible role of serum biomarkers that have been mentioned briefly in previous studie...

journal_title：Scientific reports

authors： N Zekri AR,El Kassas M,Salam ESE,Hassan RM,Mohanad M,Gabr RM,M Lotfy M,Abdel-Zaher RAT,Bahnassy AA,Ahmed OS

更新日期：2020-03-20 00:00:00

abstract：:Synapse and dendritic spine loss induced by amyloid-β oligomers is one of the main hallmarks of the early phases of Alzheimer's disease (AD) and is directly correlated with the cognitive decline typical of this pathology. The p75 neurotrophin receptor (p75NTR) binds amyloid-β oligomers in the nM range. While it was sh...

journal_title：Scientific reports

authors： Patnaik A,Zagrebelsky M,Korte M,Holz A

更新日期：2020-08-07 00:00:00

abstract：:We developed a solvothermal-induced self-assembly approach to construct three dimensional (3D) macroscopic Fe2O3 nanocubes/nitrogen-doped graphene (Fe2O3-NC/GN) aerogel as anode materials for lithium-ion batteries (LIBs). The Fe2O3 nanocubes with length of ~50 nm are homogeneously anchored on 3D GN frameworks and as s...

journal_title：Scientific reports

authors： Wang R,Xu C,Sun J,Gao L

更新日期：2014-11-25 00:00:00

abstract：:Erythropoietin (EPO) has been identified as being crucial for obesity modulation; however, its erythropoietic activity may limit its clinical application. EPO-derived Helix B-surface peptide (pHBSP) is nonerythrogenic but has been reported to retain other functions of EPO. The current study aimed to evaluate the effec...

journal_title：Scientific reports

authors： Liu Y,Luo B,Shi R,Wang J,Liu Z,Liu W,Wang S,Zhang Z

更新日期：2015-10-13 00:00:00

abstract：:More and more researchers are interested in and focused on how a limited repertoire of antibodies can bind and correspondingly protect against an almost limitless diversity of invading antigens. In this work, a series of 200-ns molecular dynamics (MD) simulations followed by principal component (PC) analysis and free ...

journal_title：Scientific reports

authors： Chen J,Wang J,Zhu W

更新日期：2016-11-10 00:00:00

abstract：:Spatially targeted, genetically-specific strategies for sustained inhibition of nociceptors may help transform pain science and clinical management. Previous optogenetic strategies to inhibit pain have required constant illumination, and chemogenetic approaches in the periphery have not been shown to inhibit pain. Her...

journal_title：Scientific reports

authors： Iyer SM,Vesuna S,Ramakrishnan C,Huynh K,Young S,Berndt A,Lee SY,Gorini CJ,Deisseroth K,Delp SL

更新日期：2016-08-03 00:00:00

abstract：:Mutations affecting the transcription factor FOXP2 cause a rare form of severe speech and language disorder. Although it is clear that sufficient FOXP2 expression is crucial for normal brain development, little is known about how this transcription factor is regulated. To investigate post-translational mechanisms for ...

journal_title：Scientific reports

authors： Estruch SB,Graham SA,Deriziotis P,Fisher SE

更新日期：2016-02-12 00:00:00

abstract：:We have developed a framework to convert an arbitrary integer factorization problem to an executable Ising model by first writing it as an optimization function then transforming the k-bit coupling (k ≥ 3) terms to quadratic terms using ancillary variables. Our resource-efficient method uses [Formula: see text] binary...

journal_title：Scientific reports

authors： Jiang S,Britt KA,McCaskey AJ,Humble TS,Kais S

更新日期：2018-12-05 00:00:00

abstract：:Radical cystectomy (RC) together with bilateral pelvic lymph node dissection remains the standard treatment for muscle invasive bladder cancer (MIBC). However, radiation-based treatments such as tri-modal therapy (TMT) involving maximally performed transurethral resection of bladder tumor (TURBT), radiotherapy (XRT), ...

journal_title：Scientific reports

authors： Ayoub M,Shinde-Jadhav S,Mansure JJ,Alvarez F,Connell T,Seuntjens J,Piccirillo CA,Kassouf W

更新日期：2019-04-23 00:00:00