Abstract:
:Stem cells are promising for the treatment of myocardial infarction (MI) and large animal models should be used to better understand the full spectrum of stem cell actions and preclinical evidences. In this study, bone marrow mesenchymal stem cells (BM-MSCs) were transplanted into swine heart ischemia model. To detect glucose metabolism in global left ventricular myocardium and regional myocardium, combined with assessment of cardiac function, positron emission tomography-computer tomography (PET-CT) and magnetic resonance imaging (MRI) were performed. To study the changes of glucose transporters and glucose metabolism-related enzymes and the signal transduction pathway, RT-PCR, Western-blot, and immunohistochemistry were carried out. Myocardium metabolic evaluation by PET-CT showed that mean signal intensity (MSI) increased in these segments at week 4 compared with that at week 1 after BM-MSCs transplantation. Moreover, MRI demonstrated significant function enhancement in BM-MSCs group. The gene expressions of glucose transporters (GLUT1, GLUT4), glucose metabolism-related enzymes phosphofructokinase (PFK), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH)) and 70-kDa ribosomal protein S6 kinase (p70s6k) in BM-MSCs injected areas were up-regulated at week 4 after BM-MSCs transplantation and this was confirmed by Western-blot and immunohistochemistry. In conclusions, BM-MSCs transplantation could improve cardiac function in swine MI model by activation of mTOR signal transduction pathway.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cai M,Shen R,Song L,Lu M,Wang J,Zhao S,Tang Y,Meng X,Li Z,He ZXdoi
10.1038/srep28250subject
Has Abstractpub_date
2016-06-20 00:00:00pages
28250issn
2045-2322pii
srep28250journal_volume
6pub_type
杂志文章abstract::It is indicated that lipids profiles are associated with carotid plaque and Atherosclerosis. However, studies about the relationship between serum lipid profiles and carotid plaque composition in Chinese Population is limited. We conducted a cross-sectional study among 3,214 participants between January 2015 and Decem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54285-w
更新日期:2019-11-29 00:00:00
abstract::The specification and growth of organs is controlled simultaneously by networks of transcription factors. While the connection between these transcription factors with fate determinants is increasingly clear, how they establish the link with the cell cycle is far less understood. Here we investigate this link in the d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04936-7
更新日期:2017-07-07 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-62381-5
更新日期:2020-04-06 00:00:00
abstract::The extracellular matrix (ECM) is a highly dynamic network constantly remodeled by a fine-tuned protein formation and degradation balance. Matrix metalloproteinases (MMPs) constitute key orchestrators of ECM degradation. Their activity is controlled by tissue inhibitors of metalloproteinases (TIMPs) and glycosaminogly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41355-2
更新日期:2019-03-20 00:00:00
abstract::At present, there is a growing interest in the study of the neurotropic activity of polyunsaturated fatty acids ethanolamides (N-acylethanolamines). N-docosahexaenoylethanolamine (DHEA, synaptamide) is an endogenous metabolite and structural analogue of anandamide, a widely studied endocannabinoid derived from arachid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80818-9
更新日期:2021-01-12 00:00:00
abstract::In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have onl...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep35278
更新日期:2016-10-12 00:00:00
abstract::Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose concentrations affect placental lipid metabolism. Placentas from women ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50626-x
更新日期:2019-10-01 00:00:00
abstract::The interaction between two different materials can present novel phenomena that are quite different from the physical properties observed when each material stands alone. Strong electronic correlations, such as magnetism and superconductivity, can be produced as the result of enhanced Coulomb interactions between ele...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21460
更新日期:2016-02-18 00:00:00
abstract::Interactions between microalgae and bacteria are often obligatory for harmful algal blooms (HABs). Here, we investigated the specific bacterial communities associated with Alexandrium tamarense and Cochlodinium polykrikoides, which cause ecological and economic damage during their blooms. To this end, the bacterial me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23634-6
更新日期:2018-03-28 00:00:00
abstract::Shoulder problems are common in patients with a cervical herniated intervertebral disc (HIVD). This study aimed to explore the incidence and risk of shoulder capsulitis/tendonitis following cervical HIVD surgery. We used data from the Taiwan "Longitudinal Health Insurance Database". We identified all patients who were...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26898
更新日期:2016-05-27 00:00:00
abstract::Medicinal plants are considered as one of the ideal sources for cancer therapy due to their bioactive contents and low toxicity to humans. Vernonia genus is one of the common medicinal plants, which has wide spread usage in food and medicine. However, there are limited studies to explore its anticancer properties. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23255
更新日期:2016-03-24 00:00:00
abstract::Single epitaxially-grown semiconductor quantum dots have great potential as single photon sources for photonic quantum technologies, though in practice devices often exhibit nonideal behavior. Here, we demonstrate that amplitude modulation can improve the performance of quantum-dot-based sources. Starting with a brigh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01397
更新日期:2013-01-01 00:00:00
abstract::The NOON state, and its experimental approximation the Holland-Burnett state, have important applications in phase sensing measurement with enhanced sensitivity. However, most of the previous Holland-Burnett state interference (HBSI) experiments only investigated the area of the interference pattern in the region imme...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36914
更新日期:2016-11-14 00:00:00
abstract::Quantum measurement is a fundamental cornerstone of experimental quantum computations. The main issues in current quantum measurement strategies are the high number of measurement rounds to determine a global optimal measurement output and the low success probability of finding a global optimal measurement output. Eac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43250-2
更新日期:2019-05-01 00:00:00
abstract::4D flow MRI enables quantitative assessment of helical flow. Current methods are susceptible to noise. To evaluate helical flow patterns in healthy volunteers and patients with bicuspid aortic valves (BAV) at 1.5 T and 3 T using pressure-based helix-extraction in 4D flow MRI. Two intraindividual 4D flow MRI examinatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59826-2
更新日期:2020-02-19 00:00:00
abstract::Complex Semi-Definite Programming (SDP) is introduced as a novel approach to phase retrieval enabled control of monochromatic light transmission through highly scattering media. In a simple optical setup, a spatial light modulator is used to generate a random sequence of phase-modulated wavefronts, and the resulting i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02716-x
更新日期:2017-05-31 00:00:00
abstract::A polarized macrophage response into inflammatory (M1) or regenerative/anti-inflammatory (M2) phenotypes is critical in host response to multiple intracellular bacterial infections. Ehrlichia is an obligate Gram-negative intracellular bacterium that causes human monocytic ehrlichiosis (HME): a febrile illness that may...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50320-y
更新日期:2019-10-01 00:00:00
abstract::Amorphous solid dispersion (ASD) is a widely employed formulation technique for drugs with poor aqueous solubility. Polymers are integral components of ASDs, but mechanisms by which polymers lead to the generation and maintenance of supersaturated solutions, which enhance oral absorption in vivo, are poorly understood...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75077-7
更新日期:2020-10-28 00:00:00
abstract::Surface ocean bubble-bursting generates aerosols composed of microscopic salt-water droplets, enriched in marine organic matter. The organic fraction profoundly influences aerosols' properties, by scattering solar radiations and nucleating water particles. Still little is known on the biochemical and microbiological c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10563-z
更新日期:2017-09-13 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-58144-x
更新日期:2020-01-21 00:00:00
abstract::Given the complex nature of the interaction between gas and solid atoms, the development of nanoscale science and technology has engendered a need for further understanding of gas transport behavior through nanopores and more tractable models for large-scale simulations. In the present paper, we utilize molecular dyna...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23629
更新日期:2016-03-29 00:00:00
abstract::A stable T h -symmetry Ti12C68 cage was systemically investigated using density functional theory. The structure of Ti12C68 is a hollow cage with twelve TiC13 subunit of three pentagons and one hexagon. The calculated frequencies are in the range 95.1 cm-1-1423.9 cm-1. There are no imaginary frequencies, showing its k...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22381-y
更新日期:2018-03-08 00:00:00
abstract::More than 20 years after the first outbreaks, the phylogenetic picture of PRRSV is still incomplete and full of gaps, especially in regards of PRRSV 1. Due to the exceptional diversity observed at the eastern borders of Europe and the low number of available sequences from Central Eastern European countries, the autho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26036-w
更新日期:2018-05-17 00:00:00
abstract::The double-slit experiment strikingly demonstrates the wave-particle duality of quantum objects. In this famous experiment, particles pass one-by-one through a pair of slits and are detected on a distant screen. A distinct wave-like pattern emerges after many discrete particle impacts as if each particle is passing th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04685
更新日期:2014-04-28 00:00:00
abstract::The favourable kinetics of 18F-fluoro-2-deoxyglucose (FDG) permits to depict cancer glucose consumption by a single evaluation of late tracer uptake. This standard procedure relies on the slow radioactivity loss, usually attributed to the limited tumour expression of G6P-phosphatase (G6Pase). However, this classical i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38973-1
更新日期:2019-02-26 00:00:00
abstract::Graphene, a honeycomb lattice of carbon atoms ruled by tight-binding interaction, exhibits extraordinary electronic properties due to the presence of Dirac cones within its band structure. These intriguing singularities have naturally motivated the discovery of their classical analogues. In this work, we present a gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15335-3
更新日期:2017-11-10 00:00:00
abstract::Organochlorine (OC) pesticides and the more persistent polychlorinated biphenyls (PCBs) have well-established dose-dependent toxicities to birds, fish and mammals in experimental studies, but the actual impact of OC pollutants on European marine top predators remains unknown. Here we show that several cetacean species...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18573
更新日期:2016-01-14 00:00:00
abstract::SNPs may restrict cell detoxification activity and be a potential risk factor for cancer chemosensitivity. We evaluated the predictive value of these polymorphisms on the sensitivity of bladder cancer patients to epirubicin and mitomycin chemotherapy instillation as well as their toxicities. SNPs were analyzed by TaqM...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14000
更新日期:2015-09-10 00:00:00
abstract::The discovery of single-phase multiferroic materials and the understanding of coupling mechanisms between their spin and polarization is important from the point of view of next generation logic and memory devices. Herein we report the fabrication, dielectric, ferroelectric, piezo-response force microscopy, and magnet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59961-w
更新日期:2020-02-19 00:00:00
abstract::Insect pheromones offer potential for managing pests of crop plants. Volatility and instability are problems for deployment in agriculture but could be solved by expressing genes for the biosynthesis of pheromones in the crop plants. This has now been achieved by genetically engineering a hexaploid variety of wheat to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11183
更新日期:2015-06-25 00:00:00