Abstract：
:Little is known about the effect of long-term diet patterns on the composition and functional potential of the human salivary microbiota. In the present study, we sought to contribute to the ongoing elucidation of dietary effects on the oral microbial community by examining the diversity, composition and functional potential of the salivary microbiota in 160 healthy vegans and omnivores using 16S rRNA gene amplicon sequencing. We further sought to identify bacterial taxa in saliva associated with host inflammatory markers. We show that compositional differences in the salivary microbiota of vegans and omnivores is present at all taxonomic levels below phylum level and includes upper respiratory tract commensals (e.g. Neisseria subflava, Haemophilus parainfluenzae, and Rothia mucilaginosa) and species associated with periodontal disease (e.g. Campylobacter rectus and Porphyromonas endodontalis). Dietary intake of medium chain fatty acids, piscine mono- and polyunsaturated fatty acids, and dietary fibre was associated with bacterial diversity, community structure, as well as relative abundance of several species-level operational taxonomic units. Analysis of imputed genomic potential revealed several metabolic pathways differentially abundant in vegans and omnivores indicating possible effects of macro- and micro-nutrient intake. We also show that certain oral bacteria are associated with the systemic inflammatory state of the host.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hansen TH,Kern T,Bak EG,Kashani A,Allin KH,Nielsen T,Hansen T,Pedersen Odoi
10.1038/s41598-018-24207-3subject
Has Abstractpub_date
2018-04-11 00:00:00pages
5847issue
1issn
2045-2322pii
10.1038/s41598-018-24207-3journal_volume
8pub_type
杂志文章abstract：:Methylation of histone H3-lysine 9 (H3K9) and H3K27 by the methyltransferase G9a and polycomb repressive complex 2 (PRC2) inhibits transcription of target genes. A crosstalk between G9a and PRC2 via direct physical interaction has been shown recently. Here, we demonstrate an alternative mechanism by which G9a promotes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18709
更新日期：2015-12-21 00:00:00
abstract：:Glaucoma is a leading cause of blindness worldwide. Purpose of this study was to identify molecular markers that were significantly correlated with presence of glaucoma and outcome of glaucoma surgery. To accomplish this, we determined the profiles of pro-inflammatory cytokines in the aqueous humor of 101 glaucoma pat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32725-3
更新日期：2018-09-28 00:00:00
abstract：:Recent advances in next-generation sequencing technologies have paved the path for a considerable amount of sequencing data at a relatively low cost. This has revolutionized the genomics and transcriptomics studies. However, different challenges are now created in handling such data with available bioinformatics platf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75270-8
更新日期：2020-10-26 00:00:00
abstract：:Abiotic stress significantly impacts growth and yield of crop plants. It is imperative for crop improvement to discover and utilize stress-tolerant functional genes. In this study, genes responding to abiotic stresses, such as freezing, salt and osmotic stress, were screened from a cDNA yeast library that was construc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37859-y
更新日期：2019-01-15 00:00:00
abstract：:This retrospective study was designed to compare prognostic relevance of magnetic resonance imaging (MRI) findings before and after neoadjuvant chemoradiotherapy (CRT). From 2002 to 2010, 399 patients who underwent surgery after CRT for rectal cancer (≥T3) and had adequate pre-CRT (mr) and post-CRT (ymr) MRI findings ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46499-9
更新日期：2019-07-11 00:00:00
abstract：:While concerns about human-induced effects on the Earth's climate have mainly concentrated on carbon dioxide (CO2) and methane (CH4), reducing anthropogenic nitrous oxide (N2O) flux, mainly of agricultural origin, also represents an opportunity for substantial mitigation. To develop a solution that induces neither the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56694-3
更新日期：2019-12-27 00:00:00
abstract：:Statins are well known to have muscle toxicity problem. Herba Cistanches (HC) is a Chinese herb traditionally used for pain in the loins and knees. Our previous in vitro study suggested that it could protect against statin-induced muscle toxicity. However, its in vivo protective effect has never been investigated. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10008-7
更新日期：2017-08-24 00:00:00
abstract：:Skyrmions in ultrathin ferromagnetic metal (FM)/heavy metal (HM) multilayer systems produced by conventional sputtering methods have recently generated huge interest due to their applications in the field of spintronics. The sandwich structure with two correctly-chosen heavy metal layers provides an additive interfaci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23799-0
更新日期：2018-04-09 00:00:00
abstract：:We report on the degradation process by water vapor of hydrogenated amorphous silicon oxynitride (SiON:H) films deposited by plasma-enhanced chemical vapor deposition at low temperature. The stability of the films was investigated as a function of the oxygen content and deposition temperature. Degradation by defects s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14291-2
更新日期：2017-10-26 00:00:00
abstract：:Biological N2 fixation (BNF) in the rhizosphere of Podocarpaceae is currently attributed to unspecific diazotrophs with negligible impact on N acquisition. Here, we report specific and high associative BNF in dead cells of root nodules of Lepidothamnus fonkii distributed in ombrotrophic peatlands of Patagonia. BNF of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39072
更新日期：2016-12-15 00:00:00
abstract：:Many efforts have been made in the last 30 years to develop more relevant in vitro models to study genotoxic responses of drugs and environmental contaminants. While 2D HepaRG cells are one of the most promising models for liver toxicology, a switch to 3D cultures that integrate both in vivo architecture and cell-cell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47114-7
更新日期：2019-07-22 00:00:00
abstract：:Herein, we propose a new strategy of maskless lithographic approach to fabricate micro/nano-porous structures by phase separation of polystyrene (PS)/Polyethylene glycol (PEG) immiscible polymer blend. Its simple process only involves a spin coating of polymer blend followed by a development with deionized water rinse...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15947
更新日期：2015-10-30 00:00:00
abstract：:Sclerotinia sclerotiorum, the causal agent of white stem rot, is responsible for significant losses in crop yields around the globe. While our understanding of S. sclerotiorum infection is becoming clearer, genetic control of the pathogen has been elusive and effective control of pathogen colonization using traditiona...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25434-4
更新日期：2018-05-09 00:00:00
abstract：:The transcriptome of the endometrium early postpartum was profiled to determine if inflammatory gene expression was elevated in cows which subsequently developed uterine disease. Endometrial cytobrush samples were collected at 7 days postpartum (DPP) from 112 Holstein-Friesian dairy cows, from which 27 were retrospect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75104-7
更新日期：2020-10-26 00:00:00
abstract：:Studies have assessed individual components of a western diet, but no study has assessed the long-term, cumulative effects of a western diet on aging and Alzheimer's disease (AD). Therefore, we have formulated the first western-style diet that mimics the fat, carbohydrate, protein, vitamin and mineral levels of wester...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21568
更新日期：2016-02-18 00:00:00
abstract：:Transcriptome diversity in adult neurons is partly mediated by RNA binding proteins (RBPs), including the RBFOX factors. RBFOX3/NeuN, a neuronal maturity marker, is strangely depleted in suprachiasmatic nucleus (SCN) neurons, and may be compensated by a change in Rbfox2 expression. In this study, we found no superfici...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10535-3
更新日期：2017-08-30 00:00:00
abstract：:Sapphirinid copepods, which are marine zooplankton, exhibit tunable structural colors originating from a layered structure of guanine crystal plates. In the present study, the coloring portion of adult male of a sapphirinid copepod, Sapphirina nigromaculata, under the dorsal body surface was characterized to clarify t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59090-4
更新日期：2020-02-10 00:00:00
abstract：:Conserving crop wild relatives (CWR) is critical for maintaining food security. However, CWR-focused conservation plans are lacking, and are often based on the entire genus, even though only a few taxa are useful for crop improvement. We used taxonomic and geographic prioritisation to identify the best locations for i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05247
更新日期：2014-06-17 00:00:00
abstract：:Signaling by members of the transforming growth factor-β (TGF-β) superfamily, such as TGF-β3 and BMP7, and oxygen tension play a pivotal role in chondrocyte biology. The objective of this research was to investigate the endogenous BMP7 expression in human osteoarthritis (OA) cartilage and the effect of oxygen tension ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27602-y
更新日期：2018-07-06 00:00:00
abstract：:There is increasing interest in the development of noninvasive diagnostic methods for early cancer detection, to improve the survival rate and quality of life of cancer patients. Identification of volatile metabolic compounds may provide an approach for noninvasive early diagnosis of malignant diseases. Here we analyz...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05196
更新日期：2014-06-06 00:00:00
abstract：:Unlike their wolf ancestors, dogs have unique social skills for communicating and cooperating with humans. Previously, significant heritabilities for human-directed social behaviors have been found in laboratory beagles. Here, a Genome-Wide Association Study identified two genomic regions associated with dog's human-d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33439
更新日期：2016-09-29 00:00:00
abstract：:From 2010 to 2012, large outbreaks of EV-A71-related- hand foot and mouth disease (HFMD) occurred annually in China. Some cases had neurological complications and were closely associated with fatal cardiopulmonary collapse, but not all children with central nervous system (CNS) involvement demonstrated a poor prognosi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23444
更新日期：2016-03-22 00:00:00
abstract：:Aerosols impact clear-sky surface irradiance () through the effects of scattering and absorption. Linear or nonlinear relationships between aerosol optical depth (τa) and have been established to describe the aerosol direct radiative effect on (ADRE). However, considerable uncertainties remain associated with ADRE due...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14376
更新日期：2015-09-23 00:00:00
abstract：:Mumps incidence in mainland China remains at a high level. Genotype F has been the predominant genotype of mumps virus (MuV) in the last 20 years in mainland China. To better understand the genetic characteristics of MuV in China, the sequences of the Small Hydrophobic (SH), Hemagglutinin-Neuraminidase (HN) and Fusion...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17474-z
更新日期：2017-12-07 00:00:00
abstract：:SeviL is a recently isolated lectin found to bind to the linear saccharides of the ganglioside GM1b (Neu5Ac[Formula: see text](2-3)Gal[Formula: see text](1-3)GalNAc[Formula: see text](1-4)Gal[Formula: see text](1-4)Glc) and its precursor, asialo-GM1 (Gal[Formula: see text](1-3)GalNAc[Formula: see text](1-4)Gal[Formula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78926-7
更新日期：2020-12-16 00:00:00
abstract：:The arrival of infected travelers from endemic regions can trigger sustained autochthonous transmission of mosquito-borne pathogens in Europe. In 2007 a Chikungunya outbreak was observed in central Italy, mostly affecting two villages characterised by a high density of Aedes albopictus. The outbreak was mitigated thro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27443-9
更新日期：2018-06-13 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-42491-5
更新日期：2019-05-03 00:00:00
abstract：:Prostate cancer is the most commonly diagnosed cancer in men with African American men disproportionally suffering from the burden of this disease. Biomarkers that could discriminate indolent from aggressive and drug resistance disease are lacking. MicroRNAs are small non-coding RNAs that affect numerous physiological...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46170-3
更新日期：2019-07-05 00:00:00
abstract：:To investigate the concentrations of rare earth elements in cereals and assess human health risk through cereal consumption, a total of 327 cereal samples were collected from rare earth mining area and control area in Shandong, China. The contents of 14 rare earth elements were determined by Inductively Coupled Plasma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10256-7
更新日期：2017-08-29 00:00:00
abstract：:Transmembrane flux of Cs+ (a K+ congener) was measured in human red blood cells (RBCs; erythrocytes) on the 10-s time scale. This is the first report on dissolution dynamic nuclear polarization (dDNP) nuclear magnetic resonance (NMR) spectroscopy with this nuclide in mammalian cells. Four technical developments regula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56250-z
更新日期：2019-12-23 00:00:00
