Association analyses of large-scale glycan microarray data reveal novel host-specific substructures in influenza A virus binding glycans.

Abstract:

:Influenza A viruses can infect a wide variety of animal species and, occasionally, humans. Infection occurs through the binding formed by viral surface glycoprotein hemagglutinin and certain types of glycan receptors on host cell membranes. Studies have shown that the α2,3-linked sialic acid motif (SA2,3Gal) in avian, equine, and canine species; the α2,6-linked sialic acid motif (SA2,6Gal) in humans; and SA2,3Gal and SA2,6Gal in swine are responsible for the corresponding host tropisms. However, more detailed and refined substructures that determine host tropisms are still not clear. Thus, in this study, we applied association mining on a set of glycan microarray data for 211 influenza viruses from five host groups: humans, swine, canine, migratory waterfowl, and terrestrial birds. The results suggest that besides Neu5Acα2-6Galβ, human-origin viruses could bind glycans with Neu5Acα2-8Neu5Acα2-8Neu5Ac and Neu5Gcα2-6Galβ1-4GlcNAc substructures; Galβ and GlcNAcβ terminal substructures, without sialic acid branches, were associated with the binding of human-, swine-, and avian-origin viruses; sulfated Neu5Acα2-3 substructures were associated with the binding of human- and swine-origin viruses. Finally, through three-dimensional structure characterization, we revealed that the role of glycan chain shapes is more important than that of torsion angles or of overall structural similarities in virus host tropisms.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhao N,Martin BE,Yang CK,Luo F,Wan XF

doi

10.1038/srep15778

subject

Has Abstract

pub_date

2015-10-28 00:00:00

pages

15778

issn

2045-2322

pii

srep15778

journal_volume

5

pub_type

杂志文章
  • Disparate subcellular location of putative sortase substrates in Clostridium difficile.

    abstract::Clostridium difficile is a gastrointestinal pathogen but how the bacterium colonises this niche is still little understood. Sortase enzymes covalently attach specific bacterial proteins to the peptidoglycan cell wall and are often involved in colonisation by pathogens. Here we show C. difficile proteins CD2537 and CD3...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08322-1

    authors: Peltier J,Shaw HA,Wren BW,Fairweather NF

    更新日期:2017-08-23 00:00:00

  • Effect of proton-conduction in electrolyte on electric efficiency of multi-stage solid oxide fuel cells.

    abstract::Solid oxide fuel cells (SOFCs) are promising electrochemical devices that enable the highest fuel-to-electricity conversion efficiencies under high operating temperatures. The concept of multi-stage electrochemical oxidation using SOFCs has been proposed and studied over the past several decades for further improving ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12640

    authors: Matsuzaki Y,Tachikawa Y,Somekawa T,Hatae T,Matsumoto H,Taniguchi S,Sasaki K

    更新日期:2015-07-28 00:00:00

  • Sublethal Dosage of Imidacloprid Reduces the Microglomerular Density of Honey Bee Mushroom Bodies.

    abstract::The dramatic loss of honey bees is a major concern worldwide. Previous studies have indicated that neonicotinoid insecticides cause behavioural abnormalities and have proven that exposure to sublethal doses of imidacloprid during the larval stage decreases the olfactory learning ability of adults. The present study sh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19298

    authors: Peng YC,Yang EC

    更新日期:2016-01-13 00:00:00

  • Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands.

    abstract::The objective of this study was to investigate the influence of the genes encoding the KIR receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 patients serologically-diagnosed with toxoplasmosis were selected and stratified according to the presence (n = 148) or absence (n = 1...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/srep36632

    authors: Ayo CM,Frederico FB,Siqueira RC,Brandão de Mattos CC,Previato M,Barbosa AP,Murata FH,Silveira-Carvalho AP,de Mattos LC

    更新日期:2016-11-09 00:00:00

  • Metabolic and transcriptional alternations for defense by interfering OsWRKY62 and OsWRKY76 transcriptions in rice.

    abstract::Metabolomic and transcriptomic approaches were used to dissect the enhanced disease resistance in the plants harbouring a RNA interfering construct of OsWRKY62 and OsWRKY76 (dsOW62/76) genes. The primary metabolic pathways were activated in dsOW62/76 compared with wild-type (ZH17) plants, revealed by increased accumul...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02643-x

    authors: Liang X,Chen X,Li C,Fan J,Guo Z

    更新日期:2017-05-30 00:00:00

  • Part 1: profiling extra cellular matrix core proteome of human fetal nucleus pulposus in search for regenerative targets.

    abstract::Intervertebral disc degeneration is accompanied by a loss of Extra-cellular matrix (ECM) due to an imbalance in anabolic and catabolic pathways. Identifying ECM proteins with anabolic and/or regenerative potential could be the key to developing regenerative therapies. Since human fetal discs grow and develop rapidly, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72859-x

    authors: Rajasekaran S,Tangavel C,Djuric N,Raveendran M,Soundararajan DCR,Nayagam SM,Matchado MS,Anand KSSV

    更新日期:2020-09-24 00:00:00

  • Projective simulation for artificial intelligence.

    abstract::We propose a model of a learning agent whose interaction with the environment is governed by a simulation-based projection, which allows the agent to project itself into future situations before it takes real action. Projective simulation is based on a random walk through a network of clips, which are elementary patch...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00400

    authors: Briegel HJ,De las Cuevas G

    更新日期:2012-01-01 00:00:00

  • Evolution of rough-surface geometry and crystalline structures of aligned TiO2 nanotubes for photoelectrochemical water splitting.

    abstract::Nowadays, increasing awareness of environment and fossil fuels protection stimulates intensive research on clean and renewable sources of energy. Production of hydrogen from water through solar-driven splitting reactions is one of the most promising approaches in the field of photoelectrochemistry (PEC). In this work ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29247-3

    authors: Zare M,Solaymani S,Shafiekhani A,Kulesza S,Ţălu Ş,Bramowicz M

    更新日期:2018-07-18 00:00:00

  • Effects of combining exercise with long-chain polyunsaturated fatty acid supplementation on cognitive function in the elderly: a randomised controlled trial.

    abstract::Multifactorial lifestyle intervention is known to be more effective for ameliorating cognitive decline than single factor intervention; however, the effects of combining exercise with long-chain polyunsaturated fatty acids (LCPUFA) on the elderlies' cognitive function remain unclear. We conducted a randomised, single-...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-020-69560-4

    authors: Tokuda H,Ito M,Sueyasu T,Sasaki H,Morita S,Kaneda Y,Rogi T,Kondo S,Kouzaki M,Tsukiura T,Shibata H

    更新日期:2020-07-31 00:00:00

  • Humans Use Predictive Gaze Strategies to Target Waypoints for Steering.

    abstract::A major unresolved question in understanding visually guided locomotion in humans is whether actions are driven solely by the immediately available optical information (model-free online control mechanisms), or whether internal models have a role in anticipating the future path. We designed two experiments to investig...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44723-0

    authors: Tuhkanen S,Pekkanen J,Rinkkala P,Mole C,Wilkie RM,Lappi O

    更新日期:2019-06-06 00:00:00

  • Self-regulation of charged defect compensation and formation energy pinning in semiconductors.

    abstract::Current theoretical analyses of defect properties without solving the detailed balance equations often estimate Fermi-level pinning position by omitting free carriers and assume defect concentrations can be always tuned by atomic chemical potentials. This could be misleading in some circumstance. Here we clarify that:...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16977

    authors: Yang JH,Yin WJ,Park JS,Wei SH

    更新日期:2015-11-20 00:00:00

  • A double-blind randomized clinical trial of high frequency rTMS over the DLPFC on nicotine dependence, anxiety and depression.

    abstract::High frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dorsolateral prefrontal cortex (L-DLPFC) is a widely applied treatment protocol for chronic smoking and major depressive disorder. However, no previous study has measured the effects of rTMS on both nicotine consumption and anxiety/dep...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80927-5

    authors: Abdelrahman AA,Noaman M,Fawzy M,Moheb A,Karim AA,Khedr EM

    更新日期:2021-01-15 00:00:00

  • Few-layer Phosphorene: An Ideal 2D Material For Tunnel Transistors.

    abstract::2D transition metal dichalcogenides (TMDs) have attracted a lot of attention recently for energy-efficient tunneling-field-effect transistor (TFET) applications due to their excellent gate control resulting from their atomically thin dimensions. However, most TMDs have bandgaps (Eg) and effective masses (m(*)) outside...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28515

    authors: Ameen TA,Ilatikhameneh H,Klimeck G,Rahman R

    更新日期:2016-06-27 00:00:00

  • Differences in prognostic relevance of rectal magnetic resonance imaging findings before and after neoadjuvant chemoradiotherapy.

    abstract::This retrospective study was designed to compare prognostic relevance of magnetic resonance imaging (MRI) findings before and after neoadjuvant chemoradiotherapy (CRT). From 2002 to 2010, 399 patients who underwent surgery after CRT for rectal cancer (≥T3) and had adequate pre-CRT (mr) and post-CRT (ymr) MRI findings ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46499-9

    authors: Song KS,Lee DW,Kim B,Hur BY,Kim MJ,Kim MJ,Hong CW,Park SC,Park HC,Sohn DK,Kim BC,Han KS,Oh JH

    更新日期:2019-07-11 00:00:00

  • Highly hydrophilic poly(vinylidene fluoride)/meso-titania hybrid mesoporous membrane for photocatalytic membrane reactor in water.

    abstract::The high hydrophobicity of poly(vinylidene fluoride) (PVDF) membrane remains an obstacle to be applied in some purification processes of water or wastewater. Herein, a highly hydrophilic hybrid mesoporous titania membrane composed of mesoporous anatase titania (meso-TiO2) materials inside the three-dimensional (3D) ma...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19148

    authors: Wang M,Yang G,Jin P,Tang H,Wang H,Chen Y

    更新日期:2016-01-12 00:00:00

  • Circulating androgen receptor combined with 18F-fluorocholine PET/CT metabolic activity and outcome to androgen receptor signalling-directed therapies in castration-resistant prostate cancer.

    abstract::The association between choline uptake and androgen receptor (AR) expression is suggested by the upregulation of choline kinase-alpha in prostate cancer. Recently, detection of AR aberration in cell-free DNA as well as early 18F-fluorocholine positron emission tomography/computed tomography (FCH-PET/CT) were associate...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15928-y

    authors: Conteduca V,Scarpi E,Caroli P,Salvi S,Lolli C,Burgio SL,Menna C,Schepisi G,Testoni S,Gurioli G,Paganelli G,Casadio V,Matteucci F,De Giorgi U

    更新日期:2017-11-14 00:00:00

  • Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration.

    abstract::Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many investigations. In this study, we used genetic and pharmacological approaches to explore the role of the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58849-z

    authors: Wooff Y,Fernando N,Wong JHC,Dietrich C,Aggio-Bruce R,Chu-Tan JA,Robertson AAB,Doyle SL,Man SM,Natoli R

    更新日期:2020-02-10 00:00:00

  • Relationship of common variants in MPP7, TIMP2 and CASP8 genes with the risk of chronic achilles tendinopathy.

    abstract::Previous etiologic studies have indicated that both environmental and genetic factors play important roles in the occurrence and development of chronic Achilles tendinopathy (AT). A recent study documented the results of the largest genome-wide association study for chronic AT to date, indicating that MPP7, TIMP2 and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54097-y

    authors: Kang X,Tian B,Zhang L,Ge Z,Zhao Y,Zhang Y

    更新日期:2019-11-26 00:00:00

  • Acoustic tweezing cytometry for mechanical phenotyping of macrophages and mechanopharmaceutical cytotripsy.

    abstract::Macrophages are immune cells responsible for tissue debridement and fighting infection. Clofazimine, an FDA-approved antibiotic, accumulates and precipitates as rod-shaped, crystal-like drug inclusions within macrophage lysosomes. Drug treatment as well as pathophysiological states could induce changes in macrophage m...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42180-3

    authors: Hong X,Rzeczycki PM,Keswani RK,Murashov MD,Fan Z,Deng CX,Rosania GR

    更新日期:2019-04-05 00:00:00

  • Improved risk stratification in prevention by use of a panel of selected circulating microRNAs.

    abstract::Risk stratification is crucial in prevention. Circulating microRNAs have been proposed as biomarkers in cardiovascular disease. Here a miR panel consisting of miRs related to different cardiovascular pathophysiologies, was evaluated to predict outcome in the context of prevention. MiR-34a, miR-223, miR-378, miR-499 an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04040-w

    authors: Keller T,Boeckel JN,Groß S,Klotsche J,Palapies L,Leistner D,Pieper L,Stalla GK,Lehnert H,Silber S,Pittrow D,Maerz W,Dörr M,Wittchen HU,Baumeister SE,Völker U,Felix SB,Dimmeler S,Zeiher AM

    更新日期:2017-07-03 00:00:00

  • Respiratory tract infections among French Hajj pilgrims from 2014 to 2017.

    abstract::Respiratory tract infections (RTIs) are common among Hajj pilgrims, but risk factors for RTIs and respiratory pathogen acquisition during the Hajj are not clearly identified. Based on previous studies, most frequent pathogens acquired by Hajj pilgrims were investigated: rhinovirus, human coronaviruses, influenza virus...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54370-0

    authors: Hoang VT,Ali-Salem S,Belhouchat K,Meftah M,Sow D,Dao TL,Ly TDA,Drali T,Ninove L,Yezli S,Alotaibi B,Raoult D,Parola P,Pommier de Santi V,Gautret P

    更新日期:2019-11-28 00:00:00

  • Detection and Quantification of CWD Prions in Fixed Paraffin Embedded Tissues by Real-Time Quaking-Induced Conversion.

    abstract::Traditional diagnostic detection of chronic wasting disease (CWD) relies on immunodetection of misfolded CWD prion protein (PrP(CWD)) by western blotting, ELISA, or immunohistochemistry (IHC). These techniques require separate sample collections (frozen and fixed) which may result in discrepancies due to variation in ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25098

    authors: Hoover CE,Davenport KA,Henderson DM,Pulscher LA,Mathiason CK,Zabel MD,Hoover EA

    更新日期:2016-05-09 00:00:00

  • Neuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial.

    abstract::Detecting neuroplastic changes during locomotor neurorehabilitation is crucial for independent primal motor behaviours. However, long-term locomotor training-related neuroplasticity remains unexplored. We compared the effects of end-effector robot-assisted gait training (E-RAGT) and bodyweight-supported treadmill trai...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-020-69367-3

    authors: Kim H,Park G,Shin JH,You JH

    更新日期:2020-07-27 00:00:00

  • Identification of candidate miRNAs in early-onset and late-onset prostate cancer by network analysis.

    abstract::The incidence of patients under 55 years old diagnosed with Prostate Cancer (EO-PCa) has increased during recent years. The molecular biology of PCa cancer in this group of patients remains unclear. Here, we applied weighted gene coexpression network analysis of the expression of miRNAs from 24 EO-PCa patients (38-45 ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69290-7

    authors: Parra-Medina R,López-Kleine L,Ramírez-Clavijo S,Payán-Gómez C

    更新日期:2020-07-23 00:00:00

  • How gluttonous cell aggregates clear substrates coated with microparticles.

    abstract::We study the spreading of cell aggregates deposited on adhesive substrates decorated with microparticles (MPs). A cell monolayer expands around the aggregate. The cells on the periphery of the monolayer take up the MPs, clearing the substrate as they progress and forming an aureole of cells filled with MPs. We study t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15665-2

    authors: Beaune G,Lam AYW,Dufour S,Winnik FM,Brochard-Wyart F

    更新日期:2017-11-16 00:00:00

  • Overlap Extension Barcoding for the Next Generation Sequencing and Genotyping of Plasmodium falciparum in Individual Patients in Western Kenya.

    abstract::Large-scale molecular epidemiologic studies of Plasmodium falciparum parasites have provided insights into parasite biology and transmission, can identify the spread of drug resistance, and are useful in assessing vaccine targets. The polyclonal nature infections in high transmission settings is problematic for tradit...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41108

    authors: Levitt B,Obala A,Langdon S,Corcoran D,O'Meara WP,Taylor SM

    更新日期:2017-01-24 00:00:00

  • Nanoemulsion-loaded hydrogel coatings for inhibition of bacterial virulence and biofilm formation on solid surfaces.

    abstract::The indiscriminate use of antibiotics has led to the emergence of drug-resistant bacteria which has become one of the biggest challenges of the twenty-first century for the researchers to combat and in turn search for novel targets which could lead to the development of effective and sustainable therapies. Inhibition ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43016-w

    authors: Prateeksha,Barik SK,Singh BN

    更新日期:2019-04-24 00:00:00

  • Abrupt climate shift in the Western Mediterranean Sea.

    abstract::One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report he...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23009

    authors: Schroeder K,Chiggiato J,Bryden HL,Borghini M,Ben Ismail S

    更新日期:2016-03-11 00:00:00

  • Coherent Response of Vietnam and Sumatra-Java Upwellings to Cross-Equatorial Winds.

    abstract::Upwelling off Vietnam in the South China Sea (SCS) and the Sumatra-Java upwelling in the Indian Ocean significantly modulate regional variation in climate. Although located in different hemispheres, these upwellings nearly concur during the boreal summer; both are the result of wind-induced Ekman divergence. Beyond se...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40246-w

    authors: Wu CR,Wang LC,Wang YL,Lin YF,Chiang TL,Hsin YC

    更新日期:2019-03-06 00:00:00

  • Coordinated activation of a cluster of MMP genes in response to UVB radiation.

    abstract::Ultraviolet (UV) B radiation is a dangerous environmental stressor, which can lead to photoaging, inflammation, immune suppression and tumour formation. A recent report has shown the transcriptional activation of several skin-specific genes including matrix metalloproteases (MMPs) in response to UV irradiation. Here, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-20999-6

    authors: Ujfaludi Z,Tuzesi A,Majoros H,Rothler B,Pankotai T,Boros IM

    更新日期:2018-02-08 00:00:00