Abstract:
:An individual's immune system is driven by both genetic and environmental factors that vary over time. To better understand the temporal and inter-individual variability of gene expression within distinct immune cell types, we developed a platform that leverages multiplexed single-cell sequencing and out-of-clinic capillary blood extraction to enable simplified, cost-effective profiling of the human immune system across people and time at single-cell resolution. Using the platform, we detect widespread differences in cell type-specific gene expression between subjects that are stable over multiple days.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Dobreva T,Brown D,Park JH,Thomson Mdoi
10.1038/s41598-020-77073-3subject
Has Abstractpub_date
2020-11-25 00:00:00pages
20540issue
1issn
2045-2322pii
10.1038/s41598-020-77073-3journal_volume
10pub_type
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