Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis.

abstract：:Mitochondrial DNA (mtDNA) mutations are commonly found in the skeletal muscle of patients with mitochondrial disease, inflammatory myopathies and sarcopenia. The majority of these mutations are mtDNA deletions, which accumulate to high levels in individual muscle fibres causing a respiratory defect. Most mtDNA deletio...

journal_title：Scientific reports

authors： Rygiel KA,Grady JP,Taylor RW,Tuppen HA,Turnbull DM

更新日期：2015-05-19 00:00:00

abstract：:Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian ooc...

journal_title：Scientific reports

authors： Zhang L,Xue X,Yan J,Yan LY,Jin XH,Zhu XH,He ZZ,Liu J,Li R,Qiao J

更新日期：2016-07-14 00:00:00

abstract：:To understand the impact of PIK3CA mutations on clinical characteristics and treatment response to epidermal growth factor tyrosine kinase inhibitors (EGFR TKIs) of lung adenocarcinoma, we examined PIK3CA and EGFR mutations in lung adenocarcinoma patients, and analyzed their clinical outcomes. Surgically excised tumor...

journal_title：Scientific reports

authors： Wu SG,Chang YL,Yu CJ,Yang PC,Shih JY

更新日期：2016-10-13 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) regulate expression of protein-coding genes in cis through chromatin modifications including DNA methylation. Here we interrogated whether lncRNA genes may regulate transcription and methylation of their flanking or overlapping protein-coding genes in livers of mice exposed to a 12-week ...

journal_title：Scientific reports

authors： Silva JP,van Booven D

更新日期：2018-08-01 00:00:00

abstract：:Gold is a noble metal typically stable as a solid in a face-centered cubic (FCC) structure under ambient conditions; however, under particular circumstances aberrant allotropes have been synthesized. In this work, we document the phase transformation of 25 nm thick nanocrystalline (NC) free-standing gold thin-film via...

journal_title：Scientific reports

authors： Suri PK,Nathaniel JE 2nd,Li N,Baldwin JK,Wang Y,Hattar K,Taheri ML

更新日期：2020-10-20 00:00:00

abstract：:For lung and many other cancers, prognosis is essentially important, and extensive modeling has been carried out. Cancer is a genetic disease. In the past 2 decades, diverse molecular data (such as gene expressions and DNA mutations) have been analyzed in prognosis modeling. More recently, histopathological imaging da...

journal_title：Scientific reports

authors： Zhang S,Fan Y,Zhong T,Ma S

更新日期：2020-09-14 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity, metabolic syndrome, and type II diabetes mellitus. Recently, circulating microRNAs (miRNAs) have been proposed as useful disease biomarkers. We examined whether circulating miRNAs, such as miR-20a, miR-27a, and miR-126, were useful biomarker...

journal_title：Scientific reports

authors： Ando Y,Yamazaki M,Yamada H,Munetsuna E,Fujii R,Mizuno G,Ichino N,Osakabe K,Sugimoto K,Ishikawa H,Ohashi K,Teradaira R,Ohta Y,Hamajima N,Hashimoto S,Suzuki K

更新日期：2019-12-11 00:00:00

abstract：:The metal complexes can demonstrate various interesting biological activities in the human body. However, the role of certain metal ions for specific cell activities is still subject to debate. This study is aimed at comparing the thermochemical properties of neotame (artificial sweetener) and α, β-fructose in gas pha...

journal_title：Scientific reports

authors： Sharma D,Kanchi S,Bathinapatla A,Inamuddin,Asiri AM

更新日期：2019-12-05 00:00:00

abstract：:Cytochrome P450 superfamily proteins play important roles in detoxification of xenobiotics and during physiological and developmental processes. To contribute to our understanding of this large gene family in insects, we have investigated the function of the cytochrome P450 gene LmCYP4G102 in the migratory locust Locu...

journal_title：Scientific reports

authors： Yu Z,Zhang X,Wang Y,Moussian B,Zhu KY,Li S,Ma E,Zhang J

更新日期：2016-07-22 00:00:00

abstract：:The concentration of CO2 in many aquatic systems is variable, often lower than the KM of the primary carboxylating enzyme Rubisco, and in order to photosynthesize efficiently, many algae operate a facultative CO2 concentrating mechanism (CCM). Here we measured the responses of a marine diatom, Thalassiosira pseudonana...

journal_title：Scientific reports

authors： Clement R,Lignon S,Mansuelle P,Jensen E,Pophillat M,Lebrun R,Denis Y,Puppo C,Maberly SC,Gontero B

更新日期：2017-02-09 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Cardelli C,Bianco V,Rovigatti L,Nerattini F,Tubiana L,Dellago C,Coluzza I

更新日期：2018-03-12 00:00:00

abstract：:Exosomes are nano-sized endosome-derived small intraluminal vesicles, which are important facilitators of intercellular communication by transporting contents, such as protein, mRNA, and microRNAs, between neighboring cells, such as in the tumor microenvironment. The purpose of this study was to understand the mechani...

journal_title：Scientific reports

authors： Su MJ,Aldawsari H,Amiji M

更新日期：2016-07-22 00:00:00

abstract：:Flavivirus-mediated inflammation causes neuronal death, but whether the infected neurons can evoke an innate immune response to elicit their own protection, is unknown. In an earlier study we have shown that neuronal RIG-I, play a significant role in inducing production and release of molecules that are related to inf...

journal_title：Scientific reports

authors： Nazmi A,Mukhopadhyay R,Dutta K,Basu A

更新日期：2012-01-01 00:00:00

abstract：:Cells in vascular walls are exposed to blood pressure variability (BPV)-induced cycle-by-cycle fluctuations in mechanical forces which vary considerably with pathology. For example, BPV is elevated in hypertension but reduced under anesthesia. We hypothesized that the extent of mechanical fluctuations applied to vascu...

journal_title：Scientific reports

authors： Bartolák-Suki E,Suki B

更新日期：2020-01-15 00:00:00

abstract：:Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We ...

journal_title：Scientific reports

authors： Moilanen JM,Löffek S,Kokkonen N,Salo S,Väyrynen JP,Hurskainen T,Manninen A,Riihilä P,Heljasvaara R,Franzke CW,Kähäri VM,Salo T,Mäkinen MJ,Tasanen K

更新日期：2017-03-22 00:00:00

abstract：:In the paradigm of materials informatics for accelerated materials discovery, the choice of feature set (i.e. attributes that capture aspects of structure, chemistry and/or bonding) is critical. Ideally, the feature sets should provide a simple physical basis for extracting major structural and chemical trends and fur...

journal_title：Scientific reports

authors： Balachandran PV,Theiler J,Rondinelli JM,Lookman T

更新日期：2015-08-25 00:00:00

abstract：:Circularly polarized laser sources with small footprints and high efficiencies can possess advanced functionalities in optical communication and biophotonic integrated systems. However, the conventional lasers with additional circular-polarization converters are bulky and hardly compatible with nanophotonic circuits, ...

journal_title：Scientific reports

authors： Liao WC,Liao SW,Chen KJ,Hsiao YH,Chang SW,Kuo HC,Shih MH

更新日期：2016-05-25 00:00:00

abstract：:Convenient drug-resistance testing of viral mutants is indispensable to effective treatment of viral infection. We developed a novel fluorometric assay for phenotypic differentiation of drug-resistant mutants of human immunodeficiency virus-I protease (HIV-PR) which uses enzymatic and peptide-specific fluorescence (FL...

journal_title：Scientific reports

authors： Zhu Q,Yu Z,Kabashima T,Yin S,Dragusha S,El-Mahdy AF,Ejupi V,Shibata T,Kai M

更新日期：2015-05-19 00:00:00

abstract：:Disseminated tumor cells (DTCs) in the bone marrow (BM) and circulating tumor cells (CTCs) in blood of breast cancer patients (pts) are known to correlate with worse outcome. Here we demonstrate a different prognostic value of DTCs and CTCs and explain these findings by early clodronate intake. CTCs (n = 376 pts) were...

journal_title：Scientific reports

authors： Kasimir-Bauer S,Reiter K,Aktas B,Bittner AK,Weber S,Keller T,Kimmig R,Hoffmann O

更新日期：2016-05-23 00:00:00

abstract：:Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma worldwide. However, the strategy of HBV to escape from the host immune system remains largely unknown. In this study, we examined extracellular vesicles (EVs) secreted from human hepatocytes infected with HBV. EVs includeing exosomes are ...

journal_title：Scientific reports

authors： Enomoto Y,Takagi R,Naito Y,Kiniwa T,Tanaka Y,Hamada-Tsutsumi S,Kawano M,Matsushita S,Ochiya T,Miyajima A

更新日期：2017-08-10 00:00:00

abstract：:This study aimed to assess the validity and functional relevance of a standardized procedure to assess lower limb muscle power by means of the 30-s sit-to-stand (STS) test when compared to leg extension power (LEP), traditional STS performance and handgrip strength. A total of 628 community-dwelling older subjects (60...

journal_title：Scientific reports

authors： Alcazar J,Kamper RS,Aagaard P,Haddock B,Prescott E,Ara I,Suetta C

更新日期：2020-10-01 00:00:00

abstract：:Hybrid carbon films composed of graphene film and porous carbon film may give full play to the advantages of both carbon materials, and have great potential for application in energy storage and conversion devices. Unfortunately, there are very few reports on fabrication of hybrid carbon films. Here we demonstrate a s...

journal_title：Scientific reports

authors： Wei H,Wei S,Tian W,Zhu D,Liu Y,Yuan L,Li X

更新日期：2014-11-14 00:00:00

abstract：:A new synchrotron-based technique for elemental imaging that combines radiography and fluorescence spectroscopy has been developed and applied to study the spatial distribution of Ag, Zr and Mo in an Al alloy during heating and melting to 700, and then re-soldification. For the first time, multi-element distributions ...

journal_title：Scientific reports

authors： Liotti E,Lui A,Connolley T,Dolbnya IP,Sawhney KJ,Malandain A,Wilson MD,Veale MC,Seller P,Grant PS

更新日期：2015-11-02 00:00:00

abstract：:We utilized several computational approaches to evaluate the binding energies of tyrosine (Tyr) and several unnatural Tyr analogs, to several orthogonal aaRSes derived from Methanocaldococcus jannaschii and Escherichia coli tyrosyl-tRNA synthetases. The present study reveals the following: (1) AutoDock Vina and ROSETT...

journal_title：Scientific reports

authors： Ren W,Truong TM,Ai HW

更新日期：2015-07-29 00:00:00

abstract：:Sentinel lymph node (SLN) mapping using dye or radioisotopes has been performed in patients with uterine cancer. Superparamagnetic iron oxide (SPIO) can be handled safely and is taken up by lymph nodes (LNs); however, its efficacy in detecting SLNs in uterine cancer remains unknown. This pilot study evaluated the use ...

journal_title：Scientific reports

authors： Murakami K,Kotani Y,Suzuki A,Takaya H,Nakai H,Matsuki M,Sato T,Mandai M,Matsumura N

更新日期：2020-05-14 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) cascades, which play crucial roles in plant development processes, are universal modules of signal transduction in eukaryotes and consist of a core module of three sequentially phosphorylated kinases: MAPK, MAPK kinase (MAPKK), and MAPKK kinase (MAPKKK). This is the first re...

journal_title：Scientific reports

authors： Jing T,Wang L,Liu H,Wuyun TN,Du H

更新日期：2017-12-18 00:00:00

abstract：:Short QT syndrome (SQTS) is a rare condition characterized by abnormally 'short' QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death. This simulation study investigated arrhythmia dynamics in multi-scale human ventricle models associated with the SQT2-related V307L KCNQ1 'gain-...

journal_title：Scientific reports

authors： Adeniran I,Whittaker DG,El Harchi A,Hancox JC,Zhang H

更新日期：2017-08-16 00:00:00

abstract：:Malaria is among the major threats to global health with the main burden of disease being in rural areas of developing countries where accurate diagnosis based on non-invasive samples is in high demand. We here present a novel molecular assay for detection of malaria parasites based on technology that may be adapted f...

journal_title：Scientific reports

authors： Hede MS,Fjelstrup S,Lötsch F,Zoleko RM,Klicpera A,Groger M,Mischlinger J,Endame L,Veletzky L,Neher R,Simonsen AKW,Petersen E,Mombo-Ngoma G,Stougaard M,Ho YP,Labouriau R,Ramharter M,Knudsen BR

更新日期：2018-03-07 00:00:00

abstract：:A combination of techniques from 3D printing, tissue engineering and biomaterials has yielded a new class of engineered biological robots that could be reliably controlled via applied signals. These machines are powered by a muscle strip composed of differentiated skeletal myofibers in a matrix of natural proteins, in...

journal_title：Scientific reports

authors： Cvetkovic C,Ferrall-Fairbanks MC,Ko E,Grant L,Kong H,Platt MO,Bashir R

更新日期：2017-06-19 00:00:00

abstract：:Brain trauma was clinically associated with increased osteogenesis in the appendicular skeleton. We showed previously in C57BL/6J mice that mild traumatic brain injury (mTBI) transiently induced bone formation in the femur via the cannabinoid-1 (CB1) receptor. Here, we subjected ICR mice to mTBI and examined the bone ...

journal_title：Scientific reports

authors： Eger M,Bader M,Bree D,Hadar R,Nemirovski A,Tam J,Levy D,Pick CG,Gabet Y

更新日期：2019-11-07 00:00:00