Deficiency of Capicua disrupts bile acid homeostasis.

abstract：:We compared markers of glucose homeostasis and their association with diabetes and impaired fasting glucose (IFG) in Fukuoka, Japanese subjects (n = 1108) and age-, gender- and menopausal status-matched participants in the Framingham Offspring Study (n = 1096). The markers examined included fasting glucose, insulin, a...

journal_title：Scientific reports

authors： Ikezaki H,Ai M,Schaefer EJ,Otokozawa S,Asztalos BF,Nakajima K,Zhou Y,Liu CT,Jacques PF,Cupples LA,Furusyo N

更新日期：2016-11-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Zhang X,Shen Q,Lei Z,Wang Q,Zheng J,Jia Z

更新日期：2020-03-06 00:00:00

abstract：:Inosine-5'-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mechanisms of regulation remain largely unknown. Using the enzyme from the industria...

journal_title：Scientific reports

authors： Buey RM,Fernández-Justel D,Marcos-Alcalde Í,Winter G,Gómez-Puertas P,de Pereda JM,Luis Revuelta J

更新日期：2017-06-01 00:00:00

abstract：:The room-temperature magnetic properties of ball-milled strontium hexaferrite particles consolidated by spark-plasma sintering are strongly influenced by the milling time. Scanning electron microscopy revealed the ball-milled SrFe12O19 particles to have sizes varying over several hundred nanometers. X-Ray powder-diffr...

journal_title：Scientific reports

authors： Stingaciu M,Topole M,McGuiness P,Christensen M

更新日期：2015-09-15 00:00:00

abstract：:Intestinal alkaline phosphatase (IAP) regulates bicarbonate secretion, detoxifies lipopolysaccharide (LPS), regulates gut microbes, and dephosphorylates proinflammatory nucleotides. IAP also exhibits anti-inflammatory effects in a Toll-like Receptor-4 (TLR-4) dependent manner. However, it is not known whether IAP indu...

journal_title：Scientific reports

authors： Singh SB,Carroll-Portillo A,Coffman C,Ritz NL,Lin HC

更新日期：2020-02-20 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of tuberculosis, has surpassed HIV as the leading cause of death due to an infectious disease worldwide, being responsible for more than 1.5 million deaths in low-income countries. In response to a pandemic threat by drug resistant strains, the tuberculosis research comm...

journal_title：Scientific reports

authors： Soto R,Perez-Herran E,Rodriguez B,Duma BM,Cacho-Izquierdo M,Mendoza-Losana A,Lelievre J,Aguirre DB,Ballell L,Cox LR,Alderwick LJ,Besra GS

更新日期：2018-08-23 00:00:00

abstract：:Aortic stenosis (AS) is the most common form of valve disease. Once symptoms develop, there is an inexorable deterioration with a poor prognosis; currently there are no therapies capable of modifying disease progression, and aortic valve replacement is the only available treatment. Our goal is to study the progression...

journal_title：Scientific reports

authors： Mourino-Alvarez L,Iloro I,de la Cuesta F,Azkargorta M,Sastre-Oliva T,Escobes I,Lopez-Almodovar LF,Sanchez PL,Urreta H,Fernandez-Aviles F,Pinto A,Padial LR,Akerström F,Elortza F,Barderas MG

更新日期：2016-06-03 00:00:00

abstract：:The vast majority of proteins do not form functional interactions in physiological conditions. We have considered several sets of protein pairs from S. cerevisiae with no functional interaction reported, denoted as non-interacting pairs, and compared their 3D structures to available experimental complexes. We identifi...

journal_title：Scientific reports

authors： Launay G,Ceres N,Martin J

更新日期：2017-01-13 00:00:00

abstract：:The identification of enhancer-target gene (ETG) pairs is vital for the understanding of gene transcriptional regulation. Experimental approaches such as Hi-C have generated valuable resources of ETG pairs. Several computational methods have also been developed to successfully predict ETG interactions. Despite these p...

journal_title：Scientific reports

authors： Zhao C,Li X,Hu H

更新日期：2016-07-20 00:00:00

abstract：:Biological hydrogen production is based on activity of specific enzymes called hydrogenases. Hydrogenases are oxygen sensitive metalloenzymes containing Ni and/or Fe atoms at the active site, catalyzing reversible reduction of protons. Generally, [Fe-Fe] hydrogenases prefer proton reduction to molecular hydrogen, a po...

journal_title：Scientific reports

authors： Mangayil R,Karp M,Lamminmäki U,Santala V

更新日期：2016-10-27 00:00:00

abstract：:Hbs1, which is homologous to the GTPase eRF3, is a small G protein implicated in mRNA quality control. It interacts with a translation-release factor 1-like protein Dom34/Pelota to direct decay of mRNAs with ribosomal stalls. Although both proteins are evolutionarily conserved in eukaryotes, the biological function of...

journal_title：Scientific reports

authors： Li Z,Yang F,Xuan Y,Xi R,Zhao R

更新日期：2019-03-01 00:00:00

abstract：:We report on a wavelet based space-scale decomposition method for analyzing the response of living muscle precursor cells (C2C12 myoblasts and myotubes) upon sharp indentation with an AFM cantilever and quantifying their aptitude to sustain such a local shear strain. Beyond global mechanical parameters which are curre...

journal_title：Scientific reports

authors： Streppa L,Ratti F,Goillot E,Devin A,Schaeffer L,Arneodo A,Argoul F

更新日期：2018-06-05 00:00:00

abstract：:Copper zinc tin sulfide (CZTS) is a promising material for harvesting solar energy due to its abundance and non-toxicity. However, its poor performance hinders their wide application. In this paper gold (Au) nanoparticles are successfully incorporated into CZTS to form Au@CZTS core-shell nanostructures. The photocatho...

journal_title：Scientific reports

authors： Zhang X,Wu X,Centeno A,Ryan MP,Alford NM,Riley DJ,Xie F

更新日期：2016-03-21 00:00:00

abstract：:An increase of nucleolar number and size has made nucleoli essential markers for cytology and tumour development. However, the underlying basis for their structural integrity and abundance remains unclear. Protein phosphatase PPM1D was found to be up-regulated in different carcinomas including breast cancers. Here, we...

journal_title：Scientific reports

authors： Kozakai Y,Kamada R,Furuta J,Kiyota Y,Chuman Y,Sakaguchi K

更新日期：2016-09-13 00:00:00

abstract：:Coordination polymerization leads to various metal-organic frameworks (MOFs) with unique physical properties and chemical functionalities. One of the challenges towards their applications as porous materials is to make MOFs optimally conductive to be used as electronic components. Here, it is demonstrated that Co-MOF-...

journal_title：Scientific reports

authors： Shiozawa H,Bayer BC,Peterlik H,Meyer JC,Lang W,Pichler T

更新日期：2017-05-26 00:00:00

abstract：:The effects of biogeographical separation and parent material differences in soil bacterial structure and diversity in offshore islands remain poorly understood. In the current study, we used next-generation sequencing to characterize the differences in soil bacterial communities in five offshore subtropical granite i...

journal_title：Scientific reports

authors： Lin YT,Lin YF,Tsai IJ,Chang EH,Jien SH,Lin YJ,Chiu CY

更新日期：2019-03-20 00:00:00

abstract：:Although carbon nanotubes (CNTs) have shown great potential for enhancing the performance of polymer matrices, their reinforcement role still needs to be further improved. Here we implement a structural modification of multi-walled CNTs (MWCNTs) to fully utilize their fascinating mechanical and electrical properties v...

journal_title：Scientific reports

authors： Yang M,Weng L,Zhu H,Zhang F,Fan T,Zhang D

更新日期：2017-12-07 00:00:00

abstract：:A novel sesquiterpene methylcyclopentenedione, penicilliumin B (1), was obtained from a deep sea-derived fungus Penicillium sp. F00120, together with three known sesquiterpene cyclohexenones (2-4). Penicilliumin B (1), presenting the first example with the sesquiterpene cyclopentenedione skeleton as natural products, ...

journal_title：Scientific reports

authors： Lin X,Wu Q,Yu Y,Liang Z,Liu Y,Zhou L,Tang L,Zhou X

更新日期：2017-09-07 00:00:00

abstract：:Enterococci are nosocomial pathogens that can form biofilms, which contribute to their virulence and antibiotic resistance. Although many genes involved in biofilm formation have been defined, their distribution among enterococci has not been comprehensively studied on a genome scale, and their diagnostic ability to p...

journal_title：Scientific reports

authors： Hashem YA,Amin HM,Essam TM,Yassin AS,Aziz RK

更新日期：2017-07-18 00:00:00

abstract：:Four plant tumorigenic strains 932, 1019, 1078T and 1081 isolated from cane gall tumors on thornless blackberry (Rubus sp.) were characterized. They shared low sequence identity with related Rhizobium spp. based on comparisons of 16S rRNA gene (≤98%) and housekeeping genes atpD, recA and rpoB (<90%). Phylogenetic anal...

journal_title：Scientific reports

authors： Kuzmanović N,Smalla K,Gronow S,Puławska J

更新日期：2018-06-13 00:00:00

abstract：:It is known that ribosomal RNA (rRNA) synthesis is regulated by cellular energy and proliferation status. In this study, we investigated rRNA gene transcription in response to cytoskeletal stress. Our data revealed that the cell shape constrained by isotropic but not elongated micropatterns in HeLa cells led to a sign...

journal_title：Scientific reports

authors： Wu TH,Kuo YY,Lee HH,Kuo JC,Ou MH,Chang ZF

更新日期：2016-06-28 00:00:00

abstract：:There are few materials that are broadly used for fabricating optical metasurfaces for visible light applications. Gallium phosphide (GaP) is a material that, due to its optical properties, has the potential to become a primary choice but due to the difficulties in fabrication, GaP thin films deposited on transparent ...

journal_title：Scientific reports

authors： Melli M,West M,Hickman S,Dhuey S,Lin D,Khorasaninejad M,Chang C,Jolly S,Tae H,Poliakov E,St Hilaire P,Cabrini S,Peroz C,Klug M

更新日期：2020-11-26 00:00:00

abstract：:This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004-2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe (pH < 7.1). Two multiple logistic regression models ...

journal_title：Scientific reports

authors： Cherubini V,Skrami E,Ferrito L,Zucchini S,Scaramuzza A,Bonfanti R,Buono P,Cardella F,Cauvin V,Chiari G,D Annunzio G,Frongia AP,Iafusco D,Patera IP,Toni S,Tumini S,Rabbone I,Lombardo F,Carle F,Gesuita R,Diabetes St

更新日期：2016-12-19 00:00:00

abstract：:We isolated a novel bacterial strain from a prokaryotic consortium associated to the psychrophilic marine ciliate Euplotes focardii, endemic of the Antarctic coastal seawater. The 16S rDNA sequencing and the phylogenetic analysis revealed the close evolutionary relationship to the Antarctic marine bacterium Marinomona...

journal_title：Scientific reports

authors： John MS,Nagoth JA,Ramasamy KP,Ballarini P,Mozzicafreddo M,Mancini A,Telatin A,Liò P,Giuli G,Natalello A,Miceli C,Pucciarelli S

更新日期：2020-06-23 00:00:00

abstract：:Gene selection is an attractive and important task in cancer survival analysis. Most existing supervised learning methods can only use the labeled biological data, while the censored data (weakly labeled data) far more than the labeled data are ignored in model building. Trying to utilize such information in the censo...

journal_title：Scientific reports

authors： Chai H,Li ZN,Meng DY,Xia LY,Liang Y

更新日期：2017-10-12 00:00:00

abstract：:Most bacterial cytochrome P450 monooxygenases (P450s or CYPs) require two redox partner proteins for activity. To reduce complexity of the redox chain, the Bacillus subtilis flavodoxin YkuN (Y) was fused to the Escherichia coli flavodoxin reductase Fpr (R), and activity was tuned by placing flexible (GGGGS)n or rigid ...

journal_title：Scientific reports

authors： Bakkes PJ,Riehm JL,Sagadin T,Rühlmann A,Schubert P,Biemann S,Girhard M,Hutter MC,Bernhardt R,Urlacher VB

更新日期：2017-08-29 00:00:00

abstract：:We summarized published data on the associations of apolipoprotein E (APOE) gene ε2/ε3/ε4 polymorphism with both cancer risk and circulating lipid profiles, aiming to examine the causal relevance between lipids and cancer risk. Article identification and data abstraction were conducted in duplicate and independently b...

journal_title：Scientific reports

authors： Yang C,Tian G,Mi J,Wei X,Li X,Li X,Wang W,Wang B

更新日期：2015-03-30 00:00:00

abstract：:Acquisition of the lower jaw (mandible) was evolutionarily important for jawed vertebrates. In humans, syndromic craniofacial malformations often accompany jaw anomalies. The basic helix-loop-helix transcription factor Hand2, which is conserved among jawed vertebrates, is expressed in the neural crest in the mandibula...

journal_title：Scientific reports

authors： Funato N,Kokubo H,Nakamura M,Yanagisawa H,Saga Y

更新日期：2016-06-22 00:00:00

abstract：:The organismic unit of heterocyst-forming cyanobacteria is a filament of communicating cells connected by septal junctions, proteinaceous structures bridging the cytoplasms of contiguous cells. This distinct bacterial organization is preserved during cell division. In Anabaena, deletion of the zipN gene could not be s...

journal_title：Scientific reports

authors： Camargo S,Picossi S,Corrales-Guerrero L,Valladares A,Arévalo S,Herrero A

更新日期：2019-02-26 00:00:00

abstract：:Polyphenol oxidases (PPOs) are ubiquitously distributed among plants, bacteria, fungi and animals. They catalyze the hydroxylation of monophenols (monophenolase activity) and the oxidation of o-diphenols (diphenolase activity) to o-quinones. PPOs are commonly present as an isoenzyme family. In walnut (Juglans regia), ...

journal_title：Scientific reports

authors： Panis F,Rompel A

更新日期：2020-07-02 00:00:00