Abstract:
:We compared markers of glucose homeostasis and their association with diabetes and impaired fasting glucose (IFG) in Fukuoka, Japanese subjects (n = 1108) and age-, gender- and menopausal status-matched participants in the Framingham Offspring Study (n = 1096). The markers examined included fasting glucose, insulin, adiponectin, and glycated albumin, as well as body mass index (BMI), use of medications, and history of diabetes. The results showed that IFG prevalence in Japanese men (15.9%) and women (7.4%) were 50% less than those observed in Framingham men (34.5%) and women (21.4%) (P < 0.001). However, the diabetes prevalence in Japanese men at 13.3% was twice as high (P < 0.01) as the rate in Framingham men at 6.5%, while these rates were similar in women. Median insulin levels in Japanese men (4.6 μIU/mL) and women (4.3 μIU/mL) were about 50% lower (P < 0.001) than those in Framingham men (10.8 μIU/mL) and women (9.9 μIU/mL), as were insulin resistance values (P < 0.001). These population differences were also observed after subjects were stratified by glucose levels. In conclusion, our data indicate that there is significantly less IFG, lower insulin levels, and insulin resistance, but higher diabetes prevalence in Fukuoka men than in Framingham men, indicating that insulin deficiency may be an important cause of diabetes in Japan.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ikezaki H,Ai M,Schaefer EJ,Otokozawa S,Asztalos BF,Nakajima K,Zhou Y,Liu CT,Jacques PF,Cupples LA,Furusyo Ndoi
10.1038/srep36725subject
Has Abstractpub_date
2016-11-10 00:00:00pages
36725issn
2045-2322pii
srep36725journal_volume
6pub_type
杂志文章abstract::We developed a reporter system that can be used in a dual manner in visualizing mature osteoblast formation. The system is based on a helper-dependent adenoviral vector (HDAdV), in which a fluorescent protein, Venus, is expressed under the control of the 19-kb human osteocalcin (OC) genomic locus. By infecting human a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46105-y
更新日期:2019-07-04 00:00:00
abstract::Restless Legs syndrome (RLS) is a common sleep disorder for which the genetic contribution remains poorly explained. In 2007, the first large scale genome wide association study (GWAS) identified three genomic regions associated with RLS. MEIS1, BTBD9 and MAP2K5/SKOR1 are the only known genes located within these loci...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30665-6
更新日期:2018-08-15 00:00:00
abstract::Ursolic acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property largely limit its clinical application and efficiency. Here, we synthesized a nanoparticle-based drug carrier composed of chitosan, UA and folate (FA-CS-UA-NPs) and demonstrated that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30782
更新日期:2016-07-29 00:00:00
abstract::This corrects the article DOI: 10.1038/srep44640. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/srep46872
更新日期:2017-06-30 00:00:00
abstract::Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the world's poorest, however vaccines are absent and drug therapy limited. Recently, public-private partnerships have developed to identify new modes of controlling leis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22063-9
更新日期:2018-03-02 00:00:00
abstract::Breast cancer is the most frequently diagnosed malignancy among women, and triple-negative breast cancer (TNBC) is a highly aggressive subtype. Increasing evidence has shown that lncRNAs are involved in tumor growth, cell-cycle, and apoptosis through interactions with miRNAs or mRNAs. However, there is still limited d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51626-7
更新日期:2019-10-22 00:00:00
abstract::Type IV secretion systems are multiprotein complexes that mediate the translocation of macromolecules across the bacterial cell envelope. In Helicobacter pylori a type IV secretion system encoded by the cag pathogenicity island encodes 27 proteins and most are essential for virulence. We here present the identificatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42876-6
更新日期:2019-04-24 00:00:00
abstract::Networks are widely used as a tool for describing diverse real complex systems and have been successfully applied to many fields. The distance between networks is one of the most fundamental concepts for properly classifying real networks, detecting temporal changes in network structures, and effectively predicting th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34944
更新日期:2016-10-11 00:00:00
abstract::Genome-wide DNA methylation and gene expression are commonly altered in pediatric acute lymphoblastic leukemia (PALL). Integrated network analysis of cytosine methylation and expression datasets has the potential to provide deeper insights into the complex disease states and their causes than individual disconnected a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58123-2
更新日期:2020-02-07 00:00:00
abstract::Transplantation of cardiomyocytes derived from induced pluripotent stem cell (iPSC-CMs) is a promising approach for increasing functional CMs during end-stage heart failure. Although major histocompatibility complex (MHC) class I matching between donor cells and recipient could reduce acquired immune rejection, innate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47134-3
更新日期:2019-07-25 00:00:00
abstract::Omega-3 fatty acids, and specifically docosahexaenoic acid (DHA), are important and essential nutrients for human health. Thraustochytrids are recognised as commercial strains for nutraceuticals production, they are group of marine oleaginous microorganisms capable of co-synthesis of DHA and other valuable carotenoids...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58728-7
更新日期:2020-02-06 00:00:00
abstract::Hepcidin, a cysteine-rich peptide hormone, secreted mainly by the liver, plays a central role in iron metabolism regulation. Emerging evidence suggests that disordered iron metabolism is a risk factor for various types of diseases including cancers. However, it remains challenging to apply current mass spectrometry (M...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43756-9
更新日期:2019-05-13 00:00:00
abstract::Responses of ecosystems to human-induced stress vary in space and time, because both stressors and ecosystem vulnerabilities vary in space and time. Presently, ecosystem impact assessments mainly take into account variation in stressors, without considering variation in ecosystem vulnerability. We developed a method t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09573-8
更新日期:2017-08-24 00:00:00
abstract::We address the impact of the spin-orbit (SO) coupling on the localization-delocalization-transition (LDT) in a spin-orbit coupled Bose-Einstein condensate in a bichromatic potential. We find that SO coupling significantly alters the threshold depth of the one of sublattices above which the lowest eigenstates transform...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31700
更新日期:2016-08-17 00:00:00
abstract::Neurotransmitter release from the presynaptic terminal is under very precise spatial and temporal control. Following neurotransmitter release, synaptic vesicles are recycled by endocytosis and refilled with neurotransmitter. During the exocytosis event leading to release, SNARE proteins provide most of the mechanical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17669
更新日期:2015-12-04 00:00:00
abstract::Millimeter wave (MMW)-induced heating represents a promising alternative for non-invasive hyperthermia of superficial skin cancer, such as melanoma. Pulsed MMW-induced heating of tumors allows for reaching high peak temperatures without overheating surrounding tissues. Herein, for the first time, we evaluate apoptotic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51731-7
更新日期:2019-10-24 00:00:00
abstract::The habit of blood feeding evolved independently in many insect orders of families. Sand flies and mosquitoes belong to separate lineages of blood-feeding Diptera and are thus considered to have evolved the trait independently. Because of this, sand fly salivary proteins differ structurally from those of mosquitoes, a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41848-0
更新日期:2019-03-29 00:00:00
abstract::Cancer hallmarks are evolutionary traits required by a tumour to develop. While extensively characterised, the way these traits are achieved through the accumulation of somatic mutations in key biological pathways is not fully understood. To shed light on this subject, we characterised the landscape of pathway alterat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25076-6
更新日期:2018-04-30 00:00:00
abstract::Phelan-McDermid Syndrome (PMS), which is defined by a deletion within 22q13, demonstrates significant phenotypic variation. Given that six mitochondrial genes are located within 22q13, including complex I and IV genes, we hypothesize that mitochondrial complex activity abnormalities may explain phenotypic variation in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19544
更新日期:2016-01-29 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a chronic disease, and dietary modification is a crucial part of disease management. Okara is a sustainable source of fibre-rich food. Most of the valorization research on okara focused more on the physical attributes instead of the possible health attributes. The fermentation of oka...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54021-4
更新日期:2019-11-26 00:00:00
abstract::Zinc is an essential trace element that plays an important role in differentiation of osteoblasts and bone modeling. This in vitro study aimed to evaluate the osteoblast differentiation of human dental pulp stem cells (DPSCs) on zinc-modified titanium (Zn-Ti) that releases zinc ions from its surface. Based on real-tim...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29462
更新日期:2016-07-08 00:00:00
abstract::The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68106-y
更新日期:2020-07-14 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-40293-3
更新日期:2019-04-09 00:00:00
abstract::A novel and facile two-step strategy has been designed to prepare high performance bi-transition-metals (Fe- and Mo-) carbide supported on nitrogen-doped graphene (FeMo-NG) as electrocatalysts for oxygen reduction reactions (ORR). The as-synthesized FeMo carbide -NG catalysts exhibit excellent electrocatalytic activit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10389
更新日期:2015-05-22 00:00:00
abstract::Using two different hydrosilylation methods, low temperature thermal and UV initiation, silicon (111) hydrogenated surfaces were functionalized in presence of an OH-terminated alkyne, a CF3-terminated alkyne and a mixed equimolar ratio of the two alkynes. XPS studies revealed that in the absence of premeditated surfac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11299
更新日期:2015-06-12 00:00:00
abstract::Despite broad implications for understanding human life history, energetics, and health, the impact of physical activity on childhood growth remains unclear. Particularly understudied is the effect of secular changes in physical activity on child development. We address these shortcomings using data spanning the trans...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18738-4
更新日期:2018-01-10 00:00:00
abstract::Elevated plasma concentrations of the ketone body β-hydroxybutyrate (BHB), an endogenous agonist of the hydroxycarboxylic acid receptor 2 (HCA2), is associated with an increased incidence of inflammatory diseases during lactation in dairy cows. In the early stages of this pathology, an increase in neutrophil recruitme...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69500-2
更新日期:2020-07-27 00:00:00
abstract::We study the impact of the direction of magnetic flux on the electron motion in GaAs/InAs core/shell nanowires. At small tilt angles, when the magnetic field is aligned nearly parallel to the nanowire axis, we observe Aharonov-Bohm type h/e flux periodic magnetoconductance oscillations. These are attributed to transpo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24573
更新日期:2016-04-19 00:00:00
abstract::The causes of Cenozoic uplift of the Colorado Plateau, southwestern USA, are strongly debated, though most hypotheses acknowledge the importance of northwest-directed subduction of the Farallon oceanic plate beneath North America since c. 100 Ma. Existing thermomechanical models suggest that the Farallon slab underthr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44628-y
更新日期:2019-05-31 00:00:00
abstract::Foods and beverage aroma results from multicomponent mixtures of volatile compounds present in the food that interact with olfactory receptors and produce a perceptual response in the brain. However, the perceptual interactions that occur when complex odor mixtures are combined are not well understood. Here we used Ga...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44064-y
更新日期:2019-05-21 00:00:00