Abstract：
:Neurotransmitter release from the presynaptic terminal is under very precise spatial and temporal control. Following neurotransmitter release, synaptic vesicles are recycled by endocytosis and refilled with neurotransmitter. During the exocytosis event leading to release, SNARE proteins provide most of the mechanical force for membrane fusion. Here, we show one of these proteins, Syntaxin1A, is SUMOylated near its C-terminal transmembrane domain in an activity-dependent manner. Preventing SUMOylation of Syntaxin1A reduces its interaction with other SNARE proteins and disrupts the balance of synaptic vesicle endo/exocytosis, resulting in an increase in endocytosis. These results indicate that SUMOylation regulates the emerging role of Syntaxin1A in vesicle endocytosis, which in turn, modulates neurotransmitter release and synaptic function.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Craig TJ,Anderson D,Evans AJ,Girach F,Henley JMdoi
10.1038/srep17669subject
Has Abstractpub_date
2015-12-04 00:00:00pages
17669issn
2045-2322pii
srep17669journal_volume
5pub_type
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