PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin.

abstract：:In cloud water, microorganisms are exposed to very strong stresses especially related to the presence of reactive oxygen species including H2O2 and radicals, which are the driving force of cloud chemistry. In order to understand how the bacterium Pseudomonas graminis isolated from cloud water respond to this oxidative...

journal_title：Scientific reports

authors： Wirgot N,Lagrée M,Traïkia M,Besaury L,Amato P,Canet I,Sancelme M,Jousse C,Diémé B,Lyan B,Delort AM

更新日期：2019-09-05 00:00:00

abstract：:The prevalence of consanguineous marriage and genetic disorders are high in Saudi Arabia. There were records on the practices of Saudis toward prenatal diagnosis (PND) and termination of pregnancy (TOP), however the sample sizes are small. This study has targeted the Saudi Arabian community and family history of genet...

journal_title：Scientific reports

authors： AbdulAzeez S,Al Qahtani NH,Almandil NB,Al-Amodi AM,Aldakeel SA,Ghanem NZ,Alkuroud DN,AlTurki A,AlQattan QA,Alghamdi A,Alhur NF,Al Taifi HA,Aljofi HE,Jermy BR,Raman V,Giambona A,Maggio A,Borgio JF

更新日期：2019-11-21 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. KCa3.1 ion channels play a critical role in TGFβ1-dependent pro-fibrotic responses in human lung myofibroblasts. We aimed to develop a human lung parenchymal model of fibrogenesis and test the efficacy of t...

journal_title：Scientific reports

authors： Roach KM,Sutcliffe A,Matthews L,Elliott G,Newby C,Amrani Y,Bradding P

更新日期：2018-01-10 00:00:00

abstract：:We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM...

journal_title：Scientific reports

authors： Xie HH,Shen H,Zhang L,Cui MY,Xia LP,Lu J

更新日期：2018-02-22 00:00:00

abstract：:Natural history collections are often plagued by missing or inaccurate metadata for collection items, particularly for specimens that are difficult to verify or rare. Avian eggshell in particular can be challenging to identify due to extensive morphological ambiguity among taxa. Species identifications can be improved...

journal_title：Scientific reports

authors： Grealy A,Langmore NE,Joseph L,Holleley CE

更新日期：2021-01-15 00:00:00

abstract：:The 28,000-year-old remains of a woolly mammoth, named 'Yuka', were found in Siberian permafrost. Here we recovered the less-damaged nucleus-like structures from the remains and visualised their dynamics in living mouse oocytes after nuclear transfer. Proteomic analyses demonstrated the presence of nuclear components ...

journal_title：Scientific reports

authors： Yamagata K,Nagai K,Miyamoto H,Anzai M,Kato H,Miyamoto K,Kurosaka S,Azuma R,Kolodeznikov II,Protopopov AV,Plotnikov VV,Kobayashi H,Kawahara-Miki R,Kono T,Uchida M,Shibata Y,Handa T,Kimura H,Hosoi Y,Mitani T,Matsumo

更新日期：2019-03-11 00:00:00

abstract：:Clinical benefit from trastuzumab and other anti-human epidermal growth factor receptor-2 (HER2) therapies in patients with HER2-positive gastric cancer (GC) remains limited by primary or acquired resistance. We aimed to investigate the impact of concomitant molecular alterations to HER2 amplification on the clinical ...

journal_title：Scientific reports

authors： Lee JY,Hong M,Kim ST,Park SH,Kang WK,Kim KM,Lee J

更新日期：2015-03-19 00:00:00

abstract：:Most Group I Clostridium botulinum strains harbor botulinum neurotoxin (bont) genes on their chromosome, while some carry these genes (including bont/a, bont/b, and bont/f) on large plasmids. Prior work in our laboratory demonstrated that Group I BoNT plasmids were mobilized to C. botulinum recipient strains containin...

journal_title：Scientific reports

authors： Nawrocki EM,Bradshaw M,Johnson EA

更新日期：2018-02-15 00:00:00

abstract：:Most traits of agricultural importance are quantitative traits controlled by numerous genes. However, it remains unclear about the molecular mechanisms underpinning quantitative traits. Here, we report the molecular characteristics of the genes controlling three quantitative traits randomly selected from three diverse...

journal_title：Scientific reports

authors： Zhang M,Liu YH,Xu W,Smith CW,Murray SC,Zhang HB

更新日期：2020-06-22 00:00:00

abstract：:Candida albicans biofilm formation is governed by a regulatory circuit comprising nine transcription factors which control a network of target genes. However, there are still unknown genes contributing to biofilm features. Thus, the GRACE library was screened to identify genes involved in mature biofilm development. T...

journal_title：Scientific reports

authors： Costa ACBP,Omran RP,Correia-Mesquita TO,Dumeaux V,Whiteway M

更新日期：2019-06-24 00:00:00

abstract：:Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date. Characteristic metabolic deregulations of HCC may enable novel biomarkers discovery for early diagnosis. A capillary electrophoresis-time of flight mass spectrometry (CE-TOF/MS)-based metabolomics approach was performed to discover and vali...

journal_title：Scientific reports

authors： Zeng J,Huang X,Zhou L,Tan Y,Hu C,Wang X,Niu J,Wang H,Lin X,Yin P

更新日期：2015-11-03 00:00:00

abstract：:The Thoroughbred horse has played an important role in both sporting and economic aspects of society since the establishment of the breed in the 1700s. The extensive pedigree and phenotypic information available for the Thoroughbred horse population provides a unique opportunity to examine the effects of 300 years of ...

journal_title：Scientific reports

authors： Todd ET,Ho SYW,Thomson PC,Ang RA,Velie BD,Hamilton NA

更新日期：2018-04-18 00:00:00

abstract：:Dysregulation of autophagy-mediated podocyte homeostasis is proposed to play a role in idiopathic membranous nephropathy (IMN). In the present study, autophagic activity and lysosomal alterations were investigated in podocytes of IMN patients and in cultured podocytes exposed to sublytic terminal complement complex, C...

journal_title：Scientific reports

authors： Liu WJ,Li ZH,Chen XC,Zhao XL,Zhong Z,Yang C,Wu HL,An N,Li WY,Liu HF

更新日期：2017-08-17 00:00:00

abstract：:Agr family includes three groups of genes, Ag1, Agr2 and Agr3, which encode the thioredoxin domain-containing secreted proteins and have been shown recently to participate in regeneration of the amputated body appendages in amphibians. By contrast, higher vertebrates have only Agr2 and Agr3, but lack Ag1, and have low...

journal_title：Scientific reports

authors： Ivanova AS,Shandarin IN,Ermakova GV,Minin AA,Tereshina MB,Zaraisky AG

更新日期：2015-01-29 00:00:00

abstract：:In the current research, to find if the combination of chitosan nerve conduits seeded with autologous bone marrow mononuclear cells (BM-MNCs) can be used to bridge 30 mm long peroneal nerve defects in goats, 15 animals were separated into BM-MNC group (n = 5), vehicle group (n = 5), and autologous nerve graft group (n...

journal_title：Scientific reports

authors： Muheremu A,Chen L,Wang X,Wei Y,Gong K,Ao Q

更新日期：2017-03-13 00:00:00

abstract：:Understanding the complex dynamics of cardio-respiratory coupling sheds light on the underlying mechanisms governing the communication between these two physiological systems. Previous research has predominantly considered the coupling at respiratory rates slower than the heart rate and shown that respiratory oscillat...

journal_title：Scientific reports

authors： Perry S,Khovanova NA,Khovanov IA

更新日期：2019-02-07 00:00:00

abstract：:We collected Solidago altissima clones to explore their leaf damage resistance, and as a result identified five accessions that exhibited variable defense abilities against the generalist herbivore Spodoptera litura. In order to characterize molecules involved in such natural variation, we focused on ethylene response...

journal_title：Scientific reports

authors： Takafuji K,Rim H,Kawauchi K,Mujiono K,Shimokawa S,Ando Y,Shiojiri K,Galis I,Arimura GI

更新日期：2020-03-24 00:00:00

abstract：:Three-dimensional (3D) spheroidal cell cultures are now recognised as better models of cancers as compared to traditional cell cultures. However, established 3D cell culturing protocols and techniques are time-consuming, manually laborious and often expensive due to the excessive consumption of reagents. Microfluidics...

journal_title：Scientific reports

authors： Khot MI,Levenstein MA,de Boer GN,Armstrong G,Maisey T,Svavarsdottir HS,Andrew H,Perry SL,Kapur N,Jayne DG

更新日期：2020-09-28 00:00:00

abstract：:Profiling immune repertoires by high throughput sequencing enhances our understanding of immune system complexity and immune-related diseases in humans. Previously, cloning and Sanger sequencing identified limited numbers of T cell receptor (TCR) nucleotide sequences in rhesus monkeys, thus their full immune repertoir...

journal_title：Scientific reports

authors： Li Z,Liu G,Tong Y,Zhang M,Xu Y,Qin L,Wang Z,Chen X,He J

更新日期：2015-05-11 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Brilha S,Ong CWM,Weksler B,Romero N,Couraud PO,Friedland JS

更新日期：2018-09-12 00:00:00

abstract：:We propose a method to accelerate small-angle scattering experiments by exploiting spatial correlation in two-dimensional data. We applied kernel density estimation to the average of a hundred short scans and evaluated noise reduction effects of kernel density estimation (smoothing). Although there is no advantage of ...

journal_title：Scientific reports

authors： Saito K,Yano M,Hino H,Shoji T,Asahara A,Morita H,Mitsumata C,Kohlbrecher J,Ono K

更新日期：2019-02-06 00:00:00

abstract：:There is a growing interest in developing microphysiological systems that can be used to model both normal and pathological human organs in vitro. This "organs-on-chips" approach aims to capture key structural and physiological characteristics of the target tissue. Here we describe in vitro vascularized microtumors (V...

journal_title：Scientific reports

authors： Sobrino A,Phan DT,Datta R,Wang X,Hachey SJ,Romero-López M,Gratton E,Lee AP,George SC,Hughes CC

更新日期：2016-08-23 00:00:00

abstract：:Jaw1/LRMP is a type II integral membrane protein that is localized at the endoplasmic reticulum (ER) and outer nuclear membrane. We previously reported that a function of Jaw1 is to maintain the nuclear shape as a KASH protein via its carboxyl terminal region, a component of linker of nucleoskeleton and cytoskeleton c...

journal_title：Scientific reports

authors： Kozono T,Sato H,Okumura W,Jogano C,Tamura-Nakano M,Kawamura YI,Rohrer J,Tonozuka T,Nishikawa A

更新日期：2021-01-12 00:00:00

abstract：:Understanding of avian nocturnal flight comes mainly from northern hemisphere species in seasonal temperate ecosystems where nocturnal flight is often precisely timed and entrained by annual photoperiod. Here we investigate patterns of nocturnal flight in waterbirds of Australian desert ecosystems that fly considerabl...

journal_title：Scientific reports

authors： McEvoy JF,Ribot RFH,Wingfield JC,Bennett ATD

更新日期：2017-12-14 00:00:00

abstract：:The airways of individuals with cystic fibrosis (CF) are abundantly colonised by Staphylococcus aureus and Pseudomonas aeruginosa. Co-infecting hypoxic regions of static mucus within CF airways, together with decreases in pulmonary function, mucus plugging and oxygen consumption by host neutrophils gives rise to regio...

journal_title：Scientific reports

authors： Pallett R,Leslie LJ,Lambert PA,Milic I,Devitt A,Marshall LJ

更新日期：2019-05-01 00:00:00

abstract：:It is estimated from twin studies that heritable factors account for at-least half of asthma-risk, of which genetic variants identified through population studies explain only a small fraction. Multi-generation large families with high asthma prevalence can serve as a model to identify highly penetrant genetic variant...

journal_title：Scientific reports

authors： Chakraborty S,Dakle P,Sinha A,Vishweswaraiah S,Nagori A,Salimath S,Prakash YS,Lodha R,Kabra SK,Ghosh B,Faruq M,Mahesh PA,Agrawal A

更新日期：2019-12-13 00:00:00

abstract：:Bony defects are a common problem in musculoskeletal surgery. Replacement with autologous bone grafts is limited by availability of transplant material. Sterilized cancellous bone, while being osteoconductive, has limited osteoinductivity. Nanofiber scaffolds are currently used for several purposes due to their capabi...

journal_title：Scientific reports

authors： Schüttler KF,Bauhofer MW,Ketter V,Giese K,Eschbach DA,Yenigün M,Fuchs-Winkelmann S,Paletta JRJ

更新日期：2020-06-12 00:00:00

abstract：:Detailed measurement of cell phenotype information from digital fluorescence images has the potential to greatly advance biomedicine in various disciplines such as patient diagnostics or drug screening. Yet, the complexity of cell conformations presents a major barrier preventing effective determination of cell bounda...

journal_title：Scientific reports

authors： Arce SH,Wu PH,Tseng Y

更新日期：2013-01-01 00:00:00

abstract：:The Late Pleistocene Campanian Ignimbrite (CI) super-eruption (Southern Italy) is the largest known volcanic event in the Mediterranean area. The CI tephra is widely dispersed through western Eurasia and occurs in close stratigraphic association with significant palaeoclimatic and Palaeolithic cultural events. Here we...

journal_title：Scientific reports

authors： Giaccio B,Hajdas I,Isaia R,Deino A,Nomade S

更新日期：2017-04-06 00:00:00

abstract：:The spinal dorsal horn (SDH) is comprised of distinct neuronal populations that process different somatosensory modalities. Somatostatin (SST)-expressing interneurons in the SDH have been implicated specifically in mediating mechanical pain. Identifying the transcriptomic profile of SST neurons could elucidate the uni...

journal_title：Scientific reports

authors： Chamessian A,Young M,Qadri Y,Berta T,Ji RR,Van de Ven T

更新日期：2018-05-01 00:00:00