Abstract：
:The prevalence of consanguineous marriage and genetic disorders are high in Saudi Arabia. There were records on the practices of Saudis toward prenatal diagnosis (PND) and termination of pregnancy (TOP), however the sample sizes are small. This study has targeted the Saudi Arabian community and family history of genetic disorders to determine the practices toward PND and TOP. The cross-sectional survey was conducted among Saudis (n = 2761) to determine their practices toward reproductive-decision making. Regression analysis was conducted to identify the association of the limiting factors, relative merits and family history on the outcomes. Total of 2507 participants returned completed questionnaire. The practice towards PND (68%) were more favorable than TOP (33%). PND was found to be a good opportunity for early diagnosis and gives parent's choice. Education, history with affected baby, prior knowledge and religious belief were significant deciding factors of PND and TOP. Down syndrome (n = 161) and sickle cell anemia (n = 152) were commonly available genetic disorder among participant's family. Respondents with autistic cases in their family have higher acceptance rate for TOP. Non-consanguineous are more willing to consider TOP than consanguineous. Participants with abnormal fetus, aged of > 36 years, married and educated Saudis were more likely consider TOP. Though, religion is the most influencing factor for not accepting TOP, comparatively willingness to PND and TOP have increased recently. Awareness campaigns about PND and TOP may increase the chances of accepting prenatal genetic diagnosis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
AbdulAzeez S,Al Qahtani NH,Almandil NB,Al-Amodi AM,Aldakeel SA,Ghanem NZ,Alkuroud DN,AlTurki A,AlQattan QA,Alghamdi A,Alhur NF,Al Taifi HA,Aljofi HE,Jermy BR,Raman V,Giambona A,Maggio A,Borgio JFdoi
10.1038/s41598-019-53655-8subject
Has Abstractpub_date
2019-11-21 00:00:00pages
17248issue
1issn
2045-2322pii
10.1038/s41598-019-53655-8journal_volume
9pub_type
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