Abstract:
:The relationship between cumulative exposure to resting heart rate (cumRHR) and mortality remain unclear in the general population. In the Kailuan cohort study, resting heart rate (RHR) was repeatedly measured at baseline and at years 2 and 4 by electrocardiogram among 47,311 adults aged 48.70 ± 11.68. The cumRHR was defined as the summed average RHR between two consecutive examinations multiplied by the time interval between with two examinations [(beats/min) * year]. A higher RHR was defined as ≥80 beats/min, and the number of visits with a higher RHR was counted. During a median of 4.06 years of follow-up, a total of 1,025 participants died. After adjusting for major traditional cardiovascular risk factors and baseline RHR, the hazard ratio for the highest versus lowest quartile of cumRHR was 1.39 (95% CI: 1.07-1.81) for all-cause mortality. Each 1-SD increment in cumRHR was associated with a 37% (HR: 1.37, 95% CI: 1.23-1.52) increased risk of death and displayed a J-shaped relationship. Compared with no exposure, adults who had a higher RHR at all 3 study visits were associated with a 1.86-fold higher risk (95% CI: 1.33-2.61) of mortality. In summary, cumulative exposure to higher RHR is independently associated with an increased risk of mortality.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhao Q,Li H,Wang A,Guo J,Yu J,Luo Y,Chen S,Tao L,Li Y,Li A,Guo X,Wu Sdoi
10.1038/srep40212subject
Has Abstractpub_date
2017-01-09 00:00:00pages
40212issn
2045-2322pii
srep40212journal_volume
7pub_type
杂志文章abstract::In the present work, we theoretically illuminate the excited state double proton transfer (ESDPT) process about a novel synthesized system 2,5-bis(benzoxazol-2-yl)thiophene-3,4-diol (BBTD). Minor changes of both structure and charge redistribution deriving from photoexcitation result in obviously different excited sta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44897
更新日期:2017-03-22 00:00:00
abstract::Five different weed plants viz. Convulvulus arvensis, Chenopodium murale, Tribulus terrestris, Trianthema portulacastrum, and Achyranthes aspera were investigated for their entomocidal and genotoxic effects against Culex quinquefasciatus mosquitoes. High mortality was observed at 72 hours in a dose dependent manner. A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63815-w
更新日期:2020-04-22 00:00:00
abstract::In this work, we demonstrate an innovative approach, combing a novel active screen plasma (ASP) technique with green chemical synthesis, for a direct fabrication of uniform Pt nanowire arrays on large-area supports. The ASP treatment enables in-situ N-doping and surface modification to the support surface, significant...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06439
更新日期:2014-09-22 00:00:00
abstract::Deoxynivalenol (DON) is one of the most abundant mycotoxins and exerts many adverse effects on humans and animals. To date, the transporting mechanism of DON in mammalian cells remains unclear. In this study, the parallel artificial membrane permeability assay (PAMPA), Transwell models and metabolic inhibitors were us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06199-8
更新日期:2017-07-19 00:00:00
abstract::Organochlorine (OC) pesticides and the more persistent polychlorinated biphenyls (PCBs) have well-established dose-dependent toxicities to birds, fish and mammals in experimental studies, but the actual impact of OC pollutants on European marine top predators remains unknown. Here we show that several cetacean species...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18573
更新日期:2016-01-14 00:00:00
abstract::A difficult problem in quantum network communications is how to efficiently transmit quantum information over large-scale networks with common channels. We propose a solution by developing a quantum encoding approach. Different quantum states are encoded into a coherent superposition state using quantum linear optics....
journal_title:Scientific reports
pub_type: 杂志文章,收录出版
doi:10.1038/srep04571
更新日期:2014-04-02 00:00:00
abstract::Gradient Mn-La-Pt catalysts with three-layered structure of manganese dioxide (MnO2), lanthanum oxide (La2O3), and Platinum (Pt) for Li-O2 battery are prepared in this study. The mass ratio of the catalysts is respectively 5:2:3, 4:2:4, and 3:2:5 (MnO2: La2O3: Pt) which is start from the side of the electrolyte. The r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34950
更新日期:2016-10-12 00:00:00
abstract::Microtubules (MTs) are long cylindrical structures of the cytoskeleton that control cell division, intracellular transport, and the shape of cells. MTs also form bundles, which are particularly prominent in neurons, where they help define axons and dendrites. MTs are bio-electrochemical transistors that form nonlinear...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30453-2
更新日期:2018-08-09 00:00:00
abstract::The focus of this study is to evaluate the efficacy of Machine Learning (ML) algorithms in the long-lead prediction of El Niño (La Niña) Modoki (ENSO Modoki) index (EMI). We evaluated two widely used non-linear ML algorithms namely Support Vector Regression (SVR) and Random Forest (RF) to forecast the EMI at various l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57183-3
更新日期:2020-01-15 00:00:00
abstract::In chickens, the sensory organs for taste are the taste buds in the oral cavity, of which there are ~240-360 in total number as estimated by scanning electron microscopy (SEM). There is not an easy way to visualize all taste buds in chickens. Here, we report a highly efficient method for labeling chicken taste buds in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37247
更新日期:2016-11-17 00:00:00
abstract::Rodents are important reservoir hosts of many important zoonotic viruses. The family Picornaviridae contains clinically important pathogens that infect humans and animals, and increasing numbers of rodent picornaviruses have recently been associated with zoonoses. We collected 574 pharyngeal and anal swab specimens fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34381
更新日期:2016-09-29 00:00:00
abstract::Whether the clinical trial treatment effect of urate-lowering therapy (ULT) in patient with chronic kidney disease (CKD) is generalizable to real-word settings is unclear. This study aimed to compare febuxostat with allopurinol for uric acid reduction and renal protection in patients with CKD. Adult CKD patients newly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67026-1
更新日期:2020-07-01 00:00:00
abstract::RNA interference has had major advances as a developing tool for pest management. In laboratory experiments, double-stranded RNA (dsRNA) is often administered to the insect by genetic modification of the crop, or synthesized in vitro and topically applied to the crop. Here, we engineered genetically modified yeast tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22587
更新日期:2016-03-02 00:00:00
abstract::The study was aimed to investigate the pathogens distribution and risk factors for PICC-related bloodstream infection in intensive care unit (ICU) patients. 402 patients placed with PICC in ICU were recruited in the study. The microbiological characteristics of PICC-related infection were investigated by Vitek 2 Compa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10037-2
更新日期:2017-11-08 00:00:00
abstract::HIV-exposed uninfected (HEU) infants are disproportionately at a higher risk of morbidity and mortality, as compared to HIV-unexposed uninfected (HUU) infants. Here, we used transcriptional profiling of peripheral blood mononuclear cells to determine immunological signatures of in utero HIV exposure. We identified 262...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54083-4
更新日期:2019-12-02 00:00:00
abstract::Birds have a remarkable ability to obtain navigational information from the Earth's magnetic field. The primary detection mechanism of this compass sense is uncertain but appears to involve the quantum spin dynamics of radical pairs formed transiently in cryptochrome proteins. We propose here a new version of the curr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09914-7
更新日期:2017-09-14 00:00:00
abstract::A growing interest in healthy eating has lead to an increase in the consumption of vegetables, associated with a rising number of bacterial outbreaks related to fresh produce. This is the case of the outbreak in Germany, caused by a O104:H4 enteroaggregative E. coli strain lysogenic for a Stx phage. Temperate Stx phag...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08169-6
更新日期:2017-08-10 00:00:00
abstract::A new electrically small antenna with size ka = 0.415 is presented, fabricated and measured in this work. This is intrinsically matched to 50 Ω, has omni-directional and linear-polarized radiation pattern in the horizontal plane with maximum directivity of 1.75 dBi and simulated radiation efficiency of 93%. The antenn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33388-w
更新日期:2018-10-09 00:00:00
abstract::Nα-acetylation is a naturally occurring irreversible modification of N-termini of proteins catalyzed by Nα-acetyltransferases (NATs). Although present in all three domains of life, it is little understood in bacteria. The functional grouping of NATs into six types NatA - NatF, in eukaryotes is based on subunit require...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28892
更新日期:2016-06-29 00:00:00
abstract::Several studies provide evidence of a link between vector-borne disease outbreaks and El Niño driven climate anomalies. Less investigated are the effects of the North Atlantic Oscillation (NAO). Here, we test its impact on outbreak occurrences of 13 infectious diseases over Europe during the last fifty years, controll...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01774
更新日期:2013-01-01 00:00:00
abstract::The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined in six subjects with motor complete (AIS B) injury at C5 or above and more than one year from time of injury. Voluntary upper limb function was evaluated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33123-5
更新日期:2018-10-19 00:00:00
abstract::Invasive alien species represent one of the major factors of global loss of biodiversity and disruption of natural ecosystems. The small Indian mongoose, Urva auropunctata, is considered one of the wild carnivore species with the greatest negative impact on global biodiversity. Understanding of the factors underpinnin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64502-6
更新日期:2020-05-04 00:00:00
abstract::Combining the advantages of structured random measurement matrix and chaotic structure, this paper introduces a color image encryption algorithm based on a structural chaotic measurement matrix and random phase mask. The Chebyshev chaotic sequence is used in the algorithm to generate the flip permutation matrix, the s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75562-z
更新日期:2020-10-29 00:00:00
abstract::Hallmarks of Retinitis Pigmentosa (RP), a family of genetic diseases, are a typical rod-cone-degeneration with initial night blindness and loss of peripheral vision, followed by decreased daylight sight and progressive visual acuity loss up to legal blindness. Great heterogeneity in nature and function of mutated gene...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06045-x
更新日期:2017-07-18 00:00:00
abstract::Adult zebrafish have the ability to regenerate cells of the central nervous system. However, few neuronal regeneration studies in adult zebrafish addressed their ability to regenerate specific types of neurons following cell specific ablation. We show here that treatment of transgenic Tg(dat:CFP-NTR) adult zebrafish w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69734-0
更新日期:2020-07-30 00:00:00
abstract::Invariant natural killer T (iNKT) cells are a specialized subset of T cells contributing to both, the innate and adaptive immune responses. In contrast to conventional T lymphocytes they recognize lipid antigens. The aim of the project is to establish a novel model system, to study iNKT-TCR - ligand interaction. An iN...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43529-4
更新日期:2019-05-15 00:00:00
abstract::The cannabinoid type 1 (CB1) receptor and the capsaicin receptor (TRPV1) exhibit co-expression and complex, but largely unknown, functional interactions in a sub-population of primary sensory neurons (PSN). We report that PSN co-expressing CB1 receptor and TRPV1 form two distinct sub-populations based on their pharmac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33307
更新日期:2016-09-22 00:00:00
abstract::Petunia × hybrida cv 'Mitchell Diploid' floral volatile benzenoid/phenylpropanoid (FVBP) biosynthesis ultimately produces floral volatiles derived sequentially from phenylalanine, cinnamic acid, and p-coumaric acid. In an attempt to better understand biochemical steps after p-coumaric acid production, we cloned and ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45183-2
更新日期:2019-06-20 00:00:00
abstract::We report the control of imazalil (IMZ) antifungal activity utilizing its non-covalent assembly with β-cyclodextrins (β-CD) and cucurbit[8]uril (CB8) macrocycles, as well as its stimuli-responsive disassembly with cadaverine. The NMR results are consistent with inclusion of a single IMZ molecule inside the cavities of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21156-9
更新日期:2018-02-12 00:00:00
abstract::The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32350
更新日期:2016-08-30 00:00:00