The microbiological characteristics and risk factors for PICC-related bloodstream infections in intensive care unit.

abstract：:The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilize...

journal_title：Scientific reports

authors： Stasyuk E,Sкuridin V,Rogov A,Zelchan R,Sadkin V,Varlamova N,Nestеrov E

更新日期：2020-03-20 00:00:00

abstract：:Obesity and inactivity are major risk factors of feline diabetes mellitus (FDM) and human type II diabetes mellitus (T2DM). In recent years, changes in the gut microbiota have been suggested as a contributing factor to T2DM. Whether the gut microbiota (GM) composition plays a role in FDM remains unknown. The aim of th...

journal_title：Scientific reports

authors： Kieler IN,Osto M,Hugentobler L,Puetz L,Gilbert MTP,Hansen T,Pedersen O,Reusch CE,Zini E,Lutz TA,Bjørnvad CR

更新日期：2019-03-18 00:00:00

abstract：:The microwave properties of nano-scale structures are important in a wide variety of applications in quantum technology. Here we describe a low-power cryogenic near-field scanning microwave microscope (NSMM) which maintains nano-scale dielectric contrast down to the single microwave photon regime, up to 109 times lowe...

journal_title：Scientific reports

authors： Geaney S,Cox D,Hönigl-Decrinis T,Shaikhaidarov R,Kubatkin SE,Lindström T,Danilov AV,de Graaf SE

更新日期：2019-08-29 00:00:00

abstract：:Glycoprotein nonmetastatic melanoma protein B (GPNMB) plays important roles in various types of cancer and amyotrophic lateral sclerosis (ALS). The details of GPNMB function and its interacting protein have not been clarified. Therefore, to identify GPNMB binding partners on the cell membrane, we used membrane protein...

journal_title：Scientific reports

authors： Ono Y,Tsuruma K,Takata M,Shimazawa M,Hara H

更新日期：2016-03-18 00:00:00

abstract：:Obesity is one of the major risk factor for cardiovascular and metabolic diseases. A disproportional accumulation of fat at visceral (VAT) compared to subcutaneous sites (SAT) has been suspected as a key detrimental event. We used non-targeted metabolomics profiling to reveal metabolic pathways associated with higher ...

journal_title：Scientific reports

authors： Otto L,Budde K,Kastenmüller G,Kaul A,Völker U,Völzke H,Adamski J,Kühn JP,Krumsiek J,Artati A,Nauck M,Friedrich N,Pietzner M

更新日期：2020-01-30 00:00:00

abstract：:Short chain fatty acids (SCFAs) produced by intestinal microbes mediate anti-inflammatory effects, but whether they impact on antimicrobial host defenses remains largely unknown. This is of particular concern in light of the attractiveness of developing SCFA-mediated therapies and considering that SCFAs work as inhibi...

journal_title：Scientific reports

authors： Ciarlo E,Heinonen T,Herderschee J,Fenwick C,Mombelli M,Le Roy D,Roger T

更新日期：2016-11-29 00:00:00

abstract：:Intestinal injury and immune dysfunction are commonly encountered after irradiation therapy. While the curative abilities of ginseng root have been reported in prior studies, there is little known regarding its role in immunoregulation of intestinal repairability in cancer patients treated with irradiation. Our curren...

journal_title：Scientific reports

authors： He LX,Zhang ZF,Zhao J,Li L,Xu T,Bin Sun,Ren JW,Liu R,Chen QH,Wang JB,Salem MM,Pettinato G,Zhou JR,Li Y

更新日期：2018-09-17 00:00:00

abstract：:Manual anthropometrics are used extensively in medical practice and epidemiological studies to assess an individual's health. However, traditional techniques reduce the complicated shape of human bodies to a series of simple size measurements and derived health indices, such as the body mass index (BMI), the waist-hip...

journal_title：Scientific reports

authors： Thelwell M,Chiu CY,Bullas A,Hart J,Wheat J,Choppin S

更新日期：2020-07-22 00:00:00

abstract：:Aluminum-based quasicrystals typically form across narrow composition ranges within binary to quaternary alloys, which makes their fabrication and characterization challenging. Here, we use combinatorial approaches together with fast characterization techniques to study a wide compositional range including known quasi...

journal_title：Scientific reports

authors： Wolf W,Kube SA,Sohn S,Xie Y,Cha JJ,Scanley BE,Kiminami CS,Bolfarini C,Botta WJ,Schroers J

更新日期：2019-05-09 00:00:00

abstract：:Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (VHHs) to the N-terminus of a human collagen XVIII trimerization domain (TIE(XVIII)) we produced monospecific...

journal_title：Scientific reports

authors： Alvarez-Cienfuegos A,Nuñez-Prado N,Compte M,Cuesta AM,Blanco-Toribio A,Harwood SL,Villate M,Merino N,Bonet J,Navarro R,Muñoz-Briones C,Sørensen KM,Mølgaard K,Oliva B,Sanz L,Blanco FJ,Alvarez-Vallina L

更新日期：2016-06-27 00:00:00

abstract：:Epidemiological knowledge of pediatric diseases may improve professionals' understanding of the pathophysiology of and risk factors for diseases and is also crucial for decision making related to workforce and resource planning in pediatric departments. In this study, a pediatric disease epidemiology knowledgebase cal...

journal_title：Scientific reports

authors： Li H,Yu G,Dong C,Jia Z,An J,Duan H,Shu Q

更新日期：2019-11-28 00:00:00

abstract：:Very little is known about how fimbriae of Bacteroidetes bacteria are assembled. To shed more light on this process, we solved the crystal structures of the shaft protein Mfa1, the regulatory protein Mfa2, and the tip protein Mfa3 from the periodontal pathogen Porphyromonas gingivalis. Together these build up part of ...

journal_title：Scientific reports

authors： Hall M,Hasegawa Y,Yoshimura F,Persson K

更新日期：2018-01-29 00:00:00

abstract：:The inactivation of pathogens in liquids has broad applications, ranging from water disinfection to food pasteurization. However, common cell inactivation methods (e.g., chlorination, ultraviolet radiation and thermal treatment) have significant drawbacks such as carcinogenic byproduct formation, energy intensiveness ...

journal_title：Scientific reports

authors： Huo ZY,Li GQ,Yu T,Feng C,Lu Y,Wu YH,Yu C,Xie X,Hu HY

更新日期：2018-10-25 00:00:00

abstract：:Coccolithophores are single-celled photosynthesizing marine algae, responsible for half of the calcification in the surface ocean, and exert a strong influence on the distribution of carbon among global reservoirs, and thus Earth's climate. Calcification in the surface ocean decreases the buffering capacity of seawate...

journal_title：Scientific reports

authors： McClelland HL,Barbarin N,Beaufort L,Hermoso M,Ferretti P,Greaves M,Rickaby RE

更新日期：2016-09-28 00:00:00

abstract：:The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory properties of cancer cells. To address this question, we experimentally me...

journal_title：Scientific reports

authors： Nair NU,Das A,Rogkoti VM,Fokkelman M,Marcotte R,de Jong CG,Koedoot E,Lee JS,Meilijson I,Hannenhalli S,Neel BG,de Water BV,Le Dévédec SE,Ruppin E

更新日期：2019-07-29 00:00:00

abstract：:Hydrogen sulfide (H2S) signaling has been considered a key regulator of plant developmental processes and defenses. In this study, we demonstrate that high levels of H2S inhibit auxin transport and lead to alterations in root system development. H2S inhibits auxin transport by altering the polar subcellular distributi...

journal_title：Scientific reports

authors： Jia H,Hu Y,Fan T,Li J

更新日期：2015-02-05 00:00:00

abstract：:Even after years of experiencing malaria, caused by infection with Plasmodium species, individuals still have incomplete immunity and develop low-density parasitemia on re-infection. Previous studies using the P. chabaudi (Pch) mouse model to understand the reason for chronic malaria, found that mice with a deletion o...

journal_title：Scientific reports

authors： Horne-Debets JM,Karunarathne DS,Faleiro RJ,Poh CM,Renia L,Wykes MN

更新日期：2016-05-24 00:00:00

abstract：:Most of the artificial low-pressure plasmas contact with physical walls in laboratories; the plasma loss at the wall significantly affects the plasma device performance, e.g., an electric propulsion device. Near the surface of the wall, ions are spontaneously accelerated by a sheath and deliver their momentum and ener...

journal_title：Scientific reports

authors： Takahashi K,Sugawara T,Ando A

更新日期：2020-01-23 00:00:00

abstract：:The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. We have shown previously that neuronal S1P accumulation is toxic leading to ER-stress and an increase in intracellular calcium. To clarify the neuronal function of S1P, we generated br...

journal_title：Scientific reports

authors： Mitroi DN,Deutschmann AU,Raucamp M,Karunakaran I,Glebov K,Hans M,Walter J,Saba J,Gräler M,Ehninger D,Sopova E,Shupliakov O,Swandulla D,van Echten-Deckert G

更新日期：2016-11-24 00:00:00

abstract：:The association of seasonal trivalent influenza vaccine (TIV) with increased infection by 2009 pandemic H1N1 (A(H1N1)pdm09) virus, initially observed in Canada, has elicited numerous investigations on the possibility of vaccine-associated enhanced disease, but the potential mechanisms remain largely unresolved. Here, ...

journal_title：Scientific reports

authors： Kim JH,Reber AJ,Kumar A,Ramos P,Sica G,Music N,Guo Z,Mishina M,Stevens J,York IA,Jacob J,Sambhara S

更新日期：2016-11-16 00:00:00

abstract：:Studies have demonstrated that inflammatory bowel disease (IBD) patients are at an increased risk of developing anxiety and/or depression. IBD patients with depression/anxiety have higher rates of hospitalization and increased disease severity than those without. So far, there is a paucity of data concerning the impac...

journal_title：Scientific reports

authors： Gao X,Tang Y,Lei N,Luo Y,Chen P,Liang C,Duan S,Zhang Y

更新日期：2021-01-14 00:00:00

abstract：:Therapies that target the signal transduction and metabolic pathways of cancer stem cells (CSCs) are innovative strategies to effectively reduce the recurrence and significantly improve the outcome of glioblastoma multiforme (GBM). CSCs exhibit an increased rate of glycolysis, thus rendering them intrinsically more se...

journal_title：Scientific reports

authors： Daniele S,Giacomelli C,Zappelli E,Granchi C,Trincavelli ML,Minutolo F,Martini C

更新日期：2015-10-23 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) patients have poor prognosis and poor response to treatment. This is largely due to PDAC being associated with a dense and active stroma and tumor fibrosis (desmoplasia). Desmoplasia is characterized by excessive degradation and formation of the extracellular matrix (ECM) genera...

journal_title：Scientific reports

authors： Willumsen N,Ali SM,Leitzel K,Drabick JJ,Yee N,Polimera HV,Nagabhairu V,Krecko L,Ali A,Maddukuri A,Moku P,Ali A,Poulose J,Menon H,Pancholy N,Costa L,Karsdal MA,Lipton A

更新日期：2019-12-24 00:00:00

abstract：:Marigold (Tagetes erecta L.) is an important ornamental plant with a wide variety of flower colors. Despite its economic value, few biochemical and molecular studies have explored the generation of flower color in this species. To study the mechanism underlying marigold petal color, we performed a metabolite analysis ...

journal_title：Scientific reports

authors： Zhang H,Zhang S,Zhang H,Chen X,Liang F,Qin H,Zhang Y,Cong R,Xin H,Zhang Z

更新日期：2020-10-08 00:00:00

abstract：:Congenital cataract is the most frequent inherited ocular disorder and the most leading cause of lifelong visual loss. The screening of pathogenic mutations can be very challenging in some cases, for congenital cataracts are clinically and genetically heterogeneous diseases. The aim of this study is to investigate the...

journal_title：Scientific reports

authors： Zhai Y,Li J,Yu W,Zhu S,Yu Y,Wu M,Sun G,Gong X,Yao K

更新日期：2017-04-27 00:00:00

abstract：:Solar thermoelectric generators (STEGs), which are used for various applications, (particularly small size electronic devices), have optical concentration systems for high energy conversion efficiency. In this study, a refraction-assisted STEG (R-STEG) is designed based on phase-change materials. As the phase-change m...

journal_title：Scientific reports

authors： Kim MS,Kim MK,Jo SE,Joo C,Kim YJ

更新日期：2016-06-10 00:00:00

abstract：:NETs constitute a network of DNA and proteins released by neutrophils in response to infectious and immunologic triggers. NET proteins are recognized as autoantigens in ANCA vasculitis; limited knowledge is available in other autoimmune pathologies. The composition of NETs produced ex vivo by resting and Phorbol-myris...

journal_title：Scientific reports

authors： Bruschi M,Petretto A,Santucci L,Vaglio A,Pratesi F,Migliorini P,Bertelli R,Lavarello C,Bartolucci M,Candiano G,Prunotto M,Ghiggeri GM

更新日期：2019-05-28 00:00:00

abstract：:The melting of glaciers and ice sheets is nowadays considered a symbol of climate change. Many complex mechanisms are involved in the melting of ice, and, among these processes, surface darkening due to organic material on bare ice has recently received attention from the scientific community. The presence of microbes...

journal_title：Scientific reports

authors： Di Mauro B,Garzonio R,Baccolo G,Franzetti A,Pittino F,Leoni B,Remias D,Colombo R,Rossini M

更新日期：2020-03-16 00:00:00

abstract：:Helicobacter pylori cagA-positive strain delivers the CagA oncoprotein into gastric epithelial cells and at the same time elicits stomach inflammation. To experimentally investigate the pathophysiological interplay between CagA and inflammation, transgenic mice systemically expressing the bacterial cagA gene were trea...

journal_title：Scientific reports

authors： Suzuki N,Murata-Kamiya N,Yanagiya K,Suda W,Hattori M,Kanda H,Bingo A,Fujii Y,Maeda S,Koike K,Hatakeyama M

更新日期：2015-05-06 00:00:00

abstract：:Ice-albedo feedback due to the albedo contrast between water and ice is a major factor in seasonal sea ice retreat, and has received increasing attention with the Arctic Ocean shifting to a seasonal ice cover. However, quantitative evaluation of such feedbacks is still insufficient. Here we provide quantitative eviden...

journal_title：Scientific reports

authors： Kashiwase H,Ohshima KI,Nihashi S,Eicken H

更新日期：2017-08-15 00:00:00