Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains.

abstract：:H5N1 highly pathogenic avian influenza virus (HPAIV) poses a huge threat to public health and the global economy. These viruses cause systemic infection in poultry and accidental human infection leads to severe pneumonia, associated with high mortality rates. The hemagglutinin (HA) of H5N1 HPAIV possesses multiple bas...

journal_title：Scientific reports

authors： Kajiwara N,Nomura N,Ukaji M,Yamamoto N,Kohara M,Yasui F,Sakoda Y,Kida H,Shibasaki F

更新日期：2020-10-22 00:00:00

abstract：:The fluorination of p-type metal phthalocyanines produces n-type semiconductors, allowing the design of organic electronic circuits that contain inexpensive heterojunctions made from chemically and thermally stable p- and n-type organic semiconductors. For the evaluation of close to intrinsic transport properties, hig...

journal_title：Scientific reports

authors： Jiang H,Ye J,Hu P,Wei F,Du K,Wang N,Ba T,Feng S,Kloc C

更新日期：2014-12-19 00:00:00

abstract：:While neurofilament light chain (NfL) measurement in serum is a well-established marker of neuroaxonal damage in multiple sclerosis (MS), data on astroglial markers in serum are missing. In our study, glial fibrillary acid protein (GFAP) and NfL were measured in cerebrospinal fluid (CSF) and serum of MS patients and p...

journal_title：Scientific reports

authors： Abdelhak A,Huss A,Kassubek J,Tumani H,Otto M

更新日期：2018-10-04 00:00:00

abstract：:The two most common techniques for absolute protein quantification are based on either mass spectrometry (MS) or on immunochemical techniques, such as western blotting (WB). Western blotting is most often used for protein identification or relative quantification, but can also be deployed for absolute quantification i...

journal_title：Scientific reports

authors： Bennett RJ,Simpson DM,Holman SW,Ryan S,Brownridge P,Eyers CE,Colyer J,Beynon RJ

更新日期：2017-04-03 00:00:00

abstract：:Embryonic cryopreservation has a relatively low survival rate because of cytoskeletal damage. However, molecular anti-freezing mechanisms have been largely unexplored. This study investigated the significance of RhoA, involved in embryonic development, and the Rho/RhoA-associated kinase (ROCK) signalling pathway in cr...

journal_title：Scientific reports

authors： Gu M,Ni H,Sheng X,Pauciullo A,Liu Y,Guo Y

更新日期：2017-07-27 00:00:00

abstract：:We studied whether in patients with stable COPD blood gases (BG), especially oxygenated hemoglobin (OxyHem) as a novel biomarker confer information on disease burden and prognosis and how this adds to the information provided by the comorbidity pattern and systemic inflammation. Data from 2137 patients (GOLD grades 1-...

journal_title：Scientific reports

authors： Trudzinski FC,Jörres RA,Alter P,Kahnert K,Waschki B,Herr C,Kellerer C,Omlor A,Vogelmeier CF,Fähndrich S,Watz H,Welte T,Jany B,Söhler S,Biertz F,Herth F,Kauczor HU,Bals R,COSYCONET consortium.

更新日期：2020-06-29 00:00:00

abstract：:Fourier ptychographic microscopy (FPM) is a novel computational coherent imaging technique for high space-bandwidth product imaging. Mathematically, Fourier ptychographic (FP) reconstruction can be implemented as a phase retrieval optimization process, in which we only obtain low resolution intensity images correspond...

journal_title：Scientific reports

authors： Bian L,Suo J,Chung J,Ou X,Yang C,Chen F,Dai Q

更新日期：2016-06-10 00:00:00

abstract：:Ankle arthrodesis with the Ilizarov method is an accepted form of treatment of advanced degenerative changes of the ankle joint. Incorrect balance and load distribution on the lower limbs may result in pain and dysfunction. The aim of the study was to assess the change of balance and load distribution in lower extremi...

journal_title：Scientific reports

authors： Morasiewicz P,Konieczny G,Dejnek M,Urbański W,Dragan SŁ,Kulej M,Dragan SF,Pawik Ł

更新日期：2018-10-24 00:00:00

abstract：:Multidimensional correlation magnetic resonance imaging (MRI) is an emerging imaging modality that is capable of disentangling highly heterogeneous and opaque systems according to chemical and physical interactions of water within them. Using this approach, the conventional three dimensional MR scalar images are repla...

journal_title：Scientific reports

authors： Pas K,Komlosh ME,Perl DP,Basser PJ,Benjamini D

更新日期：2020-02-24 00:00:00

abstract：:Antenna systems serve to absorb light and to transmit excitation energy to the reaction center (RC) in photosynthetic organisms. As the emitted (bacterio)chlorophyll fluorescence competes with the photochemical utilization of the excitation, the measured fluorescence yield is informed by the migration of the excitatio...

journal_title：Scientific reports

authors： Maróti P,Kovács IA,Kis M,Smart JL,Iglói F

更新日期：2020-08-19 00:00:00

abstract：:Extreme weather events and pest outbreaks decrease rice yields and increase their variability, presenting challenges for the agricultural agenda to increase rice productivity and yield stability in Asia. The integration of azolla, fish and ducks has been shown to create robust systems that maintain high yields under h...

journal_title：Scientific reports

authors： Khumairoh U,Lantinga EA,Schulte RPO,Suprayogo D,Groot JCJ

更新日期：2018-10-03 00:00:00

abstract：:A functional genetic switch from the lactococcal bacteriophage TP901-1, deciding which of two divergently transcribing promoters becomes most active and allows this bi-stable decision to be inherited in future generations requires a DNA region of less than 1 kb. The fragment encodes two repressors, CI and MOR, transcr...

journal_title：Scientific reports

authors： Pedersen M,Neergaard JT,Cassias J,Rasmussen KK,Lo Leggio L,Sneppen K,Hammer K,Kilstrup M

更新日期：2020-05-26 00:00:00

abstract：:The goal of the current study was to develop an asymmetric guided bone regeneration (GBR) membrane benefiting from curcumin and aspirin. The membrane was prepared using electrospinning technique and then was physic-chemically characterized by the conventional methods. The release profile of aspirin from the prepared m...

journal_title：Scientific reports

authors： Ghavimi MA,Bani Shahabadi A,Jarolmasjed S,Memar MY,Maleki Dizaj S,Sharifi S

更新日期：2020-10-23 00:00:00

abstract：:The aberrant expression of human sodium iodide symporter (NIS) in breast cancer (BC) has raised the possibility of using targeted radioiodide therapy. Here we investigate modulation of endogenous, functional NIS expression by histone deacetylase inhibitors (HDACi) in vitro and in vivo. Luciferase reporter based initia...

journal_title：Scientific reports

authors： Kelkar MG,Senthilkumar K,Jadhav S,Gupta S,Ahn BC,De A

更新日期：2016-01-18 00:00:00

abstract：:For translocated animals, behavioral competence may be key to post-release survival. However, monitoring behavior is typically limited to tracking movements or inferring behavior at a gross scale via collar-mounted sensors. Animal-bourne acoustic monitoring may provide a unique opportunity to monitor behavior at a fin...

journal_title：Scientific reports

authors： Yan X,Zhang H,Li D,Wu D,Zhou S,Sun M,Hu H,Liu X,Mou S,He S,Owen MA,Huang Y

更新日期：2019-03-26 00:00:00

abstract：:It is generally assumed that an investment into cognitive abilities and their associated cost is particularly beneficial for long-lived species, as a prolonged lifespan allows to recoup the initial investment. However, ephemeral organisms possess astonishing cognitive abilities too. Invertebrates, for example, are cap...

journal_title：Scientific reports

authors： Liedtke J,Fromhage L

更新日期：2019-10-23 00:00:00

abstract：:We report the synthesis of single-crystal iron germanium nanowires via chemical vapor deposition without the assistance of any catalysts. The assembly of single-crystal FeGe2 nanowires with tetragonal C16 crystal structure shows anisotropic magnetic behavior along the radial direction or the growth axial direction, wi...

journal_title：Scientific reports

authors： Tang S,Kravchenko I,Ward TZ,Zou Q,Yi J,Ma C,Chi M,Cao G,Li AP,Mandrus D,Gai Z

更新日期：2017-08-02 00:00:00

abstract：:Phosphorus (P) is a non-renewable resource which may be depleted within next few decades; hence high P use efficiency is need of time. Plants have evolved an array of adaptive mechanisms to enhance external P acquisition and reprioritize internal utilization under P deficiency. Tissue specific biomass and P allocation...

journal_title：Scientific reports

authors： Irfan M,Aziz T,Maqsood MA,Bilal HM,Siddique KHM,Xu M

更新日期：2020-03-09 00:00:00

abstract：:Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V). Several lines of evidence suggest that tanycytes may be involved in the regulation of energy homeostasis...

journal_title：Scientific reports

authors： Uranga RM,Millán C,Barahona MJ,Recabal A,Salgado M,Martinez F,Ordenes P,Elizondo-Vega R,Sepúlveda F,Uribe E,García-Robles MLÁ

更新日期：2017-06-16 00:00:00

abstract：:The pine wood nematode, Bursaphelenchus xylophilus, is the causal agent of pine wilt disease that has devastated pine forests in Asia. Parasitic nematodes are known to have evolved antioxidant stress responses that defend against host plant defenses. In this study, the infestation of whitebark pine, Pinus bungean, wit...

journal_title：Scientific reports

authors： Li Z,Zhang Q,Zhou X

更新日期：2016-06-07 00:00:00

abstract：:Negative hemodynamic response has been widely reported in blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging studies, however its origin is still controversial. Optical intrinsic signal (OIS) imaging can be used to study brain activity by simultaneously recording hemodynamic signals at diff...

journal_title：Scientific reports

authors： Ma Z,Cao P,Sun P,Zhao L,Li L,Tong S,Lu Y,Yan Y,Chen Y,Chai X

更新日期：2016-02-10 00:00:00

abstract：:In this report, a facile and effective one-pot oxidation-assisted dealloying protocol has been developed to massively synthesize monolithic core-shell architectured nanoporous copper@cuprous oxide nanonetworks (C-S NPC@Cu2O NNs) by chemical dealloying of melt-spun Al 37 at.% Cu alloy in an oxygen-rich alkaline solutio...

journal_title：Scientific reports

authors： Liu W,Chen L,Dong X,Yan J,Li N,Shi S,Zhang S

更新日期：2016-11-10 00:00:00

abstract：:Transfer printing, a two-step process (i.e. picking up and printing) for heterogeneous integration, has been widely exploited for the fabrication of functional electronics system. To ensure a reliable process, strong adhesion for picking up and weak or no adhesion for printing are required. However, it is challenging ...

journal_title：Scientific reports

authors： Sim K,Chen S,Li Y,Kammoun M,Peng Y,Xu M,Gao Y,Song J,Zhang Y,Ardebili H,Yu C

更新日期：2015-11-10 00:00:00

abstract：:BNip1, which functions as a t-SNARE component of the syntaxin18 complex, is localized on the ER membrane and regulates retrograde transport from Golgi to the ER. BNip1 also has a BH3 domain, which generally releases pro-apoptotic proteins from Bcl2-mediated inhibition. Previously we reported that retinal photoreceptor...

journal_title：Scientific reports

authors： Nishiwaki Y,Masai I

更新日期：2020-10-15 00:00:00

abstract：:The D40 gene encodes a kinetochore protein that plays an essential role in kinetochore formation during mitosis. Short inhibitory RNA against D40, D40 siRNA, has been shown to deplete the D40 protein in the human cancer cell line HeLa, which harbors wild-type p53, and this activity was followed by the significant inhi...

journal_title：Scientific reports

authors： Urata YN,Takeshita F,Tanaka H,Ochiya T,Takimoto M

更新日期：2015-09-08 00:00:00

abstract：:The success of mesenchymal stem cell transplantation is highly dependent on their survival and controlled fate regulation. This study demonstrates that dual-delivery of connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) from a core-shell fiber of Silk Fibroin/poly(L-lactic acid-co-ε-caprolac...

journal_title：Scientific reports

authors： Xu R,Zhao H,Muhammad H,Dong M,Besenbacher F,Chen M

更新日期：2017-08-17 00:00:00

abstract：:Diabetic nephropathy, the major cause of chronic kidney disease, is associated with progressive renal fibrosis. Recently, accumulation of periostin, an extracellular matrix protein, was shown to augment renal fibrosis. Aptamers have higher binding affinities without developing the common side effects of antibodies. Th...

journal_title：Scientific reports

authors： Um JE,Park JT,Nam BY,Lee JP,Jung JH,Kim Y,Kim S,Park J,Wu M,Han SH,Yoo TH,Kang SW

更新日期：2017-08-17 00:00:00

abstract：:The innate and adaptive immune systems fail to control HCV infection in the majority of infected individuals. HCV is an ssRNA virus, which suggests a role for Toll-like receptors (TLRs) 7 and 8 in initiating the anti-viral response. Here we demonstrate that HCV genomic RNA harbours specific sequences that initiate an ...

journal_title：Scientific reports

authors： Zhang Y,El-Far M,Dupuy FP,Abdel-Hakeem MS,He Z,Procopio FA,Shi Y,Haddad EK,Ancuta P,Sekaly RP,Said EA

更新日期：2016-07-07 00:00:00

abstract：:In this work, cerium-diethyldithiocarbamate (Ce-DEDTC) complex was synthesized as a novel anti-corrosion pigment. The structure of the synthesized pigment was characterized by employing Fourier transfer infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, inductively coupled plasma optical emission sp...

journal_title：Scientific reports

authors： Mohammadi I,Shahrabi T,Mahdavian M,Izadi M

更新日期：2020-03-19 00:00:00

abstract：:Case-control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, regardless of their onset age. Therefore, we used an event-history with risk-free model to simultaneously chara...

journal_title：Scientific reports

authors： Yang HC,Chen IC,Tsay YC,Li ZR,Chen CH,Hwu HG,Chen CH

更新日期：2017-05-16 00:00:00