Abstract：
:The goal of the current study was to develop an asymmetric guided bone regeneration (GBR) membrane benefiting from curcumin and aspirin. The membrane was prepared using electrospinning technique and then was physic-chemically characterized by the conventional methods. The release profile of aspirin from the prepared membrane was also measured by ultraviolet spectrophotometry. Also, the antibacterial activities of the membrane was evaluated. We also assessed the in vitro effects of the prepared membrane on the biocompatibility and osteogenic differentiation of dental pulp stem cells (DPSCs), and evaluated in vivo bone regeneration using the prepared membrane in the defects created in both sides of the dog's jaw by histology. The results from the characterization specified that the membrane was successfully prepared with monodispersed nanosized fibers, uniform network shaped morphology, negative surface charge and sustained release platform for aspirin. The membrane also showed antimicrobial effects against all tested bacteria. The presence of curcumin and aspirin in the asymmetric membrane enhanced osteogenic potential at both transcriptional and translational levels. The results of the animal test showed that the test area was completely filled with new bone after just 28 days, while the commercial membrane area remained empty. There was also a soft tissue layer above the new bone area in the test side. We suggested that the prepared membrane in this work could be used as a GBR membrane to keep soft tissue from occupying bone defects in GBR surgeries. Besides, the surgeries can be benefited from antibacterial activities and bone healing effects of this novel GBR membrane while, simultaneously, promoting bone regeneration.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ghavimi MA,Bani Shahabadi A,Jarolmasjed S,Memar MY,Maleki Dizaj S,Sharifi Sdoi
10.1038/s41598-020-75454-2subject
Has Abstractpub_date
2020-10-23 00:00:00pages
18200issue
1issn
2045-2322pii
10.1038/s41598-020-75454-2journal_volume
10pub_type
杂志文章abstract：:Numerous studies have reported cold atmospheric plasma cytotoxic activities in various cancer cell lines, either by direct exposure to non-thermal plasma or indirectly by activating a medium (plasma-activated medium, PAM) prior to cell treatment. We suggested the use of in vitro 3D tumor model spheroids to determine t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41408-6
更新日期：2019-03-19 00:00:00
abstract：:Despite recent advances in melanoma treatment, metastasis and resistance to therapy remain serious clinical challenges. NME1 is a metastasis suppressor, a class of proteins which inhibits metastatic spread of cancer cells without impact on growth of the primary tumor. We have identified a rare subpopulation of cells w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58996-3
更新日期：2020-02-06 00:00:00
abstract：:Despite well-established sex differences for cognition, audition, and somatosensation, few studies have investigated whether there are also sex differences in visual perception. We report the results of fifteen perceptual measures (such as visual acuity, visual backward masking, contrast detection threshold or motion ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25298-8
更新日期：2018-05-14 00:00:00
abstract：:The ability to convert photons of different wavelengths directly into mechanical motion is of significant interest in many energy conversion and reconfigurable technologies. Here, using few layer 2H-MoS2 nanosheets, layer by layer process of nanocomposite fabrication, and strain engineering, we demonstrate a reversibl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34831
更新日期：2016-10-07 00:00:00
abstract：:Manganese has long been employed as a T1-shortening agent in magnetic resonance imaging (MRI) applications, but these techniques are limited by the biotoxicity of bulk-manganese. Positron emission tomography (PET) offers superior contrast sensitivity compared with MRI, and recent preclinical PET studies employing 52gM...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03202-0
更新日期：2017-06-08 00:00:00
abstract：:The vertebrate gut is host to large communities of bacteria, and one of the beneficial contributions of this commensal gut microbiota is the increased nutritional gain from feed components that the host cannot degrade on its own. Fish larvae of similar age and under the same rearing conditions often diverge with regar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21192
更新日期：2016-02-15 00:00:00
abstract：:During development sex differences in aromatase expression in limbic regions of mouse brain depend on sex chromosome factors. Genes on the sex chromosomes may affect the hormonal regulation of aromatase expression and this study was undertaken to explore that possibility. Male E15 anterior amygdala neuronal cultures e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05658-6
更新日期：2017-07-13 00:00:00
abstract：:Malignant peripheral nerve sheath tumors (MPNST) are aggressive cancers that occur spontaneously (sporadic MPNST) or from benign plexiform neurofibromas in neurofibromatosis type 1 (NF1) patients. MPNSTs metastasize easily, are therapy resistant and are frequently fatal. The molecular changes underlying the malignant ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59789-4
更新日期：2020-02-19 00:00:00
abstract：:Patients with end stage renal disease (ESRD) suffer high mortality from arrhythmias linked to fibrosis, but are contraindicated to late gadolinium enhancement magnetic resonance imaging (MRI). We present a quantitative method for gadolinium-free cardiac fibrosis imaging using magnetization transfer (MT) weighted MRI, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35394-4
更新日期：2018-11-19 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-74970-5
更新日期：2020-10-21 00:00:00
abstract：:The present study shows the thorough investigations on optical properties and hydrodynamic diameters of glutathione (GSH) stabilized nanosilver clusters (AgNC) at different stages of synthesis and engineering for the optimized absolute quantum yield to generate fluorescent images of Dalton Lymphoma Ascites (DLA) tumou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34843-4
更新日期：2018-11-07 00:00:00
abstract：:Substance P (SP) has been implicated in major depressive disorder (MDD), with SP antagonists being studied as potential antidepressants. Although impaired neural plasticity is considered a key mechanism in MDD pathophysiology, the association between SP and brain structural changes in depression has not been investiga...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10100-y
更新日期：2017-08-29 00:00:00
abstract：:Partial suppression of the spectral diffusion of quantum dot (QD) excitons tuned to resonance of a nano-photonic cavity is reported. The suppression is caused by the Purcell enhancement of the QD-exciton recombination rate, which alters the rate of charging of the solid-state environment by the QD itself. The effect c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37677-2
更新日期：2019-02-04 00:00:00
abstract：:Agrostemma githago L. (corn cockle) is an herbaceous plant mainly growing in Europe. The seeds of the corn cockle are toxic and poisonings were widespread in the past by consuming contaminated flour. The toxic principle of Agrostemma seeds was attributed to triterpenoid secondary metabolites. Indeed, this is in part t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72282-2
更新日期：2020-09-21 00:00:00
abstract：:Cohesins are vital for chromosome organisation during meiosis and mitosis. In addition to the important function in sister chromatid cohesion, these complexes play key roles in meiotic recombination, DSB repair, homologous chromosome pairing and segregation. Egg-laying mammals (monotremes) feature an unusually complex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04560-5
更新日期：2017-06-26 00:00:00
abstract：:Recombinant human erythropoietin (rHuEPO) is a biopharmaceutical drug given to patients who have a low hemoglobin related to chronic kidney disease, cancer or anemia. However, some patients repeatedly receiving rHuEPO develop anti-rHuEPO neutralizing antibodies leading to the development of pure red cell aplasia (PRCA...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80402-1
更新日期：2021-01-15 00:00:00
abstract：:Prenatal stress is known to epigenetically program offspring physiology and behaviour, and may become a risk factor for adult complex diseases. To gain insight into the underlying environment-gene interactions, we used proton nuclear magnetic resonance spectroscopy to analyze urinary metabolomes of male and female ado...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-31230-x
更新日期：2018-08-28 00:00:00
abstract：:A method is proposed to drive an ultrafast non-adiabatic dynamics of an ultracold gas trapped in a time-dependent box potential. The resulting state is free from spurious excitations associated with the breakdown of adiabaticity, and preserves the quantum correlations of the initial state up to a scaling factor. The p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00648
更新日期：2012-01-01 00:00:00
abstract：:To determine whether regular cervical dilatation is effective for preventing cervical stenosis, and to identify the associated risk factors, in postmenopausal women after LEEP. This was a prospective randomized clinical trial in postmenopausal women who underwent LEEP at our hospital between August 2018 and May 2019. ...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-65170-2
更新日期：2020-05-22 00:00:00
abstract：:Nonstoichiometric silicon nitride SiNx is a promising material for developing a new generation of high-speed, reliable flash memory device based on the resistive effect. The advantage of silicon nitride over other dielectrics is its compatibility with the silicon technology. In the present work, a silicon nitride-base...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82159-7
更新日期：2021-01-28 00:00:00
abstract：:We developed a novel integrated technology for diver-operated surveying of shallow marine ecosystems. The HyperDiver system captures rich multifaceted data in each transect: hyperspectral and color imagery, topographic profiles, incident irradiance and water chemistry at a rate of 15-30 m2 per minute. From surveys in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07337-y
更新日期：2017-08-02 00:00:00
abstract：:The phase behaviour of a system composed of amino acid-based surfactant (sodium N-lauroylsarcosinate hydrate), 1-decanol and deionised water was investigated for vesicle formation. Changing the molar ratio of the amphiphiles, two important aggregate structures were observed in the aqueous corner of the phase diagram. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00071
更新日期：2011-01-01 00:00:00
abstract：:The exposure of humans to erionite fibres of appropriate morphology and dimension has been unambiguously linked to the occurrence of Malignant Mesothelioma. For this reason, a detailed morpho-structural investigation through Electron Microscopy techniques has been performed on erionite samples collected at two differe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16757
更新日期：2015-11-16 00:00:00
abstract：:The knowledge of diffusion processes in semiconducting alloys is very important both technologically and from a theoretical point of view. Here we show that, self-diffusion in Si1-x Ge x alloys as a function of temperature and Ge concentration can be described by the cBΩ thermodynamic model. This model connects the ac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01301-6
更新日期：2017-05-02 00:00:00
abstract：:Paeonia ostii, a member of tree peony, is an emerging oil crop with important medical and oil uses and widely cultivated in China. Dissolving the genetic diversity and domestication history of this species is important for further genetic improvements and deployments. We firstly selected 29 simple sequence repeats (SS...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04744-z
更新日期：2017-07-13 00:00:00
abstract：:High salinity frequently causes inhibition and even failure in anaerobic digestion. To explore the impact of increasing NaCl concentrations on biogas production, and reveal the microbial community variations in response to high salinity stress, the Illumina high-throughput sequencing technology was employed. The resul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01298-y
更新日期：2017-04-25 00:00:00
abstract：:Anterior-posterior body axis in all bilaterians is determined by the Hox gene clusters that are activated in a spatio-temporal order. This expression pattern of Hox genes is established and maintained by regulatory mechanisms that involve higher order chromatin structure and Polycomb group (PcG) and trithorax group (t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03011
更新日期：2013-10-22 00:00:00
abstract：:Monoclonal antibodies (mAbs) are attractive therapeutics for treating a wide range of human disorders, and bind to the antigen through their complementarity-determining regions (CDRs). Small stable proteins containing structurally retained CDRs are promising alternatives to mAbs. In this report, we present a method to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57713-4
更新日期：2020-01-21 00:00:00
abstract：:Lactic acid bacteria (LAB) are the common probiotics. Here, we investigated the antiviral protective effects of heat-killed LAB strain Lactobacillus casei DK128 (DK128) on influenza viruses. Intranasal treatment of mice with DK128 conferred protection against different subtypes of influenza viruses by lessening weight...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17487-8
更新日期：2017-12-12 00:00:00
abstract：:The 28,000-year-old remains of a woolly mammoth, named 'Yuka', were found in Siberian permafrost. Here we recovered the less-damaged nucleus-like structures from the remains and visualised their dynamics in living mouse oocytes after nuclear transfer. Proteomic analyses demonstrated the presence of nuclear components ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40546-1
更新日期：2019-03-11 00:00:00
