Abstract：
:Lactic acid bacteria (LAB) are the common probiotics. Here, we investigated the antiviral protective effects of heat-killed LAB strain Lactobacillus casei DK128 (DK128) on influenza viruses. Intranasal treatment of mice with DK128 conferred protection against different subtypes of influenza viruses by lessening weight loss and lowering viral loads. Protection via heat-killed DK128 was correlated with an increase in alveolar macrophage cells in the lungs and airways, early induction of virus specific antibodies, reduced levels of pro-inflammatory cytokines and innate immune cells. Importantly, the mice that were protected against primary viral infection as a result of heat-killed DK128 pretreatment developed subsequent heterosubtypic immunity against secondary virus infection. For protection against influenza virus via heat-killed DK128 pretreatment, B cells and partially CD4 T cells but not CD8 T cells were required as inferred from studies using knockout mouse models. Our study provides insight into how hosts can be equipped with innate and adaptive immunity via heat-killed DK128 treatment to protect against influenza virus, supporting that heat-killed LAB may be developed as anti-virus probiotics.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jung YJ,Lee YT,Ngo VL,Cho YH,Ko EJ,Hong SM,Kim KH,Jang JH,Oh JS,Park MK,Kim CH,Sun J,Kang SMdoi
10.1038/s41598-017-17487-8subject
Has Abstractpub_date
2017-12-12 00:00:00pages
17360issue
1issn
2045-2322pii
10.1038/s41598-017-17487-8journal_volume
7pub_type
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