Virological, immunological and pathological findings of transplacentally transmitted bluetongue virus serotype 1 in IFNAR1-blocked mice during early and mid gestation.

abstract：:Telomerase is a ribonucleoprotein enzyme, which maintains genome integrity in eukaryotes and ensures continuous cellular proliferation. Telomerase holoenzyme from the thermotolerant yeast Hansenula polymorpha, in addition to the catalytic subunit (TERT) and telomerase RNA (TER), contains accessory proteins Est1 and Es...

journal_title：Scientific reports

authors： Shepelev NM,Mariasina SS,Mantsyzov AB,Malyavko AN,Efimov SV,Petrova OA,Rodina EV,Zvereva MI,Dontsova OA,Polshakov VI

更新日期：2020-07-06 00:00:00

abstract：:Zinc oxy-selenide Zn(O,Se) is a novel material, that can replace the toxic CdS buffer layer in thin film solar cells and other optoelectronic devices. In this paper a systematic study of the structural, optical and electrical properties of Zn(O,Se) layers, grown by pulsed laser deposition under 50 mTorr of nitrogen ba...

journal_title：Scientific reports

authors： Abdalla A,Bereznev S,Spalatu N,Volobujeva O,Sleptsuk N,Danilson M

更新日期：2019-11-25 00:00:00

abstract：:Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms. To determine its effects on female reproductive physiology and investigate whether changes in the expression levels of genes related...

journal_title：Scientific reports

authors： Santangeli S,Maradonna F,Gioacchini G,Cobellis G,Piccinetti CC,Dalla Valle L,Carnevali O

更新日期：2016-02-25 00:00:00

abstract：:Epithelial ovarian cancer is a leading cause of death in gynecological cancers. While several systematic studies have revealed the mutation landscape of serous epithelial ovarian cancer, other non-serous subtypes of the disease have not been explored as extensively. Here we conduct exome sequencing of nine non-serous ...

journal_title：Scientific reports

authors： Teer JK,Yoder S,Gjyshi A,Nicosia SV,Zhang C,Monteiro ANA

更新日期：2017-08-29 00:00:00

abstract：:Because of the unique climate characteristics, the runoff law in mid-temperate zone is very different from other regions in spring. Accurate runoff simulation and forecasting is of great importance to spring flood control and efficient use of water resources. Baishan reservoir is located in the upper Second Songhua Ri...

journal_title：Scientific reports

authors： Tian L,Li H,Li F,Li X,Du X,Ye X

更新日期：2018-11-16 00:00:00

abstract：:The study was aimed to evaluate the performance of a newly developed non-invasive and non-contact bilirubin measurement device (AJO-Neo) as an alternative to the conventional invasive biochemical method of total serum bilirubin (TSB) estimation in preterm and term neonates suffering from hyperbilirubinemia associated ...

journal_title：Scientific reports

authors： Halder A,Adhikari A,Ghosh R,Singh S,Banerjee A,Ghosh N,Bhattacharya AM,Mandal S,Chakrabarti P,Bhattacharyya D,Altass HM,Morad M,Ahmed SA,Mallick AK,Pal SK

更新日期：2020-07-07 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) and phosphate solubilizing bacteria (PSB) could interact synergistically because PSB solubilize sparingly available phosphorous compounds into orthophosphate that AMF can absorb and transport to the host plant. Little is known about the interactions between these two groups in terms ...

journal_title：Scientific reports

authors： Nacoon S,Jogloy S,Riddech N,Mongkolthanaruk W,Kuyper TW,Boonlue S

更新日期：2020-03-18 00:00:00

abstract：:The order Chlamydiales are biphasic intracellular bacterial pathogens infecting humans and domesticated animals. Wildlife infections have also been reported, with the most studied example being Chlamydia pecorum infections in the koala, an iconic Australian marsupial. In koalas, molecular evidence suggests that spill-...

journal_title：Scientific reports

authors： Burnard D,Huston WM,Webb JK,Jelocnik M,Reiss A,Gillett A,Fitzgibbon S,Carver S,Carrucan J,Flanagan C,Timms P,Polkinghorne A

更新日期：2017-10-09 00:00:00

abstract：:Unambiguous identification of trace amounts of biochemical molecules in a complex background using terahertz spectroscopy is extremely challenging owing to the extremely small absorption cross sections of these molecules in the terahertz regime. Herein, we numerically propose a terahertz nonresonant nano-slits structu...

journal_title：Scientific reports

authors： Qin J,Cheng W,Han B,Du Y,Han Z,Zhao Z

更新日期：2020-02-28 00:00:00

abstract：:We characterized an anti-cancer fusion protein consisting of anthrax lethal factor (LF) and the catalytic domain of Pseudomonas exotoxin A by (i) mutating the N-terminal amino acids and by (ii) reductive methylation to dimethylate all lysines. Dimethylation of lysines was achieved quantitatively and specifically witho...

journal_title：Scientific reports

authors： Bachran C,Gupta PK,Bachran S,Leysath CE,Hoover B,Fattah RJ,Leppla SH

更新日期：2014-04-23 00:00:00

abstract：:Understanding the phylogeography and genetic structure of populations and the processes responsible of patterns therein is crucial for evaluating the vulnerability of marine species and developing management strategies. In this study, we explore how past climatic events and ongoing oceanographic and demographic proces...

journal_title：Scientific reports

authors： Garcia-Cisneros A,Palacín C,Ben Khadra Y,Pérez-Portela R

更新日期：2016-09-15 00:00:00

abstract：:In this work, we demonstrate an innovative approach, combing a novel active screen plasma (ASP) technique with green chemical synthesis, for a direct fabrication of uniform Pt nanowire arrays on large-area supports. The ASP treatment enables in-situ N-doping and surface modification to the support surface, significant...

journal_title：Scientific reports

authors： Du S,Lin K,Malladi SK,Lu Y,Sun S,Xu Q,Steinberger-Wilckens R,Dong H

更新日期：2014-09-22 00:00:00

abstract：:microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we rep...

journal_title：Scientific reports

authors： Leucci E,Patella F,Waage J,Holmstrøm K,Lindow M,Porse B,Kauppinen S,Lund AH

更新日期：2013-01-01 00:00:00

abstract：:In humans, the H+-coupled Fe2+ transporter DMT1 (SLC11A2) is essential for proper maintenance of iron homeostasis. While X-ray diffraction has recently unveiled the structure of the bacterial homologue ScaDMT as a LeuT-fold transporter, the exact mechanism of H+-cotransport has remained elusive. Here, we used a combin...

journal_title：Scientific reports

authors： Pujol-Giménez J,Hediger MA,Gyimesi G

更新日期：2017-07-28 00:00:00

abstract：:We here investigated whether the unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis depends on their potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response in the interest of tissue repair. Unexpectedly, after injection of MSCs which had been pr...

journal_title：Scientific reports

authors： Basu A,Munir S,Mulaw MA,Singh K,Crisan D,Sindrilaru A,Treiber N,Wlaschek M,Huber-Lang M,Gebhard F,Scharffetter-Kochanek K

更新日期：2018-04-18 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been used for cell-based therapies in regenerative medicine, with increasing importance in central and peripheral nervous system repair. However, MSCs grafting present disadvantages, such as, a high number of cells required for transplantation and low survival rate when transplanted ...

journal_title：Scientific reports

authors： Martins LF,Costa RO,Pedro JR,Aguiar P,Serra SC,Teixeira FG,Sousa N,Salgado AJ,Almeida RD

更新日期：2017-06-23 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are important drug targets with diverse therapeutic applications. However, there are still more than a hundred orphan GPCRs, whose protein functions and biochemical features remain unidentified. Gpr176 encodes a class-A orphan GPCR that has a role in circadian clock regulation in mo...

journal_title：Scientific reports

authors： Wang T,Nakagawa S,Miyake T,Setsu G,Kunisue S,Goto K,Hirasawa A,Okamura H,Yamaguchi Y,Doi M

更新日期：2020-03-10 00:00:00

abstract：:Antagonist pleiotropy, where a gene exerts a beneficial effect at early stages and a deleterious effect later on in an animal's life, may explain the evolutionary persistence of devastating genetic diseases such as Huntington's disease (HD). To date, however, there is little direct experimental evidence to support thi...

journal_title：Scientific reports

authors： Morton AJ,Skillings EA,Wood NI,Zheng Z

更新日期：2019-01-10 00:00:00

abstract：:Laser heating of gold nanospheres (GNS) is increasingly prevalent in biomedical applications due to tunable optical properties that determine heating efficiency. Although many geometric parameters (i.e. size, morphology) can affect optical properties of individual GNS and their heating, no specific studies of how GNS ...

journal_title：Scientific reports

authors： Wang Y,Gao Z,Han Z,Liu Y,Yang H,Akkin T,Hogan CJ,Bischof JC

更新日期：2021-01-13 00:00:00

abstract：:To develop an effective, safe, and convenient vaccine for the prevention of highly pathogenic avian influenza (HPAI) H5N1, we have constructed a recombinant Bacillus subtilis strain (B.S.-HA) expressing the hemagglutinin (HA) protein. Then we evaluated the immune function in chicken bone marrow derived dendritic cells...

journal_title：Scientific reports

authors： Mou C,Zhu L,Yang J,Xu W,Cheng X,Yang Q

更新日期：2016-12-16 00:00:00

abstract：:Birds have a highly specialized and efficient digestive system, but when this system originated remains uncertain. Here we report six gastric pellets attributable to the recently discovered 160-million-year-old troodontid dinosaur Anchiornis, which is among the key taxa for understanding the transition to birds. The g...

journal_title：Scientific reports

authors： Zheng X,Wang X,Sullivan C,Zhang X,Zhang F,Wang Y,Li F,Xu X

更新日期：2018-09-21 00:00:00

abstract：:To study quantitatively replicative senescence as a tumor suppressor mechanism, we investigate the distribution of a growing clonal cell population restricted by Hayflick's limit. We find that in the biologically relevant range of parameters, if the imbalance between cell division and death is moderate or low (high de...

journal_title：Scientific reports

authors： Rodriguez-Brenes IA,Wodarz D,Komarova NL

更新日期：2015-12-09 00:00:00

abstract：:Climate influences vegetation directly and through climate-mediated disturbance processes, such as wildfire. Temperature and area burned are positively associated, conditional on availability of vegetation to burn. Fire is a self-limiting process that is influenced by productivity. Yet, many fire projections assume su...

journal_title：Scientific reports

authors： Hurteau MD,Liang S,Westerling AL,Wiedinmyer C

更新日期：2019-02-26 00:00:00

abstract：:Given the rapidly expanding library of disease biomarkers and targeting agents, the number of unique targeted nanoparticles is growing exponentially. The high variability and expense of animal testing often makes it unfeasible to examine this large number of nanoparticles in vivo. This often leads to the investigation...

journal_title：Scientific reports

authors： Elias A,Crayton SH,Warden-Rothman R,Tsourkas A

更新日期：2014-07-28 00:00:00

abstract：:Ultrasound has significantly increased safety and effectiveness in regional anesthesia. However, little is known about its clinical use. We studied clinical approaches currently used by anesthesiologists, conducted a nationwide survey, and analyzed data collected in ordered logistic regression models. All active membe...

journal_title：Scientific reports

authors： Luedi MM,Upadek V,Vogt AP,Steinfeldt T,Eichenberger U,Sauter AR

更新日期：2019-06-24 00:00:00

abstract：:Objectives were to evaluate the role of canonical WNT signaling in development of the preimplantation embryo. Signaling was activated with 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine (AMBMP) and inhibited with Dickkopf-related protein 1 (DKK1). Treatment of bovine embryos with AMBMP at da...

journal_title：Scientific reports

authors： Denicol AC,Dobbs KB,McLean KM,Carambula SF,Loureiro B,Hansen PJ

更新日期：2013-01-01 00:00:00

abstract：:A novel imaging-driven technique with an integrated fluorescence signature to enable automated enumeration of two species of cyanobacteria and an alga of somewhat similar morphology to one of the cyanobacteria is presented to demonstrate proof-of-concept that high accuracy, imaging-based, rapid water quality analysis ...

journal_title：Scientific reports

authors： Jin C,Mesquita MMF,Deglint JL,Emelko MB,Wong A

更新日期：2018-06-13 00:00:00

abstract：:Human and animal infections of Enterocytozoon bieneusi (E. bieneusi) have consistently been reported worldwide, garnering public attention; however, the molecular epidemiology of E. bieneusi in the giant panda remains limited. We surveyed captive giant pandas in China for the presence of E. bieneusi by using PCR and s...

journal_title：Scientific reports

authors： Li W,Zhong Z,Song Y,Gong C,Deng L,Cao Y,Zhou Z,Cao X,Tian Y,Li H,Feng F,Zhang Y,Wang C,Li C,Yang H,Huang X,Fu H,Geng Y,Ren Z,Wu K,Peng G

更新日期：2018-04-26 00:00:00

abstract：:Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG2 have similar half-lives, yet IgG2 displays lower foetal than matern...

journal_title：Scientific reports

authors： Stapleton NM,Brinkhaus M,Armour KL,Bentlage AEH,de Taeye SW,Temming AR,Mok JY,Brasser G,Maas M,van Esch WJE,Clark MR,Williamson LM,van der Schoot CE,Vidarsson G

更新日期：2019-05-14 00:00:00

abstract：:Oil spills represent an overwhelming carbon input to the marine environment that immediately impacts the sea surface ecosystem. Microbial communities degrading the oil fraction that eventually sinks to the seafloor must also deal with hydrostatic pressure, which linearly increases with depth. Piezosensitive hydrocarbo...

journal_title：Scientific reports

authors： Scoma A,Barbato M,Hernandez-Sanabria E,Mapelli F,Daffonchio D,Borin S,Boon N

更新日期：2016-03-29 00:00:00