Abstract：
:Sorting nexin 27 (SNX27) recycles PSD-95, Dlg1, ZO-1 (PDZ) domain-interacting membrane proteins and is essential to sustain adequate brain functions. Here we define a fundamental SNX27 function in T lymphocytes controlling antigen-induced transcriptional activation and metabolic reprogramming. SNX27 limits the activation of diacylglycerol (DAG)-based signals through its high affinity PDZ-interacting cargo DAG kinase ζ (DGKζ). SNX27 silencing in human T cells enhanced T cell receptor (TCR)-stimulated activator protein 1 (AP-1)- and nuclear factor κB (NF-κB)-mediated transcription. Transcription did not increase upon DGKζ silencing, suggesting that DGKζ function is dependent on SNX27. The enhanced transcriptional activation in SNX27-silenced cells contrasted with defective activation of the mammalian target of rapamycin (mTOR) pathway. The analysis of Snx27 -/- mice supported a role for SNX27 in the control of T cell growth. This study broadens our understanding of SNX27 as an integrator of lipid-based signals with the control of transcription and metabolic pathways.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tello-Lafoz M,Rodríguez-Rodríguez C,Kinna G,Loo LS,Hong W,Collins BM,Teasdale RD,Mérida Idoi
10.1038/s41598-017-16370-wsubject
Has Abstractpub_date
2017-11-27 00:00:00pages
16361issue
1issn
2045-2322pii
10.1038/s41598-017-16370-wjournal_volume
7pub_type
杂志文章abstract：:Structural isomers, molecules having the same chemical formula but with atoms bonded in different order, are hard to identify using conventional spectroscopy and mass spectrometry. They exhibit virtually indistinguishable mass spectra when ionized by electrons. Laser mass spectrometry based on photoionization of the i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22055-9
更新日期：2018-02-28 00:00:00
abstract：:In this study, novel ZnS@In2S3 core@shell hollow nanospheres were fabricated by a facile refluxing method for the first time, and the formation mechanism of hollow structure with interior architecture was discussed based on ion-exchange Ostwald ripening. As the photocatalytic material for degradation of gaseous o-Dich...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16732-4
更新日期：2017-11-27 00:00:00
abstract：:An analysis of Candida albicans ABC transporters identified conserved related α-helical sequence motifs immediately C-terminal of each Walker A sequence. Despite the occurrence of these motifs in ABC subfamilies of other yeasts and higher eukaryotes, their roles in protein function remained unexplored. In this study w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27132
更新日期：2016-06-02 00:00:00
abstract：:Oceanic mesoscale eddies with horizontal scales of 50-300 km are the most energetic form of flows in the ocean. They are the oceanic analogues of atmospheric storms and are effective transporters of heat, nutrients, dissolved carbon, and other biochemical materials in the ocean. Although oceanic eddies have been ubiqu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24349
更新日期：2016-04-14 00:00:00
abstract：:Electrospinning can be used to mimic the architecture of an acellular nerve graft, combining microfibers for guidance, and pores for cellular infiltration. We made electrospun nerve guides, from polycaprolactone (PCL) or poly-L-lactic acid (PLLA), with aligned fibers along the insides of the channels and random fibers...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34699-8
更新日期：2018-11-13 00:00:00
abstract：:Root canal treatment is performed to treat apical periodontitis, and various procedures and techniques are currently used. Although animal models have been used in the developmental research of root canal treatment, little of this research has used small animals such as rats, because of their small size. In this study...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03628-6
更新日期：2017-06-12 00:00:00
abstract：:The relationships between polypeptide composition, sequence, structure and function have been puzzling biologists ever since first protein sequences were determined. Here, we study the statistics of occurrence of all possible pentapeptide sequences in known proteins. To compensate for the non-uniform distribution of i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33433-8
更新日期：2018-10-11 00:00:00
abstract：:Ultrathin transmission metasurface devices are designed on the basis of the Yang-Gu amplitude-phase retrieval algorithm for focusing the terahertz (THz) radiation into four or nine spots with focal spacing of 2 or 3 mm at a frequency of 0.8 THz. The focal properties are experimentally investigated in detail, and the r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28800
更新日期：2016-06-27 00:00:00
abstract：:The metabolic balance of the most extensive bioma on the Earth is a controversial topic of the global-change research. High ultraviolet radiation (UVR) levels by the shoaling of upper mixed layers and increasing atmospheric dust deposition from arid regions may unpredictably alter the metabolic state of marine oligotr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35892
更新日期：2016-10-24 00:00:00
abstract：:Accurate and detailed knowledge of California's groundwater is of paramount importance for statewide water resources planning and management, and to sustain a multi-billion-dollar agriculture industry during prolonged droughts. In this study, we use water supply and demand information from California's Department of W...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31210-1
更新日期：2018-08-27 00:00:00
abstract：:We employed RNA sequencing analysis to reveal dysregulated lncRNAs in lung cancer utilizing 461 lung adenocarcinomas and 156 normal lung tissues from 3 separate cohorts. We found that LINC00152 was highly overexpressed in lung tumors as compared to their adjacent normal tissues. Patients with high LINC00152 expression...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03043-x
更新日期：2017-06-07 00:00:00
abstract：:There is increasing interest in the development of noninvasive diagnostic methods for early cancer detection, to improve the survival rate and quality of life of cancer patients. Identification of volatile metabolic compounds may provide an approach for noninvasive early diagnosis of malignant diseases. Here we analyz...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05196
更新日期：2014-06-06 00:00:00
abstract：:Synchrotron X-ray imaging technique has been used to investigate biofluid flows in a non-destructive manner. This study aims to investigate the feasibility of the X-ray PIV technique with CO2 microbubbles as flow tracer for measurement of pulsatile blood flows under in vivo conditions. The traceability of CO2 microbub...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08840
更新日期：2015-03-06 00:00:00
abstract：:This paper illustrates the potential for seasonal prediction of wind and solar energy resources through a case study in the Yangtze River estuary. Sea surface temperature and geopotential height-based climate predictors, each with high correlation to ensuing seasonal wind speed and solar radiation at the Baoshan weath...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65281-w
更新日期：2020-05-25 00:00:00
abstract：:The MEN1 gene, which encodes the protein Menin, was investigated for its regulatory role in milk protein synthesis in mammary glands. Menin responds to nutrient and hormone levels via the PI3K/Akt/mTOR pathway. Bovine mammary epithelial cells and tissues were used as experimental models in this study. The results reve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06054-w
更新日期：2017-07-14 00:00:00
abstract：:The nutrient ecological stoichiometry of plants and soil is important for the growth and dynamics of species, but the stoichiometric relationships among leaf, litter, and soil remain poorly understood. We analyzed the carbon (C), nitrogen (N), and phosphorus (P) stoichiometry of the leaves, litter, and soil for 31 spe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12199-5
更新日期：2017-09-18 00:00:00
abstract：:Chronic pulmonary inflammation (CPI) gives rise to serious lung injuries in rheumatoid arthritis (RA) patients. However, the molecular mechanism underlying the pathogenesis of RA-associated CPI remains little understood. Here we established a novel tree shrew-based collagen-induced arthritis (TsCIA) model to study RA-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28404-y
更新日期：2018-07-03 00:00:00
abstract：:The response of olfactory receptor neurons to odor mixtures is not well understood. Here, using experimental constraints, we investigate the mathematical structure of the odor response space and its consequences. The analysis suggests that the odor response space is 3-dimensional, and predicts that the dose-response c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24091
更新日期：2016-04-07 00:00:00
abstract：:Insufficient glenoid fixation is one of the main reasons for failure in total shoulder arthroplasty. This is predominantly caused by the inert nature of the ultra-high molecular weight polyethylene (UHMWPE) used in the glenoid component of the implant, which makes it difficult to adhesively bind to bone cement or bone...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22921-6
更新日期：2018-03-16 00:00:00
abstract：:Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants linked to PD in SNCA. However, the consequences of this genetic variabi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54865-w
更新日期：2019-12-05 00:00:00
abstract：:Severe sepsis and septic shock are life-threatening conditions, with Gram-negative organisms responsible for most sepsis mortality. Systemic administration of compounds that block the action of lipopolysaccharide (LPS), a constituent of the Gram-negative outer cell membrane, is hampered by their hydrophobicity and cat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29739
更新日期：2016-07-14 00:00:00
abstract：:Temperature-modulated space-charge-limited-current spectroscopy (TMSCLC) is applied to quantitatively evaluate the density of trap states in the band-gap with high energy resolution of semiconducting hybrid lead halide perovskite single crystals. Interestingly multicomponent deep trap states were observed in the pure ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40139-y
更新日期：2019-03-04 00:00:00
abstract：:We investigate the timescales of the horizontal mass flux decay of wind remobilised volcanic particles in Argentina, associated with the tephra-fallout deposit produced by the 2011-2012 Cordón Caulle (Chile) eruption. Particle removal processes are controlled by complex interactions of meteorological conditions, surfa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71022-w
更新日期：2020-09-02 00:00:00
abstract：:Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, with encoura...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14990-w
更新日期：2017-11-02 00:00:00
abstract：:The corrosion of steel in concrete is mainly due to the chemical reaction between the chloride ions and iron ions. Indeed, this is a serious threaten for reinforced concrete structure, especially for the reinforced concrete structure in the sea. So it is urgent and important to protect concrete against chloride ions c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03359
更新日期：2013-11-28 00:00:00
abstract：:In this study, a rational combination of 200 pre-selected Carbohydrate-Active enzymes (CAZymes) and sulfatases were tested, individually or combined, according to their ability to degrade Chlorella vulgaris cell wall to access its valuable nutritional compounds. The disruption of microalgae cell walls by a four-enzyme...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41775-0
更新日期：2019-03-29 00:00:00
abstract：:Bioerosion is a process with a high socio-economic impact that contributes to coastal retreat, and likely to increase with climate change. Whereas limestone bioerosion is well explained by a combination of mechanical and chemical pathways, the bioerosion mechanisms of silicates, which are harder and chemically more re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70265-x
更新日期：2020-08-07 00:00:00
abstract：:Topical anesthetics are widely applied in order to relieve the discomfort and anxiety caused by needle insertion and other painful superficial interventions at the oral cavity. So far, there are no commercially available effective topical anesthetic formulations for that purpose, and the most of developments are relat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68247-0
更新日期：2020-07-09 00:00:00
abstract：:The cell adhesion molecule Cadherin 2 (Cdh2) plays important roles in somatic cell adhesion, proliferation and migration. Cdh2 is also highly expressed in mouse epiblast stem cells (mEpiSCs), but its function in these cells is unknown. To understand the function of Cdh2 in mEpiSCs, we compared the expression of plurip...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14722
更新日期：2015-09-30 00:00:00
abstract：:Quantitatively determining physiological parameters at a microscopic level in the retina furthers the understanding of the molecular pathways of blinding diseases, such as diabetic retinopathy and glaucoma. An essential parameter, which has yet to be quantified noninvasively, is the retinal oxygen metabolic rate (rMRO...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06525
更新日期：2014-10-06 00:00:00
