Abstract:
:Fibrin glue has been used clinically for decades in a wide variety of surgical specialties and is now being investigated as a medium for local, prolonged drug delivery. Effective local delivery of antibacterial substances is important perioperatively in patients with implanted medical devices or postoperatively for deep wounds. However, prolonged local application of antibiotics is often not possible or simply inadequate. Biofilm formation and antibiotic resistance are also major obstacles to antibacterial therapy. In this paper we test the biocompatibility of bacteriophages incorporated within fibrin glue, track the release of bacteriophages from fibrin scaffolds, and measure the antibacterial activity of released bacteriophages. Fibrin glue polymerized in the presence of the PA5 bacteriophage released high titers of bacteriophages during 11 days of incubation in liquid medium. Released PA5 bacteriophages were effective in killing Pseudomonas aeruginosa PA01. Overall, our results show that fibrin glue can be used for sustained delivery of bacteriophages and this strategy holds promise for many antibacterial applications.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rubalskii E,Ruemke S,Salmoukas C,Aleshkin A,Bochkareva S,Modin E,Mashaqi B,Boyle EC,Boethig D,Rubalsky M,Zulkarneev E,Kuehn C,Haverich Adoi
10.1038/s41598-018-38318-4subject
Has Abstractpub_date
2019-02-14 00:00:00pages
2091issue
1issn
2045-2322pii
10.1038/s41598-018-38318-4journal_volume
9pub_type
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